Proteins multiple enzyme induction. Medical search. Frequent questions

Enzyme induction and inhibition. (uninsubria.eu)
Levels of CYP3A4 activity can be decreased by inhibition of enzyme activity, or increased by induction of new protein synthesis. (aspetjournals.org)
Changes in CYP3A4 activity, either through inhibition or induction, can result in potentially serious drug-drug interactions (DDIs). (aspetjournals.org)
Calcitriol elicits anti-tumor effects mainly through the induction of cancer cell apoptosis, cell cycle arrest, differentiation, angiogenesis and the inhibition of cell invasiveness by a number of mechanisms. (jcancer.org)
The broad spectrum anti-tumor effects of calcitriol and analogs are mostly based on inhibition of cancer cell proliferation and invasiveness, induction of differentiation and apoptosis, and promotion of angiogenesis. (jcancer.org)
Lower systemic concentrations after topical administration would also be expected to result in a lower risk of drug- drug interactions resulting from NSAID-mediated displacement of drugs binding to plasma proteins or alterations in drug concentrations due to induction or inhibition of cytochrome P450 enzymes. (fagron.com)
As test cases to examine changes in protein presence associated with tumor growth inhibition, we applied SILAC-based proteomics on human colon carcinoma cells treated with galectin-4 (Gal-4). (uni-muenchen.de)
In this review multiple mechanisms are discussed, such as modulation of gene expression and signal transduction, interference with enzymes of the cellular antioxidant system and generation of reactive oxygen species (ROS), inhibition of DNA repair and DNA methylation, role in apoptosis and disruption of E-cadherin-mediated cell-cell adhesion. (cdc.gov)

We followed up on one pathway, finding that Set1-dependent H3K4 methylation primarily acts as a gene repressor during multiple stresses, specifically at genes involved in ribosome biosynthesis. (harvard.edu)
Set1-dependent repression of ribosomal genes occurs via distinct pathways for ribosomal protein genes and ribosomal biogenesis genes, which can be separated based on genetic requirements for repression and based on chromatin changes during gene repression. (harvard.edu)
The multifunctional regulator nuclear factor erythroid 2-related factor (Nrf2) is considered not only as a cytoprotective factor regulating the expression of genes coding for anti-oxidant, anti-inflammatory and detoxifying proteins, but it is also a powerful modulator of species longevity. (springer.com)
The major characteristics of Nrf2 are to some extent mimicked by Nrf2-dependent genes and their proteins including heme oxygenase-1 (HO-1), which besides removing toxic heme, produces biliverdin, iron ions and carbon monoxide. (springer.com)
A very natural place to study gene detecting and metabolizing lactose, it is known that the overall regulation is in the metabolism of the cell, and then specifically in effect of expressing the lac genes in vain is a drop in the growth rate the regulation of genes that code for enzymes and transporter of as much as 5% [1,6]. (lu.se)
Recent studies have unveiled the potential of specific genes in triggering haploid induction, a key step in double haploid technology. (techcodex.com)
Using a combination of GUS reporter genes, green fluorescent protein-tagged antibodies, and reverse transcriptase quantitative polymerase chain reaction, the team observed that OsMATL2 protein, a phospholipase enzyme, is highly expressed in pollen, primarily in the plasma membrane of cells of the japonica rice plant. (techcodex.com)
The resulting expression vector, pPH3, permits convenient insertion of structural genes containing their own translational-initiation regions, into the multiple-cloning site derived from the pUC19 plasmid. (nau.edu)
The efficiency and regulatory properties of p ugp were measured using xylE and lacZ as reporter genes, which code for the corresponding enzymes catechol-2,3-dioxygenase (C23O) and β-galactosidase (βGal), respectively. (nau.edu)
The characterization of new miRNA target genes and a unique profile for crasiRNAs has allowed for insight into multiple RNA mediated processes in the tammar, including gene regulation, species incompatibilities, centromere and chromosome function. (biomedcentral.com)

We conclude that targeted absolute LC-MS/MS quantification of drug-metabolizing enzymes and transporters can broaden the scope and significantly increase the impact of in vitro drug metabolism studies, such as induction, as an important supplement or future alternative to mRNA and activity data. (aspetjournals.org)

