Proteins genes. Medical search. Frequent questions

Hammill JT, Miyake-Stoner S, Hazen JL, Jackson JC, Mehl RA (2007) Preparation of site-specifically labeled fluorinated proteins for 19 F-NMR structural characterization. (springer.com)
Cloning and characterization of SREHP gene from an Iranian E. histolytica isolate was also studied (Rasti et al . (scialert.net)
Here, we describe the characterization of one of these mutants, per8, and the cloning of the PER8 gene. (rupress.org)
Molecular characterization of the immune system: emergence of proteins, processes, and domains. (lu.se)

With the exception of the first and last exons of genes, every other exon in the genome has splicing signals at its 5' and 3' ends and theoretically can circularize. (bcm.edu)
De Iaco also found that when DUX4 is forcibly produced in muscle cells, it turns on a whole set of genes that are expressed during zygotic genome activation. (news-medical.net)
They found that DUX4 is one of the very first genes expressed at this stage, releasing a high concentration of its protein product just before zygotic genome activation. (news-medical.net)
In line with this lead, the scientists could show that the DUX4 protein binds to the regulatory region of genes that are induced during zygotic genome activation, stimulating their expression. (news-medical.net)
The final piece of evidence came when the EPFL scientists removed the DUX gene from fertilized mouse oocytes using CRISPR/Cas9 genome editing. (news-medical.net)
The study points to DUX4, and by extension the DUX family of proteins, as the master regulator responsible for kick-starting genome expression at the earliest stage of embryonic life in humans, mouse and probably all placental mammals. (news-medical.net)
In humans, only about 1.5 percent of the human genome or DNA consists of protein-coding genes. (indiavision.com)
Researchers have now presented a new proteogenomics method, which makes it possible to track down protein coding genes in the remaining 98.5 percent of the genome, something that until now has been an impossible task to pursue. (indiavision.com)
Associate Professor and study leader Janne Lehtio's team found evidence for almost one hundred new protein-coding regions in the human genome. (indiavision.com)
Many of the new proteins encoded by pseudogenes could also be traced in other cancer cell lines, and the next objective on the researchers' agenda is to investigate if these genes in the "junkyard" of the genome play a role in cancer or other diseases. (indiavision.com)
Dr Lethio said that their study challenges the old theory that pseudogenes don't code for proteins, asserting that their method allows for protein based genome annotation in organism with complex genomes and can lead to discovery of many novel protein coding genes, not only in humans but in any species with a known DNA sequence. (indiavision.com)
Lentiviral (LV) vectors of the Retroviridae family show interesting properties for monogenic gene therapy, since they integrate into the host genome and allow long-lasting gene expression 22 . (nature.com)
The human genome contains about 20,000 protein-coding genes and about 5,000 genes that specify functional RNAs. (blogspot.com)
I hope it's just sloppy thinking when they say that their 1800 essential "genes" represent 9.2% of all genes in the genome (Wang et al. (blogspot.com)
With the accumulation of genome sequences of related species, there has been a growing demand for better and faster homology-based gene prediction programs. (sfu.ca)
First, local alignments between the query protein and the genome are assembled into gene regions where potential homologous genes are located. (sfu.ca)
A deep gene duplication, which coincided with a whole-genome duplication, gave rise to two gene lineages. (lu.se)
New insights into the genome have led to the emergence of proteomics , the study of the structure and function of an individual's entire set of expressed proteins. (cdc.gov)
In 2014, scientists developed a draft map of the human proteome , which catalogued proteins encoded by over 17,000 human genes, or about 84% of all protein-coding genes in the human genome. (cdc.gov)
Until ten years ago, it was hoped that the mapping of the human genome - all our genes - would enable us to better understand the course of different diseases. (lu.se)

These sequences are usually linked to M protein genes rather than the similar mrp or enn genes. (cdc.gov)
This helps to avoid confounding of the 180-base M protein gene segment by the similar emm- like mrp and enn sequences (see CDC Streptococcus Laboratory GAS bioinformatic pipeline for S. pyogenes external icon ). (cdc.gov)
The reports on base sequences of spider silk protein genes have gained importance as the mechanical properties of silk fibers have been revealed. (bioone.org)
This binding puts these ssDNA sequences into optimal conformations for interacting with DNA polymerases and other replication proteins. (qiagen.com)
To identify the proteins containing the corresponding amino acid sequences, we determined the N-terminal amino acid sequence of 12 spots of LMW-GSs of Norin 61 separated by two-dimensional gel electrophoresis (2DE). (unboundmedicine.com)
The N-terminal sequences of the LMW-GS spots showed that 10 of 12 groups of LMW-GSs were expressed as protein products, which included LMW-i, LMW-m, and LMW-s types. (unboundmedicine.com)
The nucleotide sequences of Serine-Rich Entamoeba histolytica Protein (SREHP) gene have already exhibited stable and significant polymorphism in the gene studies. (scialert.net)
The first nucleotide sequences have been shown the stable and significant polymorphism in the Strain Specific Gene (SSG) and the Serine-Rich E. histolytica Protein (SREHP) gene. (scialert.net)
New emm (M protein gene) sequences of group A streptococci isolated from Malaysian patients. (cdc.gov)
By using three consecutive mass analysis units in mass spectrometry, the researchers can now filter out rare protein sequences. (lu.se)
We mustn't measure anything other than the protein sequences that interest us", says Ákos Végvári. (lu.se)

