Squamous cell carcTumorKinaseProliferationResearchersProgressionPathwaysMetabolismImportance of studyingGeneOverall survivalMRNA and protein expressionCrucialRegulateGenes encodeCancerousCytoplasmMutationsOxidativeBiomarkersHeLa CellsCellular proteinsTarget proteinsPhosphorylationCancersInflammation2021ReceptorMammalianEncodesInhibitorMetastasisImmuneTumour cellEpithelial cellsViabilityMultifunctional proteinSignificantlyPrion proteinNeuronsPromotesCancerProcessesInteractsHomologsPatientsMutationMoleculesPathwayEndoplasmic reticulumPrognosticMigrationRoleAbstractImprovesRegulatesAminoHumanExpressionMembranesClinicalMyeloid progeFindingsAblation
Squamous cell carc5
- Plasma tumor necrosis factor-α and C-reactive protein as biomarker for survival in head and neck squamous cell carcinoma. (diva-portal.org)
- Tumor TNM staging is the main basis for prognosis and treatment decision for head and neck squamous cell carcinoma (HNSCC) despite significant heterogeneity in terms of outcome among patients with the same clinical stage. (diva-portal.org)
- Purpose: We evaluated X-ray repair complementing defective repair in Chinese hamster cells 1 (XRCC1) protein in head and neck squamous cell carcinoma (HNSCC) patients in association with outcome. (psu.edu)
- Oral squamous cell carcinoma, or OSCC, makes up over 90% of all head and neck cancers that involve the upper layer of the epithelium. (asbmb.org)
- Zdenka is investigating the role of WNT5A signaling in Oral Squamous cell Carcinoma. (lu.se)
Tumor26
- Scientists report that an evolutionarily conserved transcription factor may have both positive and negative effects on tumor growth depending on whether or not the tumor cells have enough oxygen. (genengnews.com)
- In this study, a possible role of plasma interleukin-2 (IL-2), interleukin-6 (IL-6), granulocyte-macrophage colony-stimulating factor (GM-CSF), tumor necrosis factor-α (TNF-α) and C-reactive protein (CRP) as biomarkers for survival of HNSCC patients was investigated. (diva-portal.org)
- Our findings indicate that CRP and TNF-α might be suitable as biomarkers in combination with tumor TNM staging for predicting survival and individualized treatment of HNSCC patients. (diva-portal.org)
- Higher levels of C-reactive protein (CRP) and tumor necrosis factor alpha (TNF-α) were detected in plasma of the patients compared with the levels in the controls. (diva-portal.org)
- Although a variety of studies have shown that Complement C11 binding protein (C1QBP) may play a tumor-promoting or tumor-suppressive role in cancer, the functions and mechanisms of C1QBP in HCC progression are under-investigating. (jcancer.org)
- A significant association of BMP-2 mRNA expression was also found with advanced tumor stage and lymph node involvement, while lower BMP-2 mRNA expression was significantly associated with poor overall survival after radical nephrectomy. (oncotarget.com)
- RNA binding motif protein 47 (RBM47) has been proven to have anti- tumor effects on many cancers , but its effect is not yet clear in renal cancer . (bvsalud.org)
- Depletion of DKK3 in a mouse model of pancreatic cancer reduces proliferating tumor cells and prolongs survival by more than double. (medicalxpress.com)
- The tumor-associated stroma is comprised mostly of pancreatic stellate cells (PSCs) and its density and possibly the cells themselves are thought to prevent current treatments from effectively killing the tumor. (medicalxpress.com)
- Hwang's lab found DKK3 to be highly expressed in pancreatic ductal adenocarcinoma (PDAC), the most common type of pancreatic cancer , and specifically by PSCs rather than cancer cells, and her team discovered different ways to silence DKK3 from acting on cancer cells as well as immune cells in the tumor microenvironment. (medicalxpress.com)
- Suppression of stromal-derived Dickkopf-3 (DKK3) inhibits tumor progression and prolongs survival in pancreatic ductal adenocarcinoma," Science Translational Medicine (2018). (medicalxpress.com)
- A solitary extra copy of Dscr1 enhances survival of mice developing spontaneous lung tumors through suppression of tumor angiogenesis. (biomedigs.org)
- One mechanism behind chemo-resistance involves the upregulation of multidrug resistance (MDR) genes (ABC transporters) that effectively transport (efflux) drugs out of the tumor cells. (muni.cz)
- To demonstrate relevance of our findings to ovarian cancer patients, we studied relative efflux in human ovarian cancer cells obtained from either patient ascites or from primary tumor. (muni.cz)
- Efflux in ascites-derived human ovarian cancer cells is associated with increased expression of ABC transporters compared to that in primary tumor-derived human ovarian cancer cells. (muni.cz)
- A new study now finds that cellular survival after radiation exposure depends on behavior of the tumor-suppressor protein p53 over time. (sciencedaily.com)
- Scientists have known these differences involve the protein p53, a well-studied tumor-suppressor protein that initiates a cell's auto-destruct programs. (sciencedaily.com)
- The protein is also a famous tumor suppressor -- around half of human cancers have p53 mutations that render it defective or suboptimal. (sciencedaily.com)
- So, the team explored whether manipulating p53 dynamics could increase tumor vulnerability, focusing on human colon cancer cell lines with unmutated, functional p53. (sciencedaily.com)
- Clear cell renal cell carcinoma (ccRCC) is the seventh most frequently diagnosed tumor in adults in Europe and represents approximately 2.5% of cancer deaths. (cancerindex.org)
- The molecular biology underlying renal cell carcinoma (RCC) development and progression has been a key milestone in the management of this type of tumor. (cancerindex.org)
- Calebin-A induced death of malignant peripheral nerve sheath tumor cells by activation of histone acetyltransferase. (cancerindex.org)
- Basal cell carcinoma (BCC) is a nonmelanocytic skin cancer (ie, an epithelial tumor) that arises from basal cells (ie, small, round cells found in the lower layer of the epidermis). (medscape.com)
- OSCC has paired human primary tumor cells and lymph node metastasis cells, making it a prime target for extracellular vesicle, or EV, analysis and for the search for molecular targets for the disease. (asbmb.org)
- A highly expressed protein in tumor cells, encoded by Tpt1 gene. (bvsalud.org)
- WNT5A act as both tumor promoter as well as tumor suppressor, depending on cell type. (lu.se)
Kinase15
- After Fas stimulation, Daxx is activated and plays its role of pro-apoptotic protein in activating the c-JUN-N-Terminal Kinase (JNK) pathway. (wikipedia.org)
- When the cell is treated with TGF-β, HIPK2, a nuclear kinase, phosphorylates Daxx and the activated Daxx in turn activates the JNK pathway (see "The Daxx Pathway" figure). (wikipedia.org)
- Fig. 2: Fructose metabolism enhances hypoxic cell survival and decreases pyruvate kinase activity. (nature.com)
- Lipopolysaccharide induced MAP kinase activation in RAW 264.7cells attenuated by cerium oxide nanoparticle s. (cdc.gov)