2004 Nov 19;16(4):549-61 Bernier-Villamor, V. , Sampson, D.A. , Matunis, M.J. & Lima, C.D. Structural basis for E2-mediated SUMO conjugation revealed by a complex between ubiquitin-conjugating enzyme Ubc9 and RanGAP1. (wikipedia.org)

The effects of culture format (i.e., sandwich culture versus conventional culture) and of dexamethasone (DEX) media concentrations on mRNA, protein, and activity levels were determined for three donors, and protein expression was compared with that in liver. (aspetjournals.org)
The approach was to relate in vitro induction data ( E max and EC 50 values) with efficacious free plasma concentrations to calculate a relative induction score. (aspetjournals.org)
Bexarotene may induce metabolic enzymes and cause a reduction in the plasma concentrations of oral or other systemic hormonal contraceptives. (pdr.net)
Enzyme activities were virtually completely repressed in the presencee of excess inorganic phosphates (P i ) and high concentrations of glucose. (nau.edu)

Using label-free quantitative proteomics, we identified the differential secretion pattern of a core subset of enzymes, including xylanases and cellulases with multiple carbohydrate-binding modules (CBMs). (biomedcentral.com)
Secretion of LEE proteins is triggered by close contact with host cells. (cdc.gov)
Furthermore, IL-17, IL-1β, and TNF-α induced a rapid activation of extracellular signal-related kinase p42/44 and p38 MAPKs, and specific MAPK inhibitors (SB203580, PD98059, and U0216) significantly reduced IL-17-, IL-1β-, or TNF-α-induced IL-6 secretion, indicating the role of MAPKs in the induction of IL-6. (aai.org)
The Salmonella pathogenicity island 1 type III secretion system (T3SS) is a protein secretion complex in Salmonella that has been engineered to secrete heterologous proteins and addresses the problems associated with bacterial protein production. (biorxiv.org)
We solve this problem by engineering the Salmonella pathogenicity island 1 type III secretion system (T3SS) to export the target protein into the cell growth media. (biorxiv.org)

Induction of canonical autophagy is mainly controlled by the AKT/mTOR and AMPK signaling pathways and relies on the activation and assembly of two macromolecular complexes, the ATG1/ULK1 and the Class III phosphatidylinositol 3-kinase (PI3K) complex (Figure 1 ) [ 5 ]. (hindawi.com)
2015). Therefore, effective che- motherapeutic drugs require multiple molecular/cellular tar- gets/pathways to control cancer cell survival/proliferation. (pi3k-inhibitors.com)
This blog entry generalizes on the concept of hormesis, discusses the multiple pathways through which hormesis takes place, and suggests a myriad of ways that ordinary people can take advantage of hormesis to maintain their health and possibly extend their lifespans. (anti-agingfirewalls.com)
Mechanistically, we found that lycopene and sorafenib could additively inhibit the mitogen-activated protein kinase (MAPK) pathways, as shown by the protein phosphorylation of ERK1/2, JNK1/2 and p38 were reduced additively. (frontiersin.org)
To characterize hCMEC/D3 cells for the presence of specific endocytic pathways, proteins involved into each pathway were selected. (helsinki.fi)
The major mechanisms of gene induction by cadmium known so far are modulation of cellular signal transduction pathways by enhancement of protein phosphorylation and activation of transcription and translation factors. (cdc.gov)

Common culture formats used for in vitro enzyme induction studies comprise conventional and sandwich cultures, the former referring to plated hepatocytes maintained on rigid substratum (e.g., collagen), whereas in the latter cells are "sandwiched" by an additional layer of either collagen or a composite of extracellular matrix proteins, such as Matrigel ( LeCluyse, 2001 ). (aspetjournals.org)
The metastasizing cells will proliferate in large numbers in situ and secrete proteolytic enzymes, such as the matrix metalloproteinases (MMPs), which degrade the extracellular matrix and blood vessel wall. (frontiersin.org)
The initial hydrolysis step of PET is facilitated by an extracellular enzyme homologous to cutinases, but with an extraordinary capability to degrade PET, hence classified as a PETase (EC 3.1.1.101). (biomedcentral.com)

