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These mobile elements can have tremendous impact on their bacterial hosts' genomes and phenotypes, which may lead to strain emergence and diversification, increased virulence or antibiotic resistance. (nih.gov)
However, finding prophages in microbial genomes remains a problem with no definitive solution. (nih.gov)
PhiSpy locates prophages by ranking genomic regions enriched in distinctive phage traits, which leads to the successful prediction of 94% of prophages in 50 complete bacterial genomes with a 6% false-negative rate and a 0.66% false-positive rate. (nih.gov)
The fact that the genus Bacteroides and proteins involved in iron acquisition and metabolism, cell wall, capsule, virulence and mucin degradation were enriched at the end of HBR suggest that both constipation and EC decreased intestinal metal availability leading to modified expression of co-regulated genes in Bacteroides genomes. (frontiersin.org)
Moreover, genetic and simple obesity share similar structural and functional features of dysbiosis, such as higher production of toxins with known potential to induce metabolic deteriorations (e.g. trimethylamine-N-oxide and indoxyl sulphate), higher abundance of genomes containing genes coding enzymes involved in the production of these toxic co-metabolites and higher abundance of pathways for biosynthesis of bacterial antigens (such as endotoxin) [13-15]. (deepdyve.com)
Many thanks to all those who are and were involved in the 'Bacterial Genomes: Accessing and Analysing Microbial Genome Data' course's development, refinements, and presentations. (futurelearn.com)
In this article, we learn how information about genes and proteins found in genomes can be stored in files. (futurelearn.com)
The IBM Functional Genomics Platform (formerly named OMXWare) is a relational database linking genotype to phenotype for over 300M biological sequences extracted from microbial genomes. (ibm.com)
Raw bacterial sequence datasets are self-consistently assembled and curated for quality yielding whole bacterial genomes. (ibm.com)
The complete collection of assembled genomes are then annotated to identify every gene and protein they contain. (ibm.com)
Linking genomes to protein domains is key to understanding phenotype in biology. (ibm.com)
Today the IBM Functional Genomics Platform has approximately 220,000 high quality bacterial and viral genomes, 64 million unique genes, 50 million unique proteins, and over 220 million unique protein domains. (ibm.com)
A catalogue of 178 reference bacterial birth, and the delivery type is the first core of species has been identified genomes distributed among different factor that has an impact. (who.int)
Identifying structural variation in haploid microbial genomes from short-read re-sequencing data using breseq. (openwetware.org)
Like group A Streptococcus, many pathogenic bacteria have completely sequenced genomes, but we don't know what most of the genes are doing. (scienceblog.com)

Prophages are phages in lysogeny that are integrated into, and replicated as part of, the host bacterial genome. (nih.gov)
In the second session of the project, a gene encoding for an esterase was amplified by PCR from a bacterial sequenced genome belonging to Thalassospira sp. (unina.it)
The bacterial genome is like a book with long strings of letters, only some of which encode the information necessary to make proteins," Bhatt said. (technologynetworks.com)
In this Step, you will learn how to download a full genome sequence and annotation files for a whole bacterial genome, from a public repository. (futurelearn.com)
Dennis Mangan and colleagues who completed the work decided to make the genome freely available to researchers worldwide by releasing it on the Comprehensive Microbial Resource website. (the-scientist.com)
The site is a tool that allows researchers to access all of the bacterial genome sequences completed to date. (the-scientist.com)
The P. gingivalis genome contains 2.3 million DNA base pairs forming 2226 genes, many of which are involved in protein synthesis and energy metabolism. (the-scientist.com)
Whole genome sequences of 58 strains of S. aureus in the public domain and data from multi-strain microarrays were compared to assess variation in the sequence of proteins known or putatively interacting with host. (biomedcentral.com)
Transposons, also known as jumping genes, are short sequences of DNA that physically move within a genome, mutating genes by jumping into them. (scienceblog.com)
If the mutation causes an interesting effect, scientists can identify the mutated gene by locating the transposon, sequencing the DNA surrounding the transposon and mapping its location in the genome. (scienceblog.com)

