OrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and Processes
MyoglobinWhalesMetmyoglobinMyoglobinuriaHemeHorsesCetaceaSperm WhaleCarbon MonoxideRhabdomyolysisPhotolysisSpectrophotometryCreatine KinaseHemeproteinsHemoglobinsSpectrum Analysis, RamanOxygenLeghemoglobinElephantsProtein ConformationHistidineBromotrichloromethaneSeals, EarlessSpectrum AnalysisCarboxyhemoglobinApoproteinsClinical Enzyme TestsLigandsKineticsSpectrophotometry, InfraredHeminElectron Spin Resonance SpectroscopyIronMagnetic Resonance SpectroscopyOxidation-Reduction
AntibodiesStructure of myoglobinOrientation of myoglobinDetermination of myoglobinConcentrations of myoglobinAcute myocardialTroponinProtein myoglobinReleased into the bloodstreamMusclesMyocardialBiomarkerSerumPigments responsibleUrineHemeCrystallographyTissueProteinsFerricKidneysBloodstreamPorphyrinCytoplasmicPeroxidasesGeneAminoMolecular weightOxygen attachedAbstractOxidationHumanTissuesMoleculesHemoglobinDiffusionStructuralMyocytesTestAccuratelyStudy
Antibodies8
  • Thus, there is a greater emphasis on detection methods using myoglobin antibodies and reagents, which, in turn, are propelling the growth of the market. (technavio.com)
  • However, there are high requirements for the proper storage and handling of myoglobin antibodies and serum specimens. (technavio.com)
  • Myoglobin antibodies need to be stored in proper conditions. (technavio.com)
  • For instance, myoglobin antibodies are stable for several weeks at 4 degrees C in an undiluted liquid form. (technavio.com)
  • In immunohistochemistry of normal tissue, myoglobin antibodies are positive in striated cardiac and skeletal muscle. (lsbio.com)
  • We use six monoclonal antibodies that target different myoglobin epitopes. (tue.nl)
  • Using information on the affinities of these antibodies to myoglobin in solution, we can determine the myoglobin orientation on the surface by studying the binding of the different antibodies using total internal reflection fluorescence microscopy. (tue.nl)
  • Development and application of antibodies to human cardiac myoglobin in rapid fluorescence Immunoassay. (siemens-healthineers.com)
Structure of myoglobin1
  • In 1958, John Kendrew and associates successfully determined the structure of myoglobin by high-resolution X-ray crystallography . (bionity.com)
Orientation of myoglobin1
  • The focus of this poster is on determining the orientation of myoglobin on the polystyrene surface. (tue.nl)
Determination of myoglobin3
  • Capillary zone electrophoresis was employed for the determination of myoglobin in human urine using end-column amperometric detection with a carbon fiber microelectrode at a constant potential of 1.80 V vs. saturated calomel electrode (SCF). (unboundmedicine.com)
  • The method can be used for the determination of myoglobin in human urine. (unboundmedicine.com)
  • The determination of myoglobin levels in animal and human serum can be performed by collecting serum specimens and conducting diagnostic tests with the aid of myoglobin test kits. (technavio.com)
Concentrations of myoglobin3
  • High concentrations of myoglobin in muscle cells allow organisms to hold their breath for a longer period of time. (wikipedia.org)
  • Myoglobin is released from damaged muscle tissue (rhabdomyolysis), which has very high concentrations of myoglobin. (wikipedia.org)
  • Serum concentrations of myoglobin have been proposed as a surrogate marker of muscle mass and function in both cachectic cancer patients and healthy non-cancer individuals. (nottingham.ac.uk)
Acute myocardial5
  • However, elevated myoglobin has low specificity for acute myocardial infarction (AMI) and thus CK-MB, cardiac troponin, ECG, and clinical signs should be taken into account to make the diagnosis. (wikipedia.org)
  • Unfortunately, myoglobin is not cardiac specific, being also found in skeletal muscle , and thus is less useful in the diagnosis of acute myocardial infarction unless used in conjunction with other markets. (online-sciences.com)
  • To evaluate the value of cardiac troponin(cTn), myoglobin(Myo) combined with heart-type fatty acid-binding protein(H-FABP) detection in the diagnosis of early acute myocardial infarction(AMI). (org.pk)
  • Sun J, Liu X, Xing X, Yang Y, Xuan H, Fu B. Value of Cardiac Troponin, Myoglobin Combined with Heart-type Fatty Acid-binding Protein Detection in Diagnosis of Early Acute Myocardial Infarction. (org.pk)
