• Identification
  • The modern techniques of molecular biology were principally responsible for their complete identification and as a consequence, several hundred cytokine proteins and genes have been identified, and the process still continues. (sinobiological.com)
  • molecular
  • Among these signals, small molecular weight chemoattractant proteins known as chemokines are potentially important contributors as they participate in both directing leukocyte migration and function. (frontiersin.org)
  • Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд. (wikipedia.org)
  • Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд. (wikipedia.org)
  • signals
  • The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormones, neurotransmitters, and light receptors, all of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. (wikipedia.org)
  • Multiple signals regulate the expression of cytokine receptors. (sinobiological.com)
  • binds
  • It binds to IL8 with high affinity, and transduces the signal through a G-protein-activated second messenger system. (wikipedia.org)
  • sequence
  • GPCRs are usually described as "superfamily" because they embrace a group of families for which there are indications of evolutionary relationship, but between which there is no statistically significant similarity in sequence. (wikipedia.org)
  • variants
  • Other splice variants, including one encoding a soluble form of the protein (GHRtr), have been observed but have not been thoroughly characterized. (wikipedia.org)
  • mice
  • Knockout studies in mice suggested that this protein inhibits embryonic oligodendrocyte precursor migration in developing spinal cord. (wikipedia.org)
  • type
  • Contains 1 to 3 copies of the Fibronectin type III domain (Pfam:PF00041) followed by two copies of the Protein-tyrosine phosphatase (Pfam:PF00102) domain. (githubusercontent.com)