At the general meeting held by the International Epizootic Office in May 2008, iridoviruses of amphibians were added to the list of pathogens of wildlife that should be monitored ( www.oie.int/aac/eng/Publicat/Cardsenglish/Ranavirus%20card_final.pdf , www.oie.int/eng/normes/fcode/en_chapitre_2.4.2.htm , and www.jcu.edu.au/school/phtm/PHTM/frogs/otherdiseases-viruses.htm ). (cdc.gov)
As such, AMPs exhibit abilities to defend their hosts against broad spectrum of infectious microbial pathogens (bacterial, viral, fungal and parasitic) and are thought to be promising alternatives to the use of antibiotics in human health and agriculture. (usda.gov)
Different emodin derivatives, including the recently reported haloemodin, which inhibits bacterial topoisomerases, can be designed to generate future drugs against resistant pathogens. (longdom.org)

He has authored over 350 peer-reviewed papers and book chapters and is co-recipient of several US and international patents on the use of the 60 kDa heat shock protein (HSP60) gene sequences as universal targets for infectious disease diagnosis and microbial species identification. (cdc.gov)
We've been more likely to make an error than to guess correctly when trying to predict which bacterial DNA sequences contain these very small genes," Bhatt said. (technologynetworks.com)
To assess how well individual gene sequences are assembled , we report the percentage of sequence covered by the longest contig that maps to a given reference sequence. (biomedcentral.com)
To assess how well gene sequences are detected for different organisms, we report the number of organisms for which the longest mapped contig covers at least half of the corresponding reference sequence. (biomedcentral.com)
In our evaluation, we find that the MEGAN assembler performs best in terms of the percentage of reference genes covered and percentage of reference gene sequences detected. (biomedcentral.com)
Based on patterns in their DNA sequences, these genes likely encode proteins in the bacterial membrane. (scienceblog.com)
The overall performance of the developed method results show that it accurately identifies the Ionpumping Haloarchaeal rhodopsin and their subtypes using known and unknown microbial rhodopsin sequences. (biomedcentral.com)

Overall, the predictive abundances indicate that, functionally, the rhizosphere bacteria had the highest gene abundances and that salinity and drought affected the above- and belowground microbiomes differently. (unboundmedicine.com)
The proteins belong to more than 4,000 new biological families predicted to be involved in, among other processes, the warfare waged among different bacterial strains as they vie for primacy in coveted biological niches, the cell-to-cell communication between microbes and their unwitting hosts, and the critical day-to-day housekeeping duties that keep the bacteria happy and healthy. (technologynetworks.com)
What's more, bacteria themselves express different genes and make proteins that may predispose certain individuals to gut inflammation or other conditions. (washington.edu)
So far, such genes have not been found in any of the free living green sulfur bacteria, indicating a specific role in the interaction. (dsmz.de)
MICR 335 will provide a fundamental knowledge of the mechanisms that bacteria use to sense their environment and adapt their gene expression to optimise their growth and survival. (otago.ac.nz)
In 2014, the MetaHIT consortium by bacteria of the genera Lacto- alytical method used: 66 from 16S published an integrated catalogue bacillus , Prevotella , and Sneathia , rDNA sequencing [11] or 57 from of 10 million bacterial genes de- whereas for infants delivered by whole-metagenome sequencing [5]. (who.int)
The Berkeley Lab PhyloChip probes samples for the 16S rRNA gene, which is involved in making proteins and is found in all bacteria and archaea. (ideaconnection.com)
Team=== We are interested in creating a microbial fuel cell that utilizes anaerobic bacteria to produce electricity. (igem.org)
Alan's section) A microbial fuel cell is a device that converts the chemical reactions of bacteria into electricity. (igem.org)
The bacteria that we are currently creating is meant to optimize the microbial fuel cell's potential, as bacteria that will glow under anaerobic conditions will reveal any weaknesses in the fuel cell, structural or otherwise, which can then be assessed and dealt with. (igem.org)
Once fully anaerobic, the bacteria continued to produce the LOV gene product. (igem.org)
We hypothesized that there must be genes in the bacteria important for invading soft tissues and surviving under the skin. (scienceblog.com)
These genes would be good targets for a vaccine or treatment because the bacteria missing these genes did not flourish in the infection site. (scienceblog.com)
This is a prime location for gene products involved in infection because many dangerous bacteria secrete toxins or proteins through the membrane to attack the host. (scienceblog.com)
Rhodopsin is a seven-transmembrane protein covalently linked with retinal chromophore that absorbs photons for energy conversion and intracellular signaling in eukaryotes, bacteria, and archaea. (biomedcentral.com)
and datamining publicly available metagenomic datasets from the human vaginal tract, to identify protein-coding gene clusters in the bacteria that make up the majority of the microbiome of the vagina. (lu.se)
a protein found in the blood that is produced in response to foreign substances (e.g., bacteria or viruses) invading the body. (cdc.gov)