substrate modification, through the cooperation of the E2 and E3 protein ligases. (wikipedia.org)
2004) V.G. Panse, U. Hardeland, T. Werner, B. Kuster and E. Hurt, A proteome-wide approach identifies sumoylated substrate proteins in yeast, J. Biol. (wikipedia.org)
280 (2005), pp. 4102-4110 Y. Zhao, S.W. Kwon, A. Anselmo, K. Kaur and M.A. White, Broad spectrum identification of cellular small ubiquitin-related modifier (SUMO) substrate proteins, J. Biol. (wikipedia.org)
The most promising candidates are classified as cutinases (EC 3.1.1.74), but the turnover rates are only low to moderate, reflecting that PET is an unnatural substrate for these enzymes [ 5 ]. (biomedcentral.com)

The activation of mitogen-activated protein kinase (MAPK) was assessed by immunoblotting. (aai.org)

To date, there is no single and clinically active drug available that inhibits the AmpC enzyme and combats multidrug resistance and its transmission in individuals. (nih.gov)
However, higher in vitro expression was observed for drug transporters, especially for multidrug resistance protein 1 and breast cancer resistance protein. (aspetjournals.org)

caspases are synthesized as inactive zymogens that can be cleaved to form active enzymes following the induction of apoptosis by stress or death receptors. (enzolifesciences.com)
Cadmium interferes with antioxidant defense mechanisms and stimulates the production of reactive oxygen species, which may act as signaling molecules in the induction of gene expression and apoptosis. (cdc.gov)

excessive citations] Metabolism Metabolic network Metabolic network modelling Johnson, E.S. Protein modification by SUMO. (wikipedia.org)

cAMP-mediated stimulation of tyrosine hydroxylase mRNA translation is mediated by polypyrimidine-rich sequences within its 3'-untranslated region and poly(C)-binding protein 2. (rochester.edu)
Induction of tyrosine hydroxylase mRNA by nicotine in rat midbrain is inhibited by mifepristone. (rochester.edu)
Expression of these proteins at mRNA level was assessed by quantitative real-time polymerase chain reaction (qRT-PCR). (helsinki.fi)
The mature miRNA is then loaded onto an Argonaute protein (Ago2 in humans) where it then interacts with and regulates the mRNA target. (biomedcentral.com)

6. Cellular and molecular pharmacology of enzyme systems, with examples. (uninsubria.eu)

Importantly, we find that chromatin regulators play far more pronounced roles during gene induction/repression than they do in steady-state expression. (harvard.edu)
Furthermore, by jointly analyzing the substrates (histone mutants) and enzymes (chromatin modifier deletions) we identify specific interactions between histone modifications and their regulators. (harvard.edu)
Further, the hypomethylated CpG site at the promoter region of PLA2G7 was identified as cg11874627, demethylation of which led to increased binding of Sp3 and expression of Lp-PLA 2 through bisulfate sequencing, chromatin immunoprecipitation assay and enzyme-linked immunosorbent assay. (biomedcentral.com)

Lysosomal enzymes then degrade the cargo contained within the autolysosome. (hindawi.com)
Our findings provide insights into the mechanism by which consortium members orchestrate their array of enzymes to degrade complex lignocellulosic biomass. (biomedcentral.com)

The sandwich culture format and 0.1 μM DEX in media retained the protein expression in the hepatocytes closest to the levels found in liver. (aspetjournals.org)
Cultured hepatocytes offer the possibility to assess long-term effects, such as enzyme induction (i.e., changes of the expression levels of molecular entities of the hepatocytes). (aspetjournals.org)
Differential expression of polycytosine-binding protein isoforms in adrenal gland, locus coeruleus and midbrain. (rochester.edu)
In addition, analysis of the coordinate expression patterns indicated that transport proteins and hypothetical proteins may play a role in bacteria processing lignocellulose. (biomedcentral.com)
The differential expression patterns of enzymes reveal the strategy of sequential lignocellulose deconstruction by EMSD5. (biomedcentral.com)
The level of cell polarization in cells grown on transwell permeable supports was characterized at multiple timepoints with four different methods: transepithelial electrical resistance (TEER) measurement, lucifer yellow permeability assay, alkaline phosphatase expression and ZO-1 expression. (helsinki.fi)
To evaluate the role of OsMATL2-the gene encoding OsMATL2 protein-in haploid induction, the team used the CRISPR/Cas9 system to generate knockout mutants (sgOsMATL2) with suppressed OsMATL2 protein expression. (techcodex.com)
The ugp promoter (p ugp ) responsible for expression of the binding-protein-dependent sn-glycerol-3-phosphate transport system in Escherichia coli was cloned into a small multicopy plasmid pTER5, a derivative of pBR322, between the transcription terminators rpoCt and t L1 . (nau.edu)
By tracing significant alterations of protein expression likely relevant for the observed phenotypic effects, the capacity of a galectin to affect the proteome of human colon cancer cells at multiple sites is revealed. (uni-muenchen.de)
CDH1 inactivating mutations, leading to loss of protein expression, are common in gastric cancer of the diffuse histotype, while alternative mechanisms modulating E-cadherin expression characterize the more common intestinal histotype. (oncotarget.com)

