• Complemented by in vitro binding studies, our data provide several atomic resolution features of SARS-CoV-2 nucleocapsid protein N-terminal domain, guiding the design of novel antiviral agents specific targeting to SARS-CoV-2. (rcsb.org)
  • Pradimicin-S (PRM-S), a small-size non-peptidic CBA, exerted antiviral activity in MDDC but not in Raji/DC-SIGN(+) cells. (unboundmedicine.com)
  • Since molecules with direct-acting antiviral (DAA) became available, the landscape of the treatment of hepatitis C virus (HCV) infection has completely changed. (wjgnet.com)
  • There were no studies of direct acting antiviral therapy and effect on patient or graft survival after kidney transplantation. (wjgnet.com)
  • This simplified national HCV clearance cascade identifies substantial gaps in cure nearly a decade since highly effective direct-acting antiviral (DAA) agents became available and will facilitate the process of monitoring progress toward national elimination goals. (medscape.com)
  • The CBAs exerted broad spectrum antiviral activity against the four DENV serotypes, laboratory-adapted viruses and low passage clinical isolates, evaluated in Raji/DC-SIGN(+) cells and in primary MDDC. (unboundmedicine.com)
  • Lianhua Qingwen (连花清瘟), which is obtained by the reduction and addition of combined Maxing Shigan decoction and Yin Qiao powder, has been widely accepted as a broad-spectrum antiviral agent in the clinic [ 6 ]. (hindawi.com)
  • The conclusion of the panel was that it would be appropriate, and possibly essential, to develop antiviral drugs for PV infection, as an additional tool to address the problems that might arise in the "postpolio" era ( 6 ). (cdc.gov)
  • GRFT can inhibit human immunodeficiency virus (HIV) infection at picomolar concentrations, surpassing the ability of most anti-HIV agents. (mdpi.com)
  • Currently, the only approved antiviral treatment for the infection is remdesivir, which can shorten recovery time for some people hospitalized with COVID-19. (medicalnewstoday.com)
  • A potential contributing factor for the declining incidence of AD could be the introduction of antiviral drugs against herpesviruses, at least in the subset of the population with HSV infection. (biomedcentral.com)
  • NHANES testing for markers of infection with hepatitis viruses will be used to determine secular trends in infection rates across most age and racial/ethnic groups, and will provide a national picture of the epidemiologic determinants of these infections. (cdc.gov)
  • A four-fold rise in the level of neutralizing antibody in blood specimens collected during the acute and convalescent phases of illness can provide evidence of recent infection. (canada.ca)
  • No specific antiviral agent is available for therapy or prophylaxis of EV 71 infection. (canada.ca)
  • HBV infection is considered the most important causative agent of HCC, with approximately 240 million people infected worldwide, especially in the Asia-Pacific and African regions [ 6 , 7 , 8 ]. (biomedcentral.com)
  • In cases where TEM technology is not available, serological tests are available to identify camelpox as the causative agent for infection. (wikipedia.org)
  • An 8-12 week short-course of well-tolerated, oral-only treatment with DAA agents is recommended for nearly all persons with HCV infection [ 5 ] and results in a cure in ≥95% of cases. (medscape.com)
  • We evaluated various carbohydrate-binding agents (CBAs) against all four described serotypes of DENV replication in Raji/DC-SIGN(+) cells and in monocyte-derived DC (MDDC). (unboundmedicine.com)
  • Previous studies have demonstrated that viral RNA helicases represent promising pharmacological targets for antiviral drugs/inhibitors, as they are implicated in viral replication and proliferation. (spandidos-publications.com)
  • Being a promising antiviral target, helicase inhibition leads to the pause of the replication, proliferation and consequently, to the survival and transmission of Flaviviridae viruses ( 3 ). (spandidos-publications.com)
  • It is a first-in-class oral small antiviral molecule which blocks HIV replication through a unique mechanism of action and, separately, also has a strong anti-inflammatory effect. (evotec.com)
  • An in vitro study that appears in the journal Redox Biology now provides the first direct evidence that nitric oxide also inhibits the replication of SARS-CoV-2. (medicalnewstoday.com)
