• Proto-Oncogene Proteins c-abl" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (jefferson.edu)
  • This graph shows the total number of publications written about "Proto-Oncogene Proteins c-abl" by people in this website by year, and whether "Proto-Oncogene Proteins c-abl" was a major or minor topic of these publications. (jefferson.edu)
  • Below are the most recent publications written about "Proto-Oncogene Proteins c-abl" by people in Profiles. (jefferson.edu)
  • Proto-Oncogene Proteins p21(ras)" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uchicago.edu)
  • Below are the most recent publications written about "Proto-Oncogene Proteins p21(ras)" by people in Profiles. (uchicago.edu)
  • MSH2 Protein LS-G29376 is a Recombinant Human MSH2 produced in Wheat Germ Extract with GST tag(s). (lsbio.com)
  • In yeast the proteins are called MutS homolog 2 (MSH2), MutL homolog (MLH1), and PMS1 which is also a homolog of MutL. (bdbiosciences.com)
  • The MSH2 gene provides instructions for making a protein that plays an essential role in repairing DNA. (medlineplus.gov)
  • The MSH2 protein joins with one of two other proteins, MSH6 or MSH3 (each produced from a different gene), to form a two-protein complex called a dimer. (medlineplus.gov)
  • Another group of proteins, the MLH1-PMS2 dimer, then binds to the MSH2 dimer and repairs the errors by removing the mismatched DNA and replicating a new segment. (medlineplus.gov)
  • MSH2 gene variants result in near or complete loss of MSH2 protein production. (medlineplus.gov)
  • MSH2 gene variants involved in Lynch syndrome may cause the production of an abnormally short or inactive MSH2 protein or prevent the production of any protein from one copy of the gene. (medlineplus.gov)
  • A decrease in functional MSH2 protein leads to an increase in unrepaired DNA errors during cell division. (medlineplus.gov)
  • Because there is some functional MSH2 protein produced from the normal copy of the gene, mismatch repair activity in Lynch syndrome is reduced but not absent, as it is in CMMRD syndrome (described above). (medlineplus.gov)
  • MutS Homolog 2 (MSH2) is a protein involved in the mismatch-repair pathway. (genomeme.ca)
  • Reports have shown Anti-MSH2 to be useful in the detection of the protein in a number of normal and neoplastic tissues, and for identifying a loss of MSH2 in tumours that are microsatellite-unstable. (genomeme.ca)
  • Seven women (5.9%) had a germline mutation: 4 had MLH1 (mutL homolog 1), 2 had MSH6 (mutS homolog 6), and 1 had MSH2 (mutS homolog 2). (mcmaster.ca)
  • 30 µg of 293 cell lysate per lane was probed with 3 µg/ml (lane 1) or 1 µg/ml (lane 2) of anti- MLH1 antibody (clone G168-728). (bdbiosciences.com)
  • The PMS2 protein joins with another protein called MLH1 (produced from the MLH1 gene) to form a two-protein complex called a dimer. (medlineplus.gov)
  • This protein forms heterodimers with the gene product of the mutL homolog 1 (MLH1) gene to form the MutL-alpha heterodimer. (nih.gov)
  • Discordant Mismatch Repair Protein Immunoreactivity in Lynch Syndrome-Associated Neoplasms: ?A Recommendation for Screening Synchronous/Metachronous Neoplasms. (uams.edu)
  • Here, we report positional cloning of Pairing homoeologous 2 (Ph2) and functional validation of the wheat DNA mismatch repair protein MSH7-3D as a key inhibitor of homoeologous recombination, thus solving a half-century-old question. (nature.com)
  • Diabetes mellitus impacts on expression of DNA mismatch repair protein PMS2 and tumor microenvironment in pancreatic ductal adenocarcinoma. (nih.gov)
  • BACKGROUND: Immunohistochemistry (IHC) for mismatch repair protein expression, microsatellite instability (MSI) testing, tumor morphology, and family history were compared to determine which screening strategy is superior in identifying Lynch syndrome (LS) in unselected women with newly diagnosed endometrial cancer (EC) who have undergone universal germline mutation testing. (mcmaster.ca)
  • The human MutS and MutL proteins form heterodimeric complexes that mediate the initial steps of MMR, including the recognition of mismatched base(s) arising from errors in replication, and signaling downstream proteins to facilitate mismatch removal. (elsevierpure.com)
  • With such models, the interactions between genes, proteins or other multiomics data can be captured and studied, and provide valuable insight into their functional relationships. (biomedcentral.com)
  • The resulting hubs (i.e. genes or proteins with a high number of interactions) may again be used to identify central genes, functionally important proteins or pathway initiators, and thus potential drug targets [ 1 ]. (biomedcentral.com)
  • One setting where integrative network analysis has a lot of potential is when there are two types of data, e.g. measured mRNA and protein, associated with the same genes. (biomedcentral.com)
  • They are important post-transcriptional regulators of gene expression in plants, metazoans, and mammals, and are predicted to control the activity of 30% of all protein-coding genes [ 2 ]. (biomedcentral.com)
  • Cellular proteins encoded by the H-ras, K-ras and N-ras genes. (uchicago.edu)
