Proteoglycan tissue inhibitor of metalloproteinase 2. Medical search. Frequent questions

The molecular changes characterising OA include the differential expression of matrix proteins, proteoglycans, collagens, metalloproteinases and their inhibitors in both cartilage and bone. (biomedcentral.com)
Genes of interest included collagens type 1 (COL1A1) and 3 (COL3A1), α2 smooth muscle actin (ACTA2), proteoglycan-4 (PRG4), matrix metalloproteinases 3, 9 and 13 (MMP3, MMP9 and MMP13), tissue inhibitor of metalloproteinase-1 (TIMP1) and aggrecanase-1 (ADAMTS4). (chapman.edu)
It can decrease progerin synthesis, increase proteoglycan production and contract collagens, therefore it can reduce wrinkles and increase firmness of the tissue. (creative-peptides.com)
A family of structurally related collagens that form the characteristic collagen fibril bundles seen in CONNECTIVE TISSUE. (lookformedical.com)
This growth factor also stimulates production of collagens, proteoglycans, elastin, fibronectin, tenascin and thrombospondin, diminishes production of extracellularly active neutral endoproteinases belonging to the matrix metalloproteinase (MMP) and serine proteinase families, and stimulates production of endogenous MMP inhibitors (tissue inhibitor of metallo-proteinase [TIMP]) and serpins (plasminogen activator inhibitor-1). (biomedcentral.com)
Background An intact composition of extracellular matrix (ECM) collagens, proteoglycans and elastic fibres are responsible for the constitutional strength of tendons and ligaments [1, 2]. (micrornaassay.com)
The main components of the aortic valve ECM are collagens, elastin, and proteoglycans (PGs) [8]. (oatext.com)

Osteoarthritis (OA) is a pathological change of a diarthrodial articulation characterised by the deterioration of articular cartilage, osteophytosis, bone remodelling, mineralisation in the periarticular tissues and a low grade non-purulent inflammation [ 1 ]. (biomedcentral.com)
The development of clefts, the loss of proteoglycan, changes in cellularity and the loss of tidemark integrity of articular cartilage of OA joints are features which characterise the disease [ 10 ] and which can be used to grade its severity. (biomedcentral.com)
It is also produced in the horse's body, and functions as a component of proteoglycans, which make up articular cartilage. (hygain.com.au)
Although ADAMTS8 is known as a proteoglycanase as a result, its just reported substrate is normally aggrecan, the predominant proteoglycan in articular cartilage (17). (acp2018.org)
Monosodium iodoacetate (MIA) is an inhibitor of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) that results in a reduction of glycolysis and causes articular cartilage changes related to the histological and morphological features of OA by impeding integration of the chondral structure and inducing cell death of chondrocytes [ 15 ]. (biomedcentral.com)
An ex vivo study showed that IGF-1 in fetal bovine serum was responsible for maintaining articular cartilage proteoglycan synthesis. (biomedcentral.com)

The HX repeats of some matrixins bind tissue inhibitor of metallopeptidases (TIMPs). (wikipedia.org)
It is suggested that the hemopexin domain facilitates binding to a variety of molecules and proteins, for example the HX repeats of some matrixins bind tissue inhibitor of metallopeptidases (TIMPs). (wikipedia.org)
Furthermore, in the previous studies, the excessive ECM production in keloidsisrelated to an increase or decrease of matrix metalloproteinases (MMP-1, -2, -3, -9, -13) and an increase of tissue inhibitor of metalloproteinases (TIMPs) [ 9 - 11 ]. (e-aaps.org)
Under normal physiological conditions, the proteolytic activity of the MMPs is controlled primarily at any of the following three known stages: transcription, activation of the zymogens, and inhibition of the active forms by various tissue inhibitors of MMPs (TIMPs). (periobasics.com)
Fibroblasts produce TIMPs (1-4), which were previously called human fibroblast collagenase inhibitors. (biomedcentral.com)
Post-translationally, ADAMTS proteases are governed by tissues inhibitors of metalloproteinases (TIMPs), connections with cell-associated glycosaminoglycans, and endocytic clearance by low-density lipoprotein receptor-related proteins 1 (LRP1) (18). (acp2018.org)
It might have an important polymorphic association at the promoter regions of several MMPs such as MMP-1 (-1607 1G/2G), MMP-2 (-1306 C/T), MMP-3 (-1171 5A/6A), MMP-9 (-1562 C/T) and TIMP-2 (-418 G/C or C/C). Tissue inhibitors of metalloproteinases (TIMPs) are naturally occurring inhibitors of MMPs, which inhibit the activity of MMPs and control the breakdown of ECM. (biomedcentral.com)
Tissue inhibitors of matrix metallo-proteinases (TIMPs) are known to have the ability to inhibit the catalytic activity of MMPs. (biomedcentral.com)
Turpeenniemi-Hujanen et al suggested that the expressions of matrix expression of MMPs as well as their tissue inhibitors the TIMPs are associated with the clinical behaviour in head and neck malignancy [ 12 ]. (biomedcentral.com)