More and more clustering algorithms are proposed to identify protein complexes with the constantly development of proteomics. (biomedcentral.com)
The scope of journal covers the whole range of the peptides and proteins which include studies related to Proteomics, Enzymology, Protein Biomarkers, Protein Engineering and Development. (primescholars.com)
Proteomics is highly linked to genomics, since the blueprint for each protein is inscribed on an organism's genes. (cdc.gov)
Some challenges for translating proteomics include technical issues in measuring proteomic markers, identifying clinically useful markers in patient samples, the need for large sample sizes to be able to distinguish protein variability among samples, and challenges in implementing strict protocols for sample handling. (cdc.gov)
ABSTRACT In order to define the protein expressional changes related to the process of meglumine antimoniate resistance in anthroponotic cutaneous leishmaniasis (CL), we performed a comparative proteomics analysis on sensitive and resistant strains of Leishmania tropica isolated from Iranian CL patients. (who.int)
The study shows the usefulness of proteomics in identifying proteins that may express differences between sensitive and resistant L. tropica isolates. (who.int)
Within the research field of proteomics, researchers study the link between proteins and disease. (lu.se)
However, mapping all our proteins, which is the initial goal of the new research field known as proteomics, will take a long time. (lu.se)

One such protein is the cytoskeleton-associated protein 5 (CKAP5), widely expressed in a variety of cells to regulate the dynamics of microtubules in human cells. (medicalxpress.com)
Wild-type TP53 can inhibit the cell cycle and activate apoptosis-related genes that induce apoptosis and regulate cell proliferation ( 10 ). (spandidos-publications.com)
It has paved the way for studying how genes regulate the most basic functions of the cell, including what proteins to produce and how to make them. (cdc.gov)
Introduction regulate choices of expressed genes as part of the macrophage/ neutrophil lineage. (lu.se)

Here you can search for genes and proteins by GenBank gi numbers, accession numbers or UniProt accession numbers. (lu.se)

How do genes direct the production of proteins? (medlineplus.gov)

The M protein gene ( emm) encodes the cell surface M virulence protein responsible for at least 100 Streptococcus pyogenes M serotypes. (cdc.gov)
The HSP70 gene family encodes the major heat shock protein of molecular weight 70,000. (blogspot.com)
The aim of this study was to investigate the expression and silencing of the S100A8 gene, which encodes the S100 calcium-binding protein A8 (S100A8), and apoptosis and phosphorylation of protein kinase B (Akt) in tissue samples of endometrial carcinoma and HEC-1A endometrial adenocarcinoma cells in vitro . (medscimonit.com)
The Hansenula polymorpha PER8 gene encodes a novel peroxisomal integral membrane protein involved in proliferation. (rupress.org)
This gene encodes the protein FIC1, also known as ATP8B1. (medscape.com)
PFIC2 is caused by a mutation in the ABCB11 gene on chromosome 2q24 that encodes the bile salt export pump (BSEP). (medscape.com)

emm typing is based on sequence analysis of the portion of the emm gene that dictates the M serotype. (cdc.gov)
The 180 bp subtype-encoding sequence consists of 60 codons encoding signal sequence (10 codons) plus the mature M protein (50 codons). (cdc.gov)
This database of trimmed 180 base entries corresponds to the first 50 residues of the mature M protein and the adjacent 10 C terminal residues of the signal sequence. (cdc.gov)
Protein assembly continues until the ribosome encounters a "stop" codon (a sequence of three nucleotides that does not code for an amino acid). (medlineplus.gov)
Zoghbi and collaborator Richard Gibbs propose to sequence these 500 genes in DNA samples from individuals with autism enrolled in the Simons Simplex Collection. (sfari.org)
Using these genetic techniques, Zoghbi and colleagues aim to pinpoint genes in which sequence variations or defects are linked to autism and determine whether these events are heritable or occur spontaneously. (sfari.org)
The sequence of PER8 predicts that its product (Per8p) is a novel polypeptide of 34 kD, and antibodies against Per8p recognize a protein of 31 kD. (rupress.org)
One of the most important steps towards the understanding of genomes is gene prediction, which is determining the positions of genes and their components (including exons and introns) on the DNA sequence. (sfu.ca)
A protein sequence (the product of gene) is used as a query to help in finding genes that are homologous to the query protein. (sfu.ca)
Distinct structural bases for sequence-specific DNA binding by mammalian BEN domain proteins. (bvsalud.org)
Together, these studies expand the DNA recognition activities of BEN factors and provide structural insights into sequence-specific DNA binding by mammalian BEN proteins . (bvsalud.org)
Proteins are formed of only 20 different amino acids, but almost all proteins are composed in such a way that part of the sequence is unique. (lu.se)
It is this unique sequence that researchers use to identify and quantify the protein. (lu.se)

