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  • Fanconi
  • pRTA also has several causes, and may occasionally be present as a solitary defect, but is usually associated with a more generalized dysfunction of the proximal tubular cells called Fanconi syndrome, in which there is also phosphaturia, glycosuria, aminoaciduria, uricosuria, and tubular proteinuria. (wikipedia.org)
  • epithelial
  • In the absence of HNF1β early nephron precursors gave rise to deformed S-shaped bodies characterized by the absence of the typical bulge of epithelial cells at the bend between the mid and lower segments. (biologists.org)
  • We showed previously that amiloride, an inhibitor of the epithelial Na channel in distal nephron, significantly lowered blood pressure in whites when compared with blacks, consistent with less Na uptake by the epithelial Na channel in blacks, probably because of lower aldosterone levels. (ahajournals.org)
  • The luminal surface of the epithelial cells of this segment of the nephron is covered with densely packed microvilli forming a border readily visible under the light microscope giving the brush border cell its name. (wikipedia.org)
  • Cuboidal epithelial cells lining the proximal tubule have extensive lateral interdigitations between neighboring cells, which lend an appearance of having no discrete cell margins when viewed with a light microscope. (wikipedia.org)
  • segments
  • Here we show that inactivation of Hnf1b in the murine metanephric mesenchyme leads to a drastic tubular defect characterized by the absence of proximal, distal and Henle's loop segments. (biologists.org)
  • The data of Chun et al, 8 therefore, provide additional evidence that alterations of renal sodium in the loop of Henle segments of the nephron might have some role in the development of hypertension, particularly in black hypertensive subjects. (ahajournals.org)
  • duct
  • In both amphibians and zebrafish the pronephros has a single nephron attached to a nephric duct, which in turn is linked to the cloaca. (wikipedia.org)
  • While this transient primordium never forms functional nephrons, the duct derived from it is essential to the development of the more complex later kidneys. (wikipedia.org)
  • filtrate
  • Nevertheless, it is at the proximal tubular level where the bulk of water, salts, and nonelectrolytes are normally retrieved from the filtrate. (springer.com)
  • It is a paired organ, consisting of a single giant nephron that processes blood filtrate produced from glomeruli or glomera- large embryonic glomeruli. (wikipedia.org)
  • kidneys
  • Although these kidneys have a simple anatomical organization with only a single nephron, the nephrons have a segmental and functional complexity that is very similar to that in more complex kidneys such as mesonephroi and metanephroi. (wikipedia.org)
  • Calcitriol is produced in the cells of the proximal tubule of the nephron in the kidneys by the action of 25-hydroxyvitamin D3 1-alpha-hydroxylase, a mitochondrial oxygenase and an enzyme which catalyzes the hydroxylation of 25-hydroxycholecalciferol (calcifediol) in the 1-alpha position. (wikipedia.org)
  • molecules
  • Protein molecules that pass through the glomerular pores are either absorbed unchanged (such as albumin), degraded in the proximal tubular cells and absorbed (such as free light chains), or excreted as fragments. (wikipedia.org)
  • glomeruli
  • Nephron morphogenesis is a complex process that generates blood-filtration units (glomeruli) connected to extremely long and patterned tubular structures. (biologists.org)
  • Nephrons were eventually characterized by glomeruli, with a dilated urinary space, directly connected to collecting ducts via a primitive and short tubule. (biologists.org)
  • site
  • The fact that abnormal sodium handling in cirrhosis has been localised predominantly to the proximal nephron, 4 a site of angiotensin II action, supports this contention. (bmj.com)
  • small
  • Sodium-dependent glucose cotransporters (or sodium-glucose linked transporter, SGLT) are a family of glucose transporter found in the intestinal mucosa (enterocytes) of the small intestine (SGLT1) and the proximal tubule of the nephron (SGLT2 in PCT and SGLT1 in PST). (wikipedia.org)
  • Transport
  • The unique importance of this transport operation derives from the fact that this active, energy-consuming transport process provides the main driving force for transepithelial water movement/ 12 ) Thus, the maintenance of an adequate and constant extracellular fluid and plasma volume depends crucially on the integrity of the proximal tubular Na+ transport system. (springer.com)