A non-fibrillar collagen that forms a network of MICROFIBRILS within the EXTRACELLULAR MATRIX of CONNECTIVE TISSUE. (lookformedical.com)
This classification was based on the notion that "collagen" was equivalent to "connective tissue", but with the present recognition of the different types of collagen and the aggregates derived from them as distinct entities, the term "collagen diseases" now pertains exclusively to those inherited conditions in which the primary defect is at the gene level and affects collagen biosynthesis, post-translational modification, or extracellular processing directly. (lookformedical.com)
Connective tissue cells which secrete an extracellular matrix rich in collagen and other macromolecules. (lookformedical.com)
In addition, nuclear factor κB (NF‑κB), c‑Jun N‑terminal kinase (JNK), extracellular signal‑regulated kinases and p38 mitogen‑activated protein kinase inhibitors and TNF‑α were used to determine the molecular mechanism of autophagy during the inflammatory conditions, and only the NF‑κB and JNK inhibitor were found to enhance the autophagy of rat NP cells. (spandidos-publications.com)
Relying upon a delicate balance between matrix synthesis and degradation, the extracellular matrix (ECM), including collagen and proteoglycans, undergoes a process of remodeling in normal IVDs. (spandidos-publications.com)
The matrix metalloproteinases (MMPs) are a family of structurally and functionally related endoproteinases that are collectively capable of degrading most of the components of the extracellular matrix (ECM) 1, 2 . (periobasics.com)
2 Physiologically, these enzymes participate in tissue remodelling 3-5 and, pathologically, they cause disruption or disintegration of extracellular matrices. (bmj.com)
Free glycosaminoglycans (GAGs) and proteoglycan- (PG-) containing GAGs, key effectors of cell surface, pericellular and extracellular microenvironments, perform multiple functions in cancer by virtue of their coded structure and their ability to interact with both ligands and receptors that regulate cancer growth [ 1 - 4 ]. (hindawi.com)
Matrix metalloproteinase-7 (MMP-7) facilitates degradation of the extracellular matrix, promoting the invasion of tumour cells, and is associated with cancer progression and metastasis. (jcancer.org)
Extracellular matrix (ECM) is a dynamic tissue that contributes to organ integrity and function, and its regulation of cell phenotype is a major aspect of cell biology. (atsjournals.org)

