Proteins enterovirus d human. Medical search. Frequent questions

Enterovirus E (formerly bovine enterovirus (BEV)) is a picornavirus of the genus Enterovirus. (wikipedia.org)
Enteroviruses (genus Enterovirus, family Picornaviridae ) are among the most common viruses infecting humans worldwide. (cdc.gov)
HRVs are classified in genus Enterovirus (HEVs) in family Picornaviridae [10] . (plos.org)
The enterovirus genus of the picornavirus family includes a large number of important human pathogens such as poliovirus, coxsackievirus, enterovirus A71, and rhinoviruses. (uu.nl)
Here we investigated the proteins recruited to the replication organelles of poliovirus, a representative of the genus Enterovirus of the Picornaviridae family. (bvsalud.org)
Epidemic hand-foot-and-mouth disease (HFMD) viral infections are usually caused by members of the Enterovirus genus, most commonly, coxsackievirus A16, A6, or enterovirus 71. (medscape.com)
Members of the human parechovirus (HPeV) species are small, nonenveloped RNA viruses that are members of the family Picornaviridae, genus Parechovirus. (blogspot.com)
HPeV-1 and HPeV-2, formerly known as echovirus 22 and echovirus 23, were originally considered to belong to the genus Enterovirus (1,2) but after genome sequencing were reclassified as members of a new genus in the family Picornaviridae (3). (blogspot.com)
Human coxsackieviruses belong to the family Picornaviridae and genus Enterovirus . (blogspot.com)

CI = 0--0.4) than infections with other enteroviruses. (cdc.gov)
NESS data allowed identification and description of a core group of consistently circulating enteroviruses that probably determine the disease burden associated with enterovirus infections. (cdc.gov)
Enteroviruses are a group of single-stranded sense RNA viruses that commonly cause infections, especially in infants and children. (medscape.com)
The cutaneous manifestations of human enterovirus infections include widespread blistering mucocutaneous reactions without any suspected drug causality. (medscape.com)
Chronic microbial infections which have been documented in patients with CFS/ME include C burnetii , parvovirus B19, C pneumoniae , hepatitis C, enteroviruses and human retroviruses. (bmj.com)
The importance of gastrointestinal symptoms in CFS/ME 13 - 15 and the known ability of enteroviruses to cause gastrointestinal infections, 16 led John and Andrew Chia to study the role of enterovirus infection in the stomach of patients with CFS/ME. (bmj.com)
The high incidence of mixed infections with enterovirus 71 and coxsackievirus 16 (17.6% of the total coxsackievirus 16-infected cases) has never before been observed in China. (medscape.com)
[ 2 ] A high incidence of mixed infections with enterovirus 71 and coxsackievirus 16 was also observed. (medscape.com)
Human parechovirus 3 and neonatal infections. (omicsdi.org)
Rhinovirus infections are the most common cause of viral illness in humans, and there is increasing evidence of their etiological role in severe acute respiratory tract infections (ARTIs). (ox.ac.uk)
Most of these exposures do not create infections or disease in humans. (bnpmedia.com)
Level 2 represents the subset of viruses that "jump" from insects or animals to humans causing infections and disease. (bnpmedia.com)
Despite the frequent infections and numerous HPeV genotypes detected in humans, information about HPeV infection in animals is scant. (blogspot.com)
Intergenerational erotic partners (IGSPs) placed young adults at an increased risk involving intimately transmitted microbe infections (STIs) which include HS-10296 EGFR inhibitor Human immunodeficiency virus and Supports. (nartsignaling.com)
Human infections with enteroviruses such as coxsackievirus A (CVA) are generally mild, but severe complications were more often reported for infections caused by enterovirus 71 (EV71) ( 1 , 2 ). (blogspot.com)