  • Do not test for myoglobin or creatine kinase-MB in the diagnosis of acute myocardial infarction . (medscape.com)
Troponin2
  • Myoglobin is also commonly used in combination with troponin proteins-which are needed for the contraction of cardiac and skeletal muscles as a marker for myocardial damage in heart attacks. (technavio.com)
  • This study was conducted to investigate the effect of cold water immersion applied after exercise on cardiac troponin T and myoglobin levels. (gazi.edu.tr)
Protein myoglobin3
  • The myoglobin blood test measures the level of the protein myoglobin in the blood. (medlineplus.gov)
  • In this work we report the results of a broadband dielectric spectroscopy study on the dynamics of a globular protein, myoglobin, in confined geometry, i.e. encapsulated in a porous silica matrix, at low hydration levels, where about only one or two water layers surround the proteins. (unipa.it)
  • The O2-storage protein myoglobin (Mb) is known to be expressed in myocytes of diving mammals in much larger quantities than those of land mammals. (elsevierpure.com)
Released into the bloodstream2
  • When muscle is damaged, myoglobin in muscle cells is released into the bloodstream. (medlineplus.gov)
  • Myoglobin is released into the bloodstream of humans when their skeletal muscles are injured as a result of trauma, ischemia, and myopathy. (technavio.com)
Muscles11
  • Diving mammals such as whales and seals have muscles with particularly high abundance of myoglobin. (wikipedia.org)
  • Myoglobin is a protein in heart and skeletal muscles. (medlineplus.gov)
  • Myoglobin has oxygen attached to it, which provides extra oxygen for the muscles to keep at a high level of activity for a longer period. (medlineplus.gov)
  • Myoglobin levels in cardiac muscles increase measurably above the baseline within two to four hours post-myocardial infarction. (technavio.com)
  • The work builds on a previous paper published in Science (2013) on ferric myoglobins, the protein in our blood that carries oxygen within muscles. (nccr-must.ch)
  • In the study discussed here, Chergui's lab looked at a more biologically relevant class of heme proteins, the ferrous myoglobins, which carry oxygen to muscles. (nccr-must.ch)
  • myoglobin is a red colour pigment found in muscles. (youth4work.com)
  • These researchers theorize that all that exercise leads to the production of a necessary oxygen storing protein called "myoglobin" in the whales' muscles. (bigislandwhalewatch.com)
  • As oxygen supply in muscles is assured by myoglobin, we propose to study some characteristic of this muscle protein in green sea turtles. (ui.ac.id)
  • Myoglobin is an oxygen storage molecule that is selectively expressed in cardiac and slow-twitch skeletal muscles that have a high oxygen demand. (elsevierpure.com)
  • In the human body, iron is present in all cells and has several vital functions -- as a carrier of oxygen to the tissues from the lungs in the form of hemoglobin (Hb), as a facilitator of oxygen use and storage in the muscles as myoglobin, as a transport medium for electrons within the cells in the form of cytochromes, and as an integral part of enzyme reactions in various tissues. (cdc.gov)
Myocardial9
  • Various research studies suggest that measuring myoglobin levels as a diagnostic aid for ruling out myocardial infarction can better predict a potential heart attack after the onset of symptoms. (technavio.com)
  • Myoglobin is considered one of the first biomarkers of myocardial damage and is usually measured after the onset of myocardial infarction. (technavio.com)
  • offers myoglobin assays for the accurate diagnosis of myocardial infarction. (technavio.com)
  • Such availability of myoglobin instruments that enable timely and accurate evaluation of patients suffering from myocardial infarction will augment the growth of the market during the forecast period. (technavio.com)
  • Myoglobin is released from recently injured myocardial cells within a few hours of Infarction. (bbisolutions.com)
  • Myoglobin measurements can be used as an aid in diagnosing myocardial infarction. (siemens-healthineers.com)