Chondrocyte metabolism is affected, leading to an increased production of enzymes, which includes metalloproteinases (eg, collagenase, stromelysin) that destroy the cartilage matrix. (medscape.com)
Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). (wikipedia.org)
Trifluoroacetyl Tripeptide-2 (Sequence: TFA-Val-Try-Val-OH) is a synthetic tripeptide, designed as a matrix metalloproteinase and an elastase inhibitor. (creative-peptides.com)
The in vitro studies were conducted to assess the effects of trifluoroacetyl-tripeptide-2 (TT2) on ECM protection, on the synthesis of proteoglycans in cell-matrix interactions, and on the synthesis of progerin in mature human normal fibroblasts, a protein recently identified as a co-inducer of cellular senescence. (creative-peptides.com)
The Effects of Botulinum Toxin A on Collagen Synthesis, Expression of MMP (matrix metalloproteinases)-1,2,9 and TIMP (tissue inhibitors of metalloproteinase)-1 in the Keloid Fibroblasts. (e-aaps.org)
Keloids are characterized by excessive extracelluar matrix (ECM) deposition such as collagen, fibronectin, elastin, and proteoglycans in the dermis. (e-aaps.org)
To investigate the therapeutic effect of BTXA on the keloids, we evaluated the mRNA expression of collagen type I, type III, MMP (matrix metalloproteinases)-1, and TIMP (tissue inhibitor of metalloproteinases)-1 on keloid fibroblasts (KFs, n=5) after administration of BTXA. (e-aaps.org)
A non-vascular form of connective tissue composed of CHONDROCYTES embedded in a matrix that includes CHONDROITIN SULFATE and various types of FIBRILLAR COLLAGEN. (lookformedical.com)
However, in degenerative IVDs the net increase of matrix-degrading proteinase activity disrupts the normal balance and leads to the breakdown of ECM ( 2 ). (spandidos-publications.com)
While not directly degrading the IVD, TNF-α and IL-1β act indirectly by promoting the production of degradative enzymes, such as matrix metalloproteinase (MMP) and a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) ( 5 - 7 ). (spandidos-publications.com)
Matrix metalloproteinase (MMP)-1, MMP13, and tissue inhibitor of metalloproteinase 1 release were measured by specific enzyme linked immunosorbent assays (ELISAs), and collagenolytic activity was measured by a bioassay using radiolabelled collagen. (ncl.ac.uk)
The generic structure of matrix metalloproteinases (MMPs). (periobasics.com)
Another type of MMPs are called as the MT-MMPs (Membrane Type Matrix Metalloproteinases) that are localized to the cell surface. (periobasics.com)
BACKGROUND/AIMS Matrix metalloproteinases (MMPs) accumulate in the tears of patients with active peripheral ulcerative keratitis (PUK) but it is unknown whether these enzymes have a central role in disease progression. (bmj.com)
The matrix metalloproteinases (MMPs) are a family of zinc and calcium ion dependent enzymes 1 of differing substrate specificity but similar structure and catalytic mechanism. (bmj.com)
The RNA expression of matrix molecules and degenerative metalloproteinases was determined via real-time PCR after a stimulation time period of 24 h. (micrornaassay.com)
Matrix metalloproteinases (MMPs) are a family of zinc-dependent proteinases that are capable of cleaving all extra cellular matrix (ECM) substrates. (biomedcentral.com)
Matrix metalloproteinase are a family of zinc dependent endopeptidases that are capable of degrading most components of the extra cellular matrix (ECM) [ 7 - 9 ]. (biomedcentral.com)
Zhang H, Wang Y, Chen T, Zhang Y, Xu R, Wang W, Cheng M, Chen Q. Aberrant Activation Of Hedgehog Signalling Promotes Cell Migration And Invasion Via Matrix Metalloproteinase-7 In Ovarian Cancer Cells. (jcancer.org)
Using fibroblasts recovered from wild-type or gene-deleted mice, invasion of three-dimensional fibrin gels proceeded in a matrix metalloproteinase (MMP)-dependent fashion. (silverchair.com)
Matrix metalloproteinase (MMP) inhibition has been proposed as a novel pharmacological approach for ICH treatment. (unav.edu)

Chondrocytes also produce protease inhibitors, including tissue inhibitors of metalloproteinases (TIMP) 1 and 2, but in amounts insufficient to counteract the proteolytic effect. (medscape.com)
In the activation step, TIMP-2 bound to MT1-MMP on the cell surface acts as a receptor for proMMP-2. (ox.ac.uk)
Subsequently, adjacent TIMP-2-free MT1-MMP activates the proMMP-2 in the ternary complex. (ox.ac.uk)
Osteopontin cleavage by ADAMTS8 was inhibited by TIMP-3, an endogenous inhibitor of ADAMTS1, 4, and 5, aswell as by TIMP-2, without any reported inhibitory activity against other ADAMTS proteases previously. (acp2018.org)
Though the MMPI/vehicle ICAT ratios in the protease inhibitors elafin, Kunitz-type protease inhibitor 1, and tissue inhibitor of metalloproteinase 1 (TIMP-1) were decreased, the elafin and Kunitz-type protease inhibitor 1 proteins have been not considerably cleaved by MMPs in vitro (data not shown), and TIMP-1 is usually a specific MMP inhibitor, although it does not inhibit MMP-14 (141). (translateinthetownships.com)
TIMP, tissue inhibitor of metalloproteases. (silverchair.com)