Calcitriol induces a number of non-genomic responses including rapid intestinal absorption of calcium, release of calcium from intracellular stores, opening of voltage-gated calcium and chloride channels, and the activation of protein kinase C, protein kinase A, phosphatidylinositol-3 kinase (PI3K) and phospholipase C ( 4 ). (jcancer.org)
In particular, the gene ZmMATL was identified as a pollen-specific phospholipase in maize that plays a role in haploid induction within the plant's reproductive processes. (techcodex.com)
Building on this discovery, researchers demonstrated the conservation of pollen-specific phospholipase A-mediated in vivo haploid induction across various monocot species including indica rice by mutating the OsMATL gene. (techcodex.com)

Keap1 is a cysteine-rich protein, known to be anchored to actin cytoskeleton [ 5 ], serving as an adaptor protein for the Cul3-dependent E3 ubiquitin ligase complex. (springer.com)
Initiator caspases (e.g. caspase-8 and -10) are activated by dimerization of the zymogen on a dedicated adaptor protein. (enzolifesciences.com)

The EspA organelle is used to transfer the translocated intimin receptor (Tir), which is then inserted into the host cell membrane, where it binds to intimin, a bacterial outer membrane protein ( 9 , 10 ) and triggers the host cytoskeletal events that lead to attaching/effacing lesion formation. (cdc.gov)
We show that PETases can be functionally displayed on the bacterial cell surface, enabling screening of enzyme activity on PET microparticles - both while anchored to the cell and following solubilization of the enzymes. (biomedcentral.com)
Proteins comprise a multibillion-dollar industry in enzymes and therapeutics, but bacterial protein production can be costly and inefficient. (biorxiv.org)

In Vitro Toxicity Studies: Cell membrane integrity: Cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc. (cdc.gov)
Direct protein quantification was applied successfully to study in vitro induction in sandwich cultured primary hepatocytes in a 24-well format using the prototypical inducers rifampicin, omeprazole, and phenobarbital. (aspetjournals.org)
The purpose of the current studies was to characterize the effect of known inducers on CYP3A4 in Fa2N-4 cells, and to determine whether these in vitro data could reliably project the magnitude of DDIs caused by induction. (aspetjournals.org)
Subsequent studies were conducted to determine the relationship between in vitro induction data and in vivo induction response. (aspetjournals.org)
assays for evaluating induction are less well characterized and the relationships between in vitro and in vivo data less clear. (aspetjournals.org)
There are several in vitro tools for assessment of CYP3A4 induction. (aspetjournals.org)
In addition, DDL-701 partially restored interferon-β induction - an element of the host immune response - in an in vitro model system. (biorxiv.org)

Moreover, enzyme preparation from EMSD5 demonstrated synergistic activities in the hydrolysis of pretreated corn stover by commercial cellulases from Trichoderma reesei . (biomedcentral.com)
The crystallinity and the limited accessibility to the ester linkages make PET unsusceptible to enzymatic hydrolysis, but a number of ester-cleaving enzymes have been reported active on the polyester [ 1 ]. (biomedcentral.com)

Here, we report the use of a targeted liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) method for concurrent quantification of multiple cytochrome P450 (P450), UDP-glucuronosyltransferase (UGT), and transporter proteins in cultured primary human hepatocytes. (aspetjournals.org)