  • These agents are designed to target specific components or processes involved in viral replication and entry into host cells. (researchpeptides.net)
  • These mechanisms highlight the diverse ways in which peptide-based agents can disrupt viral replication and reduce viral load within infected individuals. (researchpeptides.net)
  • Unlike other antimicrobials, antiviral drugs do not deactivate or destroy the microbe (in this case, the virus ) but act by inhibiting replication. (amboss.com)
  • Most antiviral agents target key enzymes required for viral replication (see " Viral life cycle " for details). (amboss.com)
  • 1 Although many of these infections are self-limiting, patients would benefit greatly from antiviral treatment, because it would reduce the significant morbidity that results in lost time from school and work and would limit the spread of these very contagious infections within households and communities. (arvojournals.org)
  • 1 At present, there is no U.S. Food and Drug Administration (FDA)-approved antiviral agent for the treatment of these infections. (arvojournals.org)
  • By testing a nationally representative sample of the U.S. population, NHANES will provide the most reliable estimates of age-specific prevalence needed to evaluate the effectiveness of the strategies to prevent these infections. (cdc.gov)
  • For hospital-acquired infections, next-generation sequencing is proving to be an invaluable tool for identifying and investigating outbreaks and also provides a better understanding of transmission at both the hospital and the community level. (cdc.gov)
  • Antiviral drugs with activity against viral DNA synthesis have been effective against HSV infections. (medscape.com)
  • Peptide-based agents have emerged as a promising approach for the treatment of viral infections. (researchpeptides.net)
  • 4. Modulation of host immune response: Some peptides can enhance the host immune response against viral infections by stimulating the production of antiviral cytokines or activating immune cells. (researchpeptides.net)
  • By targeting specific steps in the viral life cycle, these agents offer a unique approach to managing viral infections. (researchpeptides.net)
  • Antivirals are a class of medications that are used to treat viral infections. (amboss.com)
  • Currently, antiviral therapy is available only for a limited number of infections. (amboss.com)
  • Most of the antiviral drugs currently available are used to treat infections caused by HIV , herpes viruses , hepatitis B and C viruses , and influenza A and B viruses . (amboss.com)
  • These recommendations extensively revise previous influenza vaccine recommendations of the Immunization Practices Advisory Committee (ACIP) (superseding MMWR 1983;32:333-7) and provide information on the vaccine and antiviral agent available for control of influenza in the 1984-1985 influenza season and on target groups for which special influenza control programs are recommended. (cdc.gov)
  • This report updates the 2004 recommendations by the Advisory Committee on Immunization Practices (ACIP) regarding the use of influenza vaccine and antiviral agents (CDC. (cdc.gov)
  • The main goal of the regional strategy is to provide adequate, appropriate and timely technical support to all countries of the Region to enable them detect and respond efficiently to an influenza pandemic. (who.int)
  • Adding an antiviral agent to corticosteroids for treatment of Bell's palsy (a condition characterized by partial facial paralysis) is not associated with improved recovery of facial movement function, according to a meta-analysis of previously published studies in the June issue of Archives of Otolaryngology-Head & Neck Surgery . (news-medical.net)
  • Current treatment choices for Bell's palsy include corticosteroids, antiviral therapy or a combination of the two. (news-medical.net)
  • However, based on the currently available evidence, the addition of an antiviral agent to corticosteroids for the treatment of patients with Bell's palsy is not justified. (news-medical.net)
  • This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. (doctordanger.com)
  • Currently, there are no targeted therapeutic agents for the treatment of this disease, and effective treatment options remain very limited. (nature.com)
  • Their treatment included the first use of antiviral agents in patients with monkeypox. (royalfree.nhs.uk)
