• This gene encodes a protein containing an N-terminal Kruppel-associated box-containing (KRAB) domain and 13 Kruppel-type C2H2 zinc finger domains. (nih.gov)
  • ZNF322, a novel human C2H2 Kruppel-like zinc-finger protein, regulates transcriptional activation in MAPK signaling pathways. (anthropogeny.org)
  • Genome-Wide Identification and Analysis of the Genes Encoding Q-Type C2H2 Zinc Finger Proteins in Grapevine. (bvsalud.org)
  • Q-type C2H2 zinc finger proteins (ZFPs), the largest family of transcription factors , have been extensively studied in plant genomes . (bvsalud.org)
  • These proteins can then be used to build transcriptional activators or repressors in E. coli, but these methods are not well defined. (berkeley.edu)
  • In this study, we identify the zinc finger protein Zbtb18 as a transcriptional repressor that directly binds enhancer/promoter regions of genes encoding class I PI3K regulatory subunits, subsequently limiting their expression, dampening PI3K signaling and suppressing PC responses. (ox.ac.uk)
  • Cloning and characterization of a novel zinc finger protein that modulates the transcriptional activity of nuclear receptors. (semanticscholar.org)
  • Zinc finger proteins (ZFPs) can be used to predictably create a large number of unique protein-DNA interactions. (berkeley.edu)
  • BRISBANE, Calif. & BOSTON-(Zeest Media)-Sangamo Therapeutics, Inc. (Nasdaq: SGMO), a clinical-stage genomic medicine company and Chroma Medicine, Inc. (Chroma), a genomic medicine company pioneering single-dose epigenetic editing therapeutics, today announced they have entered into a research evaluation, option and license agreement to develop epigenetic medicines leveraging zinc finger proteins (ZFPs) for sequence-specific DNA recognition. (zeestmedia.com)
  • Description: A sandwich ELISA kit for detection of Zinc Finger, AN1-Type Domain Protein 6 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (operatiebrp.nl)
  • Specific sets of genes encoding proteins become activated, whereas others are repressed. (eur.nl)
  • So CCDS's gene number prediction represents a lower bound on the total number of human protein-coding genes. (wikipedia.org)
  • To carry out this role, proteins produced from genes in the GLI family attach to specific regions of DNA and help control whether particular genes are turned on or off (gene expression). (medlineplus.gov)
  • Depending on signals from Sonic Hedgehog, the GLI3 protein can either turn on (activate) or turn off (repress) other genes. (medlineplus.gov)
  • Researchers are working to identify the genes targeted by the GLI3 protein during development. (medlineplus.gov)
  • The malfunctioning protein likely alters the expression of certain genes during early development. (medlineplus.gov)
  • As a result, only half the normal amount of this protein is available to control the expression of target genes during early development. (medlineplus.gov)
  • Unlike the full-length GLI3 protein, which can turn target genes on or off, the short protein can only repress the expression of target genes. (medlineplus.gov)
  • We have learned that genes in mammalian cells are transcribed into messenger RNAs (mRNAs), which are to be translated into polypeptides (proteins). (intechopen.com)
  • El GEN para la proteína de la leucemia mieloide-linfoide suele estar muy alterado en la LEUCEMIA, combinándose con alrededor de otros 40 genes compañeros para formar PROTEÍNAS ONCOGÉNICAS DE FUSIÓN. (bvsalud.org)
  • The GENE for myeloid-lymphoid leukemia protein is commonly disrupted in LEUKEMIA and combines with over 40 partner genes to form FUSION ONCOGENE PROTEINS. (bvsalud.org)
  • Exons 1-6 of the WT1 gene encode the regulatory domain, which regulates expression of target genes, and exons 7-10 encode the 4 zinc fingers of the DNA-binding region of the WT1 protein. (medscape.com)
  • The WT1 protein mediates the mesenchymal-epithelial transition and differentiation during morphogenesis of the kidney and gonad by repressing genes that encode cell proliferation factors and by activating genes that encode markers of epithelial cell differentiation. (medscape.com)
  • Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (nih.gov)
  • The gene contains four exons and spans 23.2kb in chromosome 6p22.1 region, and transcribes a 2.7kb mRNA that encodes a protein with 402 amino acid residues. (anthropogeny.org)
  • PEP possesses multiple potential nucleic acid- and protein- binding regions: a glycine- and asparagine-rich amino terminus, four zinc finger motifs, two very acidic segments, two short basic stretches, and an alanine- and proline-rich carboxyl terminus. (wustl.edu)
  • The predicted protein contains 9 tandem C(2)H(2)-type zinc-finger motifs. (anthropogeny.org)