Cells of animals, including humans, possess proteins referred to as cannabinoid receptors. (azarius.net)
This chapter addresses the con- Coherence: carcinogenicity the induction of lung tumours, both cordance in studies of carcinogen- of tobacco smoke in humans benign and malignant, by cigarette icity and mechanisms between versus experimental animals smoke. (who.int)

These studies demonstrated ic problems associated with animal sufficient evidence that tobacco that cigarette smoke can induce tu- studies of tobacco smoke expo- smoking causes multiple types of mours of the lung and nasal cavity in sure have been recognized. (who.int)

The deficit of the enzyme inhibitor focused the researchers to work in the area. (nih.gov)
Nrf2 consists of six functional Neh domains (Neh1-Neh6), from which, the amino-terminal Neh2 domain controls binding Keap1-the inhibitor protein Kelch-like ECH-associated protein 1, that is responsible for the cytosolic sequestration of Nrf2 under physiological conditions (Fig. 2 a). (springer.com)

Prolyl oligopeptidase (PREP) is a peptidase enzyme that has several substrates. (helsinki.fi)

These improvements further our goal of making an industrially competitive protein production strain that reduces the challenges associated with plasmid induction and maintenance. (biorxiv.org)

The lac operon of E. coli is but one example of how enzyme and transporter production can be made conditional on the presence of a nutrient to catabolize. (lu.se)

SUMO enzymatic cascade catalyzes the dynamic posttranslational modification process of sumoylation (i.e. transfer of SUMO protein to other proteins). (wikipedia.org)

We therefore have systematically investigated the effects of 83 histone mutants, and 119 gene deletion mutants, on induction/repression dynamics of 170 transcripts in response to diamide stress in yeast. (harvard.edu)

Leading applications include programs in cancer, enzyme deficiency diseases and the induction of tolerance to treat autoimmune disease. (flagshippioneering.com)

Combinatorial effect of QUE and resveratrol has been found to be antiproliferative via suppression of oncogenic microRNA-27a and induction of zinc finger protein ZBTB10 against HT-29 colon cancer (Del Follo-Martinez et al. (pi3k-inhibitors.com)

Assay conditions, such as culture format and duration, media supplements etc., were reported previously to alter the phenotype and induction response of cultured hepatocytes ( LeCluyse, 2001 ). (aspetjournals.org)

On the whole, the decrease of CDH1 transcript, corresponding to the canonical protein, and the presence of CDH1a , corresponding to an alternative isoform, are likely to perturb E-cadherin-mediated signaling and cell-cell adhesion, thus contributing to intestinal-type gastric carcinogenesis. (oncotarget.com)

Autophagy is a cellular catabolic process that eliminates damaged cell organelles, unfolded proteins, and various intracellular pathogens through lysosomal degradation. (hindawi.com)
In general, autophagy degrades long-lived damaged intracellular proteins, in contrast to the ubiquitin-proteasome system, which controls the degradation of short-lived proteins [ 2 ]. (hindawi.com)
The autophagophore membrane then elongates and encloses the molecules to be degraded forming an autophagosome, which occurs in two separate conjugation reactions catalyzed by autophagy-related proteins (ATGs). (hindawi.com)
Induction of autophagy in the latter pathway is dependent on the interaction of Bcl-2 and Beclin 1. (helsinki.fi)
Since rate of autophagy in cells was not detected, it is impossible to determine, if there were changes in autophagy that were not reflected as changes in colocalization of these two proteins. (helsinki.fi)

Induction via nuclear receptor activation can significantly alter those levels, with the coregulation of multiple enzymes and transporters occurring to different extents. (aspetjournals.org)
Following a complex process of miRNA transcription, processing, and nuclear export, miRNAs are further processed by the RNaseIII enzyme, Dicer, and its cofactor TRBP. (biomedcentral.com)

Besides, these patients had a decreased total number of white blood cells and a reduced percentage of neutrophils, C-reactive protein, and procalcitonin after treatment. (bvsalud.org)