  • Its lead candidate is an antiviral treatment for smallpox. (wraltechwire.com)
  • Liver specialists at Sutter Solano Medical Center provide evaluations, treatment and access to clinical trials. (sutterhealth.org)
  • These attributes enhance the delivery of multiple therapeutic agents directly to the tumor microenvironment (TME), resulting in reversal of LC resistance to anticancer treatment. (preprints.org)
  • Table 1 provides the recommended DAKLINZA-containing treatment regimens and duration based on HCV genotype and patient population. (rxlist.com)
  • This early increase in disease incidence highlights the importance of optimizing respiratory virus prevention and treatment measures, including prompt vaccination and antiviral treatment, as outlined below. (cdc.gov)
  • The purine analogues cladribine and pentostatin are first-line agents in the treatment of HCL. (medscape.com)
  • A panel convoked by the National Research Council concluded that the use of antiviral drugs may be essential in the polio eradication strategy. (cdc.gov)
  • Therefore, research initiatives leading to the successful development of anti-PV drugs will have to rely on the current knowledge of existing picornavirus antiviral agents. (cdc.gov)
  • Antipicornavirus compounds that reached clinical trials are scarce, and despite the fact that some of these drugs have demonstrated activity against certain picornavirus-associated conditions in humans, no specific antipicornavirus agent has yet been approved by the US Food and Drug Administration (FDA) ( 8 ). (cdc.gov)
  • Data of antiviral drugs for the entire Swedish population were compiled from two different nationwide databases: the Swedish Prescribed Drug Register and the Swedish Association of the Pharmaceutical Industry. (biomedcentral.com)
  • 001), while the total annual use of antiviral drugs in Sweden gradually increased from 1984 to 2017. (biomedcentral.com)
  • To facilitate the rapid discovery of antiviral compounds with clinical potential, we developed a strategy that combines structure-assisted drug design, virtual drug screening and high-throughput screening to repurpose existing drugs to target SARS-CoV-2 M pro . (nature.com)
  • A new class of oral drugs can inhibit a wide range of SARS-CoV-2 variants, researchers report, potentially identifying new antiviral agents providing broad activity against the constantly emerging new strains of the COVID-19 virus. (newswise.com)
  • Kadoch's work on mSWI/SNF complexes over the years has led to experimental drugs currently in phase 1 trials as anti-cancer agents. (newswise.com)
  • Antiviral drugs that target the CCP virus, particularly ones that are safe and can be "easily manufactured and distributed globally," can fill the role in treating COVID-19 outside of a hospital setting. (theepochtimes.com)
  • Unlike traditional antiviral drugs, which often target viral enzymes or proteins, peptide-based agents utilize short chains of amino acids to disrupt viral mechanisms. (researchpeptides.net)
  • 4. Resistance development: While resistance to traditional antiviral drugs can emerge over time, peptide-based agents have shown a lower propensity for resistance development. (researchpeptides.net)
  • This training describes the proper disposal methods for Chemotherapeutic agents and drugs listed by the EPA as hazardous waste. (hopkinsmedicine.org)
  • The Secretariat also acknowledges that it is not possible to predict how long the research on antiviral drugs will take. (who.int)
  • NendoU is a promising target for the development of new antiviral drugs. (lu.se)
  • Generally, after SARS-CoV-2 infects the epithelial cells of the respiratory tract, antiviral and proinflammatory cytokines are released. (news-medical.net)
  • The antiviral agent cidofovir, a nucleoside analogue that inhibits adenovirus DNA polymerase, 2 was successfully tested through phase II clinical trials for this indication. (arvojournals.org)
  • Progress has also been achieved in the development of antiviral agents, and cidofovir and its analogues continue to be most promising compounds. (who.int)
  • The goal of therapy for postherpetic neuralgia (PHN) is to reduce morbidity through the use of tricyclic antidepressants, anticonvulsants, anesthetics, analgesics, corticosteroids, and antiviral agents. (medscape.com)
  • To determine whether N -chlorotaurine (NCT) demonstrates antiviral activity against adenovirus (Ad) in vitro and in the Ad5/NZW rabbit ocular model. (arvojournals.org)