- The Sda protein domain inhibits the Histidine kinase signal transduction. (wikipedia.org)
- These sporulation inhibitors are anti-kinases that bind to the histidine kinase KinA phosphotransfer protein domain and act as a molecular barricade that inhibit productive interaction between the ATP binding site and the phosphorylatable KinA His residue. (wikipedia.org)
- The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. (cancerindex.org)
- In a screen for protein phosphatase homologs that functionally interact with the autophagy-dedicated protein kinase Atg1p in yeast, we have identified Aup1p, encoded by Saccharomyces cerevisiae reading frame YCR079w. (huji.ac.il)
- The liberated HSP60 associates with and activates the IκB kinase (IKK) complex in the cytosol, which consequently induces the NF-κB-dependent expression of survival genes in nucleus. (ewha.ac.kr)
- Concomitant activation of the insulin-like growth factor-1 receptor, Akt, and extracellular signal-regulated protein kinase 1 and 2 as well as increased phosphorylation of Bad also were unique to the hippocampus of APP Sw mice. (jneurosci.org)
- Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/ threonine kinase Akt, which then phosphorylates and inactivates components of the apoptotic machinery, including BAD and Caspase 9. (scienceopen.com)
- RAF genes encode serine and threonine kinase proteins downstream of Ras in the pathway. (news-medical.net)
- Mutant B-Raf proteins that have been implicated in tumorigenesis often have elevated kinase activity, known as a gain of function mutaion. (news-medical.net)
- Conserved region 3 (CR3) is a catalytic protein kinase domain. (news-medical.net)
- Inhibition of the kinase domain is halted through binding of the Ras-binding domain, or residues 155-227 of the protein, to the Ras-GTP effector domain. (news-medical.net)
Proliferation9
- MTT analysis, PI/Annexin V staining, transwell and metabolic flux assays were performed to examine the effects of C1QBP on proliferation, apoptosis, migration, invasion, and oxidative phosphorylation of HCC cells. (jcancer.org)
- Loss-of-function assays showed that proliferation, migration and invasion of HCC cells were mitigated while cell apoptosis was augmented upon the loos of C1QBP. (jcancer.org)
- Cancer cells demand high energy production to sustain their pathological increase in proliferation rate. (hindawi.com)
- TGF-β regulates a variety of different cellular developmental processes including growth, differentiation, proliferation, and cell death. (wikipedia.org)
- RBM47 overexpression could repress the migration, invasion activity, and proliferation capacity of renal cancer cells , while RBM47 inhibition could promote the development of the malignant features through EMT signaling by RNA stability modification. (bvsalud.org)
- Recent studies have revealed that AXL contributes to leukaemic phenotypes through activation of oncogenic signalling pathways that lead to increased cell migration and proliferation. (cancerindex.org)
- Recent evidence, however, supports a dual role for macrophages in the regulation of tumour proliferation and immune control 10 , 16 , and indicates that the local tissue microenvironment plays a critical role in determining cell phenotypes. (ersjournals.com)
- Using human breast cancer cells and primary human mammary epithelial cells in vitro, Ray and colleagues found the mechanism of bitter melon extract significantly decreased proliferation, that is, cell growth and division, and induced death in breast cancer cells. (sciencedaily.com)
- MAPK pathways refer to various cellular functions, including cell proliferation, differentiation and migration. (springer.com)
Researchers23
- The surprising answer is revealed in the Aug. 27 issue of Molecular Cell, where German researchers explain how they discovered the function of Hsp12, a protective mechanism unlike any previously observed. (mytum.de)
- Yet an exhaustive investigation led by Munich-based researchers has revealed that Hsp12 is structurally and functionally different from every other stress protein that has been studied before. (mytum.de)
- The researchers found that the cellular survival mechanism provided by Hsp12 functioned under several different kinds of assault, including heat shock, oxidative stress, and osmotic stress -- a sudden change in the solution surrounding a cell that challenges its ability to regulate the flow of water through the membrane. (mytum.de)
- The researchers did find that the DNA sequences of other fungi code for proteins that could be considered Hsp12 "family members," and they identified one protein in human neurons that may have similar features. (mytum.de)
- GM-CSF, a protein that modifies the immune response to the flu, may also help reduce lung inflammation and improve survival during influenza, according to Penn State researchers. (news-medical.net)
- The researchers studied the survival and lung function of mice with influenza in the lab. (news-medical.net)
- The researchers found that the mice with GM-CSF had a better chance of survival than the other mice. (news-medical.net)
- Now researchers at MIT have discovered the vital role a protein, calprotectin, plays in this process, known as "nutritional immunity. (mit.edu)
- This calcium effect was in line with previous work by the researchers, which had shown that the protein "morphs" into a far more effective scavenger of zinc and manganese ions when calcium is present. (mit.edu)
- A new study in the journal Molecular & Cellular Proteomics characterizes the functions of CD151, a protein that researchers have found to be significant in TNBC. (asbmb.org)
- Researchers previously have demonstrated that CD151 can activate extracellular signal-related proteins as well as the intercellular signaling cascade Akt/PKB, which promotes nontumor mammary cell replication. (asbmb.org)
- The Vanderbilt researchers divided the protein into three fragments based on known domains: the N-terminal, middle and C-terminal fragments. (asbmb.org)
- To begin, the researchers identified proteins that need to pass through the endoplasmic reticulum transit area, but do not receive assistance from either known pathway. (weizmann.ac.il)
- When these genes were missing, the researchers observed accumulations of protein within the cell - proteins that had not managed to reach their destination outside of it. (weizmann.ac.il)
- Together with the Zimmerman lab, the researchers then asked whether this was occurring in a similar way in human cells. (weizmann.ac.il)
- The researchers discovered that the protein responsible for these disorders, known as prion protein (PrP), can sometimes wind up in the wrong part of a cell. (nih.gov)
- A team of researchers at the University of Konstanz analyzed the high-resolution structure of the protein FAT10. (asianage.com)
- Researchers have now investigated the protein eIF4A3 and its role in the growth of cancer cells. (sciencedaily.com)
- Pathology can also provide researchers with insights into the details of mesothelioma cells. (mesothelioma.com)