We present here a comprehensive study on the community structure and enzyme systems of a lignocellulolytic microbial consortium EMSD5 during growth on corn stover, using metagenome sequencing in combination with quantitative metaproteomics. (biomedcentral.com)
These results demonstrate that the corn stover-adapted microbial consortium EMSD5 harbors a variety of lignocellulolytic anaerobic bacteria and degradative enzymes, especially those implicated in hemicellulose decomposition. (biomedcentral.com)
Our current approaches of developing more efficient enzyme cocktails and improving biomass conversion rely largely on expanding our knowledge on the microbial degradation and utilization of plant biomass. (biomedcentral.com)

immunotoxicology--protein part of the safety assessment of drugs, chemicals, and other allergy. (cdc.gov)
It is also rec- important target organ in the safety assessment of drugs and ognized that different types of immune-mediated responses can be triggered by different classes of compounds and that some immune chemicals, as well as protein- or peptide-based products. (cdc.gov)
Hypersensitivity (allergy) is defined as humoral or individual chemicals or proteins. (cdc.gov)

The initial catabolic pathway by I. sakaiensis involves two novel enzymes. (biomedcentral.com)

This present review will emphasize on the chemistry, and structure of clinically important and potent inhibitors against AmpC enzymes. (nih.gov)

Eighteen compounds had been shown to be positive for induction, and six compounds had been shown to be negative for induction. (aspetjournals.org)
In 1938, Houston Merrit and Tracy Putnam described animal models for screening multiple compounds for antiepileptic activity in the Journal of the American Medical Association . (medscape.com)

In Fa2N-4 cells, all 18 positive controls produced greater than 2-fold maximal CYP3A4 induction, and all 6 negative controls produced less than 1.5-fold maximal CYP3A4 induction. (aspetjournals.org)
Moreover, we recently reported that lycopene inhibits the metastasis of human liver adenocarcinoma SK-Hep-1 cells by downregulation of the NADPH oxidase 4 (NOX4) proteins ( 18 ). (frontiersin.org)
Proteins of interest (POIs) must be extracted from lysed cells, purified, and resolubilized. (biorxiv.org)
RCT™ products are genetically engineered, enucleated red cells that are being developed to provide allogeneic, ready-to-use cellular therapies to patients across multiple therapeutic areas. (flagshippioneering.com)

SUMO pathway modifies hundreds of proteins that participate in diverse cellular processes. (wikipedia.org)
SUMO pathway is the most studied ubiquitin-like pathway that regulates a wide range of cellular events, evidenced by a large number of sumoylated proteins identified in more than ten large-scale studies. (wikipedia.org)

In doing so, we successfully created a Salmonella strain that eliminates the need for the inducer reagent and exports proteins at levels comparable to the inducer-activated system, ultimately reducing the cost of T3SS protein production. (biorxiv.org)

Oxidative stress generated during such stressful conditions may damage DNA and proteins, and as a consequence the cellular processes are disturbed. (springer.com)

The efficacy and favorable safety profile of daratumumab monotherapy in multiple myeloma (MM) was previously reported. (ashpublications.org)

In addition to the blood pressure criteria, proteinuria of greater than or equal to 0.3 grams in a 24-hour urine specimen, a protein (mg/dL)/creatinine (mg/dL) ratio of 0.3 or higher, or a urine dipstick protein of 1+ (if a quantitative measurement is unavailable) is required to diagnose preeclampsia. (medscape.com)

Typically, pneumonia from COVID-19 progresses rapidly with acute respiratory distress syndrome (ARDS) and septic shock, which are eventually followed by multiple organ failure due to a virus-induced cytokine storm in the body [4] . (souforum.com)

It becomes clear that there exist multiple mechanisms which contribute to the carcinogenicity of cadmium , although the relative weights of these contributions are difficult to estimate. (cdc.gov)

Further, modeling and docking studies suggest DDL-701 interacts with the active site region of the PL pro enzyme and pilot pharmacokinetic studies indicate it is brain permeable. (biorxiv.org)

Induction of tyrosine hydroxylase in the locus coeruleus of transgenic mice in response to stress or nicotine treatment: lack of activation of tyrosine hydroxylase promoter activity. (rochester.edu)
Chronic nicotine treatment leads to induction of tyrosine hydroxylase in locus ceruleus neurons: the role of transcriptional activation. (rochester.edu)
In both EHEC and EPEC, the proteins that mediate this attachment are encoded in a chromosomal pathogenicity island called the "locus of enterocyte effacement" (LEE) ( 3 ). (cdc.gov)