  • NCT demonstrated antiviral activity against adenovirus in vitro and in vivo. (arvojournals.org)
  • Substantial antiviral activity was observed in ca. 20%, which is higher than might be expected given the limited metabolic differences between viruses and their hosts. (umn.edu)
  • The frequent antiviral activity may represent phytoalexins elaborated to protect against plant viruses. (umn.edu)
  • In addition, NHANES provides the means to better define the epidemiology of other hepatitis viruses. (cdc.gov)
  • The need for more broadly acting agents against new and drug-resistant viruses is great. (newswise.com)
  • These sequence data provide a highly granular view of viral emergence and allow for a more parsimonious selection of viruses for phenotypic characterization, including antigenic analysis and susceptibility to antiviral agents. (cdc.gov)
  • 1. Effectiveness: Peptide-based agents have demonstrated efficacy against a wide range of viruses, including drug-resistant strains. (researchpeptides.net)
  • 3. Broad-spectrum activity: Unlike many conventional antivirals that are specific to a particular virus or family of viruses, peptide-based agents can be designed to have broad-spectrum activity. (researchpeptides.net)
  • ABIVAX's antiviral platform is based on its technology of inhibition mRNA biogenesis and its chemical library of more than one thousand small molecules. (evotec.com)
  • Anatomical Therapeutic Chemical (ATC) codes J05AB (J05A direct- acting antivirals: subgroup J05AB nucleosides and nucleotides excl. (biomedcentral.com)
  • To do this ABIVAX leverages three technology platforms for drug discovery: antiviral, immune enhancing and polyclonal antibodies. (evotec.com)
  • Example: Synthetic peptides known as Toll-like receptor agonists can activate immune cells and promote antiviral responses. (researchpeptides.net)
  • Our understanding of antiviral immune responses is still fragmentary and based to a great extent on experimental studies with inbred mouse lines. (helmholtz-hzi.de)
  • 2000 IU/mL who underwent hepatectomy at Zhongnan Hospital of Wuhan University between March 2013 and December 2017, of whom 157 patients received antiviral therapy (antiviral group) and 139 patients did not receive antiviral therapy (non-antiviral group), propensity score matching was used for survival analysis of patients in both groups, and subgroup analysis of major risk factors was performed. (biomedcentral.com)
  • 130 IU/L, and the presence of satellite nodules, and subgroup analysis showed that compared to HBeAg-positive patients, antiviral therapy could significantly prolonged the recurrence-free survival of HBeAg-negative patients. (biomedcentral.com)
  • Sutter care centers have a comprehensive liver disease research program that provides our patients access to many clinical trials focused on new therapies, devices and antiviral agents in the areas of viral hepatitis, liver cancer, gastroenterology and liver transplantation. (sutterhealth.org)
  • Antiviral therapy has been shown to benefit long-term survival after curative hepatectomy in patients with hepatitis B virus (HBV)-associated hepatocellular carcinoma (HCC) with high levels of HBV-DNA, but the impact of antiviral therapy on patient recurrence in patients with low levels of HBV-DNA remains less clear. (biomedcentral.com)
  • These restrictions really came to light when highly effective and curative agents, known as direct-acting antivirals (DAAs), were introduced to treat Hepatitis C nearly a decade ago. (nvhr.org)
  • [ 6 ] A national program to eliminate hepatitis C in the United States was proposed earlier this year [ 7 ] to provide an opportunity to accelerate national efforts toward eliminating hepatitis C. The Viral Hepatitis National Strategic Plan for the United States calls for ≥80% of persons with hepatitis C to achieve viral clearance by 2030. (medscape.com)
  • Overall, there are relatively few data regarding the effectiveness of antiviral therapy after curative hepatectomy for HCC, especially in patients with HBV-associated HCC with low levels of HBV-DNA, and it is still not well known whether antiviral therapy is effective in preventing recurrence of metastasis after curative hepatectomy in patients. (biomedcentral.com)
  • Overall, our findings provide insights into the complex structure and function of NendoU and offer new opportunities for the development of inhibitors. (lu.se)