  • Cellular DNA-binding proteins encoded by the rel gene (GENES, REL). (childrensmercy.org)
  • The majority of these cancer cases are caused by mutations in the human homologs of the E. Coli mutS and mutL genes. (elsevierpure.com)
  • CDC28 protein kinase regulatory subunit. (gsea-msigdb.org)
  • Protein kinase Cd and c-Abl kinase are required for transforming growth factor ß induction of endothelial-mesenchymal transition in vitro. (jefferson.edu)
  • Most benefits were demonstrated in cyclin dependent-kinase 12 ( CDK12) mutated cell lines when treated with anti-programmed cell death protein 1 (PD1) therapy. (bjbms.org)
  • Networks may be constructed from data found by high-throughput gene expression profiling technologies, such as microarray or RNA-seq [ 2 ]. (biomedcentral.com)
  • A specific mRNA molecule is transcribed from each gene, which then can be translated into a specific protein. (biomedcentral.com)
  • Thus, each gene is associated with a specific mRNA sequence and protein. (biomedcentral.com)
  • This protein is commonly associated with hereditary non-polyposis colorectal cancer, and mutations in this gene are correlated with the development of sporadic colorectal carcinoma. (genomeme.ca)
  • Target protein expression patterns in kidney development and the early postnatal period observed in this study could indicate that switching between canonical and non-canonical Wnt signaling is crucial for normal nephrogenesis, while the defective Dab1 gene product in yotari mice may promote CAKUT due to interfering with this process. (bvsalud.org)
  • The SET domain containing 2 histone lysine methyltransferase ( SETD2) gene encodes the functional domain of an enzyme that trimethylates histone H3 at lysine 36 (H3K36me3), which mediates MMR in a way that removes lesions associated with a persistently open chromatin structure in early replication, and preferentially safeguards active transcripts during replication by recruiting hMutSa which can quickly identify the mismatch to initiate the MMR reaction [ 15 , 16 ]. (biomedcentral.com)
  • The PMS2 gene provides instructions for making a protein that plays an essential role in repairing DNA. (medlineplus.gov)
  • PMS2 gene variants result in near or complete loss of PMS2 protein production. (medlineplus.gov)
  • PMS2 gene variants involved in this condition lead to the production of an abnormally short or inactive PMS2 protein from one copy of the gene. (medlineplus.gov)
  • The protein encoded by this gene is a key component of the mismatch repair system that functions to correct DNA mismatches and small insertions and deletions that can occur during DNA replication and homologous recombination. (nih.gov)
  • There is a DQHA(X)2E(X)4E motif found at the C-terminus of the protein encoded by this gene that forms part of the active site of the nuclease. (nih.gov)
  • Genomic DNA clone containing exons 2-8 for hMSH3 gene. (riken.jp)
  • of480 bp, orf160 gene was cloned in CMS line, which located in the downstream of atp4 , its N-terminal was homologous with atp6 , and the C-terminal was homologous with nuclear sequence, and encoded 159 amino acids that were homologous with membrane proteins and cell cycle protein. (chinacrops.org)
  • Protein encoded by the bcl-1 gene which plays a critical role in regulating the cell cycle. (nih.gov)
  • Specific molecular therapy can target mutated cell lines in which DNA defect repair is altered, caused by mutations of BRCA2, partner and localizer of BRCA2 (PALB2), and phosphatase and tensin homolog (PTEN) or the transmembrane protease serine 2-ERG (TMPRSS2-ERG) fusion. (bjbms.org)
  • Changes in the redox state of cells affect proteins, lipids, and nucleic acids in different ways. (hindawi.com)
  • Both methods yield antibody in solution that is free of most other soluble proteins, lipids, etc. (bdbiosciences.com)
  • MeSH D12.776.503.280.249.500 - mannose-binding lectin MeSH D12.776.503.280.249.600 - pulmonary surfactant-associated protein a MeSH D12.776.503.280.249.625 - pulmonary surfactant-associated protein d MeSH D12.776.503.499.968.900 - wheat germ agglutinin-horseradish peroxidase conjugate See List of MeSH codes (D12.776.543). (wikipedia.org)
  • According to the global cancer database (GLOBOCAN), 34650951 cases of breast cancer were detected in the world in 2020, and 11210413 patients died from this disease [1, 2]. (cttjournal.com)
  • This complex coordinates the activities of other proteins that repair errors made during DNA replication. (medlineplus.gov)
  • The altered protein cannot efficiently repair errors made during DNA replication. (medlineplus.gov)
  • The proteins have GTPase activity and are involved in signal transduction as monomeric GTP-binding proteins. (uchicago.edu)
  • This study aims to determine the protein expression patterns of acetylated α-tubulin, inversin, dishevelled-1, Wnt5a/b, and ß-catenin in developing (E13.5 and E15.5) and early postnatal (P4 and P14) kidneys of Dab1-/- (yotari) mice, their role in regulating the Wnt signaling pathway, and the possible relation to congenital anomalies of kidney and urinary tract (CAKUT). (bvsalud.org)