Classification of coxsackievirus 16A (CA16) sequences from the People's Republic of China into human enterovirus (HEV) groups. (cdc.gov)
Pöyry T , Hyypiä T , Horsnell C , Kinnunen L , Hovi T , Stanway G . Molecular analysis of coxsackievirus A16 reveals a new genetic group of enteroviruses. (cdc.gov)
Yan JJ , Su IJ , Chen PF , Liu CC , Yu CK , Wang JR . Complete genome analysis of enterovirus 71 isolated from an outbreak in Taiwan and rapid identification of enterovirus 71 and coxsackievirus A16 by RT-PCR. (cdc.gov)
Wu Y , Yeo A , Phoon MC , Tan EL , Poh CL , Quak SH , The largest outbreak of hand, foot and mouth disease in Singapore in 2008: the role of enterovirus 71 and coxsackievirus A strains. (cdc.gov)
Li L , He Y , Yang H , Zhu J , Xu X , Dong J , Genetic characteristics of human enterovirus 71 and coxsackievirus A16 circulating from 1999 to 2004 in Shenzhen, People's Republic of China. (cdc.gov)
Zhu Z , Zhu S , Guo X , Wang J , Wang D , Yan D , Retrospective seroepidemiology indicated that human enterovirus 71 and coxsackievirus A16 circulated wildly in central and southern China before large-scale outbreaks from 2008. (cdc.gov)
The recent finding of enterovirus (EV) capsid protein VP1 in pancreatic autopsy samples from the JDRF Network for Pancreatic Organ Donors with Diabetes (nPOD) supports earlier case series in which EVs (Coxsackievirus B, CVB)were isolated from pancreatic tissue and inoculated into human islets, causing functional impairment and β-cell death. (qscience.com)

Enteroviruses belong to the Picornaviridae (small RNA viruses) family. (medscape.com)
Enterovirus-D68 (EV-D68) is a positive-sense, single-stranded RNA virus of the Picornaviridae family that causes respiratory disease in children and has been implicated in recent outbreaks of acute flaccid myelitis, a severe paralysis syndrome. (umaryland.edu)

According to a study published September 16, 2019, in the journal Nature Microbiology , researchers at Stanford University and the University of California in San Francisco found that temporarily disabling a single, noncritical protein in cells (called methyltransferase SETD3) could halt the duplication of viruses, including the rhinovirus that causes most common colds. (everydayhealth.com)
Fu X, Wan Z, Li Y, Hu Y, Jin X, Zhang C (2019) National epidemiology and evolutionary history of four hand, foot and mouth disease-related enteroviruses in China from 2008 to 2016. (virosin.org)
This finding published in Nature on October 21, 2019, offers the clearest evidence to date that AFM is caused by an enterovirus (EV) that invades and impairs the central nervous system. (precisionvaccinations.com)

We think finding antibodies against enterovirus in the spinal fluid of AFM patients means the virus really does go to the spinal cord. (neurosciencenews.com)
Any chunks of viral protein cross-reacting with any antibodies present in the spinal fluid would provide evidence for a viral infection in the central nervous system. (neurosciencenews.com)
Cross-reactive peptide epitopes of Enterovirus Coxsackie B4 and human Glutamic Acid Decarboxylase detecting antibodies in Latent Autoimmune Diabetes in Adults versus Type 1 Diabetes. (unifi.it)
However, a study from China in 2011 showed that the neutralizing antibody response was not correlated with disease severity, suggesting that cellular immune response, besides neutralizing antibodies, could play a critical role in controlling the outcome of enterovirus 71 infection in humans. (medscape.com)
Enterovirus-specific antibodies were detected in the cerebrospinal fluid of 79% (11 of 14) of the AFM cases included in a new study. (contagionlive.com)
A team of investigators from the Center for Infection and Immunity (CII) at Columbia University Mailman School of Public Health, the US Centers for Disease Control and Prevention (CDC), and the University of California, San Diego analyzed the cerebrospinal fluid of AFM patients in search of enterovirus antibodies. (contagionlive.com)
Antibodies to enteroviruses were present 11 of 14 AFM patients (79%), significantly higher than controls. (contagionlive.com)
VP4 has been shown in vitro to be a target of human antibodies that enhance CVB induced synthesis of interferon α (IFN-α). (qscience.com)

