Proteins cell line tumor. Medical search. Frequent questions

Embryonic protein NODAL regulates the breast tumor microenvironment by reprogramming cancer-derived secretomes. (harvard.edu)
Adipocytes represent a major cell type in the mammary tumor microenvironment and are important for tumor growth. (jci.org)
Adipocyte-derived factors involved in tumor progression include proteins such as adiponectin, leptin, TNF-α, monocyte chemotactic protein-1 (MCP-1), IL-6, and ECM components that control tumor cell behavior within the tumor microenvironment. (jci.org)
The preclinical study demonstrated that the histamine receptor H1 (HRH1) acts in tumor-associated macrophages (TAMs) to suppress T cell activation in the tumor microenvironment. (newswise.com)
They discovered both proteins were elevated in the tumor microenvironment, but they did not appear to come from the same source. (newswise.com)
HRH1 was not present in cancer cells but was highly expressed in certain types of TAMs in the tumor microenvironment, known as M2-like macrophages, that contribute to immune suppression. (newswise.com)
The understanding of such tumor evasion mechanisms and the complex interactions that take place in the tumor microenvironment is essential to obtain successful treatments. (aacrjournals.org)
Differential expression of particular ectonucleotidases in tumor cell variants will determine whether chemotherapy-induced activation of Panx1 channels drives accumulation of immunostimulatory ATP versus immunosuppressive adenosine within the tumor microenvironment. (aspetjournals.org)
Recent evidence, however, supports a dual role for macrophages in the regulation of tumour proliferation and immune control 10 , 16 , and indicates that the local tissue microenvironment plays a critical role in determining cell phenotypes. (ersjournals.com)
However, target identification warrants a better understanding of the surfaceome and how it is modulated by the tumor microenvironment. (lu.se)
In conclusion, these findings provide important information for better understanding of the tumor microenvironment and the tumor suppressor genes in colon cancer and might help to identify new therapeutic targets for colon cancer patients. (lu.se)

Elimination of BCR/ABL-dependent intracellular signals triggers apoptosis, but it is unclear whether this activates additional cell survival and/or death pathways. (lu.se)
The transient overexpression of TCTP in HeLa cells prevented them from undergoing etoposide-induced apoptosis. (wikipedia.org)
Mutant K-RAS has been shown to have both tumor-promoting and -suppressing functions, and growing evidence suggests that the RASSF family of tumor suppressors can act as RAS apoptosis and senescence effectors. (cancerindex.org)
Induces apoptosis in human malignant glioma cell lines. (sigmaaldrich.com)
An aberrant miRNA expression could contribute to cancer development and progression [ 6 , 7 ] and could affect their target genes that are involved in many biological processes, such as cell differentiation, proliferation, apoptosis, metabolism, and development [ 8 ]. (hindawi.com)
Although the diverse tumor-promoting roles of NFκB in cancer cell proliferation, anti-apoptosis, angiogenesis, invasion and metastasis, are well established [ 3 - 9 ], much less is known about how p100, a precursor protein of NFκB2, acts as a tumor suppressor in many mammalian cells [ 10 ]. (oncotarget.com)
Our results indicated that AST inhibits cell proliferation through phase-specific cell cycle arrest and caspase-dependent apoptosis. (spandidos-publications.com)
Pannexin-1 (Panx1) channels mediate the efflux of ATP and AMP from cancer cells in response to induction of extrinsic apoptosis by death receptors or intrinsic apoptosis by chemotherapeutic agents. (aspetjournals.org)
We previously described the accumulation of extracellular ATP /AMP during chemotherapy-induced apoptosis in Jurkat human leukemia cells. (aspetjournals.org)
treatment of both lines with chemotherapeutic drugs elicited similar intrinsic apoptosis. (aspetjournals.org)
[ 6 ] NF-KB protects cells from apoptosis in response to tumor necrosis factor-alpha (TNF-alpha). (medscape.com)
In the skin, NF-KB regulates cell growth in the stratified epithelium and apoptosis. (medscape.com)

TCTP is a regulator of the cancer stem cell compartment, the tumor reversion, tumor progression and certain forms of inflammatory diseases. (wikipedia.org)
and melanoma tumor progression. (sigmaaldrich.com)
Cell cycle progression was also affected. (frontiersin.org)
Knockdown of p100 in cultured human bladder cancer cells promoted anchorage-independent growth accompanied with elevating abundance of cell-cycle-related proteins and accelerated cell-cycle progression. (oncotarget.com)
Angiogenesis is essential in the process of carcinogenesis to facilitate tumor progression and metastasis. (spandidos-publications.com)
Another important mechanism for the progression of colorectal cancer is the ability of the transformed cells to invade and traverse the basement membrane, which in turn facilitates the conversion of adenomas into carcinomas and then metastases ( 1 ). (spandidos-publications.com)
There is increasing interest in the role played by the innate and adaptive immune systems in the regulation of tumour development and progression 2 , 3 and it is anticipated that a better understanding of the molecular and cellular immunology of NSCLC will lead to the identification of novel targets for immunotherapy. (ersjournals.com)
The role of macrophage phenotypes in tumour progression has been extensively reviewed 6 - 10 . (ersjournals.com)

We identified the microRNAs (miRNAs) miR-221 and miR-222 (miR-221/222) as basal-like subtype-specific miRNAs and showed that expression of miR-221/222 decreased expression of epithelial-specific genes and increased expression of mesenchymal-specific genes, and increased cell migration and invasion in a manner characteristic of the epithelial-to-mesenchymal transition (EMT). (nih.gov)
We further demonstrated that suppression of autophagy using either pharmacological inhibitors or RNA interference of essential autophagy genes enhanced cell death induced by IM in cell lines and primary CML cells. (lu.se)
Expression levels of TCTP were down-regulated at the mRNA and protein levels during tumor suppression and by the activation of p53 and Siah-1 very well known anti-tumor genes. (wikipedia.org)
Introduction: Proteins encoded by Fanconi anemia (FA) and/or breast cancer (BrCa) susceptibility genes cooperate in a common DNA damage repair signaling pathway. (lu.se)
The Popeye domain containing (POPDC) genes encode sarcolemma-localized cAMP effector proteins. (imperial.ac.uk)
DICER1 makes an important protein that works to suppress other genes through intermediary molecules known as microRNAs. (scienceblog.com)
A second project is looking at mutations in genes that encode RNA-binding proteins and result in amyotrophic lateral sclerosis (ALS). (queensu.ca)
Kim YD, Cho JS, Kim HS, Song SH: Effect of macrolide on the interleukin-1 β-mediated MUC2/5AC genes expression and mucin secretion in human airway epithelial cells. (karger.com)
This study aimed to evaluate the expression levels of miR-34a and 11 of its bioinformatically selected target genes and proteins to test their potential dysregulation in RCC. (hindawi.com)
10 Similarly, in recent studies, at least one third of genes in diverse organisms can exhibit alternative transcription, leading to the production of N-terminally extended proteins or alternative reading frames. (biorxiv.org)
Our pipeline, ExInAtor, identifies genes with excess load of somatic single nucleotide variants (SNVs) across panels of tumour genomes. (nature.com)
We have presented a first catalogue of mutated lncRNA genes driving cancer, which will grow and improve with the application of ExInAtor to future tumour genome projects. (nature.com)
Whole genome sequencing makes it possible to comprehensively discover the mutations, and the mutated genes, that are responsible for tumour formation. (nature.com)
Genetic predisposition, which might lead to either activation of oncogenes or inhibition of tumor suppressor genes, are risk factors of colon cancer development. (lu.se)
Known PPIs of the 62 MPM associated genes were derived from Biological General Repository for Interaction Datasets (BioGRID) and Human Protein Reference Database (HPRD). (cdc.gov)
The interactome is significantly enriched with genes differentially expressed in MPM tumors compared with normal pleura and with other thoracic tumors, genes whose high expression has been correlated with un-favorable prognosis in lung cancer, genes differentially expressed on crocidolite exposure, and ex-osomederived proteins identified from malignant mesothelioma cell lines. (cdc.gov)