In contrast, the microbial metabolomes, intestinal element and metal profiles, the diversity of bacterial, archaeal and fungal microbial communities were not significantly affected. (frontiersin.org)
My current research interests are the recovery of nutrients from food processing wastes/by-products, microbial production (Protein-rich fungal biomass as animal feed or food, Polyhydroxyalkanoates, Bioethanol, Bacterial cellulose, etc.), and extraction of bioactive compounds having antimicrobial and antibiofilm agents. (hb.se)

Conclusions: Compared with healthy controls, CRS patients' serum samples showed significantly increased sero-reactivity to both bacterial and viral proteins, reflecting recent or current infection or active colonization. (elsevierpure.com)
Predicting evolutionary site variability from structure in viral proteins: buriedness, flexibility, and design. (openwetware.org)

In particular, obese women with uncontrolled eating behavior were mostly characterized by low-diversity microbial steady states, with few and poorly interconnected species (e.g. (biomedcentral.com)
Colonization of the gut starts just after birth when pioneering species interact, through surface receptors, with gut cells to promote the expression of a specific set of host genes and favour the colonization of commensal microorganisms [6]. (deepdyve.com)
To address this shortcoming, three bacterial species ( Pediococcus pentosaceus, Lactobacillus plantarum, and Enterococcus faecium ) were isolated from seaweed biomass and evolved to increasing concentrations of NaCl. (dtu.dk)
Antimicrobial peptides (AMPs) are short peptides/proteins that form key components as the first-line defense of the innate immune system in many species including mammals, lower vertebrates, fish, insects and plants. (usda.gov)
Advanced tools of 'multi-omics' technology allow researchers to identify species in the human gut and analyze the bacterial genes and protein products that affect our brain health. (washington.edu)
The team, led by Barbara Bendlin, PhD, and Frederico Rey, PhD, collected stool samples from participants and used genetic sequencing technology to identify the bacterial species present, and assess the microbial richness and diversity. (washington.edu)
Although we have been aware of polymicrobial infections, arguably for centuries, only recently has biotechnology allowed the delicate dissection of the role of individual microbial species in infections. (asmblog.org)
Interaction between species also contributes to successful microbial persistence. (asmblog.org)
It included membrane-associated proteins from 47 bacterial species and all proteins from 43 viral strains. (elsevierpure.com)

Our analysis of this data reveals an absolute protein-to-RNA ratio of 10 2 -10 4 for bacterial populations and 10 3 -10 5 for an archaeon, which is more comparable to Eukaryotic representatives' humans and yeast. (nature.com)
In this context, the exploration of temporal interplay between populations with different lifestyles (comprising metabolism, motility, sporulation, etc.) becomes of primary importance to interpret the changes in fundamental quantities in a microbial community, such as the protein-to-RNA ratio that ultimately impacts the overarching community phenotype(s). (nature.com)
Indeed, the protein-to-RNA ratio per sample of the bacterial populations matched previous calculations for the existing example from axenically cultured E. coli 2 . (nature.com)
Moreover, it is well recognized that the excessive use of broad-spectrum antibiotics can affect the relative proportions of gut microbial populations and foster bacterial resistance [24]. (deepdyve.com)
Such findings in human and mouse models point to the tantalizing prospect that restoring healthy gut bacterial composition could prevent or slow the development of Alzheimer's in at-risk populations. (washington.edu)

These receptors turn on the genes that make proteins responsible for absorbing calcium in the intestines. (sanus-q.com)

These colonies were interpreted to be opportunistic organisms and microbial cultures were not performed. (cdc.gov)
Professor Saskia Hogenhout says: "Phytoplasmas are a spectacular example of how the reach of genes can extend beyond the organisms to impact surrounding environments. (jic.ac.uk)
Gary Andersen, Todd DeSantis, and their colleagues at Berkeley Lab have invented a fast DNA microarray (PhyloChip) that is unique in its ability to identify multiple bacterial and archaeal organisms from complex microbial samples. (ideaconnection.com)
the microbiological load (i.e., number of viable organisms in or on the object or surface) or organic material on a surface or object prior to decontamination, or sterilization, also known as "bioload" or "microbial load. (cdc.gov)