The outer surface of BEV is smoother than the closely related poliovirus due to the truncation of surface protein loops in BEV. (wikipedia.org)
Phosphatidylinositol-4 kinase III beta and oxysterol-binding protein accumulate unesterified cholesterol on poliovirus-induced membrane structure. (microbiologyresearch.org)
A critical role of a cellular membrane traffic protein in poliovirus RNA replication. (microbiologyresearch.org)
The discovery of the enteroviruses and the classification of poliovirus among them. (medscape.com)
Despite research on poliovirus establishing many fundamental principles of RNA virus biology and the first transgenic animal model of disease for infection by a human virus, picornaviruses are understudied. (bvsalud.org)
Poliovirus is a small and simple virus composed of a shell, or capsid, made of protein. (microbeonline.com)
The infectious nucleic acid of poliovirus can bypass the host range specificity provided by the viral protein-cell receptor interaction. (microbeonline.com)
For example, intact poliovirus can grow only in human or primate cells, but purified poliovirus RNA can also enter and replicate in nonprimate cells. (microbeonline.com)
People acquire poliovirus infection from other humans through contact with virus-containing feces or contaminated water. (microbeonline.com)

It is also smoother than the related human rhinovirus due to the extension of a surface loop in BEV. (wikipedia.org)
ACBD3 knockout impaired replication of representative viruses from four enterovirus species and two rhinovirus species. (uu.nl)
Defining enterovirus A71 and D68, human rhinovirus C, and echoviruses 29 as prototype pathogens of this virus family may provide insight into picornavirus biology needed to establish public health strategies necessary for pandemic preparedness. (bvsalud.org)
This contrasts with the interaction of soluble ICAM-1 (sICAM-1, CD54) with human rhinovirus 3 which has been reported to have a similar affinity but 10(2)-10(3)-fold slower kinetics (Casasnovas, J. M., and Springer, T. A. (1995) J. Biol. (ox.ac.uk)

Enterovirus detections by serotype with specimen type, collection date, and demographic information are reported monthly by participating laboratories to CDC, which summarizes the data and disseminates the results. (cdc.gov)
This appears to be a particularly aggressive neurotrophic serotype of enterovirus. (medscape.com)
A third serotype of human parechovirus (HPeV) has been recently isolated from stool specimens of a young Japanese child with transient paralysis. (omicsdi.org)

Second, they processed the same 14 AFM cerebrospinal fluid samples and blood serum, along with cerebrospinal fluid samples from 11 non-AFM adults with a central nervous system condition and 10 non-AFM children with Kawasaki disease, using high density peptide microarrays that span all the capsid proteins of all species of human EV (species EV-A, EV-B, EV-C, and EV-D). (contagionlive.com)
The polyprotein encoded capsid proteins VP0 (312 aa), VP3 (229 aa), and VP1 (234 aa) and nonstructural proteins 2A (150 aa), 2B (122 aa), 2C (329 aa), 3A (117 aa), 3B (20 aa), 3C (200 aa), and 3D (469 aa). (blogspot.com)