  • Following myocadial necrosis associated with myocardial infarction (MI), myoglobin is one of the first markers to rise above normal levels, increasing measurably above baseline within 2-4 hours post-infarct, peaking at 9-12 hours, and returning to baseline within 24-36 hours. (siemens-healthineers.com)
  • 3,4 A number of reports suggest the measurement of myoglobin as a diagnostic aid in "ruling-out" myocardial infarction with negative predictive values of up to 100% reported at certain time periods after onset of symptoms. (siemens-healthineers.com)
  • Rapid diagnosis of myocardial infarction by immunoturbidimetric myoglobin measurement (letter). (siemens-healthineers.com)
Biomarker3
  • The usage of myoglobin as a biomarker for the diagnosis of ACS and muscle injuries is notably driving the myoglobin market growth, although factors such as the requirement of proper storage and handling conditions may impede the market growth. (technavio.com)
  • The usage of myoglobin as a biomarker for the diagnosis of ACS and muscle injuries is one of the key drivers supporting the myoglobin market growth. (technavio.com)
  • Damaged muscle releases large amounts of myoglobin, and it is a useful and sensitive biomarker for muscle injury and heart attacks. (lsbio.com)
Serum2
  • Age-matched groups had similar serum myoglobin and creatinine concentrations in spite of differences in their aerobic capacity. (nottingham.ac.uk)
  • Serum myoglobin is a poor predictor of muscle mass, and serum myoglobin and creatinine concentrations do not predict aerobic performance in CRC patients or healthy matched controls. (nottingham.ac.uk)
Pigments responsible2
  • Myoglobin contains hemes, pigments responsible for the colour of red meat. (wikipedia.org)
  • Myoglobin forms pigments responsible for making meat red. (bionity.com)
Urine4
  • It is not the myoglobin itself that is toxic (it is a protoxin), but the ferrihemate portion that is dissociated from myoglobin in acidic environments (e.g., acidic urine, lysosomes). (wikipedia.org)
  • Myoglobin can also be measured with a urine test . (medlineplus.gov)
  • The kidneys help remove myoglobin from the blood into the urine. (medlineplus.gov)
  • These reagents are used to determine myoglobin levels in the blood and urine samples of patients. (technavio.com)
Heme5
  • Myoglobin consists of non-polar amino acids at the core of the globulin, where the heme group is non-covalently bounded with the surrounding polypeptide of myoglobin. (wikipedia.org)
  • Like hemoglobin, myoglobin is a cytoplasmic protein that binds oxygen on a heme group. (wikipedia.org)
  • Myoglobin is a single-chain globular protein of 153 amino acids , containing a heme ( iron -containing porphyrin ) prosthetic group in the center around which the remaining apoprotein folds. (bionity.com)
  • Environment of the Heme in Myoglobins. (caltech.edu)
  • Analyses of the temperature dependences and shapes of nuclear magnetic relaxation dispersion (NMRD) signals of site-directed mutants of human myoglobin indicate that a water molecule is bound to the sixth coordination site of the ferric heme in proteins in which the valine at position 68 is changed to either aspartate (Val68Asp) or asparagine (Val68Asn). (caltech.edu)
Crystallography1
  • Myoglobin was the first protein to have its three-dimensional structure revealed by X-ray crystallography. (wikipedia.org)
Tissue5
  • Myoglobin (symbol Mb or MB) is an iron- and oxygen-binding protein found in the cardiac and skeletal muscle tissue of vertebrates in general and in almost all mammals. (wikipedia.org)
  • Instead, the binding of oxygen by myoglobin is unaffected by the oxygen pressure in the surrounding tissue. (bionity.com)
  • This preparation of Goat anti-Myoglobin was made by immunizing goats with purified Myoglobin from human cardiac tissue. (scrippslabs.com)
  • The other 15% is in the myoglobin of muscle tissue. (cdc.gov)
  • Physical activity in hot conditions causes breakdown of skeletal muscle tissue, releasing chemicals such as myoglobin that harm the kidneys' internal structures. (cdc.gov)
Proteins3
  • Despite being one of the most studied proteins in biology, its physiological function is not yet conclusively established: mice genetically engineered to lack myoglobin can be viable and fertile, but show many cellular and physiological adaptations to overcome the loss. (wikipedia.org)
