• vivo
  • This product is an active protein and may elicit a biological response in vivo, handle with caution. (abcam.com)
  • interacts
  • The protein interacts with both mothers against decapentaplegic Drosophila homolog 2 and 4 to enhance their DNA binding activity. (wikipedia.org)
  • regulates
  • In the case of stress (DNA damage, hypoxia) or low energy availability, it is activated and regulates protein synthesis down. (wikipedia.org)
  • tumor
  • such mutations inactivate the IκBα protein, thus causing NF-κB to be chronically active in the lymphoma tumor cells and this activity contributes to the malignant state of these tumor cells. (wikipedia.org)
  • pathways
  • The TSC1 and TSC2 proteins form a heterodimeric complex which acts as an important integrator of different signaling pathways controlling mTOR signaling, by regulating especially mTORC1 activity. (wikipedia.org)
  • nuclear
  • IκBα inhibits NF-κB by masking the nuclear localization signals (NLS) of NF-κB proteins and keeping them sequestered in an inactive state in the cytoplasm. (wikipedia.org)
  • cells
  • Human RPS6KA4 (NP_003933.1, 1 a.a. - 772 a.a.) full-length recombinant protein with GST tag co-expressed with His-tagged MAPK1 (NP_002736.3, 1 a.a. - 360 a.a.) expressed in baculovirus infected Sf21 cells. (abnova.com)