Enteroviruses are common human viruses associated with various clinical syndromes, from minor febrile illness to severe, potentially fatal conditions (e.g., aseptic meningitis, paralysis, myocarditis, and neonatal enteroviral sepsis). (cdc.gov)
Switching off the protein in human cells and in mice also stopped replication of viruses linked to asthma, encephalitis, and polio . (everydayhealth.com)
A different antiviral approach, known as host-directed therapy (HDT), targets host-cell proteins that viruses need in order to replicate and cause infection. (everydayhealth.com)
Like all other positive-strand RNA viruses, genome replication of enteroviruses occurs on rearranged membranous structures called replication organelles (ROs). (uu.nl)
Altogether, our data provide new insight into the central role of ACBD3 in recruiting PI4KB by enterovirus 3A and reveal the minimal domains of ACBD3 involved in recruiting PI4KB and supporting enterovirus replication.IMPORTANCE Similar to all other positive-strand RNA viruses, enteroviruses reorganize host cellular membranes for efficient genome replication. (uu.nl)
VirScan, which is a customized version of a Nobel Prize-winning technique called phage (rhymes with "beige") display, allowed Wilson's team to probe the spinal fluid of AFM patients for signs of an immune response against enterovirus and thousands of other viruses simultaneously. (neurosciencenews.com)
The researchers created molecular libraries consisting of nearly 500,000 small chunks of every protein found in the over 3,000 viruses known to infect vertebrates (including humans), as well as those that infect mosquitoes and ticks (an effort to rule out disease transmission through their bites). (neurosciencenews.com)
The genomes of positive-strand RNA viruses serve as a template for both protein translation and genome replication. (bvsalud.org)
EV-D68 uses virally-encoded proteases to cleave an autophagosome fusion SNARE protein, SNAP29, blocking delivery of autophagosome contents, including nascent viruses, to the lysosome. (umaryland.edu)
Viable CVA10 viruses were harvested by transfecting the viral mRNA into human rhabdomyosarcoma (RD) cells. (virosin.org)
A combined nasopharyngeal/oropharyngeal swab and cerebrospinal fluid sample were negative by reverse transcription-polymerase chain reaction (RT-PCR) testing for enteroviruses and human parechovirus, as well as for a panel of common respiratory pathogens and encephalitic viruses by molecular methods ( 2 ). (cdc.gov)
Of those, there are 219 known viruses that can infect and cause disease in humans. (bnpmedia.com)
How are humans infected by viruses? (bnpmedia.com)
Most viruses do not infect or cause disease in humans. (bnpmedia.com)
The pathogen pyramid (see Figure 1) illustrates the interaction viruses have with humans. (bnpmedia.com)
Level 1 represents humans being exposed to many viruses. (bnpmedia.com)
Though the study provides the most robust evidence so far that enteroviruses cause AFM, many questions around AFM and these viruses remain unanswered. (precisionvaccinations.com)
The viral protein (VP)3/VP1 region of these 5 viruses was then PCR amplified and sequenced to confirm type 1 identity (13). (blogspot.com)
Together, our work explains how Retro-2 prevents retrograde trafficking of toxins by inhibiting TA-protein targeting, describes a general CRISPR strategy for predicting the MOA of small molecules, and paves the way for drugging the TRC pathway to treat broad classes of viruses known to be inhibited by Retro-2. (elifesciences.org)

[ 3 ] Enterovirus 71 infection does not provide immunity to other strains. (medscape.com)
For example, though the AFM-causing enterovirus strains - EV-D68 and EV-A71 - were identified decades ago, they only recently seemed to have gained the ability to cause paralysis, with the D68 strain in particular responsible for the most severe cases of AFM. (precisionvaccinations.com)
Because sequence analysis of the 5′-UTR amplicon showed that this enterovirus strain was closely related to other human enterovirus A strains, another set of consensus primers (5′-TGCCCACAYCARTGGATHAA-3′ and 5′-CCTGACCACTGNGTRTARTA-3′) specific for the viral protein 2-viral protein 3 region of human enterovirus A was used for typing. (blogspot.com)