- For example, researchers found a protein on the outside of several types of cancer cells in the 1990s. (mesothelioma.com)
- Researchers from Lund have developed a completely animal-free preparation for cell culture, a medium that can be used to grow human cells, including for cancer research. (lu.se)
- It took off in 1958 when researchers discovered that fetal bovine serum (FBS) was an additive that could make cells thrive, both normal and cancerous. (lu.se)
- But in 2018, researchers in Lund started using different human proteins needed for cell survival in a cell culture medium. (lu.se)
Progression9
- Hou G, Lu Z, Wang Z, Yang X. The Mitochondrial Protein C1QBP Promotes Hepatocellular Carcinoma Progression by Enhancing Cell Survival, Migration and Invasion. (jcancer.org)
- Although drugs, for example a MEK inhibitor Refametinib [ 5 ], targeting key driver genes involved in HCC progression are being utilized for the clinical intervene, chemotherapy-resistance and the following cancer recurrence or metastasis still hinder the improvement of patient survival rates. (jcancer.org)
- The biological functions of HMGB1 are diverse in normal cells and during the start and progression of cancer. (hindawi.com)
- Thus, we conclude that ADF/cofilin activity is not generally required for induction or progression of apoptosis in mammalian cells. (nature.com)
- Importantly, the mitochondrial association of n-cofilin and ADF had no impact on apoptosis signaling because ablation of either n-cofilin, ADF, or both proteins together did not change cell death progression. (nature.com)
- 41.0 months vs. OS not reached, P = 0.009) and poorer progression-free survival (28.0 months vs. 73.0 months, P = 0.031). (psu.edu)
- These results suggest that the slow progression and lack of full-fledged Alzheimer's disease pathology in the hippocampal neurons of APP Sw mice result from the genetic reprogramming of neural cells to cope with increased levels of Aβ. (jneurosci.org)
- Sipeng Li and Xinya Li of Peking University and a research team in China reviewed literature establishing extracellular vesicles from TNBC as key players in cancer progression before focusing on the proteins transferred within those vesicles. (asbmb.org)
- Njainday's research focuses on WNT5A, and its role in tumour cell progression and plasticity. (lu.se)
Pathways11
- The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
- We investigated whether impaired regulation of bone morphogenetic protein-2 (BMP-2) via epigenetic pathways is associated with renal cell carcinoma (RCC) pathogenesis. (oncotarget.com)
- These data suggest that various nuclear mRNA export pathways, which may be indicated by different adaptor RNA binding proteins, exist in higher eukaryotes. (biomedcentral.com)
- But even with two shuttle services, the scientists noted there were still proteins that were not easily recognized by the pathways. (weizmann.ac.il)
- Together with the Weissman lab in San Francisco, the scientists revealed that this third pathway is active when the "passport" is closer to the center of the protein - the region the other two pathways have a hard time reading. (weizmann.ac.il)
- Our findings suggest that bitter melon extract modulates several signal transduction pathways, which induces breast cancer cell death," said lead researcher Ratna B. Ray, Ph.D., professor in the Department of Pathology at Saint Louis University. (sciencedaily.com)
- NF-kB or similar pathways increase the survival and growth of mesothelial cells. (mesothelioma.com)
- NF-κB pathways are associated with immunity, inflammation and cell survival. (springer.com)
- Akt pathways have effects on apoptosis, protein synthesis, metabolism and cell cycle. (springer.com)
- AMPK pathways inhibit biosynthetic pathways with energy consumption, such as protein, fatty acid and glycogen synthesis. (springer.com)
- Our laboratory focusses on how WNT5A expression is regulated in these cancers and deciphering the WNT5A signaling pathways governing cancer cell migration and invasion. (lu.se)
Metabolism6
- Some of them are the protein-coding genes for RNA polymerase subunits, ribosomal proteins, enzymes of lipid metabolism, and many other enzymes. (blogspot.com)
- Scientists working in basic, translational, and clinical cancer metabolism research are invited to join the Academy in New York on April 17th to discuss the intersection between cell signaling and metabolism. (nyas.org)
- Forkhead box protein O1 (FoXO1) is a transcription factor involved in the regulation of a wide variety of physiological process including glucose metabolism, lipogenesis, bone mass, apoptosis, and autophagy. (scienceopen.com)
- The study was conducted by Oishee Chakrabarti, Ph.D. and Ramanujan S. Hegde, M.D., Ph.D., of the NICHD Cell Biology and Metabolism Program. (nih.gov)
- With a minimalist model of metabolism, cell growth and transcriptional regulation in a microorganism, we explore how the interaction between environmental conditions and gene regulation set the growth rate of cells in the phase of exponential growth. (lu.se)
- A very natural place to study gene detecting and metabolizing lactose, it is known that the overall regulation is in the metabolism of the cell, and then specifically in effect of expressing the lac genes in vain is a drop in the growth rate the regulation of genes that code for enzymes and transporter of as much as 5% [1,6]. (lu.se)
Importance of studying1
Gene22
- Molecular Cell paper provides evidence that FOXO3a triggers transcription of HIF1 target gene, which in turn inhibits HIF-1 induced apoptosis. (genengnews.com)
- HIF-1 induced apoptosis in normal and breast cancer cells was inhibited due to FOXO3a stimulating the transcription of the HIF1 target gene, CITED2, according to Dr. Mak. (genengnews.com)
- The idea is to disrupt every gene and screen to see if it's required for cell viability in culture. (blogspot.com)
- One of the annoying things about all three papers is that they use the words "gene" and "protein-coding gene" as synonyms. (blogspot.com)
- The HSP70 gene family encodes the major heat shock protein of molecular weight 70,000. (blogspot.com)
- This is an example of the kind of gene that will be missed in the screen because the cells were not stressed during the screening. (blogspot.com)
- Expression and CpG methylation of the BMP-2 gene were analyzed using RCC cell lines, and 96 matched RCC and normal renal tissues. (oncotarget.com)
- Death-associated protein 6 also known as Daxx is a protein that in humans is encoded by the DAXX gene. (wikipedia.org)
- This gene encodes a multifunctional protein that resides in multiple locations in the nucleus and the cytoplasm. (wikipedia.org)
- Other studies showed that lack of Daxx gene caused a higher apoptotic rate in embryonic stem cells. (wikipedia.org)
- This gene may be involved in several cellular functions including growth, migration, aggregation and anti-inflammation in multiple cell types. (cancerindex.org)
- What does this gene/protein do? (cancerindex.org)
