FactorsKnown virulence factorSurface proteinsFull VirulenceDifferent virulenceInfectionHigh virulenceVarious virulencePathogenesisMechanismPathogenIntracellularVaccinia virusGenesRecombinantEffectorBindsPathogensSalmonellaGeneticsAminoPathogenicityEncodesMutantsPathogenicBacteriaResistanceIsolatesMechanismsExperimentally infectedOuter membrane proteinPathwaysLipoproteinsBacteriumCoronavirusGlycosylationHemolysinColonizationSecretion systemMutationsComputationalFunctionsHostAffectsAbstractInteractsProteomicsContributesImmunityDifferencesDomainsStrainTyphimuriumEnzymaticEpithelialRoleSequenceRegulateInhibitionApoptosisHosts
Factors12
- In both bacteria, the flagellins are essential virulence factors glycosylated by pseudaminic acid (PA). (uwo.ca)
- Further analysis and glycoprotein staining revealed that in H. pylori , the PA pathway is necessary for the glycosylation of proteins other than flagellins and for the synthesis of additional virulence factors, including LPS and urease. (uwo.ca)
- These enzymes are considered emerging virulence factors during infection because the host glycan changes. (researchgate.net)
- We report here that myricetin, but not its glycosylated form, can remarkably decrease the production of several S. aureus virulence factors, including adhesion, biofilm formation, hemolysis and staphyloxanthin production, without interfering with growth. (nature.com)
- Phage display of environmental protein toxins and virulence factors reveals the prevalence, persistence, and genetics of antibody responses. (bvsalud.org)
- This implies that additional factors contribute to virulence. (microbiologyresearch.org)
- After generating an infectious clone of Herts/33 (FL-Herts), we were able to map the location of additional virulence factors by exchanging sequences between FL-Herts and NDFLtag. (microbiologyresearch.org)
- Is the Subject Area "Virulence factors" applicable to this article? (plos.org)
- B. bronchiseptica" expresses many protein factors, such as filamentous haemagglutinin (FHA), pertactin and fimbriae. (kenyon.edu)
- All of the virulence factors of "B. bronchiseptica" allow it to weaken the host's immune defenses, leading to infection. (kenyon.edu)
- BvgA and BvgS, two-component regulatory systems, regulate these virulence factors. (kenyon.edu)
- The pathogenesis of enterococcal infections is poorly understood, but several possible virulence factors exist. (medscape.com)
Known virulence factor2
- The Yersinia enterocolitica Ail protein is a known virulence factor. (wikipedia.org)
- Bioinformatic analysis showed that C4 is conserved in six orthopoxvirus species and shares 43 % amino acid identity with VACV protein C16, a known virulence factor. (ox.ac.uk)
Surface proteins8
- Virulence-related outer membrane proteins, or outer surface proteins (Osp) in some contexts, are expressed in the outer membrane of gram-negative bacteria and are essential to bacterial survival within macrophages and for eukaryotic cell invasion. (wikipedia.org)
- Borrelia burgdorferi (responsible for Lyme disease) outer surface proteins play a role in persistence within ticks (OspA, OspB, OspD), mammalian host transmission (OspC, BBA64), host cell adhesion (OspF, BBK32, DbpA, DbpB), and in evasion of the host immune system (VlsE). (wikipedia.org)
- We have obtained some preliminary data that suggest a group of NTHi surface proteins are capable of binding to CRL. (lu.se)
- Currently, our focus is to determine whether the interaction between NTHi surface proteins and CRL can trigger an immune response, as this information will be valuable in identifying potential vaccine candidates. (lu.se)
- Myricetin affects both surface proteins and secreted proteins which indicate that its action is unrelated to inhibition of the agr quorum sensing system. (nature.com)
- The aims of this study were to describe the surface proteome of A. urinae and to analyse A. urinae genomes in search for genes encoding surface proteins. (lu.se)
- All isolates had either one or two of these asp-genes located in a conserved locus, designated Locus encoding Aerococcal Surface Proteins (LASP). (lu.se)