Knockdown of NDRG1 in SW480 to a level that is similar to that in SW620 also modulated cell cycle and proliferation in SW480 towards the status of the highly metastatic SW620. (nih.gov)
In vitro studies based on MCF-7 cell proliferation and induction of vitellogenin in primary culture of rainbow trout hepatocytes. (cdc.gov)
However, Tamoxifen Z isomer enters into the cell, competitively binding with ER to form receptor complexes, inhibiting that estrogen plays an role, and inhibiting proliferation of breast cancer cells. (lookchem.com)
Among its different constituents, Astragalus polysaccharides have been most widely studied particularly for their immunopotentiating properties, such as stimulation of murine B cell proliferation and cytokine production ( 6 ). (spandidos-publications.com)
Promisingly, they have already uncovered at least four naturally occurring chemicals in the family known as the benzophenones that are effective at preventing the proliferation of cancer cells, including multi-drug resistant varieties. (naturalnews.com)
BMP-4 treatment of AtT-20 mouse corticotrophinoma cells has an inhibitory effect on ACTH secretion and cell proliferation. (unisr.it)

The transcription factor FOSL1 (also known as Fra-1), which is found in basal-like breast cancers but not in the luminal subtype, stimulated the transcription of miR-221/222, and the abundance of these miRNAs decreased with inhibition of the epidermal growth factor receptor (EGFR) or MEK (mitogen-activated or extracellular signal-regulated protein kinase kinase), placing miR-221/222 downstream of the RAS pathway. (nih.gov)
Imatinib mesylate (IM), a potent inhibitor of the BCR/ABL tyrosine kinase, has become standard first-line therapy for patients with chronic myeloid leukemia (CML), but the frequency of resistance increases in advancing stages of disease. (lu.se)
Metformin (MTF) has been reported to target NLK (Nemo-like kinase) to inhibit non-small lung cancer cells. (cancerindex.org)
Tamoxifen is a selective estrogen response modifier (SERM), protein kinase C inhibitor and anti-angiogenetic factor. (sigmaaldrich.com)
Protein kinase C inhibitor. (sigmaaldrich.com)
We aim to study the coupling between LTCC and β adrenergic receptors in different cardiomyocyte microdomains, the distinct involvement of PKA and CAMKII (Ca2+/calmodulin-dependent protein kinase II) and explore how this functional complex is disrupted in heart failure.Methods:Global signaling between LTCCs and β adrenergic receptors was assessed with whole-cell current recordings and western blot analysis. (imperial.ac.uk)
Protein kinase C alpha inhibitor and NF-kappaB inhibitor significantly reduced pro-inflammatory cytokine release in response to SPD-MAA. (cdc.gov)
Three-hundred-seventy-five of the 10,000 proteins belong to the kinase group. (genengnews.com)
In this study, we compared how different signaling pathways determine extracellular nucleotide pools in control Jurkat cells versus Jurkat lines that lack the Fas-associated death domain (FADD) or receptor-interacting protein kinase 1 (RIP1) cell death regulatory proteins. (aspetjournals.org)
Sheng's team applied two molecules that blocked downstream chemical reactions, curbing the production of Akt - a key protein kinase that the cancer cells need to metabolize food, move, proliferate, and survive. (eurekalert.org)
The NEMO protein is required for the activation of the kinase complex. (medscape.com)

One relatively new approach is to use oncolytic adenoviruses, which selectively infect and kill cancerous cells leaving healthy cells unharmed. (helsinki.fi)
Instead, these cells influence surrounding cells to grow quickly, setting the stage for additional genetic mutations in cells that then become cancerous. (scienceblog.com)
The researchers based their work on the premise that it is proteins, and not mutations in DNA per se, that are ultimately responsible for changing somatic cells into cancerous ones. (genengnews.com)
The third, oncogene-mediated resistance, occurs when the epidermal growth factor receptor (EGFR) signals cancerous tumors to accelerate their growth, overwhelming the capacity of drugs to kill them. (naturalnews.com)
The fibrosis family of proteins is not controlled well in cancerous tissues. (survivingmesothelioma.com)
Carcinoid Tumors and Carcinoid Syndrome Carcinoid tumors are noncancerous (benign) or cancerous (malignant) growths that sometimes produce excessive amounts of hormone-like substances (such as serotonin), resulting in the carcinoid. (msdmanuals.com)

N-Myc downstream-regulated gene 1 (NDRG1) plays vital roles in tumor metastasis suppression and is frequently silenced in metastatic colon cancers. (nih.gov)
Metformin Enhances the Effect of Regorafenib and Inhibits Recurrence and Metastasis of Hepatic Carcinoma After Liver Resection via Regulating Expression of Hypoxia Inducible Factors 2α (HIF-2α) and 30 kDa HIV Tat-Interacting Protein (TIP30). (cancerindex.org)
Then, can it repress the cancer cells' metastasis potential? (scielo.br)
Thus, we conclude that As2O3 can reduce metastasis potential of NPC cells, involving inhibition of MMP-9 expression. (scielo.br)
Tumor-promoting functions of macrophages include angiogenesis, metastasis formation, and suppression of Th1-type immune responses. (aacrjournals.org)
Additionally, the expression and activity of matrix metalloproteinases (MMPs) are increased in almost every type of human cancer, which may be associated with cell invasion, metastasis and angiogenesis. (spandidos-publications.com)
It may even be possible to use lysyl oxidase inhibitors to prevent tumor metastasis. (survivingmesothelioma.com)

