AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsInformation ScienceHealth Care
Interleukin-1Interleukin-2Receptors, InterleukinInterleukin-6CytokinesInterleukin-4Interleukin-10InterleukinsInterleukin-8Interleukin 1 Receptor Antagonist ProteinTumor Necrosis Factor-alphaCells, CulturedReceptors, Interleukin-2Interferon-gammaT-LymphocytesInterleukin-12Lymphocyte ActivationRNA, MessengerRecombinant ProteinsReceptors, Interleukin-1Interleukin-1betaInterleukin-3Mice, Inbred C57BLInterleukin-5Interleukin-18Mice, Inbred BALB CLipopolysaccharidesReceptors, Interleukin-4InflammationInterleukin-13Cell LineReceptors, Interleukin-6Interleukin-11MonocytesCell DivisionGene Expression RegulationSignal TransductionReceptors, ImmunologicTh2 CellsEnzyme-Linked Immunosorbent AssayInterleukin-17Flow CytometryAntigens, CDMacrophagesSpleenInterleukin-15Molecular Sequence DataInterleukin-7Leukocytes, MononuclearCD4-Positive T-LymphocytesTumor Cells, CulturedGene ExpressionTh1 CellsKiller Cells, NaturalAntibodies, MonoclonalNF-kappa BInterleukin-13 Receptor alpha1 SubunitInflammation MediatorsBase SequenceReceptors, Interleukin-13B-LymphocytesReverse Transcriptase Polymerase Chain ReactionLymphokinesMice, KnockoutT-Lymphocytes, Helper-InducerCytotoxicity, ImmunologicCell DifferentiationSialoglycoproteinsDose-Response Relationship, DrugSTAT3 Transcription FactorLymphocytesAntigens, Differentiation, T-LymphocyteKiller Cells, Lymphokine-ActivatedGrowth SubstancesDendritic CellsMice, Inbred C3HTime FactorsDisease Models, AnimalTransfectionUp-RegulationInterleukin-1alphaAntigens, CD3KineticsPhytohemagglutininsInterleukin-23Receptors, Interleukin-1 Type IBiological MarkersMice, Inbred StrainsCytokine Receptor gp130Receptors, Interleukin-5Caspase 1Transcription, GeneticSTAT6 Transcription FactorMembrane GlycoproteinsDinoprostoneImmunoglobulin EReceptors, Interleukin-10ImmunotherapyReceptors, Interleukin-7Receptors, Interleukin-3
InflammationProcalcitoninCytokineCytokinesTumor Necros2020GenesSecretion2019BiomarkersMRNA expressionHigh-sensitivity C-reactivInversely relatedReceptorPreterm neonatesHsCRPSoluble intercellularMAPKAcuteAbstractBioactiveMonocyteResearchersStimulatesInsulin resistanceMediatesCellsMarkersNeonatesInflammatoryConcentrationPostmenopausalPathwayAntibodyActivationSB203580TissueProliferationGrowthSevereSymptomsLevels of C-reactivMolecularKinaseSimilarlySignificantlyEndogenousBoneBaselineGene expressionPlasmaClinicalHumanExpression
Inflammation13
Procalcitonin2
  • Background We aimed to assess the predictive performance of C-reactive protein ( hsCRP ), procalcitonin (PCT), and interleukin-6 ( IL-6 ) at different times points of bloodstream infections (BSI) management. (bvsalud.org)
  • Other ancillary laboratory tests-eg, complete blood count (CBC), white blood cell (WBC) count, erythrocyte sedimentation rate, C-reactive protein, procalcitonin-may also be useful, depending on the manifestations of disease under consideration. (medscape.com)
Cytokine6
  • Interleukin (IL)-6 is a cytokine produced by several cell types including antigen presenting cells (APC) such as macrophages, dendritic cells, and B cells. (nih.gov)
  • IL-6 inhibits Th1 differentiation by upregulating supressor of cytokine signaling (SOCS)-1 expression to interfere with IFNgamma signaling and the development of Th1 cells. (nih.gov)
  • Growth hormone down-regulation of Interleukin-1beta and Interleukin-6 induced acute phase protein gene expression is associated with increased gene expression of suppressor of cytokine signal-3. (utmb.edu)
  • Angiotensin II triggers an inflammatory pathway, providing a positive feedback cycle, named IL-6 amplifier, resulting in excessive immune activation and the cytokine storm associated with severe COVID-19. (neurosciencenews.com)
  • Recently, it has been shown that IL-6 also acts as a "myokine," a cytokine produced from muscle, and is elevated in response to muscle contraction ( 3 ). (dadamo.com)