- For other Gram-positive bacteria, cell wall-anchored surface proteins with an LPXTG-motif play a key role for virulence. (lu.se)
Full Virulence1
Different virulence2
- The aim of the study was to evaluate the protein similarity degree among 15 C. albicans isolates with different virulence obtained from healthy and infected human and animals. (scialert.net)
- Pathogenesis of Newcastle disease in chickens experimentally infected with viruses of different virulence. (microbiologyresearch.org)
Infection9
- This protein disappears from the bacterial surface around 2 weeks after infection. (wikipedia.org)
- A major part of virulence for Plasmodium falciparum malaria infection, the most lethal parasitic disease of humans, results from increased rigidity and adhesiveness of infected host red cells. (gla.ac.uk)
- Given that N1 promotes virus virulence, other possible functions of N1 were investigated and this revealed that N1 is an inhibitor of apoptosis in cells transfected with the N1L gene and in the context of VACV infection. (ox.ac.uk)
- A recombinant VACV expressing a C-terminally tagged version of C4 showed that, like C16, this 37 kDa protein is expressed early during infection and localizes to both the cytoplasm and the nucleus. (ox.ac.uk)
- A VACV lacking the C4L gene (vΔC4) showed no significant differences from wild-type virus in growth kinetics or spread in cell culture, but had reduced virulence in a murine intranasal model of infection. (ox.ac.uk)
- Clostridium difficile toxin B (TcdB) is a critical virulence factor that causes diseases associated with C. difficile infection. (nih.gov)
- ABSTRACT Vaccinia virus gene F12L is shown to encode a 65-kDa protein that is synthesized early and late during infection and that is not modified by glycosylation. (ox.ac.uk)
- The goal of the present investigation is to examine the effects of missense mutations in the MERS-CoV S protein on protein stability and binding affinity with DPP4 to provide insight that is useful in developing vaccines to prevent coronavirus infection. (frontiersin.org)
- These targets are critical for different biological functions but converge on virulence expression in persistent infections such as the lung infection in patients with cystic fibrosis. (luc.edu)
High virulence2
- Such results suggest a highly protein similarity degree among the most isolates with low and high virulence as well as from human and animal hosts. (scialert.net)
- This virus is very unusual in its high virulence for a broad spectrum of animals that occasionally includes humans? (scitizen.com)
Various virulence2
- In this study, we described the use of SDS-PAGE, along with PAGE techniques, to analyze the similarity of the protein profiles of the cytoplasmic extracts and cell walls of different C. albicans isolates obtained from different host conditions (human against animal isolates and patient against healthy subject isolates) with various virulence degrees. (scialert.net)
- Plant viruses have evolved various virulence strategies to overcome plant immunity. (nature.com)
Pathogenesis4
- The BteA protein rapidly kills a wide range of mammalian cells, and appears to be important in the pathogenesis, yet the mechanism of cytotoxicity is presently unknown. (whitworth.edu)
- The pathogenesis-related PR-1-like protein family comprises secreted proteins from the animal, plant, and fungal kingdoms whose biological function remains poorly understood. (uco.es)
- Analysis of virulence related gene expression and computational simulations of pivotal proteins involved in pathogenesis demonstrate that myricetin downregulates the saeR global regulator and interacts with sortase A and α-hemolysin. (nature.com)
- Pathogenesis and sporulation are complex processes that are governed by cellular signalling networks including G-protein and phospholipid signalling. (wur.nl)
Mechanism3
- However, plant viruses try to spoil this defensive mechanism by expressing one or more proteins that act as RNA silencing suppressors. (nature.com)
- The Type VI Secretion System (T6SS) is a multiprotein device that has emerged as an important fitness and virulence factor for many Gram-negative bacteria through the injection of effector proteins into prokaryotic or eukaryotic cells via a contractile mechanism. (frontiersin.org)
