• antithrombin
  • Apixaban was added to plasma from healthy subjects in the concentration range 0-1000 μg L(-1) , and analyses were performed with different reagents for activated partial thromboplastin time (APTT), prothrombin time (PT), antithrombin, protein C, and protein S. A lupus anticoagulant assay and an APTT assay with varying phospholipid concentrations were used to study the phospholipid dependence. (diva-portal.org)
  • Anticoagulants are widely used for the prevention and treatment of venous and arterial thrombosis.Factor Xa is highly protected from antithrombin-fondaparinux and antithrombin-enoxaparin when incorporated into the prothrombinase complex.However, two large, international, phase III, clinical trials with edoxaban are underway.Beyond heparin and warfarin: the new generation of anticoagulants. (valleystamp.com)
  • venous
  • Suspicion of factor V Leiden being the cause for any thrombotic event should be considered in any Caucasian patient below the age of 45, or in any person with a family history of venous thrombosis. (wikipedia.org)
  • thrombotic
  • C.A.C.P. Professor and Chair of Pharmacy.Conjunctive enhancement of enzymatic thrombolysis and prevention of thrombotic reocclusion with the selective factor Xa inhibitor, tick anticoagulant peptide. (valleystamp.com)
  • blood
  • Factor V Leiden (rs6025) is a variant (mutated form) of human factor V (one of several substances that helps blood clot), which causes an increase in blood clotting (hypercoagulability). (wikipedia.org)
  • With this mutation, the anticoagulant protein secreted (which normally inhibits the pro-clotting activity of factor V) is not able to bind normally to Factor V, leading to a hypercoagulable state, i.e., an increased tendency for the patient to form abnormal and potentially harmful blood clots. (wikipedia.org)
  • In both methods, the time it takes for blood to clot is decreased in the presence of the factor V Leiden mutation. (wikipedia.org)
  • The risk of developing a clot in a blood vessel depends on whether a person inherits one or two copies of the factor V Leiden mutation. (wikipedia.org)