ETP augmented fibrosis, angiogenesis, and inflammation through recruitment of macrophages and endothelial cells. (jci.org)
In preclinical models, blocking HRH1 on macrophages - either by genetic knockout or antihistamine treatment - decreased the immune-suppressive activity of the TAMs, leading to increased T cell activation and inhibition of tumor growth. (newswise.com)
To understand how HRH1 in TAMs influences T cell activity, the researchers looked at additional regulatory receptors on the macrophages. (newswise.com)
Here, we show that successful treatment of cervical carcinoma in mouse models with synthetic long peptide (SLP) vaccines induced influx of cytokine-producing CD8 T cells that strongly altered the numbers and phenotype of intratumoral macrophages. (aacrjournals.org)
Strikingly, complete regressions of large established tumors depended on the tumor-infiltrating macrophages that were induced by this immunotherapy, because a small-molecule drug inhibitor targeting CSF-1R diminished the number of intratumoral macrophages and abrogated the complete remissions. (aacrjournals.org)
There is a marked survival advantage for patients with nonsmall cell lung cancer (NSCLC) expressing high numbers of macrophages in their tumour islets. (ersjournals.com)
Macrophages infiltrating the tumour islets in nonsmall cell lung cancer were predominantly of the M1 phenotype in patients with extended survival. (ersjournals.com)
Thus, increasing numbers of macrophages within the tumour islets conferred a marked survival advantage, while increased numbers of macrophages in the tumour stroma were associated with worse prognosis. (ersjournals.com)
The M1 phenotype (classically activated) macrophages are thought to be induced by interferon-γ, with or without lipopolysaccharide and tumour necrosis factor (TNF)-α, and exert a cytotoxic effect against cancer cells. (ersjournals.com)
Myeloid related protein (MRP) 8/14 expression by macrophages is associated with the release of TNF-α 12 . (ersjournals.com)
M2 (alternatively activated) macrophages are thought to be modulated by IL-4 and -13 and associated with tumour formation. (ersjournals.com)
Additionally, M2 macrophages have been traditionally thought of as being the predominant macrophage phenotype in solid tumours (tumour-associated macrophages). (ersjournals.com)
Vascular endothelial growth factor (VEGF), a key component in the process of angiogenesis, is known to be produced by tumour-associated macrophages 17 , 18 , which have been traditionally reported as M2 macrophages. (ersjournals.com)

Scope includes mutations and abnormal protein expression. (cancerindex.org)
Thirteen FANCD2-monoubiquitinylation-positive FA cell lines excluded for genetic defects in the downstream pathway components and 300 familial BrCa patients negative for BRCA1/2 mutations were analyzed for genetic mutations. (lu.se)
People with HDGC caused by CDH1 gene mutations are born with one mutated copy of the gene in each cell. (medlineplus.gov)
It is unclear why CDH1 gene mutations primarily occur in the stomach lining and these other tissues. (medlineplus.gov)
Studying tumor cells for genetic mutations has led to many advances in the understanding of cancer. (scienceblog.com)
NEMO consists of 10 exons, and most mutations cause deletions of exons 4-10, resulting in a truncated protein. (medscape.com)
Hypomorphic mutations may impair but not abolish NEMO protein function. (medscape.com)

In human lung tumors, combined activation of K-RAS and inactivation of RASSF1A is closely associated with the development of the most aggressive and worst prognosis tumors. (cancerindex.org)
A heightened presence of fibrosis, or collagen cells, often signals a poorer prognosis. (survivingmesothelioma.com)
I found that presence of mast cells in colon cancer tissue was associated with better prognosis of colon cancer patients, and the presence of mast cells in polyps/tumors in a colitis-associated colon cancer mouse model was also beneficial. (lu.se)
I found that down-regulation of both these proteins is associated with poor prognosis for colon cancer patients. (lu.se)
Although recent studies suggest a less favorable prognosis for patients with germinomas secreting bhCG, no established prognostic significance of tumor markers exists. (medscape.com)

Cigana C, Assael BM, Melotti P: Azithromycin selectively reduces tumor necrosis factor alpha levels in cystic fibrosis airway epithelial cells. (karger.com)
SPD-MAA treatment significantly stimulated pro-inflammatory cytokine tumor necrosis factor-alpha (TNF-alpha) release in the macrophage cell line, RAW264.7. (cdc.gov)

NDRG1 is silenced in a highly metastatic colon cancer cell line SW620. (nih.gov)
SW480 and SW620 are two colon cancer cell lines established from the same patient with different metastatic potentials, making them an ideal model for investigation of metastatic mechanisms. (nih.gov)
In conclusion we observed unique histone modifications in two colon cancer cell lines with different metastatic potentials, indicating possible mechanisms for the down-regulation of NDRG1 in metastatic SW620. (nih.gov)
Moreover, ETP expression was associated with aggressive mammary tumor growth and high metastatic growth. (jci.org)
We also discovered that the invasiveness of metastatic colon cancer cells was alleviated following drug treatment. (spandidos-publications.com)
These findings suggest that formononetin inhibits angiogenesis and tumor cell invasion, and thus support its use in the treatment of advanced and metastatic colon cancers. (spandidos-publications.com)
RLY-4008 is currently being evaluated in a clinical trial in patients with advanced or metastatic FGFR2-altered solid tumors with a single arm, potentially registration-enabling cohort for FGFRi-naïve FGFR2-fusion CCA. (ozarksfirst.com)

It is known that arsenic trioxide (ATO) is able to inhibit the migration and invasion of solid malignant tumors, but its exact molecular mechanism remains unclear. (nih.gov)
Permissive histologic interpretation may result in the designation of some non-neoplastic Hürthle cell lesions as malignant tumors. (medscape.com)

Glioblastoma (GBM) is one of the most aggressive primary brain tumors, with a median survival time of about 14.6 months despite maximal therapy 1 . (nature.com)
They found the right target, but their studies in canine glioma patients revealed difficulties in delivery of effective doses of alphaCT1 to brain tumors in these companion animals. (eurekalert.org)

Dr. Renwick's research involves examining at microRNAs in tissue samples from neuroendocrine tumors. (queensu.ca)
Gastrointestinal neuroendocrine tumors often secrete hormones that cause diarrhea and flushing of the skin. (msdmanuals.com)
Some gastrointestinal neuroendocrine tumors can be removed surgically. (msdmanuals.com)

and cell differentiation ( SOX2 and TGFB3 ) as well as immunohistochemical assay for VEGFA, TP53, Bcl2, TGFB1, and Ki67 protein expression have been performed in 85 FFPE RCC tumor specimens. (hindawi.com)
Sheng's research team used glioblastoma cell lines and primary glioblastoma cells derived from patient tumor specimens to discover that inhibiting two specific proteins when combined with temozolomide, produced an effective "triple combinational therapy" that overcame chemoresistance. (eurekalert.org)

Both LCRF-0004 and BMS-777607 demonstrated significant anti-tumor efficacy in vitro , however BMS-777607 was far superior to LCRF-0004. (frontiersin.org)
LMP1-negative cell line HNE1 and LMP1-positive cell line HNE1-LMP1 were used as in vitro model. (scielo.br)
Human fibroblast monocultures were found to be insufficient to fully replicate in vivo fibrosis outcomes suggesting in vitro predictive potential depends upon more advanced cell culture in vitro models. (cdc.gov)