- Through collaborative efforts, we are also interested in elucidating the mechanism of allosteric regulators and rational drug design against protein targets in humans. (luc.edu)
Pathogen4
- Collectively these proteins function as a pathogen secretion system, similar to bacteria and may provide targets for antivirulence based therapies to a disease responsible for millions of deaths annually. (gla.ac.uk)
- Here we have characterized a PR-1-like protein, Fpr1, from Fusarium oxysporum, an ubiquitous fungal pathogen that causes vascular wilt disease on a wide range of plant species and can produce life-threatening infections in immunocompromised humans. (uco.es)
- The emerging lung pathogen Mycobacterium abscessus is understudied for its virulence determinants and molecular targets for diagnosis and therapeutics. (cdc.gov)
- The revelation of these species-specific orphan proteins offers a hitherto unexplored repertoire of potential targets for diagnostic, therapeutic, and vaccine research in this emerging lung pathogen. (cdc.gov)
Intracellular2
Vaccinia virus2
- Vaccinia virus (VACV) encodes many immunomodulatory proteins, including inhibitors of apoptosis and modulators of innate immune signalling. (ox.ac.uk)
- Vaccinia virus (VACV) strain Western Reserve protein C4 has been characterized and its function and contribution to virus virulence assessed. (ox.ac.uk)
Genes8
- Eight genes were identified encoding proteins required for export of the parasite adhesin PfEMP1 and assembly of knobs that function as physical platforms to anchor the adhesin. (gla.ac.uk)
- In this study, we identified five CAPGly protein-encoding genes in C. neoformans. (elsevierpure.com)
- Using an existing clone of the trout-avirulent VHSV-IVb strain MI03 (pVHSVmi), eight chimeric VHSV clones were constructed in which the coding region(s) of the glycoprotein (G), non-virion protein (NV), G and NV, or G, NV and L (polymerase) genes together, were exchanged between the two clones. (biomedcentral.com)
- These results demonstrate that the G, NV and L genes of VHSV are not, by themselves or in combination, major determinants of host-specific virulence in trout. (biomedcentral.com)
- Of note, the genes encoding these effectors and immunity proteins are widely distributed in Salmonella genomes, suggesting a relevant role in interbacterial competition and virulence. (frontiersin.org)
- The aims of this research work were to determine the patterns of antibiotic resistance in Escherichia coli isolates from the meat of wild or domestically reared pigeons from Spain, to detect the presence of virulence and antibiotic resistance genes, and to carry out a phylogenetic classification of the isolates. (mdpi.com)
- These sequences are usually linked to M protein genes rather than the similar mrp or enn genes. (cdc.gov)
- The 25 genomes had in median 13 genes encoding LPXTG-proteins (range 6-24). (lu.se)
Recombinant2
- This hypothesis was confirmed by enzymatic assays performed in purified, XAC1201 recombinant protein expressed in Escherichia coli, which revealed no significant activities previously associated with HD domains for the tested substrates. (geneticsmr.org)
- The presence of these proteins on the surface was also shown using ELISA with serum from rabbits immunized with the recombinant Asp. (lu.se)
Effector4
- Bordetella Type III Secretion System Effector A (BteA) is a virulence protein produced by members of the genus Bordetella . (whitworth.edu)
- While some effector proteins specifically target bacterial or eukaryotic cells, others can target both types of cells (trans-kingdom effectors). (frontiersin.org)
- In addition, there is limited information regarding the repertoire of effector proteins encoded within T6SS SPI-6 and T6SS SPI-19 gene clusters in S . Dublin. (frontiersin.org)
- Each antibacterial effector gene is located upstream of a gene encoding a hypothetic immunity protein, thus conforming an effector/immunity (E/I) module. (frontiersin.org)
Binds5
- Moreover, these loops form a protruding beta sheet, the edge of which presumably binds to external proteins. (wikipedia.org)
