Shown here is a gastric gastrointestinal stromal tumor (GIST). (medscape.com)
Stromal tumor refers to a type of tumor that arises from the connective tissue cells, known as stromal cells, which provide structural support to various organs and tissues in the body. (gokhanakbulut.com)
The most well-known and common type of stromal tumor is called gastrointestinal stromal tumor (GIST). (gokhanakbulut.com)
Data from Berman JJ, O'Leary TH: Gastrointestinal stromal tumor workshop. (clinicalgate.com)
Endoscopic ultrasound (EUS) of malignant gastrointestinal stromal tumor (GIST) treated with imatinib methylate. (clinicalgate.com)
Now we understand that GIST is a disease process driven by various mutations leading to overexpression or dependency on proteins. (substack.com)
Symptoms of GIST may include abdominal pain, gastrointestinal bleeding, a palpable mass, or other digestive system-related issues. (gokhanakbulut.com)
Surgical removal of the tumor is a common approach, sometimes accompanied by targeted therapy with drugs that specifically target the molecular abnormalities found in GIST cells, such as imatinib (Gleevec) or sunitinib (Sutent). (gokhanakbulut.com)
Gastrointestinal stromal tumors (GISTs) are mesenchymal neoplasms of the gastrointestinal (GI) tract and are thought to develop from the interstitial cells of Cajal, innervated cells associated with the Auerbach plexus. (medscape.com)
Vimentin is a developmentally regulated intermediate filament protein (IFP) found in cells of mesenchymal origin. (thermofisher.com)
Histologically, GISTs can be categorized as cellular spindle cell tumors (70%), epithelioid tumors (20%), or pleomorphic/mixed morphology tumors, but such histologic distinction does not carry clear prognostic significance. (medscape.com)
Unlike other IFP proteins, vimentin is expressed, along with desmin, during the early stages of cellular development. (thermofisher.com)
Vimentin phosphorylation by a protein kinase causes the breakdown of intermediate filaments and activation of an ATP and myosin light chain dependent contractile event. (thermofisher.com)
Gastric1
The esophagus also must clear any refluxed gastric contents back into the stomach and takes part in vomiting and belching. (nature.com)
Intermediate filaments1
Both proteins are present in large amounts in the intermediate filaments of this cell, so the cell appears yellow. (atozwiki.com)
Glial cells5
The cells of the brain include neurons and supportive glial cells. (wikipedia.org)
Astrocytes (from Ancient Greek ἄστρον , ástron , "star" + κύτος , kútos , "cavity", "cell"), also known collectively as astroglia , are characteristic star-shaped glial cells in the brain and spinal cord . (atozwiki.com)
[4] Apolipoprotein E transports cholesterol from astrocytes to neurons and other glial cells, regulating cell signaling in the brain. (atozwiki.com)
Astrocytes are a sub-type of glial cells in the central nervous system . (atozwiki.com)
The radial glial cells are disposed in planes perpendicular to the axes of ventricles . (atozwiki.com)
Endothelial cells6
They perform many functions, including biochemical control of endothelial cells that form the blood-brain barrier , [1] provision of nutrients to the nervous tissue, maintenance of extracellular ion balance, regulation of cerebral blood flow, and a role in the repair and scarring process of the brain and spinal cord following infection and traumatic injuries. (atozwiki.com)
These interacting tasks are carried out by a system that is ubiquitous to all vertebrates and comprises two treelike branched systems of tubules known as blood and lymphatic vessels lined by highly specialized endothelial cells. (basicmedicalkey.com)
8 The sprouting of endothelial cells is regulated by Notch signaling receptors and their Delta-like 4 (DLL4) ligand. (basicmedicalkey.com)
Precurser lymphatic endothelial cells form a distinctive cluster in mid-gestation embryos on the dorsal side of the jugular vein. (basicmedicalkey.com)
The prospero related homeobox-1 (PROX1) transcriptional factor and vascular endothelial growth factor receptor-3 (VEGFR3) are responsible for their differentiation into lymphatic endothelial cells. (basicmedicalkey.com)
5 , 9 , 17 Although endothelial cells of blood vessels and lymphatics are somewhat similar, the lymphatics lack a continuous basement membrane and are not tightly sealed by intercellular junctions, permitting the free access of interstitial tissue fluid into the vessel. (basicmedicalkey.com)
Lesions3
Seeing two objects instead of one ( diplopia ) with a binocular view can arise from ocular misalignment caused by lesions of the brainstem and cerebellum. (medscape.com)
Watch this slideshow of precancerous lesions that may lead to skin cancer over time, including melanoma, basal cell carcinoma, and squamous cell carcinoma. (medicinenet.com)
Neoplasms of nonepithelial origin, although uncommon, are lesions that a busy gastrointestinal (GI) endoscopist can expect to encounter with some regularity. (clinicalgate.com)
Nucleus2