Immumome contains information about immunity related proteins, their domain structure and the related ontology terms. (lu.se)
Here you can search for group of genes e.g. by protein domains or ontology terms. (lu.se)

The protein encoded by this gene is one of at least two lipid transfer proteins found in human plasma. (nih.gov)
PhosphoLipid transfer protein (PLTP) exerts a direct pro-inflammatory effect on rheumatoid arthritis (RA) fibroblasts-like-synoviocytes (FLS) independently of its lipid transfer activity. (nih.gov)
Some of them are the protein-coding genes for RNA polymerase subunits, ribosomal proteins, enzymes of lipid metabolism, and many other enzymes. (blogspot.com)
The protein is associated with microtubules , and Chatterjee and colleagues silenced the gene via short interfering RNA (siRNA) a molecular biological mechanism to study genes, targeting the CKAP5 encapsulated in lipid nanoparticles for in vivo delivery. (medicalxpress.com)

The flow of information from DNA to RNA to proteins is one of the fundamental principles of molecular biology. (medlineplus.gov)
The T4 Gene 32 Protein is intended for molecular biology applications. (qiagen.com)
The researchers reason that autism-related molecular pathways, such as those involved in the functioning of neuronal networks, are a good starting point in their search for potential autism genes. (sfari.org)
To characterize the low-molecular-weight glutenin subunit (LMW-GS), we developed specific PCR primer sets to distinguish 12 groups of LMW-GS genes of Norin 61 and to decide their loci with nullisomic-tetrasomic lines of Chinese Spring. (unboundmedicine.com)
Theoretische und angewandte Genetik JO - Theor Appl Genet VL - 112 IS - 2 N2 - To characterize the low-molecular-weight glutenin subunit (LMW-GS), we developed specific PCR primer sets to distinguish 12 groups of LMW-GS genes of Norin 61 and to decide their loci with nullisomic-tetrasomic lines of Chinese Spring. (unboundmedicine.com)
Here, we present a compilation of DNA and protein databases, as well as bioinformatic tools for phylogenetic reconstruction and a wide range of studies on molecular evolution. (lu.se)
Fluorescence in situ hybridization (FISH) is a molecular pathological method with high sensitivity and specificity, which uses specific DNA probes to detect chromosomal aberrations, as well as gene deletion and amplification ( 21 , 22 ). (spandidos-publications.com)
PGP9.5 is a soluble cytoplasmic protein with a molecular weight of approximately 25,000 kD. (neuromics.com)
There will be involved gene engineering and molecular biology methods such as PCR, SDS-PAGE, qPCR, western blot, DNA-protein interaction assays, flow cytometry etc. (lu.se)
By cataloguing the molecular processes by which cells maintain and modify protein levels, proteomic studies offer another dimension of information that may help advance our understanding of health and disease. (cdc.gov)

Deep sequencing has revealed thousands of eukaryotic protein-coding genes that defy the central dogma, producing circular noncoding RNAs rather than linear messenger RNAs. (bcm.edu)
For some genes, the abundance of the circular RNA exceeds that of the associated linear mRNA by a factor of 10, raising the interesting possibility that the function of some protein-coding genes may actually be to produce circular noncoding RNAs, not proteins. (bcm.edu)
In total, these results indicate that inhibition or slowing of canonical pre-mRNA processing events shifts the steady-state output of protein-coding genes towards circular RNAs, which likely helps explain why and how circular RNAs show tissue-specific expression profiles. (bcm.edu)
Some of these genes are the genes for ribosomal RNA, tRNAs, the RNAs involved in splicing, and many other types of RNA. (blogspot.com)

In order to collect information on nuclear coded mitochondrial proteins we developed MitoNuc and MitoAln, two related databases containing, respectively, detailed information on sequenced nuclear genes coding for mitochondrial proteins in Metazoa and yeast, and the multiple alignments of the relevant homologous protein coding regions. (nih.gov)
A portion of human INGAP gene was cloned and appears to be highly homologous to the hamster gene. (jci.org)
The homology-based methods, on the other hand, usually have higher specificity, but are limited to finding genes that have homologous partners. (sfu.ca)