  • This protein helps fix errors that are made when DNA is copied (DNA replication) in preparation for cell division. (medlineplus.gov)
  • A shortage of this protein eliminates mismatch repair activity and prevents the proper repair of DNA replication errors. (medlineplus.gov)
  • erythrocyte membrane protein band 4.1 l. (gsea-msigdb.org)
  • The purpose of this study was to compare the immunofluorescence patterns of autophagic markers: Light chain 3 beta (LC3B), Glucose regulating protein 78 (GRP78), Heat shock cognate 71 (HSC70) and Lysosomal-associated membrane protein 2A (LAMP2A) in the developing and postnatal kidneys of Dab1-/- (yotari) mice to those of wild-type samples. (bvsalud.org)
  • Wongsurawat T, Jenjaroenpun P, De Loose A, Alkam D, Ussery DW, Nookaew I, Leung YK, Ho SM, Day JD, Rodriguez A. A novel Cas9-targeted long-read assay for simultaneous detection of IDH1/2 mutations and clinically relevant MGMT methylation in fresh biopsies of diffuse glioma. (uams.edu)
  • ZIP4 is a ZMM protein involved in homologous recombination and may act as a hub through physical interactions with components of the chromosome axis and other ZMMs 19 . (nature.com)
  • Desmoplastic infantile ganglioglioma (DIG), is a rare tumor arising mainly during the first 2 years of life. (frontiersin.org)
  • Its ability to ubiquitinate p53 is regulated by TUMOR SUPPRESSOR PROTEIN P14ARF. (umassmed.edu)
  • The MutL-alpha heterodimer possesses an endonucleolytic activity that is activated following recognition of mismatches and insertion/deletion loops by the MutS-alpha and MutS-beta heterodimers, and is necessary for removal of the mismatched DNA. (nih.gov)
  • In a normally diploid cell (DIPLOIDY) the loss of a chromosome pair is termed nullisomy (symbol: 2N-2), the loss of a single chromosome is MONOSOMY (symbol: 2N-1), the addition of a chromosome pair is tetrasomy (symbol: 2N+2), the addition of a single chromosome is TRISOMY (symbol: 2N+1). (lookformedical.com)
  • Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A. Therefore, proteins with higher identification numbers were more conserved. (evpedia.info)
  • Immunoglobulin J Recombination Signal Sequence-Binding Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
  • Factor For Inversion Stimulation Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (childrensmercy.org)
  • In addition, survival analysis revealed that SKCM patients with low transcriptional levels of E2F1/2/3/6 were associated with a significantly better prognosis. (fortunepublish.com)
  • The index is based on the integration of public transcript, protein, and mapping information, supplemented with computational prediction. (biomedcentral.com)
  • With our method, mRNA data are demonstrated to provide highly useful prior information for protein-protein interaction networks. (biomedcentral.com)
  • Consequently, the recruitment of immune cells during chronic inflammation increases oxidative stress (OS) in the microenvironment [ 2 ]. (hindawi.com)
  • HMGB1 is an abundant protein, 10 6 molecules per cell [ 7 ], which has been postulated as a redox sensor [ 8 ]. (hindawi.com)
  • A highly abundant DNA binding protein whose expression is strongly correlated with the growth phase of bacteria. (childrensmercy.org)
  • 7) nuclear protein reflecting the level of proliferative activity (Ki-67) [4, 5]. (cttjournal.com)
  • This review describes recent advances in the role of human HMGB proteins and other proteins interacting with them, in cancerous processes related to oxidative stress, with special reference to ovarian and prostate cancer. (hindawi.com)
  • Full-length human recombinant MLH was expressed as a maltose binding-MLH fusion protein, affinity purified, and used as immunogen. (bdbiosciences.com)
  • Two outbreaks of human S. suis disease have occurred in a relatively large collection of US and Canadian S. suis serotype 2 strains. (cdc.gov)
  • 12 human S. suis serotype 2 strains isolated in Thailand 1088563. (cdc.gov)
  • RESULTS: Our results showed that astragaloside IV significantly improved AOM/DSS-induced CAC mice by inhibiting colonic shortening, preventing intestinal mucosal damage, reducing the number of tumors and, the expression of Ki67 protein. (bvsalud.org)
  • Similarly, 17% of right colon, 2% of left colon, and 2% of rectal tumors were BRAF mutant. (ox.ac.uk)
  • In the past decade, the use of immune checkpoint inhibitors (ICIs) has revolutionized the treatment of a variety of tumors, including lung cancer, melanoma, colorectal cancer, and renal cell carcinoma [ 1 , 2 ]. (biomedcentral.com)
  • While there is some controversy surrounding recent research that claims that miR-155 may display anti-oncogenic or pro-immunological benefits (Cell Rep 2:1697-1709, 2012), most research seems to point to the importance of anti-miRs, with anti-miR-155 in particular, for cancer therapy. (biomedcentral.com)
  • The emergence of immune checkpoint blockade (ICB) therapy that targets programmed cell death protein 1/programmed cell death ligand 1 (PD-1/PD-L1) or anti-cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) has markedly revolutionized the therapeutic landscape of patients with metastatic cancers [ 1 , 2 ]. (biomedcentral.com)