Six new antimicrobial peptides (AMPs) with sequence homology to the Nk-lysin (Nkl) family of proteins have been characterized and their patterns of gene expression in rainbow trout (Oncorhynchus mykiss) described. (usda.gov)
Chromosomal locations of these peptides show that nkl1 was located on chromosome arm 25q, whereas the other five nkl genes were clustered on chromosome arm 19q. (usda.gov)

It was known the features were controlled by one gene, and the team identified the molecular component as VRT-A2, part of the MADS-box family of transcription factors that act as genetic switches controlling protein synthesis. (jic.ac.uk)
Systematic humanization of yeast genes reveals conserved functions and genetic modularity. (openwetware.org)
The host genetic factors are assumed to play a critical role in tuberculosis pathogenesis, through impact on the gene expression of cytokines and chemokines, which are implicated in the host immune response. (cdc.gov)

The next steps will be to expand the study to include multiple animal models, and these experiments are already underway," said Mark Shirtliff, a co-author of the study and a professor in the Department of Microbiology and Immunology at the University of Maryland School of Medicine and the Department of Microbial Pathogenesis at the University of Maryland School of Dentistry. (scienceblog.com)

This switches on genes that synthesise anti-microbial proteins, such as cathelicidin and β defensin 2. (sanus-q.com)
Vitamin D stimulates the production of anti-microbial proteins within the body, which helps boost natural immunity and fights infections. (sanus-q.com)
Exploitation of these newly reported properties of this age-old drug could prove to be a promising solution for anti-microbial chemoresistance menace and other prevalent non-communicable diseases. (longdom.org)

The epithelium function and the mucosal associated immune system are influenced by direct host-microbiota interactions and through modulation of the microbial metabolism [7]. (deepdyve.com)

The active protein is a homodimer that binds to the interferon gamma receptor which triggers a cellular response to viral and microbial infections. (origene.com)
Mutations in this gene are associated with an increased susceptibility to viral, bacterial and parasitic infections and to several autoimmune diseases. (origene.com)
We provide specific characteristics of the illness to help doctors distinguish bacterial from viral sinus infections, and provide guidance on which antibiotics are best for appropriate and effective treatment. (cdc.gov)
Bacterial biofilms play an important role in UTIs, responsible for persistent infections leading to recurrences and relapses. (mdpi.com)
These proteins work as natural antibiotics and help the body to fight a range of bacterial and viral infections . (sanus-q.com)
Mice deficient in this gene have increased susceptibility to viral, bacterial and parasitic infections and to several autoimmune diseases. (ifn-a.com)
In a new study, McIver's laboratory and researchers at the University of Maryland School of Medicine identified two genes important for invasive group A Streptococcus infections in mice. (scienceblog.com)
The genes, subcutaneous fitness genes A (scfA) and B (scfB), may prove to be promising clinical targets in the fight against these infections, as there are no vaccines against group A Streptococcus or effective treatments for invasive infections. (scienceblog.com)
One of the most common chronic bacterial oral infections, periodontitis, affects the supporting structures of the teeth. (medscape.com)
[ 5 , 7 ] Although the underlying mechanisms are complex, the chronic inflammatory state and microbial burden in people with periodontal disease may predispose them to cardiovascular diseases in ways proposed for other infections. (medscape.com)

human gut microbiome, data repositories, large-scale and integrative computational tools, modelling, immunomodulation, drug screening Background The human gastrointestinal tract is a complex ecosystem in which eukaryotic cells continuously interact with nutrients and with the complex microbial population of the gut microbiota [1]. (deepdyve.com)

Necromass was rapidly depleted in the mesocosms within 4 days, accompanied by a strong decrease in Shannon diversity and a 10-fold increase in bacterial 16S rRNA gene copy numbers. (ufz.de)
Furthermore, potential consequences for community functioning were assessed based on 16S V4 rRNA gene profiles by indirectly inferring the abundance of functional genes based on results obtained with Piphillin. (unboundmedicine.com)