Because of their distribution in the nervous system and because n-syb, synaptotagmin, and drab3 do not appear to be in a family of functionally redundant homologs, we predict that mutation of these genes will have a profound neurological phenotype and that they are therefore good candidates for a genetic dissection in Drosophila. (jneurosci.org)
The TP53 gene mutation is the most common gene alteration in many tumors, including esophageal cancer. (spandidos-publications.com)
Although the biological significance of TP53 gene mutation is well characterized, its clinical significance in esophageal cancer remains controversial, especially as a prognostic biomarker. (spandidos-publications.com)
Therefore, the overexpression of p53 does not always indicate a mutation in the TP53 gene. (spandidos-publications.com)
Similarly, TP53 mutation does not always lead to the accumulation of p53 protein in cells. (spandidos-publications.com)
PFIC1 is caused by a genetic mutation in the ATP8B1 gene on chromosome 18q21-22. (medscape.com)
The mechanism whereby the loss of FIC1 activity results in defective bile salts excretion is unknown, but it has been hypothesized that a mutation in this protein causes phospholipid membrane instability leading to reduced function of bile acid transporters. (medscape.com)
Direct oral anticoagulants (DOACs) or warfarin can be used for prevention and treatment of venous thrombosis in patients with one (heterozygosity) or two (homozygosity) copies of the prothrombin 20210 gene mutation. (msdmanuals.com)

In particular, we are interested in determining how cellular cues can alter the ratio of linear mRNA to circular RNA for a given gene. (bcm.edu)
The researchers hope that the identification of new autism genes will pave the way for studies of protein function that may help better understand the mechanics of autism at the cellular level. (sfari.org)
The Cusack group uses X-ray crystallography and cryo electron-microscopy (cryoEM) to study the structural biology of protein-RNA complexes involved in RNA virus replication, innate immunity and cellular RNA metabolism. (embl.org)
Here we present Aura®+ , a USP 1788 compatible, low-volume, high throughput particle imaging system that can rapidly size, count, and characterize biological particles and identify them as proteins, non-proteins, cellular aggregates, or other types of molecules. (livestorm.co)
When a cell is perturbed, it responds by altering expressing levels of specific proteins and adjusting cellular functions in response to the new environmental stimuli. (cdc.gov)

DRB2 has been remarkably conserved throughout plant evolution, raising the possibility that translational repression is the ancient form of miRNA-directed gene regulation in plants, and that Dicer partnering proteins, such as human TRBP, might play a similar role in other eukaryotic systems. (nature.com)
The microarray analysis of drb2 also revealed a large set of gene transcripts that were significantly different from wild-type levels, but which are not thought to be the primary targets of miRNA-directed regulation ( Supplementary Fig. 3 ). (nature.com)
Figure 4: Translational and post-translational regulation of DRB1 and DCL1, and evolutionary conservation of DRB1 and DRB2 proteins. (nature.com)
Our results lend support to the concept of post-transcriptional RNA operons, but we further present evidence that nuclear proximity of genes may provide substantial functional regulation in mammalian single cells. (nih.gov)
For example, viral infection, stress and the regulation of other proteins can also change the aggregation of p53 protein ( 20 ). (spandidos-publications.com)
SAA protein is an acute phase reactant, like C-reactive protein (CRP), and is synthesized by hepatocytes under the transcriptional regulation of cytokines, including interleukin (IL)-1, IL-6 and tumor necrosis factor (TNF). (medscape.com)
2022 ) Gene Expression Regulation in Airway Pathogens: Importance for Otitis Media. (lu.se)

Most genes contain the information needed to make functional molecules called proteins. (medlineplus.gov)
Single-cell RNA sequencing studies on gene co-expression patterns could yield important regulatory and functional insights, but have so far been limited by the confounding effects of differentiation and cell cycle. (nih.gov)
Pseudogenes have been considered as non-functional genes, which are believed to be gene remnants that lost their function during evolution. (indiavision.com)
The study of protein complexes and protein functional modules has become an important method to further understand the mechanism and organization of life activities. (biomedcentral.com)
The clustering algorithms used to analyze the information contained in protein-protein interaction network are effective ways to explore the characteristics of protein functional modules. (biomedcentral.com)
This paper conducts an intensive study on the problems of low recognition efficiency and noise in the overlapping structure of protein functional modules, based on topological characteristics of PPI network. (biomedcentral.com)
The experimental results show that the ECTG algorithm can detect protein functional modules better. (biomedcentral.com)
We find that topological structure and attribute information are very effective in identifying protein complexes by analyzing the existing mainstream PPI network methods for identifying protein functional modules [ 12 , 13 ], even though there are not much approaches take both information into consideration. (biomedcentral.com)
Calculating the similarity between gene expression patterns (co-expression degree) by using gene expression data has an important guiding function in understanding the relationship between the corresponding proteins of the gene, and can help to identify whether different proteins have same or similar functions and whether they can be composed as protein complexes or functional modules. (biomedcentral.com)
Also list of proteins for functional categories, e.g. (lu.se)