  • Other cytokines that signal through receptors containing gp130 are Interleukin-11 (IL-11), ciliary neurotrophic factor (CNTF), cardiotrophin-1 (CT-1), cardiotrophin-like cytokine (CLC), leukemia inhibitory factor (LIF), oncostatin M (OSM), Kaposi's sarcoma associated herpes virus interleukin 6 like protein (KSHV-IL6). (dadamo.com)
Cytokines8
  • 1: In the haematopoietic microenvironment, bone marrow stromal cells play an important role in regulating haematopoiesis by expressing various cytokines, including leukaemia inhibitory factor (LIF) and interleukin-6 (IL-6). (unboundmedicine.com)
  • 4: Expression of a dominant-negative mutant form of JNK1 that blocked FCS-induced JNK activity had no effect on protein production and gene expression of these cytokines. (unboundmedicine.com)
  • IL-10 inhibits the synthesis of pro-inflammatory cytokines and suppresses antigen presentation, and normal serum half-life is only a few hours [ 6 ]. (biomedcentral.com)
  • Obesity is a metabolic disorder characterized by a chronic low-grade inflammatory state, as reflected in increased levels of circulating inflammatory markers, including pro-inflammatory cytokines and the acute phase protein C-reactive protein (CRP) ( 1 - 4 ). (frontiersin.org)
  • IL-6 is probably the best studied of the cytokines that utilise gp130 in their signalling complexes. (dadamo.com)
  • These cytokines are comonly referred to as the IL-6 like or gp130 utilising cytokines. (dadamo.com)
  • Angiopoietin‑like protein 7 (Angptl7) is one of the main paracrine cytokines in cord blood stem cells, and is capable of stimulating human hematopoietic stem and progenitor cell expansion. (spandidos-publications.com)
  • The mRNA expression levels and protein concentrations of inflammatory cytokines in the lung tissue and mouse serum were measured using reverse transcription‑quantitative PCR and ELISA, respectively. (spandidos-publications.com)
Tumor Necros2
  • In the present study, we extended this previous observation by comparing the effect of Tg and other calcium-mobilizing G-protein-coupled receptor (GPCR) agonists on the expression of different pro-inflammatory genes in response to tumor necrosis factor (TNF)-α in ASM cells. (tmu.edu.tw)
  • Graves DT, Cochran D. The contribution of interleukin-1 and tumor necrosis factor to periodontal tissue destruction. (medlineplus.gov)
20202
  • Métodos Los casos se recogieron entre enero de 2020 y junio de 2021 en el Primer Hospital Afiliado de la Universidad Médica de Xinjiang (n = 185). (bvsalud.org)
  • American journal of physical anthropology 2020 6 173 (1): 50-60. (cdc.gov)
Genes7
  • The use of luciferase-tagged IL-6 and RANTES promoter constructs demonstrated similar effects of Tg on IL-6 and RANTES genes in basal and TNF-α-stimulated conditions. (tmu.edu.tw)
  • The cyclic adenosine monophosphate (cAMP)-dependent pathway plays a minor role in this differential regulation of IL-6 and RANTES genes expression. (tmu.edu.tw)
  • Among the known genes uncovered in the screen were those encoding proteins that function in cell division, cell signalling and gene/protein expression. (elsevierpure.com)
  • Northern blot analysis documented that two transcription factor genes chosen for further study, c-myc promoter-binding protein (MBP-1) and X-box binding protein 1 (XBP-1), were up-regulated in U266 cells about 3-fold relative to the cell cycle-dependent β-actin gene 12 h after IL-6 treatment. (elsevierpure.com)
  • Both genes were also similarly up-regulated by IL-6 in factor-dependent ANBL-6 myeloma cells. (elsevierpure.com)
  • Parkinson's patients carrying mutations in PINK1 and Parkin genes have increased levels of circulating interleukin 6 and mitochondrial DNA. (neurosciencenews.com)
  • Protein-protein interaction (PPI) networks and modules were constructed to identify hub genes with the Search Tool for the Retrieval of Interacting Genes/Proteins (STRING) and Cytoscape. (researchsquare.com)
Secretion10
  • The aim of this study was to evaluate the role of mitogen-activated protein kinase (MAPK) family in serum-induced secretion of LIF and IL-6 by bone marrow stromal cells. (unboundmedicine.com)