- In humans the protein is encoded by a single gene found near the inversion telomere of a large inverted region of CHROMOSOME 5. (harvard.edu)
- Mutations in the gene coding for survival of motor neuron 1 protein may result in SPINAL MUSCULAR ATROPHIES OF CHILDHOOD. (harvard.edu)
- Survival Motor Neuron Gene Copy Number Analysis by Exome Sequencing: Assisting Spinal Muscular Atrophy Diagnosis and Carrier Screening. (harvard.edu)
- Survival factor withdrawal leads to FKHRL1 dephosphorylation, nuclear translocation, and target gene activation. (scienceopen.com)
- Within the nucleus, FKHRL1 triggers apoptosis most likely by inducing the expression of genes that are critical for cell death, such as the Fas ligand gene. (scienceopen.com)
- Then, using the advanced robotic system in Schuldiner's lab, they systematically looked at the ability of a protein to reach the endoplasmic reticulum membrane in the absence of each gene in the yeast cell, finding three that appeared to be necessary to the process of transporting these particular "problematic" proteins. (weizmann.ac.il)
- The scientists silenced the human SND2 gene - which they found has been conserved throughout evolution - and showed that here, too, the passage into the endoplasmic reticulum was defective, suggesting that this third pathway is at work in human cells as it is in yeast. (weizmann.ac.il)
- Kat - What exactly is the protein, the gene that you're looking at that's faulty in these flies? (thenakedscientists.com)
- B-Raf is a protein encoded by the BRAF gene and is involved in the RAS/MAPK pathway, which regulates cellular growth and division. (news-medical.net)
- Wiskott-Aldrich syndrome is caused by mutations in the gene that encodes the Wiskott-Aldrich syndrome protein (WASP), a cytoplasmic protein necessary for normal B- and T-cell signaling. (msdmanuals.com)
Overall survival5
- The aim of this study was to evaluate the prognostic impact of pretreatment CRP levels on overall survival (OS) and disease-free survival (DFS) in a large bicentre study of DLBCL patients. (nih.gov)
- The extremely low 5-year overall survival of patients is, in part, due to pancreatic cancer cells having several mechanisms of resistance to different chemotherapeutic treatments, one of which is their capacity to efficiently repair alkylating agent-induced DNA damage. (frontiersin.org)
- Although multiple myeloma patients younger than 66 years of age have an aggressive presentation, this did not translate into an inferior overall survival, particularly in those undergoing autologous hematopoietic stem cell transplantation. (scielo.br)
- Patients in the report had a 5-year overall survival rate of 93.1%, although survival rates were lower in children who experienced symptoms, local recurrence, or metastasis or who did not undergo treatment with surgery or surgery plus radiotherapy. (medscape.com)
- Kaplan-Meier analysis and the log rank test were applied to evaluate ovarian cancer-specific survival (OCSS) and overall survival (OS) in strata, according to SOX11 expression. (lu.se)
MRNA and protein expression1
Crucial6
- The maintenance of the steady-state equilibrium between ROS generation and elimination is crucial for cell survival, while its loss causes cell death by different mechanisms triggered by oxidative damage. (hindawi.com)
- RNA binding proteins (RBPs) are crucial for cell function, tissue growth , and disease development in disease or normal physiological processes . (bvsalud.org)
- It prevents the cell communicating the stress that it is under, which is crucial if the cell is to survive. (wikipedia.org)
- Thrombin-induced autoinhibitory element, Down syndrome crucial region-1, attenuates NFAT-dependent vascular cell adhesion molecule-1 manifestation and swelling in the endothelium. (biomedigs.org)
- These proteins provide a selective conduction of ions across cellular membranes, which is crucial for cell survival. (surrey.ac.uk)
- The new pathway functions as a 'safety net' for crucial proteins that may need to catch the next shuttle, but have their tags in inconvenient places," says Schuldiner. (weizmann.ac.il)
Regulate2
- In the cytoplasm, the encoded protein may function to regulate apoptosis. (wikipedia.org)
- This subfamily corresponds to the RRM1 of the CPEB family of proteins that bind to defined groups of mRNAs and act as either translational repressors or activators to regulate their translation. (nih.gov)
Genes encode1
- The polycomb group of genes encode proteins that enhance cell survival. (aicr.org)
Cancerous2
- This review describes recent advances in the role of human HMGB proteins and other proteins interacting with them, in cancerous processes related to oxidative stress, with special reference to ovarian and prostate cancer. (hindawi.com)
- Combined, these changes may cause normal mesothelial cells to become cancerous. (mesothelioma.com)
Cytoplasm7
- It has been reported that C1QBP is mainly localized in the mitochondrial matrix and is less expressed in the cytoplasm, nucleus and on the cell surface [ 9 - 11 ]. (jcancer.org)
- At the level of the cell, Daxx is found in the cytoplasm, interacting with Fas-receptor or other cytoplasmic molecules, as well as in the nucleus, where it interacts with some subnuclear structures. (wikipedia.org)
- It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein growth arrest-specific 6 (Gas6). (cancerindex.org)
- CPEB-2 is an RNA-binding protein that is abundantly expressed in testis and localized in cytoplasm in transfected HeLa cells. (nih.gov)
- All CPEB proteins are nucleus-cytoplasm shuttling proteins. (nih.gov)
- In the presence of survival factors, Akt phosphorylates FKHRL1, leading to FKHRL1's association with 14-3-3 proteins and FKHRL1's retention in the cytoplasm. (scienceopen.com)
- Rather than being on the cell's surface, some PrP is exposed to the cytoplasm, the gelatinous interior of the cell. (nih.gov)
Mutations3
- These are as follows: sustained proliferative signalling, cell death resistance, replicative immortality, genome instability and increased mutations, tumour-promoted inflammation, insensibility to growth repressors, deregulation of cellular energetics, evasion of immune destruction, induction of metastasis, and promotion of angiogenesis. (hindawi.com)
- Scope includes mutations and abnormal protein expression. (cancerindex.org)
- For instance, familial AD is linked to mutations in the amyloid precursor protein (APP), presenilin 1, and presenilin 2, all of which lead to increased levels of Aβ. (jneurosci.org)
Oxidative6
- Oxidative stress produces DNA damage and also induces responses, which could help the cell to restore the initial equilibrium. (hindawi.com)
- But if this is not possible, oxidative stress finally activates signals that will lead to cell death. (hindawi.com)
- The protein HMGB1 behaves as a redox sensor and its structural changes, which are conditioned by the oxidative environment, are associated with different functions of the protein. (hindawi.com)
- Consequently, the recruitment of immune cells during chronic inflammation increases oxidative stress (OS) in the microenvironment [ 2 ]. (hindawi.com)