  • Sin3 has four paired amphipathic alpha helices (PAH1 to -4) that are protein-protein interaction motifs and is the scaffold upon which the complex assembles. (psu.edu)
  • The others are the site-specific TFs or the DNA sequence-specific binding proteins. (intechopen.com)
  • Expression and purification of the mitochondrial transmembrane protein FAM210A in Escherichia coli. (rochester.edu)
  • Originally discovered as a chief regulatory protein of glucose and lipid metabolism and cell differentiation, the peroxisome proliferator-activated receptor gamma (PPARγ) is a ligand-activated transcription factor of the nuclear hormone receptor superfamily 8 . (nature.com)
  • Zinc and copper modulate differentially the P2X receptor. (cdc.gov)
  • Exploring Diseases/Traits and Blood Proteins Causally Related to Expression of ACE2, the Putative Receptor of SARS-CoV-2: A Mendelian Randomization Analysis Highlights Tentative Relevance of Diabetes-Related Traits. (cdc.gov)
  • CTCF is a protein that mediates distinct processes of gene regulation, including transcription and the structural organization of the genome. (eur.nl)
  • Using ground-breaking science, including our proprietary zinc finger genome engineering technology and manufacturing expertise, Sangamo aims to create new genomic medicines for patients suffering from diseases for which existing treatment options are inadequate or currently don't exist. (zeestmedia.com)
  • Among the established custom DNA binding domains, Cas9 is most easily scaled to facilitate genome-scale perturbations 3 , 4 due to its simplicity of programming relative to zinc finger proteins and transcription activator-like effectors (TALEs). (cdc.gov)
  • The GLI3 gene mutations that cause acrocallosal syndrome change single protein building blocks (amino acids) in a particular region of the GLI3 protein, which disrupts the protein's function. (medlineplus.gov)
  • It remains unclear how a reduced amount of the GLI3 protein disrupts development of the limbs, head, and face and causes the specific features of Greig cephalopolysyndactyly syndrome. (medlineplus.gov)
  • Although this change clearly disrupts embryonic development, it is not known how the altered function of the GLI3 protein leads to the varied signs and symptoms of Pallister-Hall syndrome. (medlineplus.gov)
  • Cas9 nuclease can be converted into an RNA-guided DNA binding protein (dCas9) via inactivation of its two catalytic domains 12 , 13 and then fused to transcription activation domains. (cdc.gov)
  • When overexpressed in COS-7 cells, ZNF322-EGFP fusion protein is detected in the nucleus and cytoplasm. (anthropogeny.org)
  • Didier Trono s'est beaucoup intéressé aux interactions entre les virus et leurs hôtes, ce qui l'a conduit à étudier la biologie de pathogènes comme le VIH et le virus de l''hépatite B, et à créer des outils de transfert génétique dérivés du VIH aujourd'hui utilisés avec succès en thérapie génique. (epfl.ch)
  • 1990. A review on biochemical roles, toxicity and interactions of zinc, copper and iron: IV. (cdc.gov)
  • 1995. Copper and zinc metabolism in health and disease: Speciation and interactions. (cdc.gov)
  • Interestingly, a protein-coding splice variant of SETD2 lacks the extended N-terminus but contains the catalytic SET domain as per the ENSEMBL database. (frontiersin.org)
  • The sympathetic nervous system regulates this function through β-adrenergic stimulation of brown mature adipocytes' dissipation of energy in the form of heat mediated by mitochondrial uncoupling protein-1 (UCP-1) activation. (springer.com)
  • This enabled them to identify a Zinc finger protein (ZNF) specifically expressed in humans and not chimpanzees and demonstrate that the human-specific ZNF (named ZNF558) is crucial for both mitochondrial homeostasis and early human brain development. (lu.se)
  • At least two mutations in the GLI3 gene have been reported in people with features of acrocallosal syndrome, a rare condition characterized by certain brain abnormalities, extra fingers and toes (polydactyly), and distinctive facial features, including widely spaced eyes (hypertelorism) and a prominent forehead. (medlineplus.gov)
  • The role of the GLI3 protein in brain and limb patterning may help explain why mutations lead to brain abnormalities, polydactyly, and the other features of acrocallosal syndrome. (medlineplus.gov)
  • The genetic changes that cause Greig cephalopolysyndactyly syndrome prevent one copy of the gene in each cell from producing any functional GLI3 protein. (medlineplus.gov)
  • Most of the mutations that cause Pallister-Hall syndrome occur near the middle of the gene, creating a premature stop signal in the instructions for making the GLI3 protein. (medlineplus.gov)