  • 5: These findings demonstrate that both ERK and p38 MAPK are involved in FCS-induced LIF secretion, whereas only p38 MAPK is important for IL-6 secretion, and that FCS-induced activation of JNK has no effect on the production of LIF and IL-6. (unboundmedicine.com)
  • TY - JOUR T1 - Role of mitogen-activated protein kinase family in serum-induced leukaemia inhibitory factor and interleukin-6 secretion by bone marrow stromal cells. (unboundmedicine.com)
  • We found that in resting cells, Tg (10-100 nM) or the bradykinin (BK) (1-10 μM) and thrombin (Thr) (1 U/ml) stimulated interleukin (IL)-6 secretion but had no effect on regulated on activation, normal T cells expressed and secreted (RANTES) levels. (tmu.edu.tw)
  • More importantly, such calcium-mobilizing agents significantly enhanced TNF-α-induced IL-6 secretion while RANTES secretion was abrogated. (tmu.edu.tw)
  • 2-Aminoethoxydiphenyl borate (APB), a blocker of store-operated calcium channels (SOCs), and bisindolylmaleimide I (Bis I), a broad-spectrum protein kinase C (PKC) inhibitor, inhibited the basal and synergic effects of IL-6 secretion in response to calcium-mobilizing agents and TNF-α, but did not prevent the abrogated effect of RANTES secretion. (tmu.edu.tw)
  • whereas Rottlerlin, a PKC-δ inhibitor, inhibited both Thr- and TNF-α-induced expression of IL-6, while BK-induced IL-6 secretion was not affected. (tmu.edu.tw)
  • However, it has been found somewhat more effective to bind IL-1 and TNF-b , and in this way reduce the secretion of IL-6 in the first place. (dadamo.com)
  • The secretion level of IL-6 in the culture supernatants was assayed by ELISA, the intracellular level of IL-6 was detected by flow cytometry and the expression of IL-6 mRNA was analyzed by RT-PCR. (dadamo.com)
  • However, after pre-treatment of neutrophils with quercetin (40 microM) for 30 min, the inducible effects of LPS on the increase of IL-6 secretion, intracellular IL-6 level and IL-6 mRNA expression by neutrophils were abrogated. (dadamo.com)
20191
  • PLoS neglected tropical diseases 2019 6 13 (6): e0007448. (cdc.gov)
Biomarkers3
  • We collected patients records of hsCRP , PCT, and IL-6 serum levels and calculated the clearance of these biomarkers on day 1, day 3, and day 5 ( hsCRP -1, hsCRP -3, hsCRP -5, so do PCT, and IL-6 ). (bvsalud.org)
  • The aim of our study was to investigate the predictive value of the biomarkers interleukin 6 (IL-6), interleukin 10 (IL-10) and lipopolysaccharide-binding protein (LBP) compared with clinical CRB and CRB-65 severity scores in patients with community-acquired pneumonia (CAP). (biomedcentral.com)
  • The biomarkers also included proteins not previously associated with COVID-19 infection. (euronews.com)
MRNA expression2
  • RT-PCR and Western blot analysis were used for determining procollagen I and III mRNA expression and protein production. (thieme-connect.com)
  • It was also found that visfatin upregulated collagen I and III production, procollagen I and III mRNA expression and protein production. (thieme-connect.com)
High-sensitivity C-reactiv1
  • METHODS: We investigated the association between hsCRP (high-sensitivity C-reactive protein), IL-6 (interluekin-6), and recurrent major adverse cardiovascular events (MACE), and stroke from individual participant data from 8420 patients with ischemic stroke/transient ischemic attack from 10 prospective studies. (ox.ac.uk)
Inversely related1
  • 3.00 mg/liter was 1.89 (95% confidence interval: 1.08, 3.31) in low- compared with high-positive-affect women, and plasma interleukin-6 was also inversely related to positive affect in women (p = 0.016). (nih.gov)
Receptor4
  • Oncostatin-M specific receptor subunit beta also known as the Oncostatin M receptor (OSMR) , is one of the receptor proteins for oncostatin M, that in humans is encoded by the OSMR gene. (wikipedia.org)