Researchers believe that disabling a protein in host cells can stop the viral infection. (everydayhealth.com)
Human rhinoviruses (HRVs) are a highly prevalent cause of acute respiratory infection in children. (plos.org)
Researchers suspect that prolonged inflammation in response to the infection may be involved in the development of acute necrotizing encephalopathy type 1, although the role of the altered RANBP2 protein in this process is unknown. (medlineplus.gov)
Virus infection is initiated by the interaction between S protein and host cell surface receptors. (newvita.com)
Picornaviruses are common human pathogens, and infection can result in a spectrum of serious illnesses, including acute flaccid myelitis, severe respiratory complications, and hand-foot-mouth disease. (bvsalud.org)
Functional analysis of several newly identified proteins revealed both pro- and anti-viral factors, including a novel component of infection-induced stress granules. (bvsalud.org)
Using both viral- and non-viral forms of autophagy induction, these data suggest that the cellular network of SNARE proteins is being redirected during infection to promote EV-D68 replication and egress from the cell. (umaryland.edu)
The role of enterovirus (EV) infection as a trigger and perpetuating factor in CFS/ME has been recognised for decades. (bmj.com)
6 In view of the tropism of enteroviruses for skeletal and cardiac muscle, research focused on enterovirus infection of skeletal muscle. (bmj.com)
enterovirus infection of skeletal muscle was therefore proposed as the likely disease mechanism. (bmj.com)
In this issue, they describe a systematic study of enterovirus infection in the stomach of 165 patients with CFS/ME, demonstrating a detection rate of EV VP1 protein of 82% in patients with CFS/ME compared with 20% in normal controls. (bmj.com)
Viral RNA polymerase, a nonstructural protein, has been termed "virus infection associated antigen" (VIAA) for diagnostic purposes but is more accurately termed "FMDV nonstructural protein 3D. (wikisource.org)
Parechovirus A (Human parechovirus, HPeV) causes symptoms ranging from severe neonatal infection to mild gastrointestinal and respiratory disease. (omicsdi.org)
New research presents additional evidence bolstering the argument that enterovirus infection may be the cause of acute flaccid myelitis (AFM), the "polio-like" disease that primarily affects children. (contagionlive.com)
Information about human parechovirus (HPeV) infection in animals is scant. (blogspot.com)
CVB-induced IFN-α plays a role in the initiation and/or maintenance of chronic CVB infection in human islets. (qscience.com)

Parechoviruses are human pathogens that cause diseases ranging from gastrointestinal disorders to encephalitis. (omicsdi.org)
Therefore, putative small molecules that could disrupt HPeV RNA-capsid protein interactions could be developed into antiviral inhibitors.Human parechoviruses (HPeVs) are pathogens that cause diseases ranging from respiratory and gastrointestinal disorders to encephalitis. (omicsdi.org)

In common with other picornaviruses, the capsid of BEV is composed of 60 copies of each of four structural proteins, VP1, VP2, VP3 and VP4, in icosahedral symmetry, at about 27 nm in diameter, and enclosing a single stranded positive sense RNA genome of about 7,500 bases. (wikipedia.org)
The virus enters human cells via endocytosis by binding the ACE2 receptor and releasing its positive-sense RNA genome. (news-medical.net)
In enteroviruses, a cloverleaf RNA structure at the 5' end of the genome functions as a switch to transition from viral translation to replication by interacting with host poly(C)-binding protein 2 (PCBP2) and the viral 3CDpro protein. (bvsalud.org)
Based on the cloverleaf structures and biophysical assays, we propose a new mechanistic model by which enteroviruses use the cloverleaf structure as a molecular switch to transition from viral protein translation to genome replication. (bvsalud.org)
The Structure of Human Parechovirus 1 Reveals an Association of the RNA Genome with the Capsid. (omicsdi.org)
VP4 is an internal capsid protein linked to the genome. (qscience.com)
A study has discovered a pathway that allows the enterovirus to successfully infect cells and promote genome release which could be a therapeutic target. (drugtargetreview.com)

two enterovirus species (echovirus types 22 and 23) were reassigned as parechovirus. (medscape.com)
Here, we present the structure of a human parechovirus 1 (HPeV-1) virion determined to a resolution of 3.1 Å. (omicsdi.org)

Microbiologists targeted a human gene that produces a protein essential to the function of numerous enteroviruses (including rhinoviruses). (everydayhealth.com)
But there are about 160 known types of human rhinoviruses (HRVs). (everydayhealth.com)
Screening respiratory samples for detection of human rhinoviruses (HRVs) and enteroviruses: comprehensive VP4-VP2 typing reveals high incidence and genetic diversity of HRV species C. (ox.ac.uk)

Enteroviruses are associated with diverse clinical syndromes ranging from minor febrile illness to severe, potentially fatal conditions (e.g., aseptic meningitis, encephalitis, paralysis, myocarditis, and neonatal enteroviral sepsis) and could be linked with the development of some chronic diseases (e.g., type 1 diabetes and dilated cardiomyopathy) ( 1,2 ). (cdc.gov)
The enteroviral 3A protein recruits PI4KB to ROs, but the exact mechanism remains elusive. (uu.nl)
ACBD3 is responsible for proper localization of enteroviral 3A proteins in host cells, which is important for 3A to recruit PI4KB. (uu.nl)