Our project offers a unique opportunity for Master's student to gain hands-on experience focused on transcriptional regulators with importance in expression of genes of outer membrane proteins that are essential in host-pathogen interaction. (lu.se)

Alberto de Iaco, a postdoc in the lab of Didier Trono at EPFL, drew upon a seemingly irrelevant study of patients suffering from a form of muscular dystrophy where mutations lead to the production in muscle cells of a protein called DUX4, which is normally detected only at the earliest stage of human embryonic development. (news-medical.net)
Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene. (jax.org)
Gene therapy has been utilized successfully to repair or inactivate mutations in animal models of monogenic human diseases 19 as well as human in vitro cells 12 . (nature.com)
Mutations in specific genes - such as neuroligins, which help relay signals between neurons - have also been linked to autism. (sfari.org)
All recognized mutations for AD are associated with increased deposition of amyloid-beta (Abeta), a peptide fragment comprising 39-43 amino acids that derive from the catabolism of the amyloid precursor protein (APP) molecule. (medscape.com)

I want to know about specific genes so I can see if the results conform to expectations. (blogspot.com)

Altogether, these results demonstrate that SARS-CoV-2 could induce HERV-W envelope protein expression and suggest its involvement in the immunopathogenesis of certain COVID-19-associated syndromes and thereby its relevance in the development of personalized treatment of patients. (unmc.edu)

Silks are composed principally of proteins with a predominance of alanine, serine and glycine and silk proteins are able to undergo irreversible transformations from soluble protein to insoluble fibres. (bioone.org)
Amyloidosis comprises a heterogeneous group of diseases in which normally soluble plasma proteins are deposited in the extracellular space in an abnormal, insoluble, fibrillar form. (medscape.com)

The ability to knock out human genes using CRISPR technology has opened to door to testing for essential genes in tissue culture cells. (blogspot.com)

These covariations form a network with biological properties, outlining known and novel gene interactions. (nih.gov)
COV00701 The SARS-CoV-2 membrane protein (M Protein) is the most abundantly expressed Coronavirus structural protein in host cells, and mediates viral assembly via interactions with other viral proteins. (topsan.org)
Dynamical models based upon known interactions between these master genes, such as mutual antagonism and autoregulation, fail to make the system bistable, a desired feature for robust lineage determination. (lu.se)

Studies of the human proteome have enabled scientists to track protein synthesis, modification, and degradation over time and across different cell types. (cdc.gov)
Because the proteome is a continuously changing set of proteins that differs from cell to cell, it is challenging for scientists to capture and study it. (cdc.gov)
We are now trying to look at the whole proteome, i.e. all the proteins in a certain type of cell at a certain time. (lu.se)

Here, we characterize several mammalian BEN domain (BD) factors, including from two NACC family BTB-BEN proteins and from BEND3, which has four BDs. (bvsalud.org)

A few genes produce regulatory molecules that help the cell assemble proteins. (medlineplus.gov)
Here we show that the form of regulatory action directed by a plant miRNA is determined by DRB2, a DICER-LIKE1 (DCL1) partnering protein. (nature.com)

Using RNAi screening in Drosophila cells, we identified many hnRNPs, SR proteins, core spliceosome, and transcription termination factors that control the outputs of reporter and endogenous genes. (bcm.edu)
Because synaptic transmission is fundamentally similar between vertebrates and invertebrates, vesicle proteins from vertebrates that are important for synaptic transmission should be present in Drosophila as well. (jneurosci.org)
One previously reported candidate (syb), a Drosophila homolog of the vamp or synaptobrevin proteins, has been shown to be expressed at very low levels in neurons and is most abundant in the gut. (jneurosci.org)
Northern analysis and in situ hybridizations to mRNA indicate that the novel vamp, as well as the genes for synaptotagmin (syt) and rab3 (drab3), is expressed in the Drosophila nervous system. (jneurosci.org)

In addition to regulating the size of HDL particles, this protein may be involved in cholesterol metabolism. (nih.gov)
What they should detect is all of the genes required in core metabolism. (blogspot.com)

It seemed possible that these genes are regulated by transcription factors that are themselves regulated by miRNAs, and at a translational level by a process involving DRB2. (nature.com)
Gene expression is regulated by proteins known as transcription factors. (ku.edu)
Gene reporter technology (GRT) has opened several new avenues for monitoring biological events including the activation of transcription factors, which are central to the study of nutrigenomics. (oregonstate.edu)

The ab initio methods are usually sensitive in finding genes in novel genomes but often produce many false positives. (sfu.ca)
We compiled SITs from 37 diatom genomes to characterize shifts in selection following gene duplications and marine- freshwater transitions. (lu.se)

