Mupirocin is chemically a carboxylic acid. (wikipedia.org)
In E. coli IleS, a single amino acid mutation was shown to alter mupirocin resistance. (wikipedia.org)
Pseudomonic acid inhibits isoleucine-tRNA ligase in bacteria, leading to depletion of isoleucyl-tRNA and accumulation of the corresponding uncharged tRNA. (wikipedia.org)
Mupirocin is a mixture of several pseudomonic acids, with pseudomonic acid A (PA-A) constituting greater than 90% of the mixture. (wikipedia.org)
Also present in mupirocin are pseudomonic acid B with an additional hydroxyl group at C8, pseudomonic acid C with a double bond between C10 and C11, instead of the epoxide of PA-A, and pseudomonic acid D with a double bond at C4` and C5` in the 9-hydroxy-nonanoic acid portion of mupirocin. (wikipedia.org)
Its final phase involves removal of the tertiary hydroxyl group from pseudomonic acid B, PA-B, producing the fully active PA-A in a complex series of steps. (birmingham.ac.uk)
Mupirocin, formerly termed pseudomonic acid A, is a novel antibacterial agent with a unique chemical structure and mode of action apart from other antibiotic agents. (drugbank.com)
Of the commonly used agents, mupirocin (pseudomonic acid) ointment has been shown to be 97% effective in reducing S aureus nasal carriage. (johnshopkins.edu)
It is also called pseudomonic acid thanks to its major metabolite, derived from submerged fermentation of Pseudomonas fluorescens (a common Gram-negative, rod-shaped bacterium). (healthguidenet.com)
Most strains of Pseudomonas fluorescens are also resistant to mupirocin as they produce the antibiotic and it's possible other species of Pseudomonas may be resistant as well. (wikipedia.org)
Produced by fermentation using the organism Pseudomonas fluorescens, mupirocin is a naturally-occurring antibiotic that displays a broad-specturm activity against many gram-positive bacteria and certain gram-negative. (drugbank.com)
Antibacterial1
Mupirocin is an antibacterial used topically as an ointment or cream on the skin to treat impetigo and skin infections caused by Staphylococcus aureus and Streptococcus pyogenes. (e-lactancia.org)
Gentamicin1
We screened the Nebraska Transposon Mutant Library of 1920 single-gene inactivations in S. aureus strain JE2, for increased susceptibility to the anti-staphylococcal antimicrobials (ciprofloxacin, oxacillin, linezolid, fosfomycin, daptomycin, mupirocin, vancomycin, and gentamicin). (frontiersin.org)
Intranasal1
Intranasal mupirocin before surgery is effective for prevention of post-operative wound infection with Staphylcoccus aureus and preventative intranasal or catheter-site treatment is effective for reducing the risk of catheter site infection in persons treated with chronic peritoneal dialysis. (wikipedia.org)
Aureus5
Mupirocin is used as a topical treatment for bacterial skin infections (for example, boils, impetigo, or open wounds), which are typically due to infection by Staphylococcus aureus or Streptococcus pyogenes. (wikipedia.org)
Two distinct populations of mupirocin-resistant S. aureus were isolated. (wikipedia.org)
4% of S aureus nasal carriers who received mupirocin acquired S aureus health care-related infections compared with 7.7% of S aureus nasal carriers who received placebo (P = .02). (johnshopkins.edu)
The S aureus surgical-site infection rate was not reduced significantly, but carriers who received mupirocin before cardiothoracic or general surgery operations had almost 50% fewer S aureus surgical-site infections than carriers who received placebo. (johnshopkins.edu)
Antibiotic3
Mupirocin, sold under the brand name Bactroban among others, is a topical antibiotic useful against superficial skin infections such as impetigo or folliculitis. (wikipedia.org)
Mupirocin is not a viable antibiotic against MuH strains. (wikipedia.org)
The mupirocin trans-AT polyketide synthase pathway, provides a model system for manipulation of antibiotic biosynthesis. (birmingham.ac.uk)
Most strains of Cutibacterium acnes, a causative agent in the skin disease acne vulgaris, are naturally resistant to mupirocin. (wikipedia.org)
Infections1
Mupirocin is active against the organisms responsible for the majority of skin infections, e.g. (healthguidenet.com)
Antibiotics1
citation needed] The mechanism of action of mupirocin differs from other clinical antibiotics, rendering cross-resistance to other antibiotics unlikely. (wikipedia.org)
Resistant2
A plasmid expressing mupLMNOPVCFU+macpE together with a derivative of the producer P. fluorescens strain NCIMB10586 lacking the mup cluster allowed conversion of PA-B to PA-A . MupN converts apo-mAcpE to holo-form while MupM is a mupirocin-resistant isoleucyl tRNA synthase, preventing self-poisoning. (birmingham.ac.uk)
All MRSA isolates were vancomycin-susceptible and more than 68% of MRSA isolates with SCC mec type IIIA were mupirocin resistant. (biomedcentral.com)
One infant whose mother was treated for mastitis with mupirocin at the breast twice daily (in addition to intravenous teicoplanin and ceftriaxone) did not present any problems. (e-lactancia.org)
Works1
Mupirocin is mainly efficacious against Gram-positive aerobes and works by binding to bacterial isoleucyl transfer RNA synthetase. (healthguidenet.com)