- N is the major structural protein which tightly binds the RNA genome. (biomedcentral.com)
- The SARS-CoV-2 virus, however, acts sort of the same way using a spiky protein that easily binds to ACE2 (angiotensin-converting enzyme 2), the receptor protein of both SARS-CoV and SARS-CoV-2, which is abundantly present human lung epithelial cells and small intestine. (gulfnews.com)
- A key component in the virulence of MERS-CoV is the Spike (S) protein, which binds with the host membrane receptor dipeptidyl peptidase 4 (DPP4). (frontiersin.org)
- Trouw L., Nilsson S., Goncalvez I., Landberg G. and Blom A. M. (2005) C4b-binding protein binds to necrotic cells and DNA, which limits DNA release and inhibits complement activation. (lu.se)
Pathogens2
- H. pylori and C. jejuni are Gram-negative gastro-intestinal pathogens whose virulence is highly affected by protein glycosylation. (uwo.ca)
- However, there has been a dearth of research on CAP-Gly proteins in fungal pathogens, including Cryptococcus neoformans, which is a global cause of fatal meningoencephalitis in immunocompromised patients. (elsevierpure.com)
Salmonella3
- Members of this group include: PagC, required by Salmonella typhimurium for survival in macrophages and for virulence in mice Rck outer membrane protein of the S. typhimurium and S. enteritidis virulence plasmid Ail, a product of the Yersinia enterocolitica chromosome capable of mediating bacterial adherence to and invasion of epithelial cell lines OmpX from Escherichia coli that promotes adhesion to and entry into mammalian cells. (wikipedia.org)
- PhoP/PhoQ: macrophage-specific modulators of Salmonella virulence? (wikipedia.org)
- T3SS is an essential component for the virulence of pathogenic Gram-negative bacteria, such as Salmonella and Chlamydia. (lu.se)
Genetics3
- So far, only the polygalacturonases PG1 and PG2 and the xylanase XYN11A were proved by reverse genetics to be required for virulence. (unipd.it)
- This study describes molecular characterization and construction of an infectious clone of the virulent VHSV-Ia strain DK-3592B from Denmark, and application of the clone in reverse genetics to investigate the role of selected VHSV protein(s) in host-specific virulence in rainbow trout (referred to as trout-virulence). (biomedcentral.com)
- Finally, we tested whether aphid genetics can be used to further dissect the genetic mechanisms of biotype virulence in aphids. (usda.gov)
Amino9
- OspA and OspB share 53% amino acid identity and likely have a similar antiparallel "free-standing" β sheet protein structure associated with the outer membrane surface via a lipidated NH2-terminal cysteine residue. (wikipedia.org)
- We designed and constructed a library of 95,601 56- amino acid peptide tiles spanning 14,430 proteins with "toxin" or " virulence factor " keyword annotations. (bvsalud.org)
- Virulence of Newcastle disease virus (NDV) is mainly determined by the amino acid sequence surrounding the fusion (F) protein cleavage site, since host proteases that cleave the F protein of virulent strains are present in more tissues than those that cleave the F protein of non-virulent strains. (microbiologyresearch.org)
- Deduced amino acid sequences at the fusion protein cleavage site of Newcastle disease viruses showing variation in antigenicity and pathogenicity. (microbiologyresearch.org)
- Mutational analysis indicated that interaction of p25 with either BvIAA2 or BvIAA6 requires full-length proteins as even single amino acid residue substitutions abolished the interactions. (ifz-goettingen.de)
- EvoRator2: predicting site-specific amino acid substitutions based on protein structural information using deep learning Journal of Molecular Biology: 435(14):168155. (tau.ac.il)
- This protein is 1,353 amino acids in length, and the monomers assemble to form a homotrimer. (frontiersin.org)
- These proteins had a signal sequence in the amino-terminal end and a cell. (lu.se)
- These proteins had a signal sequence in the amino-terminal end and a cell wall-sorting region in the carboxy-terminal end, which contained an LPATG-motif, a hydrophobic domain and a positively charged tail. (lu.se)
Pathogenicity1
