• factor
  • The three most common hereditary defects (found in a substantial proportion of patients presenting with venous thrombosis) include activated protein C resistance caused by replacement of Arg506 by Gln in the factor V gene (factor V Leiden), a prothrombin polymorphism (G20210A) that causes elevated plasma prothrombin levels, and hyperhomocysteinemia. (wordpress.com)
  • Tissue factor (TF) is a transmembrane cell surface glycoprotein of 45 to 50 kDa that forms a complex with activated factor VII, initiating blood coagulation and leading to the focal production of thrombin via the successive activation of factor IX, factor X, and prothrombin. (ahajournals.org)
  • Factor V Leiden (FVL) mutation and prothrombin 20210 (PT 20210) mutation tests are two tests often used together to help diagnose the cause of inappropriate blood clot (thrombus) formation, including deep vein thrombosis (DVT) and/or venous thromboembolism (VTE). (labtestsonline.org)
  • Factor V and prothrombin are two coagulation factors essential for proper blood clot formation. (labtestsonline.org)