Further studies of this new finding aims to use it to find "therapeutic weapons" against disease-causing genes or a cell's overactive guide RNA. (isaaa.org)
The turnover of proteins is one of the cell's most essential processes and is necessary for responding to external stimuli and for maintaining homeostasis . (cdc.gov)

2022 ) Protein domain-dependent vesiculation of Lipoprotein A, a protein that is important in cell wall synthesis and fitness of the human respiratory pathogen Haemophilus influenzae . (lu.se)
Genes Dev;36(3-4): 225-240, 2022 02 01. (bvsalud.org)

The type of RNA that contains the information for making a protein is called messenger RNA (mRNA) because it carries the information, or message, from the DNA out of the nucleus into the cytoplasm. (medlineplus.gov)
After differentiating the mutant and corrected cells into lung organoids, we show expression of SFTPB mRNA during endodermal and organoid differentiation but the protein product only after organoid differentiation. (nature.com)
S100A8 mRNA and S100A8 protein levels were detected by quantitative reverse transcription-polymerase chain reaction (qRT-PCR) and Western blotting. (medscimonit.com)

RNA-silencing requires an Argonaute protein and guide RNA called microRNA. (isaaa.org)
Though Argonaute2 is not the only type of Argonaute protein, it appears to be the only Argonaute protein capable of terminating target RNA directly. (isaaa.org)

GXD's primary emphasis is on endogenous gene expression during development. (jax.org)
We show here that in vitro exposure to SARS-CoV-2 activates the expression of the human endogenous retrovirus (HERV) HERV-W proinflammatory envelope protein (ENV) in peripheral blood mononuclear cells from a subset of healthy donors, in ACE2 receptor and infection-independent manner. (unmc.edu)

A type of RNA called transfer RNA (tRNA) assembles the protein, one amino acid at a time. (medlineplus.gov)
Previously, we worked on aminoacyl-tRNA synthetases, which play an essential role in protein synthesis by charging specifically their cognate tRNA(s) with the correct amino acid and editing mischarged amino acids if necessary (Palencia et al . (embl.org)

Wan W, Huang Y, Wang Z, Russell WK, Pai PJ, Russell DH, Liu WR (2010) A facile system for genetic incorporation of two different noncanonical amino acids into one protein in Escherichia coli . (springer.com)
They collected data from 229 individuals with Parkinson's (21 of whom had a known genetic variation in their GBA gene). (cureparkinsons.org.uk)
The scientists also discovered genetic variations outside of the GBA gene - in different areas of our DNA - that can influence GBA GCase protein levels in different areas of the brain. (cureparkinsons.org.uk)
This last finding is particularly important as it may be able to help explain why some individuals without a genetic variation in their GBA gene can have reduced levels of the GCase protein in parts of the brain that are affected by Parkinson's. (cureparkinsons.org.uk)
Genetic diversity of Iranian E. dispar isolates based on the SREDP was more polymorphic in comparison of Serine-Rich Entamoeba histolytica Protein (SREHP) of the E. histolytica isolates as well as were different from a few known SREDP genes. (scialert.net)
In the present study, the genetic variability of E. dispar strains based on the SREDP gene locus was analyzed using RFLP-nested PCR and sequencing of the obtained genes. (scialert.net)
Despite their genetic distinctiveness, PFIC1 and PFIC2 have few clinical differences, and both are caused by the absence of a gene product required for canalicular export and bile formation. (medscape.com)
We develop a computational model for the hematopoietic erythroid-myeloid lineage decision, which is determined by a genetic switch involving the genes PU.1 and GATA-1. (lu.se)
The diagnosis is made by genetic analysis of the prothrombin 20210 gene using blood samples. (msdmanuals.com)

Upon inhibiting RNA polymerase II termination, circular RNA levels were similarly increased due to readthrough transcripts extending into downstream genes and being subjected to backsplicing. (bcm.edu)
The update on RNA-silencing focused on Argonaute2, which is a protein that can switch-off a gene by intercepting and slicing the gene's RNA transcripts before they are translated as proteins. (isaaa.org)

Transmembrane protein 88 inhibits transforming growth factor-β1-induced-extracellular matrix accumulation and epithelial-mesenchymal transition program in human pleural mesothelial cells through modulating TGF-β1/Smad pathway. (nih.gov)
Washington - Researchers have found close to one hundred novel human gene regions that code for proteins and a number of these regions are so-called pseudogenes, which may be linked to cancer. (indiavision.com)
They have assembled a collection of proteins known to be implicated in these pathways and then screened a library of all human brain proteins to find other proteins that interact with those in the collection. (sfari.org)
Sandwalk: How many human protein-coding genes are essential for cell survival? (blogspot.com)
Three-dimensional atomic structure of a human protein which is mainly involved in regulating the activities of cells has been identified by the Scripps Research Institute. (isaaa.org)
Aberrant promoter methylation of insulin-like growth factor binding protein-3 gene in human cancers. (nih.gov)
In summary, our results showed that IGFBP-3 methylation played an important role in the silencing of its expression, suggesting that IGFBP-3 may act as a tumor suppressor gene in several human cancers examined. (nih.gov)

