• mitogen-activa
  • Isoform 1 modulates the stress response to hypoxia and cytokines, such as interleukin-1 beta (IL1B) and this is dependent on its interaction with MAPK8IP1, which assembles mitogen-activated protein kinase (MAPK) complexes. (uniprot.org)
  • RAF kinases participate in the RAS-RAF-MEK-ERK signal transduction cascade, also referred to as the mitogen-activated protein kinase (MAPK) cascade. (wikipedia.org)
  • The intracellular DORN1 kinase domain is subsequently activated, resulting in several cellular responses such as mitogen-activated protein kinase activation, increased cytosolic calcium concentration and reactive oxygen species (ROS) production, ultimately leading to the induction of defence gene expression. (wikipedia.org)
  • Mitogen-activated protein kinase kinase kinase 8 is an enzyme that in humans is encoded by the MAP3K8 gene. (wikipedia.org)
  • phosphorylate
  • Can also phosphorylate the following substrates that are commonly used to establish in vitro kinase activity: casein, MBP and histone H2B, but it is not sure that this is physiologically relevant (By similarity). (uniprot.org)
  • They observed unique substrate specificity and chromatographic properties of the products of the lipid kinase, leading to the discovery that this phosphoinositide kinase had the unprecedented ability to phosphorylate phosphoinositides on the 3' position of the inositol ring. (wikipedia.org)
  • UniProt
  • p>When browsing through different UniProt proteins, you can use the 'basket' to save them, so that you can back to find or analyse them later. (uniprot.org)
  • regulates
  • Serine/threonine kinase that regulates several signal transduction pathways. (uniprot.org)
  • Regulates centrosome separation (essential for the formation of bipolar spindles and high-fidelity chromosome separation) by phosphorylating centrosomal proteins such as CROCC, CEP250 and NINL, resulting in their displacement from the centrosomes. (uniprot.org)
  • lipid kinase
  • May act by activating the lipid kinase phosphatidylinositol 4-kinase beta (PI4KB) at the TGN for the local synthesis of phosphorylated inositol lipids, which induces a sequential production of DAG, phosphatidic acid (PA) and lyso-PA (LPA) that are necessary for membrane fission and generation of specific transport carriers to the cell surface. (uniprot.org)
  • cytosolic
  • TGF beta receptor 1 has been shown to interact with: Caveolin 1, Endoglin, FKBP1A, FNTA, Heat shock protein 90kDa alpha (cytosolic), member A1 Mothers against decapentaplegic homolog 7, PPP2R2A, STRAP, TGF beta 1, and TGF beta receptor 2. (wikipedia.org)
  • tumor
  • When PKM2 is mainly in the less active dimeric form, which is the case in tumor cells, all glycolytic intermediates above pyruvate kinase accumulate and are channelled into synthetic processes, which branch off from glycolytic intermediates such as nucleic acid-, phospholipid-, and amino acid synthesis. (wikipedia.org)
  • mammalian
  • The mRNA surveillance protein hSMG-1 functions in genotoxic stress response pathways in mammalian cells. (springer.com)
  • It is composed of ataxia telangiectasia mutated (ATM), ataxia telangiectasia and Rad3 related (ATR), DNA-dependent protein kinase (DNA-PK) and mammalian target of rapamycin (mTOR). (wikipedia.org)