  • This protein heterodimerizes with interleukin 6 signal transducer to form the type II oncostatin M receptor and with interleukin 31 receptor A to form the interleukin 31 receptor, and thus transduces oncostatin M and interleukin 31 induced signaling events. (wikipedia.org)
  • IL-6 triggers the formation of protein complexes of gp130 and the IL-6 receptor activating the receptor. (dadamo.com)
  • One important drug in this field is the anti IL- 6 receptor antibody (MRA), used as one of new therapeutic approaches in rheumatic arthritis. (dadamo.com)
Preterm neonates1
  • Bronchopulmonary dysplasia (BPD) is the most critical complication in preterm neonates and is an independent risk factor affecting long-term cognitive development ( 1 - 6 ). (spandidos-publications.com)
HsCRP6
  • Serial serum hsCRP -3, IL-6 -3, PCT-1, PCT-3, and PCT-5 were statistically higher in BSI mortality than survivors . (bvsalud.org)
  • Antecedentes Nuestro objetivo fue evaluar el rendimiento predictivo de la proteína C reactiva ( hsCRP ), procalcitonina (PCT) e interleucina-6 ( IL-6 ) en distintos momentos del tratamiento de pacientes con infecciones del torrente sanguíneo. (bvsalud.org)
  • Los valores de los niveles séricos de hsCRP , PCT e IL-6 se obtuvieron de los registros de los pacientes y calculamos la depuración de estos biomarcadores en el día 1, el día 3 y el día 5 ( hsCRP -1, hsCRP -3, hsCRP -5, PCT e IL-6 ). (bvsalud.org)
  • Los valores séricos seriados de hsCRP -3, IL-6 -3, PCT-1, PCT-3 y PCT-5 fueron estadísticamente más elevados en los pacientes fallecidos de infecciones del torrente sanguíneo que en los supervivientes . (bvsalud.org)
  • Comparing the top with the bottom quarters (Q4 versus Q1), IL-6 (RR, 1.35 [95% CI, 1.09-1.67]) and hsCRP (RR, 1.31 [95% CI, 1.07-1.61]) were associated with MACE after adjustment. (ox.ac.uk)
  • HsIL-6 and hsCRP were increased in obesity and were overall associated with TRP metabolic pathways alterations. (frontiersin.org)
Soluble intercellular2
  • The association between major depression and levels of soluble intercellular adhesion molecule 1, interleukin-6, and C-reactive protein in patients with recent acute coronary syndromes. (ucla.edu)
  • Plasma levels of soluble intercellular adhesion molecule 1 (sICAM-1) and interleukin-6 (IL-6) and the serum level of C-reactive protein were measured in 481 patients 2 months after hospitalization for acute coronary syndromes. (ucla.edu)
MAPK4
  • 3: Both PD98059 (MAPK/ERK kinase inhibitor) and SB203580 (p38 MAPK inhibitor) attenuated FCS-induced LIF protein production and gene expression. (unboundmedicine.com)
  • Orthologous to human MAPKAPK2 (MAPK activated protein kinase 2). (nih.gov)
  • Proinflammatory Effect of Endothelial Microparticles Is Mitochondria Mediated and Modulated Through MAPKAPK2 (MAPK-Activated Protein Kinase 2) Leading to Attenuation of Cardiac Hypertrophy. (nih.gov)
  • Downstream signaling activation of the OSMR-gp130 complex along the JAK1 pathway leads to IL-6 signalling which is linked with activation of the MAPK cascade, PI3K cascade and STAT3 activation. (wikipedia.org)
Acute4
  • IL-6 is involved in the acute phase response, B cell maturation, and macrophage differentiation. (nih.gov)
  • LBP is an acute-phase protein that is increased 30-fold within 24-48 h of infection [ 7 ] and it forms complexes with bacterial lipopolysaccharides. (biomedcentral.com)
  • We previously showed that recombinant human growth hormone (GH) treatment after burn down-regulated acute phase protein (APP) production and gene expression in vivo. (utmb.edu)
  • IL-6 is one of the most important mediators of fever and of the acute phase response. (dadamo.com)
Abstract1
  • abstract = "We investigated the contributions of lipoteichoic acid and M protein to reversible and irreversible adhesion of group A streptococci and the effects of such adhesion on release of interleukin-6. (tau.ac.il)
Bioactive1
Monocyte1
Researchers4
  • According to researchers, interleukin 6 plays a critical role in how exercise helps to reduce body fat. (neurosciencenews.com)