Subject to confirmation of the hypotheses herein generated, our work could help guide the design of microbiome-based precision interventions, aimed at rewiring microbial networks to support a healthy diet-microbiome-gut-brain axis, thus counteracting obesity and related complications. (biomedcentral.com)
Salinity significantly affected root microbiome beta-diversity according to weighted abundances (p = 0.032) but had no significant effect on the relative abundances of microbial taxa (p = 0.568). (unboundmedicine.com)
Now, researchers at the Stanford University School of Medicine have discovered that these microbial hitchhikers - collectively known as the human microbiome - are churning out tens of thousands of proteins so small that they've gone unnoticed in previous studies. (technologynetworks.com)
If the shapes and functions of these proteins can be recreated in the lab, they could help researchers advance scientific understanding of how the microbiome affects human health and pave the way for new drug discovery. (technologynetworks.com)
Bhatt and her colleagues wondered if answers might be found in the small proteins they knew were likely to wiggle through the nets cast by other studies focusing on the microbiome. (technologynetworks.com)
Important applications can be built on top of the Functional Genomics Platform including services to annotate biological function in the microbiome, predict antimicrobial resistance (AMR), develop molecular targets for health interventions, or to expand our fundamental knowledge of microbial life. (ibm.com)
The colonic microbiome view is controversial, some people Metagenomics of the Human Intes- is the most diverse and also the best consider the gut microbiota to be tinal Tract (MetaHIT) consortium re- characterized microbial community. (who.int)

The objective for the study was to examine the effects of salinity and drought on above- and belowground spinach microbiomes and evaluate seasonal changes in their bacterial community composition and diversity. (unboundmedicine.com)
Mutations were observed in genes affecting the ion balance in the cell, the composition of the cell membrane and proteins acting as regulators. (dtu.dk)
PhyloChip has also already been used to study biological degradation of toxic chemicals, bioremediation of uranium, microbial composition of the atmosphere due to climate change, and the pathogenic colonization of lungs in intubated patients. (ideaconnection.com)

Here we report the temporal measurements of absolute RNA and protein levels per gene within a mixed bacterial-archaeal consortium. (nature.com)

Processes such as host-microbe crosstalk, immune activation and inflammation, microbe-microbe signalling, microbial metabolism and antimicrobial activity are bioactive in the human gut [3]. (deepdyve.com)
2012. Regulation of antimicrobial peptide gene expression by nutrients and by-products of microbial metabolism. . (oregonstate.edu)
2014. Regulation of the human cathelicidin antimicrobial peptide gene by 1α,25-dihydroxyvitamin D3 in primary immune cells. . (oregonstate.edu)
2014. Synergistic induction of human cathelicidin antimicrobial peptide gene expression by vitamin D and stilbenoids. . (oregonstate.edu)
2013. Curcumin induces human cathelicidin antimicrobial peptide gene expression through a vitamin D receptor-independent pathway. . (oregonstate.edu)

While the field of microbiology has adapted to the study of complex microbiomes via modern meta-omics techniques, we have not updated our basic knowledge regarding the quantitative levels of DNA, RNA and protein molecules within a microbial cell, which ultimately control cellular function. (nature.com)

The observed progressive decrease in defecation frequency and concomitant increase in the electrical conductivity (EC) preceded or took place in absence of significant changes at the taxonomic, functional gene, metabolome and intestinal metal profile levels. (frontiersin.org)
A full structural and functional protein characterization was carried on and in addition, the enzyme was able to form diamond crystals which diffracted at 1.7 Å. (unina.it)
A fosmid containing an ORF encoding a gene with potential esterase/lipase activity was detected by functional screening on tributyrin agar plates. (unina.it)
A biochemical approach highlighted protein features with a functional characterization methodology. (unina.it)
Pathways and functional genes analysis of soil, rhizosphere, and phyllosphere showed that the most abundant functional genes were mapped to membrane transport, DNA repair and recombination, signal transduction, purine metabolism, translation-related protein processing, oxidative phosphorylation, bacterial motility protein secretion, and membrane receptor proteins. (unboundmedicine.com)
The CGS is a state-of-the-art facility for gene discovery, molecular microbiology, functional genomics, PCR, comparative expressomics, molecular diagnostics and confocal imaging. (centerforgenomicsciences.org)
However, the most variant protein domains were the putative functional regions and there is biological evidence that variants can be functional, arguing they do play a role. (biomedcentral.com)

which exhibited low transcriptional activity, especially of genes involved in secondary bile acid biosynthesis and neuroendocrine signaling (i.e., production of neurotransmitters, indoles and ligands for cannabinoid receptors). (biomedcentral.com)

Methods: We profiled IgG and IgA antibodies to individual microbial proteins in serum samples of CRS patients and controls using a novel high-throughput microarray protein technology, Nucleic Acid Programmable Protein Array (NAPPA). (elsevierpure.com)
a foreign substance, usually protein or carbohydrate substance (as a toxin or enzyme) capable of stimulating an immune response, usually the production of antibodies. (cdc.gov)

With the advent of various, anti-bacterial properties of emodin may come in rescue to combat emerging drug resistant microbial and parasitic strains. (longdom.org)