  • Sutter's nationally recognized Center for Liver Disease Management and Transplantation serves as a collaborative hub for liver disease care and research, providing access to internationally known liver specialists and investigational therapies. (sutterhealth.org)
  • We have very limited understanding of the underlying mechanisms for differential individual responses to the same viral agents, vaccines and antiviral therapies in humans. (helmholtz-hzi.de)
  • These findings suggest that antiviral therapy may have a positive impact on reducing recurrence in patients with HBV-associated hepatocellular carcinoma. (biomedcentral.com)
  • The pharmaceutical products provided by us are processed with utmost care from quality assured chemical compounds and the latest machines as per the industry set standards. (doctordanger.com)
  • One of these compounds (ebselen) also exhibited promising antiviral activity in cell-based assays. (nature.com)
  • When the camelpox virus is identified as the causative agent, the disease can be treated with anti-viral medications. (wikipedia.org)
  • Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of coronavirus disease 2019 (COVID-19). (lu.se)
  • The aim of this editorial is to provide a succinct informative overview to guide respiratory healthcare professionals on the frontline. (ersjournals.com)
  • The goal of antivirals is to shorten the clinical course, prevent complications, prevent the development of latency and/or subsequent recurrences, decrease transmission, and eliminate established latency. (medscape.com)
  • The aim of antiviral therapy is to minimize symptoms and infectivity as well as to shorten the duration of illness. (amboss.com)
  • This statement discusses the presently available medical-control measures, immunoprophylaxis with vaccines, and prophylaxis or therapy with the antiviral drug, amantadine. (cdc.gov)
  • The annual prevalence of antiviral use between 1984 and 2017 were extracted from two nation-wide databases-the Swedish Prescribed Drug Register (SPDR) and the Swedish Association of the Pharmaceutical Industry (LIF). (biomedcentral.com)
  • Only weak antiviral activity of the CBAs was detected when administered after the virus attachment step. (unboundmedicine.com)
  • Griffithsin's antiviral activity stems from its ability to bind terminal mannoses present in high-mannose oligosaccharides and crosslink these glycans on the surface of the viral envelope glycoproteins. (mdpi.com)
  • An improved plaque reduction assay for antiviral activity was developed and used to examine extracts from sixty-one higher plants. (umn.edu)
  • Our aim was to describe the annual prevalence of herpes simplex virus (HSV) reactivation in relation to solar ultraviolet (UV) radiation and antiviral drug use in the Swedish adult population. (biomedcentral.com)
  • A panel was convened by the National Research Council to evaluate the potential for an antiviral drug as one of the tools to minimize poliomyelitis risk after OPV cessation. (cdc.gov)
  • We operate worldwide providing the highest quality stand-alone and integrated drug discovery solutions, covering all activities from target-to-clinic to meet the industry's need for innovation and efficiency in drug discovery (EVT Execute). (evotec.com)
  • The declining time trend of HSV reactivation in a Swedish cohort coincides with a steady increase of antiviral drug use in the Swedish general population. (biomedcentral.com)
  • In the last three to four months, emerging publications provide conclusive data on the profound efficacy of the anti-parasite, anti-viral drug, anti-inflammatory agent called ivermectin in all stages of the disease," Kory said. (theepochtimes.com)
  • However, some studies have also shown no difference in prognosis of HBV-associated HCC patients with antiviral drug therapy [ 20 , 21 ]. (biomedcentral.com)
  • To this end, we conducted a retrospective study to assess the effect of antiviral drug therapy on recurrence and survival after hepatectomy in patients with HBV-associated HCC with low levels of HBV-DNA. (biomedcentral.com)
  • Our Daklinza (daclatasvir) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. (rxlist.com)
  • ABX464, its most advanced compound, is currently in Phase 2 clinical trials for providing a sustained remission for patients with HIV/AIDS. (evotec.com)
