• mice
  • Again the effect was more pronounced in AM+/− mice, which showed increases in cardiac myocyte size, protein synthesis, and fibroblast proliferation. (ahajournals.org)
  • FGF9 and FGF20 maintain the stemness of nephron progenitors in mice and man. (nih.gov)
  • Activation of D5 receptors is shown to promote expression of brain-derived neurotrophic factor and increase phosphorylation of protein kinase B in rat and mice prefrontal cortex neurons. (wikipedia.org)
  • Bmp7
  • Sufficiency was shown in vitro where Fgf20 or Fgf9 (alone or together with Bmp7) maintained isolated metanephric mesenchyme or sorted nephron progenitors that remained competent to differentiate in response to Wnt signals after 5 or 2 days in culture, respectively. (nih.gov)
  • genes
  • These genes contain several in-frame stop codons that prevent these genes from transcribing a functional protein. (wikipedia.org)
  • The following are categorized as SIBLING proteins: osteopontin (OPN) bone sialoprotein (BSP) dentin matrix protein 1 (DMP1) dentin sialophosphoprotein (DSPP) matrix extracellular phosphoglycoprotein (MEPE) The genes coding for members of the SIBLING protein family are similarly organized and are all located on human chromosome 4q21-23. (wikipedia.org)
  • filtrate
  • The ascending limb is impermeable to water (because of a lack of aquaporin, a common transporter protein for water channels in all cells except the walls of the ascending limb of the loop of Henle) but permeable to solutes, but here Na+, Cl−, and K+ are actively transported into the medullary space, making the filtrate hypotonic (with a higher water potential). (wikipedia.org)
  • actin
  • 3. Other ROCK targets NHE1 (a sodium hydrogen exchanger, involved in focal adhesions and actin organisation) intermediate filament proteins: Vimentin, GFAP (glial fibrillaric acidic protein), NF-L (neurofilament L protein) F-actin binding proteins: Adducin, EF-1α (elongation factor, translation co-factor), MARCKS (myristylated alanine-rich C kinase substrate), Caponin (unknown function), and ERM (involved in linkage of the actin cytoskelton to the plasma membrane). (wikipedia.org)
  • kinase
  • ERK activation was suppressed by protein kinase C inhibition to a greater degree in AM+/− myocytes. (ahajournals.org)
  • In addition, treatment of cardiac myocytes with recombinant AM suppressed Ang II-induced ERK activation via a protein kinase A-dependent pathway. (ahajournals.org)
  • Rho-associated protein kinase (ROCK) is a kinase belonging to the AGC (PKA/ PKG/PKC) family of serine-threonine kinases. (wikipedia.org)
  • gene
  • Claudin-9 is a protein that in humans is encoded by the CLDN9 gene. (wikipedia.org)
  • GO annotations related to this gene include identical protein binding and structural molecule activity. (wikipedia.org)
  • Claudin-6 is a protein that in humans is encoded by the CLDN6 gene. (wikipedia.org)
  • Dopamine receptor D5, also known as D1BR, is a protein that in humans is encoded by the DRD5 gene. (wikipedia.org)
  • Sodium-dependent phosphate transport protein 2A also known as Na+-Pi cotransport (NaPi-2a) or solute carrier family 34, member 1 (SLC34A1) is a protein in humans that is encoded by the SLC34A1 gene. (wikipedia.org)
  • Hippocalcin-like protein 1 is a protein that in humans is encoded by the HPCAL1 gene. (wikipedia.org)
  • The protein encoded by this gene is a member of neuron-specific calcium-binding proteins family found in the retina and brain. (wikipedia.org)
  • Angiopoietin-related protein 2 also known as angiopoietin-like protein 2 is a protein that in humans is encoded by the ANGPTL2 gene. (wikipedia.org)
  • Pepsin A is a protein that in humans is encoded by the PGA5 gene. (wikipedia.org)
  • Kelch-like protein 3 is a protein in humans that is encoded by the KLHL3 gene. (wikipedia.org)
  • This gene is ubiquitously expressed and encodes a full-length protein which has an N-terminal BTB domain followed by a BACK domain and six kelch-like repeats in the C-terminus. (wikipedia.org)
  • cellular
  • In this proposal we will elucidate mechanisms by which the adjacent cellular environment regulates nephron progenitor cell renewal, and test the potential of kidney organoids to model these processes. (grantome.com)
  • ROCK plays a role in a wide range of different cellular phenomena, as ROCK is a downstream effector protein of the small GTPase Rho, which is one of the major regulators of the cytoskeleton. (wikipedia.org)
  • phosphorylation
  • ROCK increases the activity of the motor protein myosin II by two different mechanisms: Firstly, phosphorylation of the myosin light chain (MLC) increases the myosin II ATPase activity. (wikipedia.org)
  • It is also possible that phosphorylation of collapsin response mediator protein-2 (CRMP2) by ROCK inhibits CRPM2 function of promoting axon outgrowth, resulting in growth cone collapse. (wikipedia.org)
  • niche
  • These findings identify a long-sought-after critical component of the nephron stem cell niche and hold promise for long-term culture and utilization of these progenitors in vitro. (nih.gov)
  • In the first project period we defined signaling pathways that control renewal of nephron progenitors, and in this application we propose to extend these studies to the important question of how niche signals control the balance between renewal and differentiation. (grantome.com)
  • Scientifically, we propose novel developments of the model for progenitor cell turnover in the nephron progenitor niche. (grantome.com)
  • blood
  • The great quantity of useful water that is excreted is reabsorbed back into the blood as the nephron first descends into the deeper tissues of the kidney. (asknature.org)
  • Urinalysis results might also show white blood cells, a common indicator of infection or inflammation, and increased protein, which can indicate nephron damage. (mayoclinic.org)
  • Normally the only components of the blood that are not filtered into Bowman's capsule are blood proteins, red blood cells, white blood cells and platelets. (wikipedia.org)
  • glycoprotein
  • The family of non-collagenous proteins known as SIBLING proteins, standing for small integrin-binding ligand, N-linked glycoprotein, are components of the extracellular matrix of bone and dentin. (wikipedia.org)
  • ANGPTL2 protein is a secreted glycoprotein with homology to the angiopoietins and may exert a function on endothelial cells through autocrine or paracrine action. (wikipedia.org)
  • inflammation
  • Angiopoietin-like protein 2 maintains tissue homeostasis by promoting adaptive inflammation and subsequent tissue reconstruction, whereas an excess of ANGPTL2 activation induced by prolonged stress promotes the breakdown of tissue homeostasis due to chronic inflammation, promoting the development of metabolic diseases. (wikipedia.org)
  • interaction
  • These kelch-like repeats promote substrate ubiquitination of bound proteins via interaction of the BTB domain with the CUL3 (cullin 3) component of a cullin-RING E3 ubiquitin ligase (CRL) complex. (wikipedia.org)