Encodes2
- encodes a putative lipoprotein, designated outer membrane protein P4 (OmpP4). (biomedcentral.com)
- The M protein gene ( emm) encodes the cell surface M virulence protein responsible for at least 100 Streptococcus pyogenes M serotypes. (cdc.gov)
Mutants1
- Effect of fusion protein cleavage site mutations on virulence of Newcastle disease virus: non-virulent cleavage site mutants revert to virulence after one passage in chicken brain. (microbiologyresearch.org)
Pathogenic1
Bacteria2
- This molecule can bind to proteins and regulate the swimming behaviour of bacteria and the production of biofilm. (ucalgary.ca)
- Unfortunately, these attributes are also important virulence weapons for bacteria to infect human bodies. (ucalgary.ca)
Resistance1
- It also has a role in the resistance against attack by the human complement system a Bacteriophage lambda outer membrane protein, Lom OspA/B are lipoproteins from Borrelia burgdorferi. (wikipedia.org)
Isolates2
- Regarding to the virulence and host aspects, the means S D of high virulent and low virulent isolates as well as human and animal isolates were 85.8 and 85.6% in PAGE, respectively. (scialert.net)
- 2005). Different types of electrophoretic techniques have been used for the characterization or typing of C. albicans isolates including separation of chromosomes, DNA fragments, isoenzymes, cell wall glycoproteins and whole cell proteins (Asakura et al . (scialert.net)
Mechanisms5
- OmpP4 may be dispensable for virulence because of redundant mechanisms in H. ducreyi for heme acquisition and NAD utilization. (biomedcentral.com)
- Deletions in the stalk of the influenza neuraminidase (NA) surface protein are associated with increased virulence, but the mechanisms responsible for this enhanced virulence are unclear. (nih.gov)
- Mechanisms of virulence on the aphid side of the plant-insect interaction are not well understood. (usda.gov)
- Thus, it will be of great interest to explore the function of the Asp proteins of A. urinae to establish a better understanding of the molecular mechanisms by which A. urinae cause disease. (lu.se)
- Mark L., Lee W. H., Villoutreix B. O., Proctor D., Blackbourn, D., Spiller B. O. and Blom A. M. (2004) KSHV complement control protein mimics human molecular mechanisms for inhibition of the complement system. (lu.se)
Experimentally infected1
- To test whether OmpP4 was necessary for virulence in humans, eight healthy adults were experimentally infected. (biomedcentral.com)
Outer membrane protein1
- Although OmpX has the same beta-sheet topology as the structurally related outer membrane protein A (OmpA) InterPro: IPR000498, their barrels differ with respect to the shear numbers and internal hydrogen-bonding networks. (wikipedia.org)
Pathways1
- Aphid proteins involved in the tricarboxylic acid cycle, immune system, cell division, and anti-apoptosis pathways were found to be up-regulated in biotype H relative to other biotypes. (usda.gov)
Lipoproteins1
- A genome-wide survey for N-terminal signal sequences using bioinformatic tools (Psortb 2.0 and SignalP 3.0) combined with a strategy of the subtraction of lipoproteins and proteins containing multiple transmembrane domains yielded 116 secretory proteins. (cdc.gov)
Bacterium3
- A previous study showed that disruption of the ORF XAC1201 from the Xac 306 strain by transposon Tn5 decreased bacterium virulence in the Rangpur lime host (Citrus limonia L. Osbeck). (geneticsmr.org)
- In this case, the bacterium needs to change its virulence, which is its ability to efficiently infect the host. (ucalgary.ca)
- This bacterium produces the protein TdcA that reacts to the temperature of the bacterium's surroundings. (ucalgary.ca)
Coronavirus2
- These viruses occur as 2 pathotypes with an enigmatic, even controversial, relationship: the low-virulence or nonvirulent feline enteric coronavirus (FECV) and the highly lethal feline infectious peritonitis virus (FIPV). (cdc.gov)
- These findings provide further information on how mutations in coronavirus S proteins effect protein function. (frontiersin.org)
Glycosylation2