The blue material shows DNA visualized with DAPI stain, and reveals the nucleus of the astrocyte and of other cells. (atozwiki.com)
It is believed to be involved with the intracellular transport of proteins between the nucleus and plasma membrane. (thermofisher.com)
Melanoma1
In addition, mtDNA stress in TFAM-deficient mouse melanoma cells produces tumours that are more resistant to doxorubicin in vivo. (regenerativemedicine.net)
GISTs2
GISTs are typically defined by the expression of c- KIT (CD117) in the tumor cells, as these activating KIT mutations are seen in 85-95% of GISTs. (medscape.com)
Patients with pediatric-type GISTs present with a purely epithelioid or mixed epithelioid/spindle cell cellularity. (medscape.com)
Differentiation2
In brief, vascular endothelial growth factor-A (VEGF-A), which is a part of a large superfamily of growth factors, is required for differentiation of endothelial precursor cells. (basicmedicalkey.com)
Deletion mapping demonstrated single copy loss of a contiguous 1p36 terminal region encompassing many important neurodevelopmental genes, among them four HES genes implicated in regulating neural stem cell differentiation, and TP73 , a monoallelically expressed gene. (biomedcentral.com)
Characteristic1
Gastroparesis syndromes (GpS) are a spectrum of disorders presenting with characteristic symptoms increasingly recognized as being gastrointestinal (GI) neuromuscular disorders (NMDs). (bvsalud.org)
Maternally1
The mammalian genome comprises nuclear DNA (nDNA) derived from both parents and mitochondrial DNA (mtDNA) that is maternally inherited and encodes essential proteins required for oxidative phosphorylation. (regenerativemedicine.net)
Neurons1
There are more than 86 billion neurons in the brain, and a more or less equal number of other cells. (wikipedia.org)
Tissues1
Therefore, we propose that damage to and subsequent release of mtDNA elicits a protective signalling response that enhances nDNA repair in cells and tissues, suggesting that mtDNA is a genotoxic stress sentinel. (regenerativemedicine.net)
Cellular1
The fundamental premise here, and this is an oversimplification, is that at some point in the cellular life cycle, a mutation in one of these proteins promotes further cell growth, propagation of a clonal population and subsequent favorable selection. (substack.com)
Cerebral1
Human immunodeficiency virus (HIV), however, utilizes a totally different mechanism: it reaches cerebral microglial cells using a "Trojan horse" mechanism that involves infection of macrophages. (pafrinhibitors.com)
Brain1
[3] Another study reports that astrocytes are the most numerous cell type in the brain. (atozwiki.com)
Body1
The complex architecture of the human body requires an efficient life-support system that transports gases, liquids, and other nutrients as well as circulating cells that play important roles in body defense systems. (basicmedicalkey.com)
Cycle1
Cell death is a normal occurrence in the cell cycle of life. (hormonesmatter.com)
Expression1
Cells eventually become dependent on expression of this protein, which is usually a tyrosine kinase (the subfamily of proteins in which KIT exists). (substack.com)
Type1
This type often has astrocytic endfoot processes that physically connect the cells to the outside of capillary walls when they are in proximity to them. (atozwiki.com)
Present2
Müller cells of the retina and Bergmann glia cells of the cerebellar cortex represent an exception, being present still during adulthood. (atozwiki.com)
Thousands of copies of the circular mtDNA are present in most cell types that are packaged by TFAM into higher-order structures called nucleoids1. (regenerativemedicine.net)
Human1
The standard vascular markers used in pathologic differential diagnosis of vascular conditions include von Willebrand factor (vWF), factor VIII-associated protein, platelet endothelial cell adhesion molecule-1 (CD31), human hematopoietic progenitor cell antigen (CD34), v- ets avian erythroblastosis virus E26 oncogene homolog (ERG), human herpes virus 8 (HHV-8), latency-associated nuclear antigen (LANA1), podoplanin (D2-40), and PROX1. (basicmedicalkey.com)
Treatment1
This Antibody was verified by Cell treatment to ensure that the antibody binds to the antigen stated. (thermofisher.com)
Made2
If the danger is not resolved and the immune battles must rage on, the mitochondria begin the complicated process of reallocating resources until the battle is won or the decision is made to institute what can only be described as suicide - cell death. (hormonesmatter.com)
All sorts of mechanisms will be employed to reallocate and reinforce needed battlements, but they will be for naught, further depleting already scarce host resources, until the decision is made, within the mitochondria, to begin pulling back, withdrawing, and ultimately casting the final orders of cell death. (hormonesmatter.com)
Signs1
having evolved over two billion years to identify and communicate signs of danger to the cells within which they reside. (hormonesmatter.com)