  • Myoglobin belongs to the globin superfamily of proteins, and as with other globins, consists of eight alpha helices connected by loops. (wikipedia.org)
  • SDS-PAGE analysis showed that green sea turtle myoglobin ran together with horse myoglobin as 17 kDa molecular weight proteins. (ui.ac.id)
Ferric1
Kidneys2
  • The released myoglobin is filtered by the kidneys, but is toxic to the renal tubular epithelium and so may cause acute kidney injury. (wikipedia.org)
  • When the level of myoglobin is too high, it can damage the kidneys. (medlineplus.gov)
Bloodstream1
Porphyrin1
Cytoplasmic1
  • Myoglobin (MYO) is a small cytoplasmic oxygen-binding protein located in the skeletal and cardiac muscle. (sekbio.com)
Peroxidases2
Gene3
  • In humans, myoglobin is encoded by the MB gene. (wikipedia.org)
  • In vitro and in vivo studies revealed that hypoxia in the presence or absence of exercise-induced stimuli reprograms calcium signaling and modulates myoglobin gene expression. (elsevierpure.com)
  • The present study unveils a previously unrecognized mechanism where the hypoxia-mediated regulation of calcium transients from different intracellular pools modulates myoglobin gene expression. (elsevierpure.com)
Amino1
Molecular weight1
Oxygen attached1
Abstract1
  • abstract = "Simultaneous immobilization of myoglobin protein (Mb) and synthetic porphyrins was conducted by using synthetic bilayer membrane composed of a phosphate-bearing amphiphile. (elsevierpure.com)
Oxidation3
  • The colour that meat takes is partly determined by the degree of oxidation of the myoglobin. (wikipedia.org)
  • Hydrogen peroxide-dependent oxidation of indole producing indigo has been catalyzed by engineered myoglobins (Mbs). (rsc.org)
  • As a model system we study the adsorption of myoglobin on polystyrene surfaces with well-defined oxidation states. (tue.nl)
Human3
  • Recombinant protein encompassing a sequence within the center region of human Myoglobin. (lsbio.com)
  • Protective effect of thymoquinone on glycation of human myoglobin induced by d-ribose. (bvsalud.org)
  • This study explores the interaction between d-ribose and human myoglobin (HMb), as well as the protective effect of thymoquinone (TQ) on glycation . (bvsalud.org)
Tissues1
  • Myoglobin is a small haeme-containing protein of 17.5KDa that imparts the red colour to meat and is the primary oxygen-carrying protein of muscle tissues. (bbisolutions.com)
Molecules1
  • In future we will quantify the interaction of single oriented myoglobin molecules with the surface using magnetic tweezers. (tue.nl)
Hemoglobin3
  • Myoglobin is distantly related to hemoglobin. (wikipedia.org)
  • Compared to hemoglobin, myoglobin has a higher affinity for oxygen and does not have cooperative binding with oxygen like hemoglobin does. (wikipedia.org)
  • Myoglobin can take the forms oxymyoglobin (MbO2), carboxymyoglobin (MbCO), and metmyoglobin (met-Mb), analogously to hemoglobin taking the forms oxyhemoglobin (HbO2), carboxyhemoglobin (HbCO), and methemoglobin (met-Hb). (wikipedia.org)
Diffusion1
  • Myoglobin (MB) is an iron- and oxygen-binding haemoprotein of the globin superfamily that contributes to intracellular oxygen storage and transcellular facilitated diffusion of oxygen. (lsbio.com)
Structural1
  • Photolysis-induced structural changes in single crystals of carbonmonoxy myoglobin at 40 K. Nat.Struct.Biol. (expasy.org)
Myocytes1
  • Myoglobin (Mb) is highly concentrated in the myocytes of diving animals, in comparison with those of land animals, and is thought to play a crucial role in their adaptation as the molecular aqualung. (rcsb.org)
Test2
  • Our study aimed to test the hypothesis that plasma myoglobin and creatinine concentration could accurately predict skeletal muscle mass and aerobic capacity in colorectal cancer (CRC) patients and matched healthy controls and thereby an indicative of aerobic performance. (nottingham.ac.uk)
  • The Acute Care™ myoglobin assay is an in vitro diagnostic test for the measurement of myoglobin in heparinized whole blood /plasma. (siemens-healthineers.com)
Accurately1
Study1
  • In the present study, adult mice exposed to 10% oxygen for periods up to 3 wk exhibited increased myoglobin expression only in the working heart, whereas myoglobin was either diminished or unchanged in skeletal muscle groups. (elsevierpure.com)