  • The researchers identified these proteins as Interleukin 6 (IL-6) and Interleukin 8 (IL-8). (sciencedaily.com)
  • The researchers used a method called mass spectrometry to quickly test for the presence and quantity of various proteins in the blood plasma. (euronews.com)
  • The researchers now think it may be possible to alleviate symptoms by using drugs that target these proteins. (euronews.com)
Stimulates2
  • Hasty, David L. / M protein mediated adhesion of M type 24 Streptococcus pyogenes stimulates release of interleukin-6 by HEp-2 tissue culture cells . (tau.ac.il)
  • In the muscle and fatty tissue IL-6 stimulates energy mobilization which leads to increased body temperature. (dadamo.com)
Insulin resistance1
  • 1. Makino T, Noguchi Y, Yoshikawa T, Doi C, Nomura K. Circulating interleukin 6 concentrations and insulin resistance in patients with cancer. (dadamo.com)
Mediates2
  • These data suggest that lipoteichoic acid mediates reversible adhesion and that M protein is required for irreversible adhesion and for inducing release of interleukin-6 from HEp-2 cells. (tau.ac.il)
  • IL-6 mediates its responses through cell surface receptors that include the transmambrane protein gp130. (dadamo.com)
Cells17
  • 2: Transformed human bone marrow stromal cells (HS-5) were stimulated with foetal calf serum (FCS) to produce LIF and IL-6. (unboundmedicine.com)
  • IL-6 activates transcription mediated by nuclear factor of activated T cells (NFAT) leading to production of IL-4 by nai;ve CD4(+) T cells and their differentiation into effector Th2 cells. (nih.gov)
  • IL-6 is secreted by a variety of cells such as T-lymphocytes, macrophages, endothelial cells and epithelial cells. (biomedcentral.com)
  • Interleukin-6 (IL-6) is implicated in the in vivo proliferation of malignant plasma cells in multiple myeloma. (elsevierpure.com)
  • To define the molecular basis of the IL-6-induced mitogenic response in myeloma cells, we applied STAR (subtractive transcriptional amplification of mRNA), a new differential expression analysis technology, to isolate mRNAs preferentially expressed in IL-6-treated versus untreated cultures of the factor-responsive myeloma cell line U266. (elsevierpure.com)
  • The gene expression of AGP and ATT were also measured in HepG2 cells transfected with pEF-Flag-l/mSOCS-3 plasmid after IL-1beta or IL-6 treatment. (utmb.edu)
  • APP gene expression was significantly decreased in cells transfected with plasmid over expressing SOCS-3 after IL-6 and IL-1beta treatment. (utmb.edu)
  • Only unencapsulated streptococci that expressed both lipoteichoic acid and M protein remained stably adherent to HEp-2 cells throughout multiple washes. (tau.ac.il)
  • Streptococci expressing both M protein and lipoteichoic acid induced release of interleukin-6 from HEp-2 cells, whereas an isogenic, M-negative mutant failed to induce release of interleukin-6. (tau.ac.il)
  • The team discovered that as two types of cancer cells reproduced and created more crowded conditions in the test site, these cells secreted certain proteins that encouraged migration. (sciencedaily.com)
  • IL-6 and IL-8 seem to deliver a message to cancer cells, telling them to move away from the densely populated primary tumor," said lead author Jayatilaka, who recently earned her doctorate in chemical and biomolecular engineering as a member of Wirtz's lab team and earlier received her undergraduate degree from Johns Hopkins' Whiting School of Engineering. (sciencedaily.com)
  • Another competitor drug, Actemra , works by blocking the protein interleukin 6 (IL-6) from connecting to cells. (drugwatch.com)
  • summarize the increasing role of cellular immunity in paraneoplastic pemphigus, evidenced by lesional mononuclear cells and elevated IL-6 levels in sera from paraneoplastic pemphigus patients. (medscape.com)
  • Interleukins are a group of proteins that are made primarily in immune system cells. (medlineplus.gov)
  • Interleukin-1 alpha is initially produced as a relatively long protein that is trapped within cells. (medlineplus.gov)