- Understanding how each pathway affects virulence will reveal the best targets for the development of glycosylation inhibitors to treat these major infections. (uwo.ca)
- The MERS-CoV S protein has 21 N-linked glycosylation sites (Wang et al. (frontiersin.org)
Hemolysin1
- Hemolysin/bacteriocin is a plasmid-encoded protein that generally is accepted as a virulence factor. (medscape.com)
Colonization1
- Interestingly, while both systems have been linked to virulence and host colonization in S . Dublin, an antibacterial activity has not been detected for T6SS SPI-6 in this serotype. (frontiersin.org)
Secretion system1
- Previous work in this area has been on modeling the assembly structure of the type III secretion system and prediction of the high-resolution structures of homo-oligomeric proteins using limited experimental data from Nuclear Magnetic Resonance (NMR) in order to speed up the process of structure determination. (lu.se)
Mutations2
- We investigated the effects of MERS-CoV S protein viral mutations on protein stability and binding affinity. (frontiersin.org)
- In addition, we studied all DPP4 mutations and found the functional substitution R336T weakens both DPP4 protein stability and S-DPP4 binding affinity. (frontiersin.org)
Computational2
- Computational sequence comparison revealed that related proteins are encoded by all sequenced chordopoxviruses. (ox.ac.uk)
- Dr. Liu's research group primarily employs X-ray crystallography in combination with mechanistic, biological and computational methods to study proteins involved in bacterial infections and other human diseases. (luc.edu)
Functions1
- Putting together the obtained structures like snapshots, key knowledge on the biological functions of those critical proteins can be deduced. (luc.edu)
Host5
- The phage protein Lom is expressed during lysogeny, and encode host-cell envelope proteins. (wikipedia.org)
- Geminiviruses hijack the host DNA repairing proteins for their amplification. (nature.com)
- Having learned about its new location, P. aeruginosa changes its virulence strategy as it aims to settle down inside its new host. (ucalgary.ca)
- This difference in autotransporter proteins could possibly contribute to the bacteria's host specificity and the different diseases they cause [9]. (kenyon.edu)
- This macromolecular assembly comprises more than 20 conserved proteins that form a series of ring-like structures and a needle-shaped protrusion, which allows the transport of proteins into a host cell. (lu.se)
Affects1
- However, little is known regarding the possible function of the hypothetical protein XAC1201 and how it affects the virulence of Xac 306. (geneticsmr.org)
Abstract1
- abstract = "Microtubules are involved in mechanical support, cytoplasmic organization, and several cellular processes by interacting with diverse microtubule-associated proteins such as plus-end tracking proteins, motor proteins, and tubulin-folding cofactors. (elsevierpure.com)
Interacts4
- Previously, we showed that BNYVV p25 virulence factor interacts with BvIAA28, a transcriptional repressor acting at early stages of LR initiation. (ifz-goettingen.de)
- However, it was not clear whether p25 interacts with other Aux/IAA proteins. (ifz-goettingen.de)
- Here, by adopting bioinformatics, in vitro and in vivo protein interaction approaches we show that p25 interacts also with BvIAA2 and BvIAA6. (ifz-goettingen.de)
- In silico analysis suggested that XAC1201 interacts with the flagellar proteins FliM and FliL, known to be an important factor for virulence. (geneticsmr.org)
Proteomics4
- This characteristic makes biotype H ideal for comparative proteomics to investigate the basis of biotype virulence in aphids. (usda.gov)
- In this study, we used comparative proteomics to identify protein expression differences associated with virulence. (usda.gov)
- In-solution digested bottom-up proteomics from various growth phases identified a total of 517 proteins, while 2D-GE proteomics identified 33 proteins. (cdc.gov)
- Two proteins, denoted Aerococcal surface protein (Asp) 1 and 2, were through the use of mass spectrometry based proteomics found to quantitatively dominate the aerococcal surface. (lu.se)
Contributes1