- Indeed, inhibition of the HSP60 release or HSP60-IKK interaction sensitizes the cancer cells to mild oxidative stress and regresses the tumorigenic growth of cancer cells in the mouse xenograft model. (ewha.ac.kr)
- Thus, this study reveals a novel mitonuclear survival axis responding to oxidative stress. (ewha.ac.kr)
Biomarkers2
- The aim for this thesis was to investigate rapid and low cost blood based biomarkers which could indicate the risk of HNC, recurrence of the disease or the survival of HNC patients. (diva-portal.org)
- In paper I, a possible role of plasma cytokines or proteins associated with immune response or inflammation, as biomarkers for the survival of HNC patients was investigated. (diva-portal.org)
HeLa Cells1
- It was demonstrated that the depletion of THOC5 does not affect bulk poly (A)+ RNA export, but does affect Hsp70 mRNA export in Hela cells. (biomedcentral.com)
Cellular proteins1
- Many cellular proteins are reversibly modified by O-linked N-acetylglucosamine (O-GlcNAc) moieties on Ser and Thr residues. (scienceopen.com)
Target proteins2
- For such cases, it is conceivable to develop a cancer drug inhibiting the enzymes that link FAT10 and the target proteins. (asianage.com)
- It catalyzes phosphorylation of serine and threonine on target proteins, converting adenosine triphosphate (ATP) to adenosine diphosphate (ADP). (news-medical.net)
Phosphorylation2
- The subcellular localization and function of this protein are modulated by post-translational modifications, including sumoylation, phosphorylation and polyubiquitination. (wikipedia.org)
- Immunoblotting was performed on the cell lysates to evaluate the effect of cerium oxide nanoparticle treatment on LPS induced changes in Mitogen Activated Protein Kinases (MAPK) p-38, ERK 1/2, and SAPK/JNK phosphorylation. (cdc.gov)
Cancers2
- High mobility group B (HMGB) proteins have been previously related to the onset and progressions of cancers of different origins. (hindawi.com)
- Nuclear factor-kappaB (NF-B) has a vital part in cell survival and inhibition of NF-B had proven to be an efficient restorative pathway for numerous cancers though little is usually known about the underlying mechanism. (biomedigs.org)
Inflammation1
- The fibers irritate mesothelial cells, causing inflammation. (mesothelioma.com)
20211
- Aug. 5, 2021 For a cell to grow and divide, it needs to produce new proteins. (sciencedaily.com)
Receptor4
- Daxx, a Death domain-associated protein, was first discovered through its cytoplasmic interaction with the classical death receptor Fas. (wikipedia.org)
- Daxx interacts with the TGF-β type II receptor by binding of C-terminal domain of the protein. (wikipedia.org)
- It tests negative for the three main targets of hormonal and protein receptor therapies: estrogen receptors, progesterone receptors and an upregulation of HER2 protein. (asbmb.org)
- 19 normal healthy in- receptor protein (CD117) that is structurally dividuals were recruited as a control group. (who.int)
Mammalian2
- In summary, our work demonstrates that in mammalian cells ADF/cofilin activity is not generally required for efficient induction of apoptosis. (nature.com)
- By restraining mammalian forkhead proteins, SIRT1 also reduces forkhead-dependent apoptosis. (scienceopen.com)
Encodes1
- BRAF encodes the B-Raf protein, which is involved in signal transduction inside cells. (news-medical.net)
Inhibitor3
- In molecular biology, the protein domain Sda is short for suppressor of dnaA or otherwise known as sporulation inhibitor A. It is found only in bacteria. (wikipedia.org)
- Otherwise, it may function as a translational inhibitor when dephosphorylated and bind to a protein such as maskin or neuroguidin, which blocks translation initiation through interfering with the assembly of eIF-4E and eIF-4G. (nih.gov)
- Inhibition of VCP either by genetic depletion or the pharmacologic inhibitor CB-5083 increased ubiquitination and degradation of p53-R273H, leading to cell death. (aacrjournals.org)
Metastasis3
- Dickkopf-3 (DKK3), is produced by the stromal cells but acts on the neighboring cancer cells to increase their growth, metastasis and resistance to therapy. (medicalxpress.com)
- AXL significantly promotes tumour cell migration, invasion and metastasis, as well as angiogenesis. (cancerindex.org)
- In contrast, WNT5A expression is associated with increased metastasis and reduced survival in melanoma patients. (lu.se)
Immune3
- Metabolically active cells, neutrophils, and macrophages from the immune system produce high levels of ROS. (hindawi.com)
- Targeting DKK3 in a pancreatic cancer mouse model boosted immune cell infiltration and more than doubled survival. (medicalxpress.com)
- This project will grow brain immune cells call microglia from blood cells of people with ALS. (cdc.gov)
Tumour cell2
- A novel human anti-AXL monoclonal antibody attenuates tumour cell migration. (cancerindex.org)
- f FAT10, for example, links to proteins that suppress tumour growth, they are degraded and the tumour cell can grow more easily. (asianage.com)
Epithelial cells2
- RBM47 expression in renal cancer cell lines was reduced significantly when compared to normal renal tubular epithelial cells . (bvsalud.org)
- Finally, analysis of the mechanism by which multimeric alpha-lactalbumin induces apoptosis in transformed epithelial cells could lead to the design of antitumor agents. (lu.se)
Viability2
- In the intestine, which is normally more resistant to radiation, the addition of the drug reduced cell viability and survival. (sciencedaily.com)
- Viability studies demonstrate that Aup1p is required for efficient survival of cells in prolonged stationary phase cultures, implying a pro-survival role for mitophagy under our working conditions. (huji.ac.il)
Multifunctional protein1
- Complement C11 binding protein (C1QBP, also named p32 and HABP1) is a multifunctional protein which plays a pivotal role in diverse cellular processes such autophagy and cell apoptosis [ 7 , 8 ]. (jcancer.org)
Significantly4
- Combination of upregulated CRP and TNF-α in the patient plasma was significantly related to shorter patient survival, independent of clinical stage. (diva-portal.org)
- BMP-2 mRNA expression was significantly enhanced in RCC cells by 5-aza-2'-deoxycitidine treatment. (oncotarget.com)
- In particular, the loss of ALKBH6 in human pancreatic cancer cells increases alkylating agent-induced DNA damage and significantly decreases cell survival. (frontiersin.org)
- In the extended survival group, M1 islet density was significantly increased compared with M2 density, 70% of islet macrophages were positive for M1 markers versus 38% for M2, and the islet:stromal ratio of M1 macrophages was markedly increased compared with M2. (ersjournals.com)
Prion protein1
- Briefly, they contain the human APP 695 with the double mutation K670N and M671L (Swedish mutation) and are driven by the prion protein promoter. (jneurosci.org)
Neurons1
