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  • leaflets
  • Narrowing of the passage through the MITRAL VALVE due to FIBROSIS, and CALCINOSIS in the leaflets and chordal areas. (curehunter.com)
  • Pulmonary valve dysplasia is a distinct pathological entity consisting of markedly thickened, deformed, and largely immobile pulmonary valve leaflets. (biomedsearch.com)
  • Stenosis can also result in insufficiency if thickening of the annulus or leaflets results in inappropriate leaf closure. (wikipedia.org)
  • This defect is characterized by the presence of only two valve leaflets and affects up to 1% of the population, making it one of the most common cardiac abnormalities. (wikipedia.org)
  • Processes that lead to aortic insufficiency usually involve dilation of the valve annulus, thus displacing the valve leaflets, which are anchored in the annulus. (wikipedia.org)
  • The valves incorporate leaflets or cusps, which are pushed open to allow blood flow and which then close together to seal and prevent backflow. (wikipedia.org)
  • The mitral valve is also called the bicuspid valve because it contains two leaflets or cusps. (wikipedia.org)
  • The tricuspid valve has three leaflets or cusps and is on the right side of the heart. (wikipedia.org)
  • The techniques of mitral valve repair include inserting a cloth-covered ring around the valve to bring the leaflets into contact with each other (annuloplasty), removal of redundant/loose segments of the leaflets (quadrangular resection), and re-suspension of the leaflets with artificial (Gore-Tex) cords. (wikipedia.org)
  • The entire Delrin structure was covered with seamless Dacron velour and at a later stage, the margins of the scalloped edges were covered with a thin layer of pericardium in an attempt to prevent or reduce the abrasion of the leaflets when in contact with this margin during valve closure. (wikipedia.org)
  • diastolic
  • This amount of blood is known as the end diastolic volume (EDV), and the mitral valve closes at the end of atrial contraction to prevent a reversal of blood flow. (wikipedia.org)
  • backflow
  • These two arteries receive blood from the ventricles and their semilunar valves permit blood to be forced into the arteries, and prevent backflow from the arteries into the ventricles. (wikipedia.org)
  • surgical
  • Although surgical replacement of the PV is efficacious, artificial valves inevitably fail and require re-intervention. (stanford.edu)
  • Treatment of damaged valves may involve medication alone, but often involves surgical valve repair (valvuloplasty) or replacement (insertion of an artificial heart valve). (wikipedia.org)
  • In the past two decades, some surgeons have embraced surgical techniques to repair the damaged native valve, rather than replace it. (wikipedia.org)
  • The traditional surgical approach to a mitral valve repair is a full or partial sternotomy, in which the surgeon cuts through the breastbone at the center of the chest to access the heart. (wikipedia.org)
  • echocardiography
  • Exercise echocardiography is an underutilized tool in pediatrics with current applications including detecting segmental wall abnormalities, assessing the utility of global ventricular function, and measuring pulmonary hemodynamics. (stanford.edu)
  • ejection
  • Inhalation leads to an increase in intrathoracic negative pressure, which increases the capacity of pulmonary circulation, thereby prolonging ejection time. (wikipedia.org)
  • abnormal
  • Murmurs may also be the result of various problems, such as narrowing or leaking of valves, or the presence of abnormal passages through which blood flows in or near the heart. (wikipedia.org)
  • More often the mitral valve becomes abnormal with age (degenerative) or as a result of rheumatic fever. (wikipedia.org)
  • heart valve
  • Also disclosed is a method of making a bioprosthetic heart valve using biological material that has been treated by controlled autolysis and a method of treating a mammal having a defective heart valve using a bioprosthetic heart valve made, in part, by controlled autolysis. (google.com)
  • 2. The bioprosthetic heart valve of claim 1, wherein the bioprosthetic valve additionally comprises a generally tubular stent having an inflow end and an outflow end, and wherein the at least one leaflet is positioned in relation to the stent such that the reciprocal motion of the at least one leaflet occurs as blood flows from the inflow end of the stent through the outflow end of the stent. (google.com)
  • 3. The bioprosthetic heart valve of claim 2, wherein the stent has a generally circular cross-section. (google.com)
  • 4. The bioprosthetic heart valve of claim 2, wherein the stent has an inner surface and an outer surface and wherein the at least one leaflet is attached to the inner surface. (google.com)
  • 5. The bioprosthetic heart valve of claim 2, wherein the stent comprises non-biological material. (google.com)
  • 6. The bioprosthetic heart valve of claim 1, wherein the at least one region of the biological material that is rendered substantially acellular is substantially all of the leaflet. (google.com)
  • 7. The bioprosthetic heart valve of claim 1, wherein the biological material is porcine. (google.com)
  • 8. The bioprosthetic heart valve of claim 7, wherein the biological material is a leaflet of a heart valve or a fragment of a leaflet of a heart valve. (google.com)
  • 10. The bioprosthetic heart valve of claim 1, wherein the controlled autolysis additionally comprises the step of fixing the biological material after the exposing step. (google.com)
  • 11. The bioprosthetic heart valve of claim 1, wherein the biological material is derived from at least one animal selected from the group consisting of a bovine, a porcine, an ovine, a Macropodidae, a non-human primate, a human and a combination of any of the foregoing. (google.com)
  • 13. The bioprosthetic heart valve of claim 1, wherein the non-cellular structural components include at least one structural component selected from the group consisting of collagen, elastin, laminin, teninsin, actinin, proteoglycans, a fragment of any of the foregoing, and a combination of any of the foregoing. (google.com)
  • The Edwards SAPIEN™ THV is a biological heart valve manufactured with treated bovine pericardial tissue that is mounted into a balloon expandable stainless steel open cell stent. (clinicaltrials.gov)
  • A heart valve normally allows blood to flow in only one direction through the heart. (wikipedia.org)
  • A heart valve opens or closes incumbent on differential blood pressure on each side. (wikipedia.org)
  • In 1923 Dr. Elliott Cutler of the Peter Bent Brigham Hospital performed the world's first successful heart valve surgery - a mitral valve repair. (wikipedia.org)
  • The pericardial heart valve was invented by Marian Ionescu, a British surgeon working at the General Infirmary in Leeds, England. (wikipedia.org)
  • He created this artificial bioprosthetic heart valve as a three-cusp structure made of chemically treated bovine pericardium attached to a Dacron cloth-covered titanium frame. (wikipedia.org)
  • It is flexible and shock absorbent, essential qualities for a tissue heart valve support. (wikipedia.org)