In tumor necrosis factor (TNF)-alpha-stimulated human aortic endothelial cells, beta-sitosterol was found to significantly inhibit vascular adhesion molecule 1 and intracellular adhesion molecule 1 expression. (drugs.com)

The kinases play a part in the continuous reproduction process of tumor cells," adds Dr. Küster. (genengnews.com)

The p53 Family Coordinates Wnt and Nodal Inputs in Mesendodermal Differentiation of Embryonic Stem Cells. (harvard.edu)
also known as ASH1), neurogenic differentiation factor 1 (NeuroD1), yes-associated protein 1 (YAP1) and POU class 2 homeobox 3 (POU2F3). (cancerindex.org)
It is involved in p53 pathways and is implicated in cell death/survival signaling, the cell cycle, and differentiation, thereby playing a regulatory role in carcinogenesis [ 12 ]. (hindawi.com)
Evidence is accumulating that small G proteins are involved in the regulation of cell growth and differentiation. (nii.ac.jp)
We have found that the levels of smg p21 mRNA increase in hematopoietic leukemiae cells after their differentiation into hematopoietic cells. (nii.ac.jp)
We have also found that smg p25A is mainly detected inneural tissues by use of its specific monoclonal antibody, and that the levels of smg p25A mRNA increase in PC12 cells after their differentiation into neuron-like cells. (nii.ac.jp)
therefore, definitive differentiation of Hürthle cell carcinoma from Hürthle-cell adenoma is based on vascular invasion and/or capsular invasion, as well as on permanent histologic sections or extrathyroidal tumor spread and lymph node and systemic metastases. (medscape.com)

Often this is because not enough of the drug can get into the tumor to generate an anti-tumor effect. (survivingmesothelioma.com)
In addition, I also found that the pro-inflammatory mediator LTC4 via CysLTR2 can induce the expression of 15-PGDH through the JNK pathway, which indicate that LTC4 via CysLTR2 has an anti-tumor effect. (lu.se)

Koontongkaew S, Monthanapisut P, Saensuk T: Inhibition of arachidonic acid metabolism decreases tumor cell invasion and matrix metalloproteinase expression. (karger.com)
These changes in gene expression alter cell metabolism, tissue re-modeling, and even organismal responses such as increases in heart rate and ventilation. (nobelprize.org)
Background: Reactive aldehydes such as acetaldehyde and malondialdehyde generated as a result of alcohol metabolism and cigarette smoke exposure lead to the formation of malondialdehyde-acetaldehyde-adducted proteins (MAA adducts). (cdc.gov)

This master thesis is a part of a project aiming to set up immunoaffinity-purification/MS based method in order to analyse the ligandome and determine T-cell recognized cancer associated antigens from tumor cells. (helsinki.fi)
Our data indicate that certain GSL antigens, especially SGGLs, GD3, and OAc-GD3, are expressed in neural tumor cells and may be considered as tumor-associated antigens that represent important biomarkers for neural tumors. (karger.com)
Immunotherapies with antibody-drug-conjugates (ADC) and CAR-T cells, targeted at tumor surface antigens (surfaceome), currently revolutionize clinical oncology. (lu.se)

All sera had high titers of antibodies of the IgM isotype against SGPG (titers over 1:3,200), especially in tumors such as meningiomas, germinomas, orbital tumors, glioblastomas, medulloblastomas, and subependymomas. (karger.com)
In this research project, we have investigated the C-terminal structures of small G proteins, purified the regulatory proteins for small G proteins, and made monoclonal antibodies against small G proteins and their regulatory proteins. (nii.ac.jp)
Among these regulatory proteins, we have cloned the cDNAs of smg p21 GDS, smg p25A GDI, and rho GDI, and made monoclonal antibodies against them. (nii.ac.jp)

William Kaelin, Jr. was in 1995 engaged in the study of the von Hippel-Lindau tumor suppressor gene, and after isolation of the first full-length clone of the gene showed that it could suppress tumor growth in VHL mutant tumorigenic cell lines. (nobelprize.org)
The second, tumor-suppressor-gene-mediated resistance, results from a mutation to protein p53 that makes cancer cells enormously aggressive and resistant. (naturalnews.com)
I found that the tumor suppressor gene 15-PGDH is down-regulated in colon cancer patients as well as in colon cancer cell lines. (lu.se)

The only ligand recognized to bind MST1R (RON) is Macrophage Stimulating 1 (MST1), also known as Macrophage Stimulating Protein (MSP) or Hepatocyte Growth Factor-Like Protein (HGFL). (frontiersin.org)
Malondialdehyde-acetaldehyde-adducted surfactant protein alters macrophage functions through scavenger receptor A. (cdc.gov)
CD204) mediates the uptake of modified proteins, we hypothesized that the effects of MAA-modified proteins on macrophage function are primarily mediated through SRA. (cdc.gov)
Conclusions: In conclusion, our data demonstrate that SRA is important for MAA-adducted protein-mediated effect on macrophage functions. (cdc.gov)
These changes of the intratumoral myeloid composition coincided with macrophage recruitment by chemokines, including CCL2 and CCL5, and were completely dependent on a vaccine-induced influx of tumor-specific CD8 T cells. (aacrjournals.org)
Incubation of tumor cells with T cell-derived IFNγ and TNFα recapitulated the chemokine profile observed in vivo , confirming the capacity of antitumor CD8 T cells to mediate macrophage infiltration of tumors. (aacrjournals.org)

TCTP knockdown in primary mammary tumor cells, results in increased p53 expression and a decreased number of stem-like cancer cells. (wikipedia.org)
Collagen VI (COL6) is highly expressed in adipose tissue, upregulated in the obese state, and enriched in breast cancer lesions and is a stimulator of mammary tumor growth. (jci.org)
Hence, the adipocyte, as a major constituent of the mammary tumor stroma ( 3 ), is a likely contributor to tumor growth. (jci.org)