  • A Feature Paper should be a substantial original Article that involves several techniques or approaches, provides an outlook for future research directions and describes possible research applications. (mdpi.com)
  • Thus, macrophages not only inhibit viral dissemination but can sense infected cells and infectious viral particles to subsequently elicit antiviral and proinflammatory programs. (news-medical.net)
  • It is usually well tolerated and provides good coverage of most infectious agents, but it is not effective against Mycoplasma and Legionella species. (medscape.com)
  • There is a great need for effective antivirals against SARS-CoV-2 in the ongoing COVID-19 pandemic. (medicalnewstoday.com)
  • To date, no antiviral agent has shown to be effective in treating the disease [ 2 ]. (ersjournals.com)
  • So she and her students did the experiments and found that embelin was very effective as an anti-viral agent. (vassar.edu)
  • Evans, CH, Hooks, JJ & Detrick, B 1991, ' Leukoregulin: A new biotherapeutic cytokine in the search for more effective anti-viral pharmacologic agents ', Military medicine , vol. 156, no. 4, pp. 155-159. (johnshopkins.edu)
  • Acyclovir (Zovirax) provides initial, recurrent, and suppressive therapy for genital HSV. (medscape.com)
  • Researchers in Australia investigated the cell type that can effectively sense SARS-CoV-2 and trigger the release of antiviral and inflammatory cytokine mediators. (news-medical.net)
  • A small clinical study suggests that inhaled nitric oxide at low concentrations not only works as a vasodilator for SARS patients - improving oxygenation of their blood - but also as an antiviral agent. (medicalnewstoday.com)
  • In addition to antiviral effects, previous research suggests that it boosts the amount of oxygen in the blood by dilating blood vessels in parts of the lung where airflow is highest. (medicalnewstoday.com)
  • Additional well-designed randomized controlled trials are needed to assess the potential value of antiviral addition to the recovery of facial palsy with more confidence. (news-medical.net)
  • The existing pharmacophoric model was tested for its application to the Spondweni helicase model as a potential inhibitor of its functionality and potential future use in design experiments of novel anti‑SPONV agents. (spandidos-publications.com)
  • While she was here, I gave her a sample of this compound (embelin) to study as a potential anti-viral agent against the herpes simplex virus because we thought it would behave as a good inhibitor. (vassar.edu)
  • This approach enables the accurate detection of all known potential human parasitic agents present in a blood sample with a single test. (cdc.gov)
  • Peptide-based anti-viral agents exert their effects through various mechanisms depending on the specific target virus. (researchpeptides.net)
  • 2. Safety profile: Peptide-based agents generally exhibit favorable safety profiles, with minimal off-target effects compared to traditional antivirals. (researchpeptides.net)
  • HCV-specific information and prevention messages should be provided to infected patients by health care professionals who are knowledgeable about HCV transmission. (aafp.org)
  • The researchers are yet to prove that the gas has antiviral effects when inhaled, so they now plan to conduct further research in animal models of COVID-19. (medicalnewstoday.com)
  • Peptide-based anti-viral agents offer several advantages over conventional treatments. (researchpeptides.net)
  • However, ongoing research efforts are focused on addressing these limitations and optimizing the efficacy and safety profiles of peptide-based anti-viral agents. (researchpeptides.net)
  • This agent inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins. (medscape.com)
  • This agent inhibits bacterial protein synthesis by binding with the 30S and, possibly, the 50S ribosomal subunit(s). (medscape.com)
  • The possible modulation of the components of nanomedicine, their surface functionalization, and encapsulation of various active therapeutics provide promising tools to bypass crucial biological barriers. (preprints.org)
  • and 3) there have been significant advances in the development of antiviral agents with improved efficacy against HCV. (cdc.gov)
  • And it was the travel ban triggered by the pandemic itself, Rossi said, that provided the four scientists with the opportunity to conduct their research. (vassar.edu)