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  • sequence
  • GPCRs are usually described as "superfamily" because they embrace a group of families for which there are indications of evolutionary relationship, but between which there is no statistically significant similarity in sequence. (wikipedia.org)
  • signals
  • The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormones, neurotransmitters, and light receptors, all of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. (wikipedia.org)
  • novel
  • Novel research has identified a microRNA that is able to downregulate CCR6 in cancer cell lines. (wikipedia.org)
  • variants
  • Alternatively spliced transcript variants that encode the same protein have been described for this gene. (wikipedia.org)
  • Other splice variants, including one encoding a soluble form of the protein (GHRtr), have been observed but have not been thoroughly characterized. (wikipedia.org)
  • mice
  • Knockout studies in mice suggested that this protein inhibits embryonic oligodendrocyte precursor migration in developing spinal cord. (wikipedia.org)
  • type
  • Contains 1 to 3 copies of the Fibronectin type III domain (Pfam:PF00041) followed by two copies of the Protein-tyrosine phosphatase (Pfam:PF00102) domain. (githubusercontent.com)
  • Antibody
  • This approach is versatile and applicable to other membrane proteins such as ATP binding cassette (ABC) transporters and has been adapted into an antibody screening platform. (ubc.ca)
  • molecular weight
  • These factors represent a family of low molecular weight secreted proteins that primarily function in the activation and migration of leukocytes although some of them also possess a variety of other functions. (sinobiological.com)
  • Among these signals, small molecular weight chemoattractant proteins known as chemokines are potentially important contributors as they participate in both directing leukocyte migration and function. (frontiersin.org)
  • responses
  • Binding of chemokines to this protein induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration. (genecards.org)
  • novel
  • Novel research has identified a microRNA that is able to downregulate CCR6 in cancer cell lines. (wikipedia.org)
  • inflammatory
  • Chemokines have conserved cysteine residues that allow them to be assigned to four groups: C-C chemokines (RANTES, monocyte chemoattractant protein or MCP-1, monocyte inflammatory protein or MIP-1α, and MIP-1β), C-X-C chemokines (IL-8 also called growth related oncogene or GRO/KC), C chemokines (lymphotactin), and CXXXC chemokines (fractalkine). (sinobiological.com)
  • binds
  • It binds to IL8 with high affinity, and transduces the signal through a G-protein-activated second messenger system. (wikipedia.org)
  • migration
  • Knockout studies in mice suggested that this protein inhibits embryonic oligodendrocyte precursor migration in developing spinal cord. (wikipedia.org)
  • high
  • Structural studies are challenged by the intrinsic difficulty associated with purifying these receptors in high quality and quantity. (ubc.ca)
  • type
  • Contains 1 to 3 copies of the Fibronectin type III domain (Pfam:PF00041) followed by two copies of the Protein-tyrosine phosphatase (Pfam:PF00102) domain. (githubusercontent.com)