Translationally controlled tumor protein (TCTP) is a protein that in humans is encoded by the TPT1 gene. (wikipedia.org)
What does this gene/protein do? (cancerindex.org)
What pathways are this gene/protein implicaed in? (cancerindex.org)
Results: A previously identified co-purifying protein with PALB2 was identified, MRG15 (MORF4L1 gene). (lu.se)
The CDH1 gene provides instructions for making a protein called epithelial cadherin or E-cadherin. (medlineplus.gov)
involving the other copy of the CDH1 gene must occur in the cells of the stomach lining during a person's lifetime. (medlineplus.gov)
When both copies of the CDH1 gene are mutated in a particular cell, that cell cannot produce any functional E-cadherin. (medlineplus.gov)
When the research team looked at PPB tumors to see if there is any DICER1 protein being made from the remaining normal copy of the gene, they were surprised by the results: "We expected to see that the tumor cells had no DICER1 protein giving us a nice explanation for why the tumor cells had gone haywire. (scienceblog.com)
It has a lot of information that makes a gene into a protein, so it is a good diagnostic and therapeutic target," he explains. (queensu.ca)
16-membered) on MUC5AC and MUC2 gene expression and secretion from human airway epithelial cells. (karger.com)
AZM and MDM attenuated PMA-induced MUC5AC and MUC2 gene and protein expression in NCI-H292 cells. (karger.com)
While RelA/p50 heterodimer is the predominantly form and plays a major regulatory role in mammalian cells, the RelB/p100 is also expressed and acts as the alterative pathway regulating its downstream gene expression [ 2 ]. (oncotarget.com)
Animal cells undergo fundamental shifts in gene expression when there are changes in the oxygen levels around them. (nobelprize.org)
Through the combined work of these three laureates it was thus demonstrated that the response by gene expression to changes in oxygen is directly coupled to oxygen levels in the animal cell, allowing immediate cellular responses to occur to oxygenation through the action of the HIF transcription factor. (nobelprize.org)
Novel PPIs were predicted by applying the HiPPIP algorithm, which computes features of protein pairs such as cellular localization, molecular func-tion, biological process membership, genomic location of the gene, and gene expression in microar-ray experiments, and classifies the pairwise features as interacting or noninteracting based on a random forest model. (cdc.gov)

Moreover, TCTP was described as a pro-survival protein antagonizing BAX function. (wikipedia.org)
Using The Cancer Genome Atlas and other publicly available patient cancer data, the team also discovered that high expression of HRH1 in tumors was correlated with markers of T cell dysfunction, poor responses to checkpoint inhibitors and poorer survival outcomes. (newswise.com)
Then the survival cells were collected to investigate their potential of colony formation, attachment, invasion, and migration. (scielo.br)
The findings could significantly delay tumor recurrence resulting from chemoresistance and prolong survival in glioblastoma patients, according to Sheng. (eurekalert.org)
Malignant pleural mesothelioma (MPM) is an aggressive cancer affecting the outer lining of the lung, with a median survival of less than one year. (cdc.gov)

image: Glioblastoma cells, pictured above, are notoriously aggressive and evade front-line cancer treatments. (eurekalert.org)
Here, we decode the surfaceome and endocytome and its remodeling by hypoxic stress in glioblastoma (GBM), the most common and aggressive brain tumor in adults. (lu.se)

These therapeutic methods, including but not limited to oncolytic virus therapies, T-cell therapies and cancer vaccines, are based on the body's ability to recognize mutated antigen peptides presented on the cell surface by MCH-receptors (also known as HLA-receptors in humans) and the disposal of the malignant cells by cytotoxic T-cells. (helsinki.fi)
However, recent studies in many organisms and in humans have revealed significant protein sequence variation due to the presence of somatically acquired genetic variants, alternative transcription, and mRNA splicing, which are not necessarily annotated in reference databases. (biorxiv.org)

Translationally controlled tumor protein (TCTP) is involved in a wide range of molecular interactions with biological and nonbiological partners of various chemical compositions such as proteins, peptides, nucleic acids, carbohydrates, or small molecules. (wikipedia.org)
4. In silico prediction if the immunogenicity of selected peptides and assessing their source proteins. (helsinki.fi)
In silico methods were successfully used to characterize previously identified HLA-restricted peptides and one previously identified immunogenic T-cell epitope. (helsinki.fi)

1991. Promotion of mouse lung tumors by bioaccumulated polychlorinated aromatic hydrocarbons. (cdc.gov)
In contrast, fucosyl-GM1 was not found to restrict to small cell lung carcinoma cells. (karger.com)
PPB is a tumor that appears to arise out of a localized area of abnormal lung development. (scienceblog.com)
The team theorizes that something else must happen to the normal copy of DICER1 in lung cells for a tumor to develop. (scienceblog.com)
During lung development the cells that line the airways and the cells that make up the support structures have to communicate. (scienceblog.com)
The cancer presents as cysts in early stages and progresses to solid lung tumors over time. (scienceblog.com)
Molecular subtypes of small cell lung cancer: a synthesis of human and mouse model data. (cancerindex.org)
Small cell lung cancer (SCLC) is an exceptionally lethal malignancy for which more effective therapies are urgently needed. (cancerindex.org)
Nonsmall cell lung cancer (NSCLC) is the most common cause of cancer-related death worldwide. (ersjournals.com)
Monocytes activated by tumour-derived microvesicles from pancreatic, colon and lung cancer cell lines have been found to show increased expression of human leukocyte antigen (HLA)-DR and a resulting increase in production of reactive oxygen intermediates and TNF-α 11 . (ersjournals.com)

To further investigate the physiological processes 40 underlying GBM cell movement, this study aimed to image and analyze distinct GBM invasive growth patterns found in vivo , similar to those observed in patients. (nature.com)
However, in vivo genetic screens require stable expression of several components that in most cases are not derived from murine cells, which represents a major obstacle in the context of cancer immunology. (aacrjournals.org)
Both genome-editing capacity and normal in vivo behavior of all tested cell lines remain largely unaltered using this novel strategy. (aacrjournals.org)
Rae-1 protein expression on tumor cell lines has been implicated in in vivo tumor rejection. (rndsystems.com)
Preclinically, RLY-4008 demonstrated FGFR2-dependent killing in cancer cell lines and induced regression in in vivo models, while minimal inhibition of other targets was observed, including other members of the FGFR family. (ozarksfirst.com)
AtT-20 cells stably transfected with a dominant-negative form of the BMP-4 signal cotransducer Smad-4 or the BMP-4 inhibitor noggin have increased tumorigenicity in nude mice, showing that BMP-4 has an inhibitory role on corticotroph tumorigenesis in vivo. (unisr.it)

TCTP in the human is a growth-related, calcium-binding protein. (wikipedia.org)
Translationally controlled tumor protein was first discovered in 1989 as a cDNA sequence obtained from a human mammary carcinoma cDNA library with proves derived from the translationally controlled, growth-related mouse tumor protein TCTP. (wikipedia.org)
TCTP was originally described as a growth related protein of tumor cells. (wikipedia.org)
If the estrogen receptor (ER) is present in breast cancer cells, estrogen enters into tumor cells and binds with ER, promoting mRNA and DNA synthesis of tumor cells, stimulating tumor cell growth. (lookchem.com)
The loss of this protein prevents it from acting as a tumor suppressor, contributing to the uncontrollable growth and division of cells . (medlineplus.gov)
Loss of DICER1 in the airway lining cells could disrupt this communication, possibly setting the stage for abnormal growth. (scienceblog.com)
Our results highlight the crucial role of ETP as an obesity-associated factor that promotes tumor growth in the context of adipocyte interactions with tumor and stromal cells. (jci.org)
Taken together, our studies not only for the first time establish p100 as a key tumor suppressor of bladder cancer growth, but also identify a novel molecular cascade of PHLPP2/CREB/miR-302d that mediates the tumor suppressive function of p100. (oncotarget.com)
Our previous findings demonstrated that formononetin initiates growth-inhibitory and pro-apoptotic activities in human colon cancer cells. (spandidos-publications.com)
The vascular endothelial growth factor (VEGF) is a well characterized angiogenic factor known to stimulate angiogenesis within a tumor ( 1 ). (spandidos-publications.com)
Subsequent study using multiple human cancer cell lines, including those of the colon, stomach and liver, further indicated the universal growth-inhibitory and pro-apoptotic effects of AST. (spandidos-publications.com)
Targeting fibrosis can prevent collagen formation, it may delay tumor growth in mesothelioma. (survivingmesothelioma.com)
The new study, in combination with the Sheng Lab's 2015 study published in Cancer Research , is the first to depict a specific channel protein and its enzymatic interactions with signaling molecules driving tumor growth that may underlie chemotherapy resistance in glioblastomas that don't express the DNA-repairing protein MGMT - as well as a novel therapeutic approach. (eurekalert.org)
In previous studies of gliomas, increased levels of the connexin 43 protein suppressed tumor growth. (eurekalert.org)
Overall, only about 33% of Hürthle cell tumors demonstrate signs of that invasive growth that indicates malignancy and the possibility of metastasizing. (medscape.com)