Enteroviruses 76, 89, 90 and 91 represent a novel group within the species Human enterovirus A. J Gen Virol . (medscape.com)
Molecular identification of 13 new enterovirus types, EV79-88, EV97, and EV100-101, members of the species Human Enterovirus B. Virus Res . (medscape.com)
HRV species A, B, and C variants were detected in 14%, 1.8%, and 6.8%, respectively, of 456 diagnostic respiratory samples from 345 subjects (6 samples also contained enteroviruses), predominantly among children under age 10 years. (ox.ac.uk)

For the enteroviruses, replication organelles form at Golgi membranes in a process that utilizes PI4KIIIβ. (microbiologyresearch.org)
Our results showed that, in contrast to the enteroviruses and the cardioviruses, FMDV replication does not require PI4KIII (PI4KIIIα and PI4KIIIβ), and PI4P levels do not increase in FMDV-infected cells and PI4P is not seen at replication organelles. (microbiologyresearch.org)
This construct biotinylated multiple host and viral proteins on the replication organelles. (bvsalud.org)
The proteomics characterization of biotinylated host proteins identified multiple proteins previously associated with enterovirus replication, as well as more than 200 new factors recruited to the replication organelles. (bvsalud.org)

The rotavirus nonstructural protein 4 (NSP4) is responsible for the increase in cytoplasmic calcium concentration through a phospholipase C-dependent and phospholipase C-independent pathways in infected cells. (ac.ir)

People were hung up on the fact that enteroviruses were rarely detected in the cerebrospinal fluid of AFM patients. (neurosciencenews.com)

Unfortunately, no drugs or vaccines have been approved for the treatment of human coronaviruses, but there is an urgent need for in-depth research on emerging human infectious coronaviruses. (newvita.com)

Autophagy is a regulated process of cytosolic degradation in eukaryotic cells which maintains cellular homeostasis by degrading damaged organelles, protein aggregates, microbes and other xenobiotics in the cytoplasm. (umaryland.edu)

6 Using a monoclonal antibody, enterovirus VP1 protein was detected in the circulation of 44 of 87 patients with CFS/ME. (bmj.com)
Description: The HIB19 monoclonal antibody reacts with human CD19, a 95 kDa transmembrane glycoprotein. (thermofisher.com)

Chen P et al (2012) Molecular determinants of enterovirus 71 viral entry: cleft around GLN-172 on VP1 protein interacts with variable region on scavenge receptor B2. (virosin.org)
In conclusion, this study established a protocol for enterovirus and HPeV virus identification that combines conventional and molecular methods and would be beneficial for HPeV diagnosis. (omicsdi.org)

It is shown that increasing of intracellular calcium concentration in rotavirus infected cells is associated with the activation of some members of protein kinases family such as calcium/calmodulin-dependent kinase II, which plays a crucial role in replication and pathogenesis of the virus. (ac.ir)
The rotavirus enterotoxin NSP4 mobilizes intracellular calcium in human intestinal cells by stimulating phospholipase C-mediated inositol 1, 4, 5-trisphosphate production. (ac.ir)
Rotavirus stimulates release of serotonin (5-HT) from human enterochromaffin cells and activates brain structures involved in nausea and vomiting. (ac.ir)

Impact of host protein dynamics on picornavirus RNA 5? (uci.edu)

Pretending the cold virus is a key trying to get into the lock [referring to the host cell], researchers have disabled a protein on the cell so the virus cannot infect those cells. (everydayhealth.com)

The specificity of the anti-HPeV VP0 antibody was demonstrated on immunofluorescence assay, showing that this antibody was specific for HPeV but not enteroviruses. (omicsdi.org)