- BrainStorm Cell Therapeutics), uses mesenchymal stem cells harvested from patients' own bone marrow that are engineered to secrete neurotrophic factors, proteins important for the survival and function of neurons. (medscape.com)
Promotes4
- C1QBP is correlated with a poor prognosis of HCC patients and promotes the survival, migration and invasion of HCC cells. (jcancer.org)
- Downregulation of RNA binding protein 47 predicts low survival in patients and promotes the development of renal cell malignancies through RNA stability modification. (bvsalud.org)
- Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. (scienceopen.com)
- It actually promotes the survival of cells which is great in one sense, but also, you don't want to. (thenakedscientists.com)
Cancer41
- Tak W. Mak, Ph.D., from the Campbell Family Institute for Breast Cancer Research at Princess Margaret Hospital in Toronto, and colleagues found that hypoxia stimulates an HIF1-dependent increase in a protein called FOXO3a. (genengnews.com)
- Our results reveal a pro-survival role for FOXO3a in normal cells and cancer cells that are adapting to hypoxic stress," explains Dr. Mak. (genengnews.com)
- Cancer cells try to avoid the overproduction of reactive oxygen species by metabolic rearrangements. (hindawi.com)
- In cancer cells, ROS production is mainly due to overexpression of the NADPH oxidase [ 3 ]. (hindawi.com)
- While a balance between enhanced ROS production and detoxification can be maintained, cancer cells will proliferate and survive. (hindawi.com)
- Commonly used radio- and chemotherapies are prooxidant strategies that alter cancer cells through ROS modulation and induce cell death [ 5 , 6 ]. (hindawi.com)
- Consequently, several human diseases, including cancer and neurodegenerative disorders, are caused by defects in this highly regulated form of cell death. (nature.com)
- However, whether ascites drives multidrug resistance in ovarian cancer cells awaits elucidation. (muni.cz)
- Here, we demonstrate that when cultured with ascites derived from ovarian cancer-bearing mice, a murine ovarian cancer cell line became less sensitive to paclitaxel, a first line chemotherapeutic agent for ovarian cancer patients. (muni.cz)
- Moreover, incubation of murine ovarian cancer cells in vitro with ascites drives efflux function in these cells. (muni.cz)
- Immortalized cell lines developed from human ascites show increased susceptibility to efflux inhibitors (MRP1, BCRP) compared to a cell line derived from a primary ovarian cancer, suggesting an association between ascites and efflux function in human ovarian cancer. (muni.cz)
- Previously, Lahav and colleagues revealed the dynamic behavior of p53 over time and how it affects cancer drug efficacy, cell fate, and more. (sciencedaily.com)
- To probe the effects of p53 behavior, the team used an experimental anti-cancer drug to inhibit MDM2, a protein that degrades p53. (sciencedaily.com)
- CPEB-4 is overexpressed in a large variety of tumors and is associated with many mRNAs in cancer cells. (nih.gov)
- Here, we tested whether ALKBH6 plays a significant role in preventing alkylating DNA damage and decreasing genomic instability in pancreatic cancer cells. (frontiersin.org)
- Furthermore, in silico analysis from The Cancer Genome Atlas (TCGA) database suggests that overexpression of ALKBH6 provides better survival outcomes in patients with pancreatic cancer. (frontiersin.org)
- Overall, our data suggest that ALKBH6 is required to maintain the integrity of the genome and promote cell survival of pancreatic cancer cells. (frontiersin.org)
- Several alkylating agents are commonly used in chemotherapy but may induce DNA damage to cancer cells as well as normal cells. (frontiersin.org)
- Bmi-1 is a protein that is over expressed in skin cancer cells. (aicr.org)
- We champion the latest and most authoritative scientific research from around the world on cancer prevention and survival through diet, weight and physical activity, so that we can help people make informed lifestyle choices to reduce their cancer risk. (aicr.org)
- What role does the protein CD151 play in triple-negative breast cancer? (asbmb.org)
- What group of proteins are candidates for targeting oral cancer? (asbmb.org)
- They found increased expression levels of ITGB1, a known prognostic marker for cancer, and the protein CD151 in TNBC serum samples. (asbmb.org)
- There is a marked survival advantage for patients with nonsmall cell lung cancer (NSCLC) expressing high numbers of macrophages in their tumour islets. (ersjournals.com)
- Macrophages infiltrating the tumour islets in nonsmall cell lung cancer were predominantly of the M1 phenotype in patients with extended survival. (ersjournals.com)
- Nonsmall cell lung cancer (NSCLC) is the most common cause of cancer-related death worldwide. (ersjournals.com)
- The present authors have previously shown that the anatomical microlocalisation of macrophages in NSCLC strongly predicts patient survival, regardless of cancer stage 4 . (ersjournals.com)
- The M1 phenotype (classically activated) macrophages are thought to be induced by interferon-γ, with or without lipopolysaccharide and tumour necrosis factor (TNF)-α, and exert a cytotoxic effect against cancer cells. (ersjournals.com)
- Monocytes activated by tumour-derived microvesicles from pancreatic, colon and lung cancer cell lines have been found to show increased expression of human leukocyte antigen (HLA)-DR and a resulting increase in production of reactive oxygen intermediates and TNF-α 11 . (ersjournals.com)
- Obviously, there's a danger that you don't want to have cells living so long that they're actually replicating uncontrollably and you get into territories of cancer which is not good. (thenakedscientists.com)
- Bitter melon extract, a common dietary supplement, exerts a significant effect against breast cancer cell growth and may eventually become a chemopreventive agent against this form of cancer, according to results of a recent study. (sciencedaily.com)
- Additional studies are needed to further understand the molecular targets of bitter melon extract in cancer cells, as well as for establishing its in vivo efficacy. (sciencedaily.com)
- Agarwal gave a note of caution, stating that while these results do provide hope as an anti-cancer agent, it is important to establish the validity of these results in animal models before adding them to one's diet to inhibit breast cancer cell growth. (sciencedaily.com)
- Ray and colleagues are currently conducting follow-up studies using a number of cancer cell lines to examine the anti-proliferative effect of the extract. (sciencedaily.com)
- This also applies to cancer cells. (sciencedaily.com)
- That mutation has been found in papillary thyroid carcinoma, colorectal cancer, melanoma, and non-small cell lung cancer. (news-medical.net)
- While investigating the effect of human milk on bacterial adherence to a human lung cancer cell line, we were surprised to discover that the milk killed the cells. (lu.se)
- For example, in breast cancer loss of WNT5A protein is associated with poor survival. (lu.se)