In addition, expression of the mutant MT1-MMP lacking the catalytic domain (MT1PEX-F) efficiently inhibited complex formation of the full-length enzymes and activation of pro MMP-2. (ox.ac.uk)
9 This enzyme, together with the collagenase produced by neutrophils and classified as MMP-8, are the only mammalian enzymes known to be capable of initiating hydrolysis of fibrillar type I collagen, 2 10 the major component of the corneal stroma. (bmj.com)
The gelatinases MMP-2 and MMP-9 are enzymes that will hydrolyse type IV collagen, the major component of basement membranes. (bmj.com)
MMPs now comprise a group of 18 different enzymes in man, including the classic fibroblast collagenase MMP-1 (collagenase-1), the mesenchymal form of MMP-8 (collagenase-2) and MMP-13 (collagenase-3). (biomedcentral.com)
There is clear experimental evidence that these compounds are inhibitors of metalloproteinase enzymes and prevent the softening of cartilage that occurs with inflammation. (hygain.com.au)
Ivanušec A, Šribar J, Križaj I. Secreted Phospholipases A 2 - not just Enzymes: Revisited. (ijbs.com)
The physiological roles of sPLA 2 s as enzymes have been very well described, while their functions as ligands are still poorly known. (ijbs.com)
Secreted phospholipases A 2 (sPLA 2 s) (EC 3.1.1.4) are a structurally related group of low-molecular-mass enzymes (14-18 kDa) that catalyse the hydrolysis of glycerophospholipids (phospholipids hereafter) at their sn -2 position, to produce lysophospholipids and free fatty acids. (ijbs.com)
Protein levels of inflammatory enzymes (iNOS, COX-2), pro-inflammatory cytokines (TNF-α, IL-1β), and inflammatory mediators (NF-κB, IκB) in cartilaginous tissues were determined by western blot analysis. (biomedcentral.com)
IAS (20 mg/kg) effectively suppressed the induction of inflammation-mediated enzymes (iNOS and COX-2) and pro-inflammatory cytokines (TNF-α and IL-1β). (biomedcentral.com)
SHINBARO inhibited PGE 2 and anti-type II collagen antibody production and modulated the balance of inflammatory enzymes, mediators, and cytokines in the MIA-induced osteoarthritis rat model. (biomedcentral.com)

Keloid fibroblasts (KFs) are not different from human normal dermal fibroblastsin size and shape, however, KFs can proliferate more than normal fibroblasts and produce high level of ECM such as collagen, fibronectin, elastin, and proteoglycans [ 3 - 5 ]. (e-aaps.org)
Moreover, the collagen, proteoglycan and elastin biosynthesis of tendon and ligament derived fibroblasts was determined using validated methods like western blotting, alcian blue staining or 14[C]-incorporation assay. (micrornaassay.com)

Other than water, the mesoglea is composed of several substances including fibrous proteins like collagen and heparan sulphate proteoglycans. (pearltrees.com)
Since the last overview of sPLA 2 -binding proteins (sPLA 2 -BPs) 10 years ago, several important discoveries have occurred in this area. (ijbs.com)
The structural diversity of sPLA 2 -BPs reveals sPLA 2 s as very promiscuous proteins, and we offer some structural explanations for this nature that makes these proteins evolutionarily highly advantageous. (ijbs.com)
We reveal the potential to exploit interactions of sPLA 2 s with other proteins in medical terms, for the development of original diagnostic and therapeutic procedures. (ijbs.com)
Finally, the further GIX sPLA 2 s are found in venom of marine snails, and GXIA and GXIB sPLA 2 s are plant proteins. (ijbs.com)
ECM consists of proteins and polysaccharides distributed in many different tissues of the body. (biomedcentral.com)
Some of the proteins are usually not themselves membrane proteins but are likely to become bound to the cell by means of interactions with membrane-tethered molecules like heparan sulfate proteoglycans and receptors (Fig. 1B and D) or by interaction with exosites on the stabilized inhibited mature MMP-14, a type of "substrate trap" (Fig. 1E). (translateinthetownships.com)

