• vitro
  • Here, we report on the identification and functional characterization of the protein phosphatase Pgam5 in vitro and in vivo in Xenopus . (biologists.org)
  • The preclinical agent, KTN0182A, is an anti-KIT, pyrrolobenzodiazepine (PBD)-containing antibody-drug conjugate which shows anti-tumor activity in vitro and in vivo against a range of tumor types. (wikipedia.org)
  • binds
  • The latter is phosphorylated by Csk, which inhibits Lck because the protein folds up and binds its own SH2 domain. (wikipedia.org)
  • interaction
  • CD4 is an accessory protein for MHC class-II antigen/T-cell receptor interaction. (githubusercontent.com)
  • Region of homology to semaphorins (Sema domain), which includes the full α-chain and the N-terminal part of the β-chain Cysteine-rich MET-related sequence (MRS domain) Glycine-proline-rich repeats (G-P repeats) Four immunoglobulin-like structures (Ig domains), a typical protein-protein interaction region. (wikipedia.org)
  • bind
  • All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. (wikipedia.org)
  • murine
  • Goat anti_Mouse IgG Coated white stripwell plate mus musculus murine Goat anti_Mouse IgG Coated white stripwell plate detects proteins from variouse species most likely human. (antibody-antibodies.com)
  • fusion protein
  • The Bcr-Abl oncoprotein oligomerisation domain found at the N-terminus of BCR is essential for the oncogenicity of the BCR-ABL fusion protein. (wikipedia.org)
  • transmembrane
  • It is composed of an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic protein-tyrosine phosphatase domains. (githubusercontent.com)
  • Lck then phosphorylates and activates ZAP-70, which in turn phosphorylates another molecule in the signaling cascade called LAT (short for Linker of Activated T cells), a transmembrane protein that serves as a docking site for a number of other proteins, the most important of which are Shc-Grb2-SOS, PI3K, and phospholipase C (PLC). (wikipedia.org)
  • mammalian
  • Three mammalian homologues have been characterized, which all differ in their ability to function as adaptor proteins due to the differing lengths of their C-terminal UBA domains: c-Cbl: ubiquitously expressed, 906 and 913 amino acids in length in humans and mice respectively Cbl-b: ubiquitously expressed, 982 amino acids long. (wikipedia.org)
  • Recombinant
  • Human BRAK protein CXCL14 Human Recombinant produced in E.coli is a single, non-glycosylated, polypeptide chain containing 88 amino acids and having a molecular mass of 10.66 kDa. (antibody-antibodies.com)
  • cellular
  • It deals with the structure and function of cellular components such as proteins, carbohydrates, lipids, nucleic acids and other biomolecules. (wikipedia.org)
  • HGFR
  • c-Met, also known as hepatocyte growth factor receptor (HGFR), RCCP2, scatter factor (SF) receptor, and AUTS9, is a heterodimeric protein composed of one alpha and one beta subunit. (clontech.com)
  • The c-Met (HGFR) assay can be used to measure soluble human c-Met protein in serum, EDTA plasma, or cell culture supernatants. (clontech.com)
  • These products are affinity-purified IgG antibodies that recognize human c-Met (HGFR) protein. (clontech.com)
  • domain
  • All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. (wikipedia.org)
  • human
  • GENTAUR suppliers human normal cells, cell lines, RNA extracts and lots of antibodies and ELISA kits to Human proteins as well as GRAP2, 1_330aa, Human, His tag, E.coli. (antibody-antibodies.com)
  • Human GRB7 is located on the long arm of chromosome 17, next to the ERBB2 (alias HER2/neu) proto-oncogene. (wikipedia.org)
  • cell
  • The N-terminal tail of Lck is myristoylated and palmitoylated, which tethers the protein to the plasma membrane of the cell. (wikipedia.org)
  • Two cytokines that down modulate FLT3 activity (& block FLT3-induced hematopoietic activity) are: TNF-Alpha (Tumor necrosis factor-alpha) TGF-Beta (Transforming growth factor-beta) TGF-Beta especially, decreases FLT3 protein levels and reverses the FLT3L-induced decrease in the time that hematopoietic progenitors spend in the G1-phase of the cell cycle. (wikipedia.org)
  • domains
  • Following MET activation, transphosphorylation occurs on Tyr 1234 and Tyr 1235 C-terminal region contains two crucial tyrosines (Tyr 1349 and Tyr 1356), which are inserted into the multisubstrate docking site, capable of recruiting downstream adapter proteins with Src homology-2 (SH2) domains. (wikipedia.org)
  • transcription
  • BAG3 is able to stimulate the expression of cytoskeleton proteins in response to mechanical tension by activating the transcription regulators YAP1 and WWTR1. (wikipedia.org)
  • The protein encoded by TAL1 is a basic helix-loop-helix transcription factor. (wikipedia.org)