Cytochrome P4503A4 (CYP3A4) is the principal drug-metabolizing enzyme in human liver. (aspetjournals.org)
Cytochrome P4503A4 (CYP3A4) is the major drug-metabolizing enzyme in human liver and is responsible for the clearance of many commonly used drugs, including benzodiazepines, statins, calcium channel blockers, and HIV protease inhibitors. (aspetjournals.org)
HELLP syndrome (hemolysis, elevated liver enzymes, low platelet count) may complicate severe preeclampsia. (medscape.com)

However, the interaction between different community members and the dynamics of enzyme complements during the lignocellulose deconstruction process remain poorly understood. (biomedcentral.com)

EspB, a protein thought to be involved in pore formation, is transferred to the host cell by this conduit and is found in both the host cell membrane and cytosol ( 7 ). (cdc.gov)
EspB, with the aid of a second membrane lytic protein, EspD, forms pores in the host cell as part of the translocation mechanism ( 8 ). (cdc.gov)

The carbohydrate-active enzyme (CAZyme) annotation revealed that representatives of Firmicutes encoded a broad array of enzymes responsible for hemicellulose and cellulose deconstruction. (biomedcentral.com)
Finally, we combine the two most promising genomic modifications to build a constitutively active T3SS capable of secreting a range of heterologous proteins at titers comparable to those reported with synthetic induction of hilA . (biorxiv.org)

that have been engineered to replace missing enzymes for patients living with a variety of rare diseases, to kill tumors, and to upregulate or downregulate the immune system to treat both cancer and autoimmune disorders. (flagshippioneering.com)

The use of isolated transglutaminase enzymes from microbiological sources in industrial food processing has allowed certain processes to be simplified, resulting in energy and cost savings. (theceliacscene.com)
1D annotation analysis of the results indicated down-regulation of DNA replication-associated processes, while protein presence for secretory and transport functions appeared increased. (uni-muenchen.de)

It has been suggested that CB1 activation may help reduce symptoms associated with certain medical conditions such as chronic pain, multiple sclerosis, nausea caused by chemotherapy, and vomiting caused by HIV/AIDS medications. (azarius.net)

Induction of protein sumoylation by cellular stresses, J. Biol. (wikipedia.org)

The levels of metabolizing enzymes and transporters expressed in hepatocytes are decisive factors for hepatobiliary disposition of most drugs. (aspetjournals.org)
Drug-drug interactions (DDIs) caused by induction of CYP3A4 can result in decreased exposure to coadministered drugs, with potential loss of efficacy. (aspetjournals.org)
Concomitant dosing of highly protein-bound drugs is unlikely to affect its disposition. (drugs.com)
The unique Versatile™ cream base has been developed for superior patient satisfaction and flexibility for many therapy regimens, including pain management with multiple drugs. (fagron.com)

Anatomy8

Organisms6

Diseases1

Chemicals and Drugs51

Analytical, Diagnostic and Therapeutic Techniques and Equipment11

Phenomena and Processes26

Information Science4

Inhibition8

Genes10

Drug-metabolizing enzymes and1

Ubiquitin-conjug1

Concentrations4

Secretion5

Pathways6

Extracellular3

Substrate4

Mitogen-activa1

Multidrug resistance2

Apoptosis2

Metabolism1

MRNA4

Pharmacology1

Chromatin3

Degrade2

Expression10

Phospholipase3

Adaptor protein2

Bacterial3

Vitro7

Hydrolysis2

Human hepatocytes1

Humans2

Induce1

Inhibitor2

Substrates1

Plasmid1

Transporter1

Enzymatic1

Mutants1

Deficiency1

Zinc1

Assay1

Canonical1

Autophagy5

Nuclear2

Reactive1

Microbial3

Chemicals3

Catabolic1

Potent1

Compounds2

Cells4

Pathway2

Eliminates1

Cellular processes1

Myeloma1

Quantitative1

Cytokine1

Carcinogenicity1

Permeable1

Locus3

Liver3

Dynamics1

Membrane2

Active2

Diseases1

Processes2

Sclerosis1

Stresses1

Drugs4