- Here, we tested the hypothesis that, like its homolog, H. ducreyi OmpP4 contributes to virulence and stimulates production of bactericidal antibodies. (biomedcentral.com)
Immunity2
- Heat-shock protein 90 (HSP90) chaperones play an essential role in plant defence by assisting the folding of client proteins needed for immunity. (nature.com)
- The virulence of is associated with its invasive suppression and capacity of adaptive immunity. (biomedigs.org)
Differences1
- Nevertheless, comparison of NDV strains that carry exactly the same F protein cleavage site shows that significant differences in virulence still exist. (microbiologyresearch.org)
Domains1
- OspA from Borrelia burgdorferi is an unusual outer surface protein, it has two globular domains which are connected with a single-layer β-sheet. (wikipedia.org)
Strain2
- Here we use microsecond molecular dynamics simulations to explore the effect of stalk deletion on enzymatic activity, contrasting NA proteins from the A/swine/Shandong/N1/2009 strain both with and without a stalk deletion. (nih.gov)
- Dr. Joe Harrison , PhD, associate professor and microbiologist, biochemist, and molecular geneticist in the Department of Biological Sciences - together with a transdisciplinary team of researchers - has shown how a P. aeruginosa strain learns about a temperature change and decides to switch its virulence program into 'settling' mode. (ucalgary.ca)
Typhimurium1
- 2009 Typhimurium virulence continues to be from the capability to evade and suppress the sponsor immune system. (biomedigs.org)
Enzymatic1
- Enzymatic deglycosylation analysis uncovered a second set of H. pylori proteins glycosylated with an unknown sugar synthesized by a PA-independent pathway. (uwo.ca)
Epithelial1
- NTHi utilizes a variety of proteins to adhere to and colonize the surface of epithelial cells, which is crucial for its invasion. (lu.se)
Role3
- Additionally, we show that multiple proteins play a role in generating increased rigidity of infected erythrocytes. (gla.ac.uk)
- Our DAB biosynthesis mutant was deficient in at least one glycoprotein and was avirulent in a chicken model, underscoring the role of this pathway in virulence. (uwo.ca)
- Thus, the role of the XAC1201 protein in Xac 306 virulence seems to be related to flagellar motility, although a non-classic role for the HD domain cannot be dismissed. (geneticsmr.org)
Sequence6
- Remarkably, although N1 shows no sequence similarity to cellular proteins, its three-dimensional structure closely resembles Bcl-xL and other members of the Bcl-2 protein family. (ox.ac.uk)
- The 180 bp subtype-encoding sequence consists of 60 codons encoding signal sequence (10 codons) plus the mature M protein (50 codons). (cdc.gov)
- This database of trimmed 180 base entries corresponds to the first 50 residues of the mature M protein and the adjacent 10 C terminal residues of the signal sequence. (cdc.gov)
- The sequence of the SzP protein gene, or szP, has been shown to vary greatly between different strains of S. zooepidemicus and the variable regions of szP can be used to genetically differentiate strains within the subspecies. (cdc.gov)
- A homology search against the M. tuberculosis database identified nine additional secretory protein homologs that lacked a secretory signal sequence. (cdc.gov)
- We are also interested in understanding how oligomerization specificity is encoded in protein sequence and structure, in particular in coiled-coils. (lu.se)
Regulate1
- A number of the cytoskeletonassociated proteins (CAPs) contain the CAP-glycine-rich (CAP-Gly) domain, which is evolutionarily conserved and generally considered to bind to a-tubulin to regulate the function of microtubules. (elsevierpure.com)
Inhibition1
- Unlike antibacterials that aim to inhibit cell growth, antivirulence therapies are based on the inhibition of bacterial virulence. (nature.com)
Apoptosis1
- The pore-forming BCL-2 family proteins mediate mitochondrial poration to initiate apoptosis through protei-protein and protein-lipid interactions. (portlandpress.com)
Hosts1
- Here, we confirmed that disruption of ORF XAC1201 reduces Xac 306 virulence in two different hosts, delaying the onset of typical symptoms. (geneticsmr.org)