Mechanistically, p100 inhibited Cyclin D1 protein translation by activating the transcription of LARP7 and its hosted miR-302d, which could directly bind to 3′-UTR of cyclin d1 mRNA and inhibited its protein translation. (oncotarget.com)
SPD-MAA treatment significantly increased SRA mRNA expression, but had no effect on surface receptor protein expression. (cdc.gov)

It has been hypothesized that inactivation of the RASSF1A tumor suppressor facilitates K-RAS-mediated transformation by uncoupling it from apoptotic pathways such as the Hippo pathway. (cancerindex.org)
The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
for example, in 1858 Louis Pasteur was the first to show that there is a complex balance of oxygen use in animal cells, and that cells use multiple pathways to accomplish energy con-version (Pasteur, 1858). (nobelprize.org)
Thus, extracellular nucleotide accumulation during regulated tumor cell death involves interplay between ATP/AMP efflux pathways and different cell-autonomous ectonucleotidases. (aspetjournals.org)

Our previous study demonstrated that tumor-suppressor circular RNAs (circRNAs) can be specifically secreted outside of colorectal cancer (CRC) cells within exosomes to maintain tumor cell fitness. (bvsalud.org)

Blocks estradiol-stimulated VEGF production in breast tumor cells. (sigmaaldrich.com)

In addition, we have analyzed serum antibody titers against SGPG, GD3, and OAc-GD3 in patients with neural tumors by ELISA and HPTLC immunostaining. (karger.com)
These aldehydes can adduct to different proteins such as bovine serum albumin and surfactant protein A or surfactant protein D (SPD). (cdc.gov)
Measurements of serum and CSF tumor markers are a valuable component of the preoperative evaluation. (medscape.com)

The presence of high CA-125 levels, along with the imaging findings of nodular peritoneal thickening, suggests the possibility of peritoneal serosal carcinoma, which is a type of cancer that affects the lining of the abdominal cavity (peritoneum). (researchgate.net)
We could validate these findings by immunofluorescence analyses in patient tumors and by increased expression in the hypoxic core of GBM spheroids. (lu.se)
The skin findings in incontinentia pigmenti represent changes in the epidermal cells. (medscape.com)

The expression is lower in kidney and renal cells. (wikipedia.org)
Flow cytometric analysis provided essential information of the cell line HLA-1 expression. (helsinki.fi)
Additional information of PD-L1 expression can be used to evaluate cell line's immune-evasion abilities. (helsinki.fi)
Today, several proteomics approaches (such as chemical, quantitative and functional proteomics, including the analyses of protein expression profiles, protein interaction networks and post-translational modifications) are widely carried out by clinicians and pharmaceutical companies. (mdpi.com)
In this Perspectives article, we review and synthesize these recent lines of evidence and propose a working nomenclature for SCLC subtypes defined by relative expression of these four factors. (cancerindex.org)
The mechanistic data demonstrated that HRH1 acts in TAMs to drive cells toward an immune-suppressive M2-like state and to increase membrane expression of the inhibitory checkpoint VISTA, ultimately leading to dysfunctional T cells and a suppressed anti-tumor response. (newswise.com)
The advanced pathological grade was associated with strong TGFB1, VEGFA, and Ki67 protein expression and absent Tp53 staining. (hindawi.com)
Here, we are, for the first time, to report that p100 protein expression was dramatically decreased in bladder cancers of N-butyl-N-(4-hydroxybutyl)-nitrosamine (BBN)-treated mice and human patients. (oncotarget.com)
Furthermore, p100 suppressed the expression of PHLPP2 (PH domain and leucine-rich repeat protein phosphatases 2), thus promoting CREB phosphorylation at Ser133 and subsequently leading to miR-302d transcription. (oncotarget.com)
Expression and effective removal of Cas9 and vector components are monitored using fluorescent reporter proteins. (aacrjournals.org)
On the basis of the expression of CD11b, CD11c, F4/80, Ly6C, Ly6G, and MHC II, we identified four myeloid subpopulations that increased in numbers from 2.0-fold to 8.7-fold in regressing tumors. (aacrjournals.org)
The differences in extracellular ATP/AMP accumulation correlated with cell-line-specific expression of ectonucleotidases that metabolized the released ATP/AMP. (aspetjournals.org)
In contrast, the RIP1-deficient cells were defined by increased expression of tartrate-sensitive prostatic acid phosphatase as a broadly acting ectonucleotidase. (aspetjournals.org)
Likewise, advances in mass spectrometry proteomics now permit highly sensitive and accurate studies of protein expression at the whole proteome-scale. (biorxiv.org)
While their expression tends to be lower than protein-coding mRNAs, lncRNAs are thought to be highly expressed in a subset of cells in a population 6 . (nature.com)
In this study, we report that bone morphogenetic protein-4 (BMP-4) is expressed in the corticotrophs of human normal adenohypophysis and its expression is reduced in corticotrophinomas obtained from Cushing's patients compared with the normal pituitary. (unisr.it)
Indeed, retinoic acid induces both BMP-4 transcription and expression and its antiproliferative action is blocked in Smad-4dn- and noggin-transfected Att-20 cells that do not respond to BMP-4. (unisr.it)
Additionally, METTL3 was proved to regulate the expression and methylation level of circ -0,000,953 through YTHDF2 (YTH N6-methyladenosine RNA binding protein 2). (bvsalud.org)
I investigated the underlying mechanisms/signaling triggered by these tumor suppressors in colon cancer cells and whether the re-expression of these tumor suppressors could be an attractive therapeutic strategy for treatment of colon cancer patients. (lu.se)
Therefore, the expression of embryonic proteins, such as alpha-fetoprotein (AFP) and bhCG, are indicative of malignant germ cell elements. (medscape.com)
Significant variability in expression of tumor markers is such that the absence of AFP or bhCG does not rule out a mixed germ cell tumor. (medscape.com)