Lipid envelope which is studded with structural protein including the membrane (M) glycoprotein, the envelope (E) protein, and the spike (S) glycoprotein [ 11 ]. (newvita.com)
The S protein would be cleaved by the cellular serine proteases TMPRSS2 into S1 and S2 subunits, which are responsible for receptor recognition and membrane fusion [ 12 , 13 ]. (newvita.com)

The virus has not been shown to transmit from animals to humans. (wikipedia.org)
The virus has been investigated for its antitumor capabilities, as it is capable of replicating within breast cancer cell lines and producing a cytopathic effect in human monocytes. (wikipedia.org)
But many experts remained skeptical of the enterovirus hypothesis, instead proposing that AFM is an autoimmune disorder or is caused by some other, as-yet-undiscovered virus. (neurosciencenews.com)
They maintained that until there was ample evidence of the virus invading the human nervous system, the link between EVs and AFM remained unproven. (neurosciencenews.com)
Microbes which have been shown to trigger CFS/ME include enteroviruses, Epstein-Barr virus, Chlamydia pneumoniae , parvovirus B19, Coxiella burnetii , Borna disease virus, varicella zoster virus, cytomegalovirus, and human herpesvirus type 6 (HHV-6). (bmj.com)
Measured in anti-viral assays using HeLa human cervical epithelial carcinoma cells infected with encephalomyocarditis (EMC) virus. (bio-techne.com)
Recombinant Human IFN-beta Protein Binding Activity Recombinant Human IFN‑ beta (Catalog # 8499-IF) exhibits anti-viral activity in HeLa human cervical epithelial carcinoma cells infected with encephalomyocarditis (EMC) virus. (bio-techne.com)
Determination of the affinity and kinetic constants for the interaction between the human virus echovirus 11 and its cellular receptor, CD55. (ox.ac.uk)
A virus is a small infectious agent that contains RNA or DNA genetic material and has a protein outer shell. (bnpmedia.com)
Tissue samples of heart, lung, spleen, and rectum, and nasopharyngeal and rectal swab specimens were positive for enterovirus by virus culture in a rhabdomyosarcoma cell line. (blogspot.com)

An overview of the evolution of enterovirus 71 and its clinical and public health significance. (cdc.gov)
As clinical signs are fairly nonspecific and bovine enterovirus is ubiquitous in cattle populations, other causes of disease must be ruled out before diagnosing enterovirus as the cause of disease. (wikipedia.org)
Clinically, enteroviruses can be divided into polio and non-polio enteroviruses owing to the different clinical patterns and outcomes. (medscape.com)
Not for any clinical, therapeutic, or diagnostic use in humans or animals. (genetex.com)

Researchers detected immunological remnants of enterovirus in the nervous systems of more than 12 patients with acute flaccid myelitis (AFM). (neurosciencenews.com)

Enterovirus-Cardiomyocyte Interactions: Impact of Terminally Deleted Genomic RNAs on Viral and Host Functions. (uci.edu)
Such regulation may occur through protein-RNA interactions or allosteric RNA-RNA effects between stem-loops on the 5'-UTR. (news-medical.net)
We found that interactions among pentamers in the HPeV-1 capsid are mediated by the N termini of VP0s, which correspond to the capsid protein VP4 and the N-terminal part of the capsid protein VP2 of other picornaviruses. (omicsdi.org)

The protein has been localized to both the cytoplasm and to cellular membranes. (genetex.com)
Post-transcriptional regulation of gene expression: Role of AU-rich Element binding proteins in rotaviral mRNA translation, and cellular RNA splicing and polyadenylation. (edu.in)

By testing ACBD3 and PI4KB mutants that abrogate the ACBD3-PI4KB interaction, we showed that this interaction is crucial for enterovirus replication. (uu.nl)
Our findings open up a possibility for targeting ACBD3 or its interaction with enteroviruses as a novel strategy for the development of broad-spectrum antienteroviral drugs. (uu.nl)
Besides, Protein Disulfide Isomerase A3 (PDIA3) has been identified as an interactor of PSA, thus a binding ELISA assay was conducted to detect the interaction of recombinant human PSA and recombinant human PDIA3. (genetex.com)
CRISPRi genetic interaction analysis revealed Retro-2 activity resembles disruption of the transmembrane domain recognition complex (TRC) pathway, which mediates post-translational ER-targeting and insertion of tail-anchored (TA) proteins, including SNAREs required for retrograde transport. (elifesciences.org)