- Despite methodological differences, findings evidence that although IBC presents particular features (lower survival rate and worse prognostics than most types of breast cancer), very few studies examine its epidemiology and specific risk factors in depth and use any other therapeutic approaches than those commonly used for other breast cancer subtypes. (bvsalud.org)
- With an average survival rate of three years, IBC accounts for about 2.5% of all breast cancer types in the US. (bvsalud.org)
- This has sparked a lot of interest in many parts of Europe and also with the US Food and Drug Administration (US FDA), not least because it can be used to grow normal cells but also in cancer research. (lu.se)
Processes4
- It has been associated with heterochromatin and PML-NBs (Promyelocytic Leukaemia nuclear bodies) and has been implicated in many nuclear processes including transcription and cell cycle regulation. (wikipedia.org)
- To test the relevance of ADF/cofilin activity for apoptotic processes, we here employed a genetically well-defined system of mouse embryonic fibroblasts (MEFs) devoid of any ADF/cofilin activity and challenged these cells with well-characterized apoptosis inducers. (nature.com)
- Several recent reports suggest that mitophagy is a selective process that targets damaged mitochondria, whereas other studies imply a role for mitophagy in cell death processes. (huji.ac.il)
- Plays also an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodelling processes in endothelial cells. (lu.se)
Interacts4
- It interacts with a wide variety of proteins, such as apoptosis antigen Fas, centromere protein C, and transcription factor erythroblastosis virus E26 oncogene homolog 1 (ETS1). (wikipedia.org)
- CPEB-1 is an RNA-binding protein that interacts with the cytoplasmic polyadenylation element (CPE), a short U-rich motif in the 3' untranslated regions (UTRs) of certain mRNAs. (nih.gov)
- CD151 is a scaffolding protein that interacts with integrin receptors. (asbmb.org)
- The team intends to investigate how nsp3 interacts with two other nonstructural proteins known to coordinate to form double-membrane vesicles out of the ER to replicate coronaviruses. (asbmb.org)
Homologs2
- Aup1p is highly similar to a family of protein phosphatase homologs in animal cells that are predicted to localize to mitochondria based on sequence analysis. (huji.ac.il)
- How similar are nonstructural proteins between coronavirus homologs? (asbmb.org)
Patients19
- The survival of HNC patients has only improved marginally during the last decade. (diva-portal.org)
- Bioinformatic approaches were employed for checking the expression of C1QBP in HCC patient samples and the association between C1QBP mRNA expression and survival rates of patients with HCC or the promoter methylation of C1QBP . (jcancer.org)
- Finally, we suggested that C1QBP is correlated with genes encoding ribosome RPL-related proteins and mitochondrial MRPL-related proteins in HCC patients. (jcancer.org)
- Although patients with HCC have been benefiting from the development of various effective therapeutic approaches, the five-year survival rate is still rather low (around 12% as reported in China) [ 2 ]. (jcancer.org)
- Experimental Design: XRCC1 protein expression was assessed by immunohistochemical (IHC) staining of pretreatment tissue samples in 138 consecutive HNSCC patients treated with surgery (n = 31), radiation (15), surgery and radiation (23), surgery and adjuvant chemoradiation (17), primary chemoradiation (51), and palliative measures (1). (psu.edu)
- In patients treated with nonchemoradiation modalities, there was no survival difference by XRCC1 expression. (psu.edu)
- Conclusions: In HNSCC, high XRCC1 protein expression is associated with poorer survival, particularly in patients receiving chemoradiation. (psu.edu)
- We retrospectively analyzed clinical characteristics, response to treatment and survival of 282 patients with active newly-diagnosed multiple myeloma, comparing results between patients younger and older than 65 years. (scielo.br)
- Outcome and survival of myeloma patients diagnosed 2008-2015. (scielo.br)
- The aims of the present study were to describe clinical features at diagnosis, response to treatment and survival in 282 patients with active newly-diagnosed MM (NDMM) and compare outcomes between patients younger and older than 65 years. (scielo.br)
- Patients with monoclonal gammopathy of unknown significance, smoldering MM, plasma cell leukemia and amyloidosis were excluded. (scielo.br)
- CD68 + macrophages expressing markers of a cytotoxic M1 phenotype or a noncytotoxic M2 phenotype were identified in the islets and stroma of surgically resected tumours from 20 patients with extended survival (median 92.7 months) and 20 with poor survival (median 7.7 months), using immunohistochemistry. (ersjournals.com)
- The islet density of both M1 and M2 macrophages was markedly increased in extended compared with poor survival patients. (ersjournals.com)
- Currently, even in patients with stage IA disease, the 5-yr survival after putatively curative surgical resection is only 67% 1 . (ersjournals.com)
- The association between prognosis and islet macrophage count has been confirmed recently by others in an independent cohort of patients 5 but the stromal macrophage counts in that study were not associated with survival. (ersjournals.com)
- Trial patients had a median survival of about two years. (mesothelioma.com)
- Le pourcentage de CD44 dans les lymphocytes T périphériques était significativement plus élevé chez les patients que chez les témoins, comme détecté par la cytométrie en flux. (who.int)
- En outre, il y avait une aug- mentation significative de la forme soluble du c-kit dans le sérum des patients atteints de pemphigus vulgaire actif par rapport aux témoins. (who.int)
- Results: SOX11 expression was associated with an improved survival of patients with high grade EOC, although not independent of stage. (lu.se)
Mutation1
- Tg2576 mice overexpress a mutant form of human amyloid precursor protein with the Swedish mutation (APP Sw ), resulting in high β-amyloid (Aβ) levels in the brain. (jneurosci.org)
Molecules5
- HMGB1 is an abundant protein, 10 6 molecules per cell [ 7 ], which has been postulated as a redox sensor [ 8 ]. (hindawi.com)
- Analysis of the resulting sptPALM images revealed that single-molecule transmembrane proteins, which are internalized into a cell via endocytosis, colocalize in space and time with plasma membrane domains enriched in clathrin light-chain molecules. (nih.gov)
- They found that the mice that had been given large amounts of a special cytokine -- molecules that warn other cells that there's an infection or other trauma in the body -- called GM-CSF, had better survival and lung function than the other mice. (news-medical.net)
- Proteins are made up of long chains of molecules known as amino acids. (nih.gov)
- CD117 by immunohistochemical methods sion molecules, involved in cell-cell and in order to clarify the role of the infiltrating cell matrix interactions and thought to take inflammatory cells in the pathomechanisms part in cell motility [ 2,3 ]. (who.int)
