Protein StabilityProtein BindingProtein Interaction MappingTwo-Hybrid System TechniquesMolecular Sequence DataModels, MolecularProtein Structure, TertiaryAmino Acid SequenceEnzyme StabilityProtein ConformationBinding SitesDrug StabilityTranscription FactorsBase SequenceCell LineProtein DenaturationThermodynamicsProtein FoldingRNA StabilityMutationProteinsUbiquitinationCircular DichroismProteasome Endopeptidase ComplexTemperatureProteolysisProtein Structure, SecondaryUbiquitinGuanidineProtein EngineeringAmino Acid SubstitutionMutagenesis, Site-DirectedProtein UnfoldingUbiquitin-Protein LigasesCalorimetry, Differential ScanningHot TemperatureHalf-LifeKineticsProtein Processing, Post-TranslationalUreaHEK293 CellsHydrogen BondingRNA, MessengerMuramidaseSolventsPhosphorylationHydrogen-Ion ConcentrationRecombinant ProteinsEscherichia coliTransition TemperatureMutation, MissenseModels, ChemicalStatic ElectricityStructure-Activity RelationshipCell Line, TumorMutant ProteinsAmino Acid MotifsNuclear ProteinsTranscription, GeneticDNA-Binding ProteinsHydrophobic and Hydrophilic InteractionsRecombinant Fusion ProteinsLeupeptinsSpectrometry, FluorescenceCrystallography, X-RayGene Expression RegulationBacterial ProteinsSignal TransductionComputer SimulationTumor Suppressor Protein p53Models, BiologicalProto-Oncogene Proteins c-mdm2HeLa CellsCOS CellsSequence AlignmentTransfectionSequence Homology, Amino AcidAmino AcidsSaltsPoint MutationProteasome InhibitorsLysineProtein Structure, QuaternarySumoylationSerinePlasmidsSolubilityF-Box ProteinsImmunoprecipitationMultiprotein ComplexesRNA, Small InterferingEntropyProtein MultimerizationTumor Suppressor ProteinsSolutionsDimerizationTime FactorsBlotting, WesternRibonucleasesSequence Analysis, Protein