MMPs are secreted by a variety of connective tissue and pro-inflammatory cells including fibroblasts, osteoblasts, endothelial cells, macrophages, neutrophils, and lymphocytes. (periobasics.com)
In addition to connective tissue and ECM components, proteinase inhibitors such as α1-proteinase inhibitor, antithrombin-III and α2-macroglobulin are selectively cleaved by MMPs. (periobasics.com)
13 The suggestion that these MMPs may be involved in PUK is based on the observation that MMP-2 production is upregulated in keratocytes cultured from perforated corneas of patients with PUK, and the finding that the quantity of MMP-9 in tear samples taken from eyes of patients with rheumatoid arthritis is correlated with the extent of PUK progression in the corresponding corneas. (bmj.com)
MMPs-TIPMs complexes in normal and diseased tissue and cells. (upatras.gr)

check details Previous experimental studies confirmed the stimulatory impact of these bioactive collagen peptides on the ECM biosynthesis of joint cartilage tissue [6-8]. (micrornaassay.com)

Another study has demonstrated that both serum and synovial fluid from rheumatoid arthritis (RA) could not stimulate chondrocyte proteoglycan synthesis once the IGF-1 function was blocked by a primary antibody [ 6 ]. (biomedcentral.com)

In this study, we demonstrate that MT1-MMP forms a homophilic complex through the hemopexin-like (PEX) domain that acts as a mechanism to keep MT1-MMP molecules close together to facilitate proMMP-2 activation. (ox.ac.uk)
Cell type and tissue specific alterations in fine GAG structure, which are strictly predetermined [ 8 - 10 ], allow these molecules to modulate with high specificity different cellular processes [ 7 ]. (hindawi.com)

We survey right here that ADAMTS8 displays striking distinctions in substrate repertoire, susceptibility to endogenous inhibitors, and endocytic legislation weighed against ADAMTS1, 4, 5, and 15. (acp2018.org)

Cross-linked fibrin is deposited in tissues surrounding wounds, inflammatory sites, or tumors and serves not only as a supporting substratum for trafficking cells, but also as a structural barrier to invasion. (silverchair.com)

HA is synthesized in the absence of a protein core at the inner face of the plasma membrane and consequently found in the form of free chains whereas other GAG types are covalently bound into protein cores to form proteoglycans (PGs). (hindawi.com)
Additionally, immunohistochemistry (IHC) was performed in multiple ovarian cancers, benign tumours and normal tissues to evaluate Gli2 and MMP-7 protein expression. (jcancer.org)
SDC-1 mRNA and protein levels were down-regulated in human colorectal carcinoma tissues. (biomedcentral.com)
In this paper, we verified the mRNA and protein expression of SDC-1 in human colorectal carcinoma tissues and focused on the biological cellular effects of SDC-1 on human colorectal carcinoma cell lines (SW620, SW480 and LOVO), by evaluating cell viability, apoptosis, migration and adhesion. (biomedcentral.com)

Secreted phospholipases A 2 (sPLA 2 s) participate in a very broad spectrum of biological processes through their enzymatic activity and as ligands for membrane and soluble receptors. (ijbs.com)

The power of ADAMTS8 to cleave various other proteoglycans, such as for example biglycan and versican, has up to now not really been reported. (acp2018.org)

MMP-2 and MMP-9 (also known as gelatinases based on their substrate preference) contain fibronectin-like domain repeats which aid in substrate binding. (periobasics.com)