Inactivity and hypoxia resulted in a significant increase in the genus Bacteroides in HBR, in genes coding for proteins involved in iron acquisition and metabolism, cell wall, capsule, virulence, defense and mucin degradation, such as beta-galactosidase (EC3.2.1.23), α-L-fucosidase (EC3.2.1.51), Sialidase (EC3.2.1.18), and α-N-acetylglucosaminidase (EC3.2.1.50). (frontiersin.org)
Subinhibitory concentrations of tetracycline affect virulence gene expression in a multi-resistant Salmonella enterica subsp. (mcmaster.ca)
This suggests these proteins are not essential for virulence. (biomedcentral.com)

My coauthors and I developed the Infectious Diseases Society of America (IDSA)'s Clinical Practice Guideline for Acute Bacterial Rhinosinusitis in Children and Adults to help physicians make sense of how to best diagnose and treat rhinosinusitis. (cdc.gov)
Read the full-text "IDSA Clinical Practice Guideline for Acute Bacterial Rhinosinusitis in Children and Adults online at http://cid.oxfordjournals.org/content/54/8/1041.full.pdf+html or pick up the April 15 issue of Clinical Infectious Diseases . (cdc.gov)
Many factors have contributed to the persistence and increase in the occurrence of infectious diseases, such as societal changes, health care, food production, human behaviour, environmental change, public health infrastructure and microbial adaptation [2]. (who.int)

You'll be based primarily within the Infection and Immunity research group at Bath where you'll work with researchers at the forefront of microbial research, strengthening your ability to work as a scientist. (bath.ac.uk)
If symptoms last for 10 days without improvement, or include fever of 102 degrees or higher with nasal discharge and facial pain lasting three to four days, or if symptoms seem to improve after 4 to 7 days only to worsen again, the infection is likely bacterial and should be treated with antibiotics. (cdc.gov)
The guidelines advise against the current standard of care, amoxicillin, and instead recommend using amoxicillin-clavulanate for treatment if a bacterial infection is suspected. (cdc.gov)
I will focus on a few recent discoveries that illustrate types of microbial collaborations during infection. (asmblog.org)
The recent success gut microbial genes, obtained after has fantastic potential, it has only of faecal microbiota transplantation, sequencing whole faecal microbiota been about 10 years since the sci- especially in the context of Clostridi- metagenomes from 124 European indi- entific community first realized its im- um difficile infection, argues for such viduals [4]. (who.int)
The researchers identified 273 scf genes as potentially involved in establishing infection under the skin, but two genes stood out: scfA and scfB. (scienceblog.com)

We explored the metagenomic, metabolomic and trace metal makeup of intestinal microbiota and environment in healthy male participants during the run-in (5 day) and the following three 21-day interventions: normoxic bedrest (NBR), hypoxic bedrest (HBR) and hypoxic ambulation (HAmb) which were carried out within a controlled laboratory environment (circadian rhythm, fluid and dietary intakes, microbial bioburden, oxygen level, exercise). (frontiersin.org)
Under healthy conditions, the in- nomes obtained from individuals crobiota resembles the mother's skin testinal microbiota is considered to on three continents, including 760 microbial community, composed of be a stable community, influenced samples from Europe. (who.int)
In addition we will address important areas of modern epidemiology such as the influence of early life factors on adult health and disease, but also the importance of the gene-diet-microbiota interaction for body function and health. (lu.se)

A research project will provide hands-on experience with many of the skills and techniques that are used in a microbial genetics laboratory. (otago.ac.nz)

You'll also have the opportunity to use our specialist facilities, including computational methods to analyse large biological datasets to answer the 'big' questions in microbiology, from bacterial epidemiology to evolution. (bath.ac.uk)
This technology provides a critical tool for the spatiotemporal targeting of potent bacterial therapeutics in a variety of biological and clinical scenarios. (nature.com)
Because they are so small - fewer than 50 amino acids in length - it's likely the proteins fold into unique shapes that represent previously unidentified biological building blocks. (technologynetworks.com)
Protein domains are fundamental objects of biochemistry delivering the biological activity of the microorganism. (ibm.com)

Small proteins, they reasoned, are more likely than their larger cousins to slip through the cell membrane to ferry messages - or threats - to neighboring host or bacterial cells. (technologynetworks.com)
TLR5, a Type I membrane protein belonging to the Toll-like receptor family, participates in the innate immune response to microbial agents. (prosci-inc.com)