We took advantage of a strict dependence of enterovirus replication on a host protein GBF1, and established a stable cell line expressing a truncated GBF1 fused to APEX2 peroxidase that effectively supported viral replication upon inhibition of the endogenous GBF1. (bvsalud.org)
RNA metabolism proteins, many of which normally localize in the nucleus, constituted the largest group, underscoring the massive release of nuclear factors into the cytoplasm of infected cells and their involvement in viral replication. (bvsalud.org)

Multiple enterovirus serotypes exist. (cdc.gov)
Predominant serotypes and ranking of individual enteroviruses changed over time. (cdc.gov)

While the genetic and immunological components of disease are not in question, the capacity for EVs to evolve is completely unexplored in the pathogenesis of human T1D. (qscience.com)

Non-polio enteroviruses commonly cause illness such as HFM, herpangina, and conjuncitivitis but can also cause more burdensome conditions, such as aseptic meningitis and myocarditis. (medscape.com)

The architecture of virions is composed of nucleic acid and nucleocapsid protein to form the helical nucleocapsid. (newvita.com)

For all HEV-A sequences, together with sequences from 2 outgroups, shzh00-1 showed possible recombination with CA4 and enterovirus 71A. (cdc.gov)
We confirmed the close relationship of their structural proteins but showed apparent additional recombination events in the 2A gene and 3′UTR of the HRV-Ca strain. (plos.org)

Based on CVA10 replicon RNA, SRIPs with either the enterovirus A71 (EVA71) capsid or the CVA10 capsid were generated. (virosin.org)

CSF and Serum evaluation for herpes zoster enterovirus 71 influenza Ebstein-Barr pathogen and mycoplasma were bad. (cancer-pictures.org)

Western blot analysis was performed as a confirmation test for both expression of NSP4 protein and activation of calcium/calmodulin-dependent kinase II. (ac.ir)
Calcium/calmodulin-dependent protein kinase II: an unforgettable kinase. (ac.ir)
12. Braun AP, Schulman H. The multifunctional calcium/calmodulin-dependent protein kinase: from form to function. (ac.ir)
13. Meyer T, Hanson PI, Stryer L, Schulman H. Calmodulin trapping by calcium-calmodulin-dependent protein kinase. (ac.ir)

There are four structural viral proteins, of which VP1 has been shown to elicit protective immunity in cattle ( Bachrach 1977 ). (wikisource.org)

Among the viral proteins, the polyprotein cleavage intermediates were overrepresented, suggesting that the GBF1 environment is linked to viral polyprotein processing. (bvsalud.org)

IL-1R2 Protein, Human (HEK293) is a recombinant human IL-1R2 protein and is expressed in HEK293 cells. (medchemexpress.com)

The findings provide the clearest evidence to date that AFM is caused by an enterovirus (EV) that invades and impairs the central nervous system. (neurosciencenews.com)

A total of 74 HPeV isolates, 7 non?polio-enteroviruses and 12 HPeV negative cell culture supernatant were used for evaluating the efficiency of the anti-HPeV VP0 antibody. (omicsdi.org)

Oxysterol-binding protein family I is the target of minor enviroxime-like compounds. (microbiologyresearch.org)

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Vaccines1

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Monoclonal antibody2

Molecular2

Rotavirus3

Picornavirus1

Infect1

Specificity1

Membrane2

Virus10

Clinical4

Acute flaccid myelitis1

Interactions3

Cellular2

Interaction4

Viral replication2

Serotypes2

Pathogenesis1

Commonly1

Nucleic acid1

Recombination2

CVA101

Pathogen1

Kinase4

Elicit1

Polyprotein1

Recombinant human1

Impairs1

Isolates1

Family1