Despite improved surgical techniques, the tendon-to-bone healing rate is unsatisfactory due to difficulties in restoring the delicate transitional tissue between bone and tendon. (wjgnet.com)
RNA extraction For RNA extraction, bone marrow samples have been imme diately submerged in 2 ml Trizol, stored at 80 C until eventually more processed. (micrornainhibitors.com)

Circulating plasminogen activator inhibitor-1 (PAI-1) activity and interleukin-6 (IL-6) were measured in plasma samples and local inflammation was assessed by neutrophil infiltration. (unav.edu)

Synovial macrophage production of metalloproteinases, as well as cytokines such as interleukin (IL) 1, tumor necrosis factor (TNF)-alpha, occurs. (medscape.com)
Proteoglycan degradation contributing to the pathogenesis of intervertebral disc (IVD) degeneration is induced by inflammatory cytokines, such as tumor necrosis factor‑α (TNF‑α) and interleukin‑1β (IL‑1β). (spandidos-publications.com)
These cytokines can directly attack myelinating oligodendrocytes (OLs) [ 2 ] or indirectly impair the OL-neuron coupling by polarizing microglia into the M1 (pro-inflammatory) state, which then activate reactive neurotoxic A1 astrocytes by secreting Il-1α, TNFα, and the complement component 1q (C1q) [ 3 ]. (encyclopedia.pub)

ADAMTS8 comprises a prodomain (Pro), a metalloproteinase (Mp) domains, a disintegrin-like (Dis) domains, a central thrombospondin-like (TSR) theme, a cysteine-rich (CR) domains, a spacer (Sp) domains, and a C-terminal TSR theme (Fig.?1gene locus is tightly associated with the locus in both human beings and mice (PMID17509843), suggesting an close romantic relationship with this protease especially, about which there is certainly scarce information also. (acp2018.org)

Furthermore, expression of MT1PEX-F inhibited proMMP-2 activation and Matrigel invasion activity of invasive human fibrosarcoma HT1080 cells. (ox.ac.uk)
Structure of intermediate filament Intermediate filaments (IFs) are cytoskeletal components found in the cells of vertebrate animal species,[1][2] and perhaps also in other animals, fungi, plants, and unicellular organisms. (pearltrees.com)
Generally, sPLA 2 s are secreted from cells and require micromolar to millimolar Ca 2+ to be catalytically competent. (ijbs.com)
Mariano García Arranz has the following conflict of interest: MGA is inventor on 2 patents entitled "Identification and isolation of multipotent cells from non-osteochondral mesenchymal tissue" (10157355957US) and "Use of adipose tissue-derived stromal stem cells in treating fistula" (US11/167061). (wjgnet.com)
One of the reasons for this is the acquisition of Gem resistance (Gem‑R). To elucidate the mechanism of Gem‑R, two Gem‑R PaCa cell lines were established from AsPC‑1 and MIA PaCa‑2 cells. (cancerindex.org)
These processes transform valvular interstitial cells into osteoblastic ones, which results in calcification of valve tissue [6-7]. (oatext.com)
Glaucoma leads to the loss of retinal ganglion cells and their axons but also to tissue remodelling which involves both the optic nerve head and the retina. (molvis.org)
In addition, the efficacy of EGb761 in the Abeta-induced 3-(4,5 dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) reduction in PC12 cells was examined. (molvis.org)
Thus, chondrocyte metabolism in the adjacent cartilage is relatively low, and these cells cannot easily migrate to the damaged site [ 2 ]. (biomedcentral.com)

Importantly, cell-associated and tumor microenvironment glycosaminoglycans (GAGs)/proteoglycan (PG) content and distribution are markedly altered during tumor pathogenesis and progression. (hindawi.com)

Improving the blood flow to joint tissues by preventing clots in small blood vessel. (hygain.com.au)

It occurs during tissue and organ formation and has a critical role in the pathogenesis of degenerative diseases, such as osteoarthritis and Alzheimer's disease ( 10 , 11 ). (spandidos-publications.com)