The new confocal imaging facility at the Center for Genomics Sciences (CGS) is dedicated primarily to the study of bacterial biofilms and human disease. (centerforgenomicsciences.org)
The facility combines confocal scanning laser microscopy and real-time time lapse imaging of bacterial biofilms growing in situ without having to fix or dehydrate the sample significantly reducing artifacts. (centerforgenomicsciences.org)

Their proteomes comprised various proteins for uptake and transport functions and amino acid metabolization. (ufz.de)
Vitamin D binds to receptors in cells and controls the synthesis of various proteins that your body needs to carry out a wide range of functions - to survive and to be healthy. (sanus-q.com)

The encoded protein is secreted by cells of both the innate and adaptive immune systems. (origene.com)
However, ionizing radiation carries the risk of damage to host immune cells and engineered microbial cells 31 . (nature.com)
The PlanHab wash-out period corresponded to a profound life-style change (i.e., reintroduction of exercise) that resulted in stepwise amelioration of the negative physiological symptoms, indicating that exercise apparently prevented the crosstalk between the microbial physiology, mucin degradation and proinflammatory immune activities in the host. (frontiersin.org)
Many surface protein genes were missing or truncated, unlike immune evasion genes, and several distinct variants were identified. (biomedcentral.com)
Surprisingly, sequenced strains from four animal S. aureus strains had surface and immune evasion proteins remarkably similar to those found in human strains, yet putative targets of these proteins vary substantially between different hosts. (biomedcentral.com)
Surface and immune evasion genes are candidates for S. aureus vaccines, and their distribution and functionality is key. (biomedcentral.com)

Many phototrophs are auxotrophic for the synthesis of vitamins that are provided by their bacterial partners, which in turn benefit from the released exudates. (dsmz.de)

The TLR5 gene lies in a locus that is associated with susceptibility to Salmonella. (prosci-inc.com)

Formerly, researchers relied on bacterial cultures to identify the microbes present in an environmental or medical sample. (ideaconnection.com)

To tackle the problem, Sberro decided to compare potential small-protein-coding genes among many different microbes and samples. (technologynetworks.com)
A blog for sharing appreciation of the width and depth of microbes and microbial activities on this planet. (asmblog.org)

Barrier agains t pathogen s gut bacterial genes in the MetaHIT ation when attempting to extrapolate [10], although Proteobacteria, Ver- catalogue were also well represent- results obtained in mouse models to rucomicrobia, and Fusobacteria are ed in the other metagenomes that the situation in humans. (who.int)

In this study, a weighted phage detection algorithm, PhiSpy was developed based on seven distinctive characteristics of prophages, i.e. protein length, transcription strand directionality, customized AT and GC skew, the abundance of unique phage words, phage insertion points and the similarity of phage proteins. (nih.gov)
It also plays a role in mediating detection of bacterial flagellins. (prosci-inc.com)

In order to perform studies of such design and test if previously defined quantitative data about the functioning of microorganisms (i.e., protein-to-RNA ratio) is applicable to real world consortia, we must first sample microbial communities across transition events and employ quantification techniques that are absolute. (nature.com)

After cloning and gene heterologous expression in E. coli, the recombinant protein was obtained as high level in soluble form and then purified to homogeneity. (unina.it)
Gene cloning and expression were followed by a production of the recombinant protein in a soluble form. (unina.it)
In this study, we identified six genes with sequence homology to Nkl and characterized their patterns of mRNA expression and abundances in rainbow trout (Oncorhynchus mykiss). (usda.gov)
Clearly, interspecies bacterial communication influences the regulation of gene expression. (asmblog.org)
The bacterial nucleoid and its influence on gene expression. (otago.ac.nz)
Regulation of gene expression by proteins and small RNAs. (otago.ac.nz)
Increased expression of specific heat shock proteins (HSPs) in CD patients protects intestinal epithelial cells (IECs) from death. (dal.ca)
We plan to implement an oxygen-sensitive promoter to induce expression of the glowing gene. (igem.org)
Based on different gene expression profiles, subtypes of macrophages (eg, M1, M2), which have different roles in amplifying or limiting the inflammatory response, have been identified. (msdmanuals.com)

The application of molecular techniques such as the polymerase chain reaction to produce DNA fingerprints and other 16S ribosomal RNA gene (ribotyping) methods of strain analysis have been employed to differentiate P. penneri from P. vulgaris and P. mirabilis strains. (wikipedia.org)
The new findings show how the bacterial protein known as SAP05 manipulates plants by taking advantage of some of the host's own molecular machinery. (jic.ac.uk)