  • Disruption of zfs1 reduced both hypersensitivity of the ras1(Val17) mutant to the mating pheromone and uncontrolled mating response caused by mutational activation of Gpa1, the G protein a subunit coupled to the mating pheromone receptors. (elsevierpure.com)
  • the large 7.2-kb segment encodes the Z matrix and the large polymerase proteins, and the small 3.4-kb segment encodes the glycoprotein and nucleoprotein ( 1 ). (cdc.gov)
  • Cardiac differentiation involves a cascade of coordinated gene expression that regulates cell proliferation and matrix protein formation in a defined temporal-spatial manner. (anthropogeny.org)
  • VvZFP10-GFP and VvZFP46-GFP fusion proteins were localized in the nucleus of tobacco cells , and VvZFP10 is the most responsive gene among all VvZFPs with the highest relative expression level to MeJA, ABA, SA and low- temperature (4 °C) stress. (bvsalud.org)
  • Scope includes mutations and abnormal protein expression. (cancerindex.org)
  • Protein expression and purification. (rochester.edu)
  • Myeloid-lymphoid leukemia protein is a transcription factor that maintains high levels of HOMEOTIC GENE expression during development. (bvsalud.org)
  • The deduced zfs1 gene product of 404 amino acids showed similarity to a mouse growth factor-inducible nuclear protein Nup475. (elsevierpure.com)
  • Estrogens are important regulators of growth and differentiation in (range, 0 -9 fmol/mg protein, median 0.7). (lu.se)
  • 1992. Auditory event-related potential (P300) in relation to peripheral nerve conduction in workers exposed to lead, zinc, and copper: Effects of lead on cognitive function and central nervous system. (cdc.gov)
  • 1992. Use of zinc acetate to treat copper toxicosis in dogs. (cdc.gov)
  • Electrophoretic mobility shift assays detected allele-dependent nuclear protein binding in A549 cells for 8 of 21 variants. (cdc.gov)
  • Association of Vitamin D, Zinc and Selenium Related Genetic Variants With COVID-19 Disease Severity. (cdc.gov)
  • Together, these results suggest that ZNF322 is a member of the zinc-finger transcription factor family and may act as a positive regulator in gene transcription mediated by the MAPK signaling pathways. (anthropogeny.org)
  • Proteins in the GLI family function in the same molecular pathway as a protein called Sonic Hedgehog. (medlineplus.gov)
  • The Zinc-finger protein ASCIZ regulates B cell development via DYNLL1 and Bim. (ozgene.com)
  • Based on the high sequence conservation within the conserved domains, we suggest that these proteins could have a regulatory function. (usu.edu)
  • This unusual protein may play a role in the process of gene activation, or possibly in RNA processing, for a defined set of developmentally regulated loci. (wustl.edu)
  • The frameshift mutation results in the formation of a truncated protein which cannot fold properly, promoting aggregation, and subsequent deposition in tubular cells. (medscape.com)
  • The phylogenetic tree analysis of the amino acid sequences of VvZFP, VaZFP, VrZFP, and AtZFP proteins showed that they were closely related and were divided into six subgroups. (bvsalud.org)
  • A reference map of the human binary protein interactome. (nih.gov)
  • Architecture of the human interactome defines protein communities and disease networks. (nih.gov)
  • Description: A competitive ELISA for quantitative measurement of Human AN1 type zinc finger protein 6(ZFAND6) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. (operatiebrp.nl)
  • 1976. The in vitro effect of zinc on the inhibition of human *-aminolevulinic acid dehydratase by lead. (cdc.gov)
  • Although SETD2 is functionally important, the protein does not accumulate in human cells. (frontiersin.org)
  • Zinc finger protein 695 is a protein that in humans is encoded by the ZNF695 gene. (wikipedia.org)
  • SARS-CoV-2 Is Restricted by Zinc Finger Antiviral Protein despite Preadaptation to the Low-CpG Environment in Humans. (cdc.gov)
  • Protein folding stabilities are a major determinant of oxidation rates for buried methionine residues. (rochester.edu)
  • ZAD zinc finger protein Kipferl guides Rhino to piRNA clusters. (oeaw.ac.at)
  • also known as ATMIN/ZNF822), a protein with dual functions in the DNA damage response and as a transcription factor, leads to progressive cell loss from the pre-B stage onwards and severely diminished splenic B cell numbers in mice. (ozgene.com)
  • Radial and median nerve conduction velocities in workers exposed to lead, copper, and zinc: A follow-up study for 2 years. (cdc.gov)
  • 1994. Inhibition of Na+-glucose cotransport in kidney cortical cells by cadmium and copper: Protection by zinc. (cdc.gov)
  • The Effect of Circulating Zinc, Selenium, Copper and Vitamin K on COVID-19 Outcomes: A Mendelian Randomization Study. (cdc.gov)