In this form, known as diffuse gastric cancer, there is no solid tumor. (medlineplus.gov)
This often leads to solid tumor fibrosis and poor clinical outcomes for patients. (survivingmesothelioma.com)

Long viewed by researchers as "information carriers," RNA regained the spotlight in the early 2000s, following a series of discoveries showing that another class of RNA, named microRNA, plays a key role in controlling messenger RNAs and their protein products. (queensu.ca)

1 Department of Molecular Diagnostics and Cancer Cell Biology, Genentech Inc., South San Francisco, CA 94080, USA. (nih.gov)
In cases where there is nodular peritoneal thickening, ovarian cancer, and ascites, the source of ascites can be the result of various factors, including the presence of cancer cells in the peritoneal cavity. (researchgate.net)
CA-125 is a tumor marker that is often elevated in cases of ovarian cancer, although it can also be elevated in other conditions. (researchgate.net)
1. Peritoneal involvement: Cancer cells can spread to the peritoneum, leading to inflammation and the production of fluid. (researchgate.net)
To gain deeper insight into this pathway and its influence on cancer risk, we searched for novel components through protein physical interaction screens. (lu.se)
Even though the idea of an immune system actively searching for and disposing of potential mutated tumor cells is over a century old, only recent developments in various fields such as mass spectrometry, immuno-checkpoint blockade strategies and in silico modelling have enabled the realization of the full potential of recruiting immune system to fight cancer and the possibilities of personalized therapies. (helsinki.fi)
Preliminary MTS assay is used to determine linear range and optimal time frame for the PBMC/cancer cell co-culture killing assay. (helsinki.fi)
Another challenge is the cell entry of oncolytic adenovirus, which is mainly mediated by the Coxsackie-Adenovirus receptor and this receptor is downregulated in various cancer cells. (helsinki.fi)
In order to overcome these limitations, this study explored the possibility to use cancer cell derived extracellular vesicles (EVs) as drug delivery system for oncolytic adenovirus. (helsinki.fi)
however, because this type of cancer is hidden underneath the stomach lining, it is usually not diagnosed until the cancer has become widely invasive. (medlineplus.gov)
A lack of E-cadherin also impairs cell adhesion, increasing the likelihood that cancer cells will not come together to form a tumor but will invade the stomach wall and metastasize as small clusters of cancer cells into nearby tissues. (medlineplus.gov)
Looking closer at this relationship, we discovered that histamine, through its receptor HRH1, can promote cancer cell immune evasion and resistance to immunotherapy. (newswise.com)
Immune checkpoint inhibitors , a type of immunotherapy , work by blocking certain checkpoint proteins that regulate the activity of T cells, unleashing the T cells to mount an anti-tumor response and eliminate cancer cells. (newswise.com)
Conversely, cancer cells appear to be a major source of increased histamine levels in patient samples and cancer cell lines. (newswise.com)
Scientists from the Technical University of Munich (TUM) have decoded the proteome of 59 tumor cell lines and say that they have found new ways to explain why cancer drugs do not have the same effect on all patients suffering from the disease. (genengnews.com)
The team identified over 10,000 different proteins in cancer cells. (genengnews.com)
The researchers used NCI-60 tumor cell lines which came from the U.S. National Cancer Institute. (genengnews.com)
The TUM group also showed that the protein pattern of the cells determines the effectiveness of cancer drugs. (genengnews.com)
We investigated how the cell lines react to 108 different cancer drugs and found that there are indeed proteins that indicate whether a cell will respond to certain therapeutic agents, or whether it will be resistant to the drug," explains Hannes Hahne, Ph.D. a TUM expert in mass spectrometry techniques. (genengnews.com)
In the present study, we aimed to further examine the potential of formononetin in controlling angiogenesis and tumor cell invasiveness in human colon cancer cells and tumor xenografts. (spandidos-publications.com)
In recent years, we focused on investigating the anti-carcinogenic properties of total Astragalus saponins (AST) in human colon cancer cells and tumor xenografts. (spandidos-publications.com)
In their research, Efferth and Kuete are testing the African plants against a cancer cell line that uses three separate drug-resistance strategies. (naturalnews.com)
The first, known as transporter-mediated resistance, occurs when a substance called P-glycoprotein causes drugs to be prematurely flushed out of cancer cells. (naturalnews.com)
11 And human diseases, including cancer in particular, tend to be defined by the presence of proteins with altered and pathogenic sequences. (biorxiv.org)
Fibrosis acts as a barrier, stopping drugs from getting into the cancer tumor. (survivingmesothelioma.com)
By sequencing pairs of normal and tumour genomes from large patient cohorts, projects such as the ICGC (International Cancer Genome Consortium) and TCGA (The Cancer Genome Atlas) aim to create definitive driver mutation catalogues for all common cancers 1 , 2 . (nature.com)
We provide a quantitative ranking of more than 600 surface resident and endocytosed proteins, and their regulation by hypoxia, serving as a resource to the cancer research community. (lu.se)
Interestingly immune cells as mast cells and inflammatory mediators as LTC4 play an important role in colon cancer. (lu.se)
The aim of my thesis was to evaluate the clinical significance of the tumor suppressors 15-PGDH and WNT5A in colon cancer patients. (lu.se)
My results show that treatment of colon cancer cells with Foxy-5, a WNT5A mimicking peptide, leads to up-regulation of 15-PGDH through JNK/AP-1 pathway. (lu.se)
Hürthle cell carcinoma of the thyroid gland is an unusual and relatively rare type of differentiated thyroid cancer. (medscape.com)
We performed a first-of-kind evaluation of two transcriptome-based precision cancer medicine methodologies to predict tumor sensitivity to a comprehensive repertoire of clinically relevant oncology drugs, whose mechanism of action we experimentally assessed in cognate cell lines. (cdc.gov)
Leiomyosarcoma (cancer of smooth muscle cells) can develop in the wall of the small intestine. (msdmanuals.com)

Expressing TCTP in U2OS (human bone osteosarcoma epithelial cells) protected them from cell death induced by etoposide over various concentrations and durations of exposure. (wikipedia.org)
This protein is found within the membrane that surrounds epithelial cells, which are the cells that line the surfaces and cavities of the body. (medlineplus.gov)
These effects were partially mediated through enhanced TGF-β signaling, which contributes to tissue fibrosis and epithelial-mesenchymal transition (EMT) of tumor cells. (jci.org)
Confluent NCI-H292 human mucoepidermoid airways epithelial cells were pretreated with AZM or MDM for 2 h and then stimulated with 200 nmol/l phorbol 12-myristate 13-acetate (PMA) for 8 h. (karger.com)
The present study demonstrates that AZM and MDM suppress the synthesis of mucin and TNF-α from human airway epithelial cells. (karger.com)
Shimizu T, Shimizu S: Azithromycin inhibits mucus hypersecretion from airway epithelial cells. (karger.com)

