• systemic
  • Clopidogrel in infants with systemic-to-pulmonary-artery shunts. (nih.gov)
  • In a multicenter, double-blind, event-driven trial, we randomly assigned infants 92 days of age or younger with cyanotic congenital heart disease and a systemic-to-pulmonary-artery shunt to receive clopidogrel at a dose of 0.2 mg per kilogram of body weight per day (467 infants) or placebo (439 infants), in addition to conventional therapy (including aspirin in 87.9% of infants). (nih.gov)
  • Clopidogrel therapy in infants with cyanotic congenital heart disease palliated with a systemic-to-pulmonary-artery shunt, most of whom received concomitant aspirin therapy, did not reduce either mortality from any cause or shunt-related morbidity. (nih.gov)
  • 9 In systemic arteries, SPC-induced vasoconstriction is reported to be mediated via pertussis toxin-sensitive G i proteins, inositol triphosphate-induced Ca 2+ release, Rho kinase (RhoK)-mediated Ca 2+ sensitization, and Ca 2+ entry via voltage-dependent L-type channels, 1,2,10 although in some arteries Ca 2+ sensitization may be the major mechanism. (ahajournals.org)
  • ductus
  • Structurally normal heart except for a prominent main pulmonary artery at the level of the origin of the ductus arteriosus. (medhelp.org)
  • Normal Doppler pattern in ductus venosus, normal flow pattern in the umbilical artery (fetal and placental ends), normal flow pattern in the uterine arteries. (medhelp.org)
  • intrapulmonary
  • We examined whether subcontractile concentrations of SPC (≤1 μmol/L) modulated vasoreactivity of rat intrapulmonary arteries using myography and measurement of intracellular [Ca 2+ ]. (ahajournals.org)
  • SPC also potentiated the responses to prostaglandin F 2α and U436619, which activate a 2-aminoethoxydiphenylborane sensitive nonselective cation channel in intrapulmonary arteries. (ahajournals.org)
  • SPC (1 μmol/L) caused translocation of PKCδ to the perinuclear region and cytoskeleton of cultured intrapulmonary artery smooth muscle cells. (ahajournals.org)
  • We present the novel finding that low, subcontractile concentrations of SPC potentiate Ca 2+ entry in intrapulmonary arteries through both voltage-dependent and independent pathways via a receptor-dependent mechanism involving PKCδ. (ahajournals.org)
  • 6,7 In contrast, we reported recently that, in rat small intrapulmonary arteries (IPAs), the SPC-induced elevation of intracellular [Ca 2+ ] is primarily because of activation of a voltage-independent Ca 2+ entry pathway that is insensitive to pertussis toxin and Ca 2+ release from stores. (ahajournals.org)
  • occur
  • This may occur as a result of heart problems such as heart failure, lung or airway disease such as COPD or scleroderma, or thromboembolic disease such as pulmonary embolism or emboli seen in sickle cell anaemia. (wikipedia.org)
  • Pulmonary complications occur in up to 50% of patients. (wikipedia.org)
  • lumen
  • This line was initiated in January, 1979 by P. Del Vecchio from artery lumen scrapings dispersed by enzyme treatment. (atcc.org)
  • core temp, Systolic, diastolic, central venous pressure CVP (measured from the atrium by the third lumen simultaneously) and pulmonary artery pressure are input, a comprehensive flow vs pressure map can be calculated. (wikipedia.org)
  • blood
  • interlobar artery - inferior and larger branch, supplies blood to the middle and inferior lobes of the lung. (wikipedia.org)
  • There have also been reports of hardening of the vessels around the band due to buildup of calcium deposits and scarring of the pulmonary artery wall beneath the band, which can also inhibit blood flow. (wikipedia.org)
  • Erosion of the band through the pulmonary artery has been reported, which can lead to the formation of blood clots. (wikipedia.org)