Elevated levels of Transforming growth factor (TGF)-β and platelet derived growth factor (PDGF) have been found in keloid tissue along with aberrant levels of their activity. (e-aaps.org)
TGF-β also induces production of PDGF, which controls the rate of granulation tissue formation and stimulates collagen production during the later stages of wound healing [ 7 ]. (e-aaps.org)

This may be effected by autoimmune diseases that involve ocular tissue or by ocular diseases that induce an inflammatory response. (bmj.com)

These can diffuse back into the cartilage and directly destroy tissue or stimulate chondrocytes to produce more metalloproteinases. (medscape.com)

Periarticular soft-tissue swelling is evident. (medscape.com)

Ingenuity pathway examination the dyes regulated genes in pediatric AML To investigate possible biological Inhibitors,Modulators,Libraries interactions of differ ently regulated genes, datasets representing genes with altered expression profile derived from serious time PCR array analyses had been imported in to the Ingenuity Pathway Evaluation Instrument. (micrornainhibitors.com)

4] Though they share common elements, their tissue distribution and binding kinetics are quite different, reflecting their divergent roles in various pathophysiological processes. (pearltrees.com)

Osteoarthritis (OA) results from an imbalance between breakdown and repair of the tissues in the synovial joints. (medscape.com)
Stage 2 involves the fibrillation and erosion of the cartilage surface, with a subsequent release of proteoglycan and collagen fragments into the synovial fluid. (medscape.com)

A fibrillar collagen consisting of three identical alpha1(III) chains that is widely distributed in many tissues containing COLLAGEN TYPE I. It is particularly abundant in BLOOD VESSELS and may play a role in tissues with elastic characteristics. (lookformedical.com)

ECM environment provides appropriate conditions for cell growth, cell differentiation and survival of tissues. (biomedcentral.com)

Syndecan-1 (SDC-1) is a crucial membrane proteoglycan, which is confirmed to participate in several tumor cell biological processes. (biomedcentral.com)

As a lethal gynaecological malignancy, ovarian cancer is the leading cause of cancer-related death among females worldwide [ 1 , 2 ], with an incidence rate ranked third among all malignant tumours. (jcancer.org)

These results suggest that the down regulation of collagen III expression, the up regulation of MMP-1, and increased MMP-2 enzymatic activity on KFs after BTXA administration are able to decrease the excess collagen deposition in keloids. (e-aaps.org)

Homophilic complex formation of MT1-MMP facilitates proMMP-2 activation on the cell surface and promotes tumor cell invasion. (ox.ac.uk)

The pathologic hallmark of scleroderma is progressive fibrosis of tissues. (medscape.com)

OA is characterized into two gatherings as indicated by its etiology: essential (idiopathic or non-awful) and optional (as a rule because of injury or mechanical misalignment) [ 2 ]. (alliedacademies.org)

2] The mesoglea also contains wandering amoebocytes that play a role in phagocytosing debris and bacteria. (pearltrees.com)

Several sPLA 2 isoforms have been described in mammals. (ijbs.com)
sPLA 2 isoforms have unique tissue and cellular distributions, and therefore it is evident that individual sPLA 2 s have distinct enzyme-activity-related biological functions. (ijbs.com)

Anatomy35

Organisms13

Diseases19

Chemicals and Drugs127

Analytical, Diagnostic and Therapeutic Techniques and Equipment26

Phenomena and Processes36

Disciplines and Occupations1

Information Science3

Collagens7

Articular cartilage6

TIMPs9

Extracellular10

Matrix21

TIMP6

Enzymes11

Elastin2

Proteins7

MMPs4

Biosynthesis1

Synthesis1

Molecules2

Endogenous1

Tumors1

Protein4

Receptors1

Cleave1

Fibronectin1

Bone2

Plasminogen1

Cytokines3

Thrombospondin1

Cells9

Glycosaminoglycans1

Joint tissues1

Pathogenesis1

PDGF2

Inflammatory response1

Chondrocytes1

Periarticular1

Interactions1

Roles1

Synovial2

Characteristics1

Cell differentiation1

Membrane1

Malignant1

Decrease1

Tumor cell1

Pathologic1

Injury1

Role1

Isoforms2