  • The shorter form of this protein is secreted by immune system cells to influence the functions of other cells. (medlineplus.gov)
  • T). This variation affects the production of interleukin-1 alpha within cells. (medlineplus.gov)
Markers1
  • The authors assessed associations between positive affect, cortisol sampled over the day, and inflammatory markers (C-reactive protein and interleukin-6) among 2,873 healthy members of the Whitehall II study. (nih.gov)
Neonates2
  • A prospective study was conducted on 162 umbilical cord blood samples of healthy term neonates at the Mount Hope Women's Hospital in Trinidad to determine reference values for interleukin-6, tumour necrosis factor-alpha and C-reactive protein. (uwi.edu)
  • To determine normal ranges for interleukin-6 (IL-6), tumour necrosis factor-alpha (TNF-α) and C-reactive protein (CRP) in umbilical cord blood from healthy term neonates at the Mount Hope Women's Hospital (MHWH), Trinidad. (uwi.edu)
Inflammatory2
  • Thus, our data suggested that quercetin might exert its anti-inflammatory effect through negatively modulating pro-inflammatory factors, such as IL-6. (dadamo.com)
  • So we're going to go through its inflammatory modulating effects of what's called BMPs, which I'm going to refer to pretty frequently throughout the presentation, that's called bone morphogenetic proteins. (chiroeco.com)
Concentration5
  • Measurements of C-reactive protein (CRP) concentration and erythrocyte sedimentation rate (ESR) are frequently ordered jointly in clinical practice. (jabfm.org)
  • The concentration of lipopolysaccharide-binding protein (LBP) is increased during bacterial infections [ 7 ]. (biomedcentral.com)
  • The OD value is proportional to the concentration of Rabbit IL-6. (caslab.com)
  • You can calculate the concentration of Rabbit IL-6 in the samples by comparing the OD of the samples to the standard curve. (caslab.com)
  • Interluekin-6 concentration was significantly correlated with dietary carbohydrate ( r = 0.15), saturated fatty acid ( r = 0.15) and glycaemic load ( r = 0.15). (who.int)
Postmenopausal1
  • Inhibitors of IL-6 (including estrogen) are used to treat postmenopausal osteoporosis. (dadamo.com)
Pathway1
  • Suggested pathway of interaction leading to Secreted of IL-6 and some of its possible effects. (dadamo.com)
Antibody3
  • The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to Rabbit IL-6. (caslab.com)
  • Then a biotinylated detection antibody specific for Rabbit IL-6 and Avidin-Horseradish Peroxidase (HRP) conjugate are added successively to each micro plate well and incubated. (caslab.com)
  • Only those wells that contain Rabbit IL-6, biotinylated detection antibody and Avidin-HRP conjugate will appear blue in color. (caslab.com)
Activation3
  • Since IL-6 is abundantly produced by APC, it is a likely source of early Th1/Th2 control during CD4(+) T cell activation. (nih.gov)
  • Today's webinar, "Breakthrough in Stem Cell Activation: The First Oral Protein Complex for Tissue Regeneration. (chiroeco.com)
  • Really excited today to talk about breakthrough in stem cell activation through an oral protein complex. (chiroeco.com)
SB2035801
Tissue1
  • COMP, IL-6, and CPK appeared insufficiently sensitive to reflect isolated tissue stress or damage, and suggest longer exposure times or larger sample sizes may be required. (cdc.gov)
Proliferation1
  • The proliferation of cardiac fibroblasts (CFs) and excessive extracellular matrix protein accumulation are the basic pathological processes of myocardial fibrosis. (thieme-connect.com)
Growth1
  • as such, they may play a role in IL-6-mediated growth control in multiple myeloma. (elsevierpure.com)
Severe7
  • 3) severe dysfunction of one or more nine patients reported to CDC, seven from published case extrapulmonary organ systems (e.g., hypotension or shock, reports, and summarizes the findings in 11 patients described cardiac dysfunction, arterial or venous thrombosis or throm- in three case series in peer-reviewed journals ( 4-6 ). (cdc.gov)