Downregulation of the protein levels by siRNA in HTR-8/SVneo (Homo sapiens placenta cells) was associated with a reduced cellular calcium-uptake activity and buffering capacity. (wikipedia.org)
Nearly all anti-tumor drugs are targeted against cellular proteins," says Bernhard Küster, Ph.D., TUM chair of proteomics and bioanalytics. (genengnews.com)
Oncocytic cells in the thyroid are often called Hürthle cells, and oncocytic change is defined as cellular enlargement characterized by an abundant eosinophilic granular cytoplasm as a result of accumulation of altered mitochondria. (medscape.com)

Here, we report a novel molecular target and antimetastatic mechanism of ATO in head and neck squamous cell carcinoma (HNSCC). (nih.gov)
Subsequently, the effect of an additional small molecular inhibitor, BMS-777607 (which targets MST1R (RON), MET, Tyro3, and Axl) also resulted in a decreased proliferative capacity of MPM cells. (frontiersin.org)
Publications] Kaibuchi,K.: 'Molecular cloning and characterization of the stimulatory GDP/GTP exchange protein(GDS)for smg p21s,ras p21ーlike small GTPーbinding proteins. (nii.ac.jp)
Although the precursor protein of NFκB2 (p100) is thought to act as a tumor suppressor in mammalian cells, the molecular mechanism of its anti-tumor activity is far from clear. (oncotarget.com)
but the molecular mechanisms underlying how cells adapt to variations in oxygen supply were unknown until the prize-winning work described here. (nobelprize.org)
In addition to their histologic characteristics, germ cell tumors retain molecular characteristics of their primordial lineage. (medscape.com)

Research in 1997 shown that TCTP is not a tumor- or tissue-specific protein, but is expressed ubiquitously from plants to mammals. (wikipedia.org)
The NCI-60 cell lines represent the most common tumor diseases in nine tissues (such as brain, breast, bowel, skin, and blood tissue). (genengnews.com)
More than 5,000 of the 10,000 proteins identified are present in varying abundances in tumor cell lines of all types of tissue. (genengnews.com)
Non-germ cell tumors can derive from pineal parenchymal cells, as well as from surrounding tissue. (medscape.com)

Down-regulation of TCTP can induce tumor reversion, and in combination with some drugs that decrease the level of TCTP and will lead to kill tumor cells. (wikipedia.org)
We employed a comprehensive approach for global and dynamic profiling of the surfaceome and endocytosed (endocytome) proteins and their regulation by hypoxia in patient-derived GBM cultures. (lu.se)

Morphogen and community effects determine cell fates in response to BMP4 signaling in human embryonic stem cells. (harvard.edu)
and human embryonic stem cells(hESCs). (sigmaaldrich.com)
The skin manifestations occur along the lines of Blaschko, which represent the routes of embryonic cell migration. (medscape.com)

Other biological markers for germ cell tumors include lactate dehydrogenase isoenzymes and placental alkaline phosphatase, although these are less specific. (medscape.com)

Tumor size is an important feature for biological behavior. (medscape.com)

We have purified and characterized several GDP/GTP exchange proteins (GDP dissociation stimulator (GDS) and GDP dissociation inhibitor (GDI)) and GTPase activating Proteins (GAP) for small G proteins. (nii.ac.jp)

The tumor size and the number of proliferating cells were reduced in the tumor tissues obtained from the formononetin-treated group. (spandidos-publications.com)

Mass spectrometry-based proteomics now enables genome-scale measurements of proteomes from diverse cells, tissues, and organisms. (biorxiv.org)
Importantly, we highlight the limited correlation between transcriptomics and proteomics, emphasizing the critical role of membrane protein enrichment strategies and quantitative mass spectrometry. (lu.se)

These proteins are associated with fibrosis in many cancers, including mesothelioma. (survivingmesothelioma.com)
AFP is a glycoprotein produced by fetal yolk sac elements and is produced by a wide range of cancers , including gastric , liver, and colon adenocarcinoma , as well as extracranial germ cell tumors. (medscape.com)

Glioblastoma often resists front-line chemotherapies, including temozolomide, a drug that damages DNA and triggers tumor cell death. (eurekalert.org)
To me, the most novel finding in this study is that we discovered connexin 43 selectively binds to the PIK3CB/p110beta protein, enabling certain glioblastoma cells to gain chemoresistant traits," Sheng said. (eurekalert.org)

The founding member of the nodal signaling ligand family of proteins. (harvard.edu)
A new study is looking at how a family of proteins called lysyl oxidases can help solve this problem. (survivingmesothelioma.com)
Collagen production is controlled by a family of proteins called lysyl oxidases. (survivingmesothelioma.com)

Irregular tumor borders can be suggestive of tumor invasiveness and associated histologic malignancy. (medscape.com)

Targeting melanoma with front-line therapy does not abrogate Nodal-expressing tumor cells. (harvard.edu)

PG2 integrates genome and transcriptome sequencing to incorporate protein variants containing amino acid substitutions, insertions, and deletions, as well as non-canonical reading frames, exons, and other variants caused by genomic and transcriptomic variation. (biorxiv.org)

[ 4 ] in a series of 23 patients, the mean tumor size was significantly greater for carcinomas than adenomas (3.1 cm vs 1.9 cm). (medscape.com)

The inoculation of engineered tumor cell lines in immunocompetent mice results in either tumor rejection or an aberrant response to immunotherapy, making the experiments technically impossible in the first case or providing inconsistent results in the latter. (aacrjournals.org)

Anatomy23

Organisms12

Diseases68

Chemicals and Drugs55

Analytical, Diagnostic and Therapeutic Techniques and Equipment45

Phenomena and Processes58

Disciplines and Occupations1

Information Science4

Health Care4

Microenvironment11

Apoptosis12

Progression8

Genes16

Proliferation6

Kinase11

Cancerous6

Metastasis7

Macrophages13

Mutations7

Prognosis5

Necrosis factor alpha2

Metastatic7

Malignant tumors2

Brain tumors2

Neuroendocrine tumors3

Specimens2

Vitro3

Endothelial cells1

Kinases1

Differentiation7

Anti-tumor effect2

Metabolism3

Antigens3

Antibodies3

Suppressor Gene3

Macrophage6

Mammary tumor3

Gene15

Survival5

Aggressive2

Humans2

Peptides3

Lung10

Vivo6

Growth15

MRNA2

Pathways4

Colorectal Cancer1

Breast tumor1

Serum3

Findings3

Expression21

Solid tumor2

RNAs1

Cancer33

Epithelial6

Cellular3

Molecular6

Tissue4

Regulation2

Embryonic3

Lactate dehydrogenase1

Behavior1

Inhibitor1

Tissues obtained1

Proteomics2

Cancers2

Glioblastoma2

Family of proteins3

Invasiveness1

Melanoma1

Variants1

Significantly1

Immunotherapy1