Pathway5
- This pathway normally regulates stress-induced cell death. (wikipedia.org)
- The expression of transthyretin, a protein shown to sequester Aβ and prevent amyloid fibril formation in vitro , and several genes in the insulin-signaling pathway, e.g., insulin-like growth factor-2, were increased selectively in the hippocampus of APP Sw mice. (jneurosci.org)
- The first pathway for transferring proteins into the endoplasmic reticulum was discovered in the 1980s," says Schuldiner. (weizmann.ac.il)
- But this finding was not the whole story: Although many proteins use the SRP pathway to get to the endoplasmic reticulum membrane, this shuttle system seemed to have trouble identifying other outward-bound proteins. (weizmann.ac.il)
- This suggested that there was another pathway to catch the proteins that SRP misses," says Schuldiner. (weizmann.ac.il)
Endoplasmic reticulum4
- It is essential for neuron survival and present on the endoplasmic reticulum (ER). (nih.gov)
- For most of these proteins, getting to the outside of the cell involves passage through an organelle called the endoplasmic reticulum. (weizmann.ac.il)
- These are proteins that, if they are not efficiently transported to the endoplasmic reticulum, the cell dies. (weizmann.ac.il)
- one on the ribosome (the cell's protein-manufacturing complex) and the other two at the "gates" of the endoplasmic reticulum. (weizmann.ac.il)
Prognostic3
- Here, we demonstrated the expression and the prognostic role of RBM47 in public databases and clinical samples of clear cell renal carcinoma (ccRCC) with bioinformatics analysis . (bvsalud.org)
- Survival is variable, depending on the different prognostic factors, ranging from months to more than 10 years. (scielo.br)
- Conclusions: SOX11 is a functionally associated protein in EOC with prognostic value for high-grade tumours. (lu.se)
Migration1
- In particular, the interchangeable modes of migration tumour cells utilise during invasion and the factors involved. (lu.se)
Role5
- Ion channels in living cells are examples of where quantum effects can play a role in biology. (surrey.ac.uk)
- To study the role of THOC5/Fms interacting protein in vivo , we generated THOC5/Fms interacting protein knockout mice. (biomedcentral.com)
- Here, we report an unexpected messenger role for heat shock protein 60 (HSP60) as a mitochondrial-releasing protein factor that couples stress-sensing signaling and cell survival machineries. (ewha.ac.kr)
- Pemphigus vulgaris (PV) is a life-threate- disorders and to shed a light on the role of ning blistering skin disease in which pa- mast cells in autoimmune diseases [ 7 ]. (who.int)
- Furthermore, overexpression of SOX11 in EOC cell lines confirmed the growth regulatory role of SOX11. (lu.se)
Abstract2
- abstract = "Autophagy is a catabolic membrane-trafficking process that occurs in all eukaryotic cells and leads to the hydrolytic degradation of cytosolic material in the vacuolar or lysosomal lumen. (huji.ac.il)
- abstract = "Mitochondria communicate with other cellular compartments via the secretion of protein factors. (ewha.ac.kr)
Improves1
- Here we show that dietary fructose improves the survival of intestinal cells and increases intestinal villus length in several mouse models. (nature.com)
Regulates2
- CPEB-3 is a sequence-specific translational regulatory protein that regulates translation in a polyadenylation-independent manner. (nih.gov)
- They determined that CD151 regulates the intracellular trafficking of proteins as well as regulating when the cell secretes these proteins using extracellular vesicles. (asbmb.org)
Amino2
- The B-Raf protein has 766 amino acids in three conserved domains. (news-medical.net)
- Over time, more complex solutions were developed - for example using sugar for energy supply and amino acids for protein production. (lu.se)
Human9
- Sandwalk: How many human protein-coding genes are essential for cell survival? (blogspot.com)
- The human genome contains about 20,000 protein-coding genes and about 5,000 genes that specify functional RNAs. (blogspot.com)
- The ability to knock out human genes using CRISPR technology has opened to door to testing for essential genes in tissue culture cells. (blogspot.com)
- S. aureus bacteria and human white blood cells. (mit.edu)
- Biodistribution of onasemnogene abeparvovec DNA, mRNA and SMN protein in human tissue. (harvard.edu)
- The team began their experiments in yeast cells, whose basic functions are nearly identical to those of human cells, and then tested their results in human cells. (weizmann.ac.il)
- However, it has rarely been considered that human milk may also contain substances bioactive toward host cells. (lu.se)
- 1998. Protection of human upper respiratory tract cell lines against sulphur mustard toxicity by hexamethylenetetramine (HMT). (cdc.gov)
- Our results mean that growing human cells is closer to the environment in which they normally grow. (lu.se)
Expression6
- In addition, BMP-2 overexpression induced p21 WAF1/CIP1 and p27 KIP1 expression, and cellular apoptosis in RCC cells. (oncotarget.com)
- Daxx is uniformly expressed throughout the body, except in the testes and thymus, which have especially high expression of the protein. (wikipedia.org)
- No expression of Daxx leads to malfunction of S phase and cells with two nuclei are formed. (wikipedia.org)
- During expression of protein-coding genes, pre-mRNAs are transcribed in the nucleus and undergo several RNA-processing steps. (biomedcentral.com)
- FoXO1 activity is regulated in response to different physiological or pathogenic conditions by changes in protein expression and post-translational modifications. (scienceopen.com)
- Myeloid related protein (MRP) 8/14 expression by macrophages is associated with the release of TNF-α 12 . (ersjournals.com)
Membranes1
- Communications are carried out by proteins - both the numerous proteins that are situated on the cells' outer membranes to receive the messages and the messengers themselves, which are secreted to the outside of the cell. (weizmann.ac.il)
Clinical3
- High levels of C-reactive protein (CRP), an acute phase protein, proofed being associated with decreased clinical outcome in small-scale studies in diffuse large B-cell lymphoma (DLBCL). (nih.gov)
- Most data regarding the impact of age on survival mainly come from clinical trials developed before the current therapy choices were in use. (scielo.br)
- Our research using these cells will help determine if an individual is suited to a clinical trial for a particular type of drug. (cdc.gov)
Myeloid proge1
- Committed myeloid progenitor cells and cells with long term reconstituting potential were lost from bone marrow within four days after poly injection. (biomedcentral.com)
Findings1
- The findings were published in the current issue of the journal Cell. (nih.gov)
Ablation1
- Consistently, ablation of VCP markedly retarded growth of cultured PDAC cells and xenograft PDAC tumors. (aacrjournals.org)