  • IL-6 and LBP levels on enrollment in the study were significantly higher for patients with a severe course of CAP than for those who did not have severe CAP. (biomedcentral.com)
  • In receiver operating characteristic analyses, the area under the curve values for of IL-6 (0.689), IL-10 (0.665) and LPB (0.624) in a severe course of CAP were lower than that of CRB-65 (0.764) and similar to that of CRB (0.69). (biomedcentral.com)
  • IL-6, IL-10 and LBP concentrations were increased in patients with a CRB-65 score of 3-4 and a severe course of CAP. (biomedcentral.com)
  • The predictive power of IL-6, IL-10 and LBP for a severe course of pneumonia was lower than that of CRB-65. (biomedcentral.com)
  • It has been hypothesized that patients with severe COVID-19 have elevated levels of antifibrinolytic proteins, which create a hypofibrinolytic state, with subsequent failure of clot lysis. (thieme-connect.com)
  • [ 6 ] HELLP syndrome is a severe form of preeclampsia and involves hemolytic anemia, elevated liver function tests (LFTs), and low platelet count. (medscape.com)
Symptoms2
  • A 2017 study found that a 12-week exercise program caused changes in IL-6 levels and was associated with a reduction in symptoms in those with mild to moderate depression. (psychcentral.com)
  • Capuron, L., Ravaud, A., Miller, A. H. & Dantzer, R. Baseline mood and psychosocial characteristics of patients developing depressive symptoms during interleukin-2 and/or interferon-α cancer therapy. (nature.com)
Levels of C-reactiv1
  • Although there was no significant association between depression and IL-6, there was an interaction between depression and statin therapy for levels of C-reactive protein. (ucla.edu)
Molecular2
  • IL-6 promotes Th2 differentiation and simultaneously inhibits Th1 polarization through two independent molecular mechanisms. (nih.gov)
  • Thus, by using two independent molecular mechanisms, IL-6 plays a dual role in Th1/Th2 differentiation. (nih.gov)
Kinase1
  • Enables protein serine/threonine kinase activity. (nih.gov)
Similarly1
  • [ 6 ] Similarly, hypertension was absent in 16% of cases reviewed in the United States. (medscape.com)
Significantly1
  • The accuracy of both CRB and CRB-65 was increased significantly by including IL-6 measurements. (biomedcentral.com)
Endogenous1
  • While the induction of Th2 differentiation by IL-6 is dependent upon endogenous IL-4, inhibition of Th1 differentiation by IL-6 is IL-4- and NFAT-independent. (nih.gov)
Bone1
  • So the complex itself is composed of what's called bone morphogenetic proteins. (chiroeco.com)
Baseline2
  • On bivariate analysis, baseline IL-6 was associated with MACE (RR, 1.26 [95% CI, 1.10-1.43]) and recurrent stroke (RR, 1.18 [95% CI, 1.05-1.32]), per unit increase logeIL-6. (ox.ac.uk)
  • WML volumes were determined at baseline and longitudinally over 6 years. (lu.se)
Gene expression2
  • IL-1beta and IL-6 induced AGP and ATT gene expression and protein production, respectively, which was down-regulated by GH treatment. (utmb.edu)
  • GH attenuates IL-1beta or IL-6 induced APP gene expression, which is associated with increased expression of SOCS-3. (utmb.edu)
Plasma1
  • This ELISA kit applies to the in vitro quantitative determination of Rabbit IL-6 concentrations in Serum, plasma and other biological fluids. (caslab.com)
Clinical2
  • I've been practicing for over 11 years and I have a multidisciplinary clinical practice now with 6 other providers based in Fairfield, Connecticut. (chiroeco.com)
  • However, histopathological examinations have revealed weak correlations between clinical features and pulp status[6]. (researchsquare.com)
Human1
  • In the present study, we investigated the effects of quercetin on IL-6 production by LPS-stimulated neutrophils in human. (dadamo.com)
Expression1
  • The experiment results showed that neutrophils cultured with medium or quercetin alone did not express IL-6, but LPS (100 ng/ml) induced IL-6 expression of neutrophils. (dadamo.com)