Seaweed biomass has been proposed as a promising alternative carbon source for fermentation processes using microbial factories. (dtu.dk)

Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. (origene.com)

The NirB gene is reliant on FNR (Fumarate and nitrate reductase) which allows the promoter to activate when there is no oxygen present, as well as facilitates in the regulation of transcription that is responsible for the growth under anaerobic environment. (igem.org)

a bacterial induced inflammation of the lining of the heart and its valves. (cdc.gov)

Adherence is an essential step required for bacterial colonisation of a new host. (biomedcentral.com)

High temperature protein G (HtpG), a gene encoding a bacterial HSP, is less abundant in pediatric CD patients than in healthy individuals. (dal.ca)

The positive clones employing the largest halo size were sequenced and a gene encoding a putative lipase was found. (unina.it)
Putative large exoproteins and a putative protein with a RTX toxin-type ß-roll could be identified. (dsmz.de)

The majority of existing tools rely on detecting genomic regions enriched in protein-coding genes with known phage homologs, which hinders the de novo discovery of phage regions. (nih.gov)
Genomic DNA of the nkl1-4 genes consisted of five exons and four introns, whereas the nkl-like a & b genes consisted of four exons and three introns. (usda.gov)
Symbiosis genes" of the epibiont were identified by genomic approaches. (dsmz.de)

But the proteins' miniscule size had made it difficult to identify and study them using traditional methods. (technologynetworks.com)
bacteriorhodopsin, halorhodopsin, xanthorhodopsin, sensoryrhodopsin and marine prokaryotic Ion-pumping rhodopsins like actinorhodopsin, proteorhodopsin have been utilized to develop the methods that accurately identified the ion pumping haloarchaeal and other type I microbial rhodopsins. (biomedcentral.com)

2016). Dynamic metabolic exchange governs a marine algal-bacterial interaction. (dsmz.de)

The developed web server ( https://bioinfo.imtech.res.in/servers/rhodopred ) can identify the Ion Pumping Haloarchaeal rhodopsin proteins and their subtypes. (biomedcentral.com)

These active receptors switch on some genes that synthesise many different proteins and enzymes that control how your body function. (sanus-q.com)

This protein binds to TIRAP and MyD88 via their respective TIR domains TLR5 is highly expressed in liver, and is detected in lung and at very low levels in most other tissues. (prosci-inc.com)
Xanthorhodopsin, originally found in Salinibacter ruber binds to salinixanthin-like carotenoids that bind specifically to the rhodopsin protein. (biomedcentral.com)

Sandwich ELISA analysis of mouse IFN-γ protein using GTX02927 Interferon gamma antibody [AN18] as coating antibody and GTX02943-02 Interferon gamma antibody [R4-6A2] (Biotin) as detecting antibody. (genetex.com)
Phylogenetic analysis revealed a conserved structure of Nkls among the teleosts and further protein sequence analyses suggests that all six nkl genes fall within the Nkl sub-family of the Saposin family of proteins. (usda.gov)
We present a new method for performing gene-centric assembly, called protein-alignment-guided assembly, and provide an implementation in our metagenome analysis tool MEGAN. (biomedcentral.com)
Predicting bacterial growth conditions from metabolic output by flux balance analysis. (openwetware.org)

Anatomy1

Organisms7

Diseases1

Phenomena and Processes3

Genomes15

Genome10

Pathogens3

Sequences7

Bacteria17

Fungal2

Viral Proteins2

Species9

Populations5

Make proteins1

Organisms4

Peptides2

Genetic3

Pathogenesis1

Anti-microbial3

Interactions1

Infections10

Complex microbial1

RRNA2

Microbiome7

Composition3

Archaeal1

Antimicrobial5

Molecules1

Functional7

Biosynthesis1

Antibodies2

Parasitic1

Virulence3

Infectious3

Infection6

Microbiota3

Genetics1

Biological4

Membrane2

Biofilms2

Various proteins2

Immune6

Synthesis1

Susceptibility1

Researchers1

Microbes2

Pathogen1

Detection2

Microorganisms1

Expression9

Molecular2

Biomass1

Recombinant protein1

Regulation1

Inflammation1

Adherence1

Abundant1

Putative2

Genomic3

Methods2

Interaction1

Subtypes1

Enzymes1

Binds2

Analysis4