We find that nuclear organization has the greatest impact, and that genes encoding for physically interacting proteins specifically tend to covary, suggesting importance for protein complex formation. (nih.gov)
By looking only at genes that are essential for cell survival, they are ignoring all those genes that are specifically required in other cell types. (blogspot.com)

The TP53 gene plays an important role in regulating the cell cycle, apoptosis and DNA damage repair ( 8 , 9 ). (spandidos-publications.com)

Overall, more than 20 genes and chromosomal regions are known to cause autism when defective but together, these account for only around 10 percent of cases. (sfari.org)

Immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH) were performed to detect the expression of p53 protein and gene deletion in ESCC tissue samples from different ethnic groups in Xinjiang, in order to analyze their association with clinicopathological characteristics and patient prognosis, as well as the sensitivity and specificity of the two methods. (spandidos-publications.com)
Immunohistochemistry (IHC) was used to detect expression of the S100A8 protein in 74 tissue samples of endometrial cancer and 22 normal endometrial tissue samples. (medscimonit.com)
Expression Atlas ( http://www.ebi.ac.uk/gxa ) is an added value database that provides information about gene and protein expression in different species and contexts, such as tissue, developmental stage, disease or cell type. (oregonstate.edu)
[ 1 ] It is characterized by extracellular tissue deposition of fibrils that are composed of fragments of serum amyloid A (SAA) protein, a major acute-phase reactant protein, produced predominantly by hepatocytes. (medscape.com)
The tissue fibril involved in AA amyloidosis consists of a 7500-dalton cleavage product of the SAA protein. (medscape.com)

The life cycle of a protein starts with a blueprint transcribed from a gene, followed by folding, which translates the blueprint to a three-dimensional structure that allows it to carry out its biological function, and ends with degradation. (cdc.gov)

The T4 Gene 32 Protein has exhibited an ability to enhance the performance of several DNA synthesis-related activities in secondary-structure rich regions, including PCR amplification and DNA sequencing. (qiagen.com)
Improved yields and quality of templates may be achieved with the use of DNA-binding proteins in amplification and sequencing reactions. (qiagen.com)

The T4 Gene 32 Protein also stimulates the rate of synthesis of T4 DNA Polymerase on primed-single-stranded substrates showing a 5-10-fold increase in synthesis rate. (qiagen.com)
The ability of T4 Gene 32 Protein to enhance the performance of several DNA synthesis-related activities is based on its essential function in the replication of bacteriophage T4. (qiagen.com)

The two main categories of gene prediction methods are ab initio methods and homology-based methods. (sfu.ca)
In this thesis, I present a homology-based gene prediction framework that utilizes protein homology in determining positions of protein-coding genes. (sfu.ca)
In particular, it runs hundreds of times faster than GeneWise, a popular homology-based gene prediction program, while being competitive in accuracy. (sfu.ca)

The algorithm can effectively remove the noise data reflected by calculating the topological structure characteristic values in the PPI network through the similarity of gene expression patterns, and also properly use the information hidden in the gene expression data. (biomedcentral.com)
The extensive but relatively balanced history of duplications and losses, together with paralog-specific expression patterns, suggest diatoms continuously balance gene dosage and expression dynamics to optimize silicon transport across major environmental gradients. (lu.se)
protein patterns of subjects with leish- Cell culture maniasis [17]. (who.int)

One of the annoying things about all three papers is that they use the words "gene" and "protein-coding gene" as synonyms. (blogspot.com)

Developing a protein function module recognition method ECTG based on Topological Features and Gene expression data for Protein Complex Identification. (biomedcentral.com)
ECTG(Evolutionary Clustering Algorithm Based on Topological Features and Gene expression data for Protein Complex Identification). (biomedcentral.com)

A total of about 700 genes out of the 3661 predicted protein-coding genes correspond to integral membrane proteins. (harvard.edu)
We show that Per8p is an integral membrane protein of the peroxisome and that it is concentrated in the membranes of newly formed organelles. (rupress.org)

Transmembrane protein 88 exerts a tumor-inhibitory role in thyroid cancer through restriction of Wnt/β-catenin signaling. (nih.gov)
The aim of the present study was to investigate the association between tumor protein 53 (TP53) gene deletion and protein expression and clinical features in esophageal squamous cell carcinoma (ESCC), and to evaluate the predictive value of these two characteristics in the prognosis of ESCC. (spandidos-publications.com)
The positive rate of p53 protein expression was 54.5% (201/369) in the multi‑ethnic group, and was significantly different between sex (P=0.026) and between tumor differentiation groups (P=0.032). (spandidos-publications.com)
Tumor protein 53 ( TP53 ) is a recognized tumor suppressor gene located on chromosome 17q13.1. (spandidos-publications.com)

The researchers sought to better understand how the GBA gene affects the variability between individuals with Parkinson's. (cureparkinsons.org.uk)

Through the processes of transcription and translation, information from genes is used to make proteins. (medlineplus.gov)
The conserved structure and neuronal expression pattern of these genes indicate that they may function in processes that are required for both vertebrate and invertebrate synaptic transmission. (jneurosci.org)

Among other things, the research shows that some pseudogenes produce proteins indicating that they indeed have a function. (indiavision.com)
Here, we describe the application of this approach to produce a protein with two distinct chemical functionalites which can be selectively labeled with two fluorescent dyes. (springer.com)
This suggests that in most patients with PFIC-2, the gene defect is sufficiently severe to produce no product or a protein that cannot be inserted into the canalicular membrane. (medscape.com)
We need to know more about the proteins that our genes produce. (lu.se)
We have around 20 000 genes that can produce at least 500 000 proteins. (lu.se)

They won't detect any of the genes required for spermatogenesis or embryonic development. (blogspot.com)
Certain molecules are always present at very high levels, while other, pathogenic proteins may only be present at very low levels and thus be difficult to detect. (lu.se)

Our preliminary study using 2D isolates were recovered from liq- new cases throughout the world cu- gel electrophoresis in drug sensitive/ uid nitrogen, and sub-cultured in taneous leishmaniasis (CL) remains resistant strains of L. tropica showed RPMI1640 medium (Gibco/BRL) a serious public health problem in that some proteins were differentially supplemented with 10% fetal bovine numerous countries [1,2]. (who.int)

Next, they looked at mouse embryonic stem cells, which contain the mouse version of the DUX4 gene (called simply DUX). (news-medical.net)
When in culture, a small fraction of these cells exhibit at any given time the gene expression pattern of 2-cell stage embryos, before cycling back to the features of more advanced embryonic cells. (news-medical.net)
We apply a tailored experimental design that eliminates these confounders, and report thousands of intrinsically covarying gene pairs in mouse embryonic stem cells. (nih.gov)

We investigated the hypothesis that a novel gene encoding a constituent of Ilotropin was expressed in the hamster pancreas undergoing islet neogenesis. (jci.org)
This data suggests that the INGAP gene is a novel pancreatic gene expressed during islet neogenesis whose protein product is a constituent of Ilotropin and is capable of initiating duct cell proliferation, a prerequisite for islet neogenesis. (jci.org)

COV00601 The SARS-CoV-2 envelope protein (E Protein) is the smallest of the four main structural proteins and is abundantly expressed in host cells during the viral replication phase. (topsan.org)
Finally, comparison with our previous invertebrate BEN structures, along with additional structural predictions using AlphaFold2 and RoseTTAFold, reveal distinct strategies for target DNA recognition by different types of BEN domain proteins . (bvsalud.org)

Keyword search in the descriptions of proteins also implemented here. (lu.se)
The approach points to a framework for lineage commitment studies in general and could aid the search for lineage-determining genes. (lu.se)

Numerous factors shape the evolution of protein-coding genes, including shifts in the strength or type of selection following gene duplications or changes in the environment. (lu.se)
Episodic diversifying selection was detected but not associated with gene duplications or habitat shifts. (lu.se)

This involves actions such as the autolytic removal of residues to generate the mature form of the protein. (yeastrc.org)

Anatomy11

Organisms46

Diseases12

Chemicals and Drugs89

Analytical, Diagnostic and Therapeutic Techniques and Equipment20

Psychiatry and Psychology2

Phenomena and Processes76

Disciplines and Occupations1

Technology, Industry, Agriculture5

Information Science4

Geographicals1

Characterization4

Genome20

Sequences11

Proteomics8

Regulate4

UniProt1

Production of proteins1

Encodes6

Sequence13

Ontology2

Lipid4

Molecular10

RNAs4

Homologous3

Mutation8

Cellular5

Regulation7

Functional10

Host-pathogen1

Mutations5

Specific genes1

Induce1

Soluble2

CRISPR1

Interactions3

Proteome3

Mammalian1

Regulatory2

Drosophila4

Metabolism2

Transcription factors3

Genomes2

Cell's2

20222

MRNA3

ARGONAUTE2

Endogenous2

Amino acid2

Genetic9

Transcripts2

Human7

Specifically2

Apoptosis1

Chromosomal1

Tissue5

Biological1

Amplification2

Synthesis2

Homology3

Patterns3

Synonyms1

Identification2

Integral2

Tumor4

Variability1

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Produce5

Detect2

Strains1

Embryonic3

Constituent2

Structural2

Search2

Shifts2

Residues1