Protein bound polysaccharide polysaccharides. Medical search. Frequent questions

PSK is a protein polysaccharide consisting of a beta-glucan β-1,4 main chain with β-1,3 and β-1,6 side chains. (wikipedia.org)
Maitake is a rich source of beta-glucan, a long chain polysaccharide known for its ability to support immune defenses. (vitacart.com)

Polysaccharide-K (Krestin, PSK) is a protein-bound polysaccharide isolated from the mycelium of Trametes versicolor. (wikipedia.org)
PSK), also known as krestin, is a unique protein-bound polysaccharide, which has been used as a chemoimmunotherapy agent in the treatment of cancer in Asia for over 30 years. (nih.gov)

PSK and Polysaccharopeptide (PSP) are both protein-bound polysaccharides which are derived from the CM-101 and COV-1 strains of the fungus Coriolus versicolor by Japanese and Chinese researchers, respectively. (nih.gov)

Both polysaccharide preparations have documented anticancer activity in vitro, in vivo and in human clinical trials, though PSK has been researched longer and has therefore undergone more thorough laboratory, animal and clinical testing. (nih.gov)

Recent studies showed that a subset of polysaccharides could protect neurons from the oxidative insults of free reactive radicals and amyloid peptide, raising the possibility of their use for the treatment of neurodegenerative diseases. (neurodegenerationresearch.eu)
This depends, in turn, upon whether specific active peptide sequences in specific proteins are accessible to arriving cells such as neutrophils and macrophages. (nanomedicine.com)
This method was simple and inexpensive, but suffered from limited stability of the protein layer owing to exchange with other proteins in solution via the Vroman effect, and also from presentation of biologically active peptide sequences [ 1443 ]. (nanomedicine.com)

Higher selectivity of binding is achieved by extending binding sites through additional direct and water-mediated contacts between oligosaccharides and the protein surface. (embl.de)
This work lays a solid foundation for the automated analysis of heterogeneous mixtures of natural glycans, such as LMWHs and other complex oligosaccharides and polysaccharides. (bvsalud.org)

Current pneumococcal vaccines use the pneumococcal capsular polysaccharides as antigens to generate serotype-specific antibodies, which facilitate serotype-specific clearance of pneumococci through opsonophagocytosis ( 4 ). (cdc.gov)
Bacteriophage tailspikes and bacterial O-antigens as a model system to study weak-affinity protein-polysaccharide interactions. (mpg.de)

Increasing the affinity of an O-antigen polysaccharide binding site in Shigella flexneri bacteriophage Sf6 tailspike protein. (mpg.de)
Early-arriving proteins may be partially or wholly displaced by later-arriving proteins that have a greater affinity for the particular surface, a phenomenon widely known as the Vroman effect [ 950 , 1442 ]. (nanomedicine.com)
If nanorobots have a higher affinity for protein binding sites than certain drugs used in concert with the nanorobots during a nanomedical treatment, then those drugs could be displaced, consequently increasing the number of biologically active drug molecules and increasing the risk of toxic drug levels [ 5489 ]. (nanomedicine.com)
Relatively low affinity binding sites for monosaccharides are formed at shallow indentations on protein surfaces. (embl.de)

Up until current years, researcher had put all polysaccharides together with other carbohydrates such as starches and sugars. (slideshare.net)
For structural analysis of asparagine-linked carbohydrates, sugars are released from the protein backbone by enzymes such as PNGase F ( NEB #P0704 ). (neb.com)
Milk proteins are often used as emulsifiers (agents that can help prevent oil and water from separating) whereas polysaccharides (long chains of carbohydrates), are used as thickeners and gelling agents in a variety of food products ranging from mayonnaise to ice cream. (usda.gov)

2005) In children with acute lymphoblastic leukemia who received high-dose methotrexate, oxidative damage to proteins as well as other factors was related to toxic side effects. (pinestreetfoundation.org)

Both of these showed the presence of multiple 6 carbohydrate binding modules (CBM6) with Aga16B having two homologs of CBM6 and Aga86E having three (2). (kenyon.edu)
Many of these domains function as calcium-dependent carbohydrate binding modules. (embl.de)

Glycosylation defines the adhesive properties of glycoconjugates and it is largely through glycan-protein interactions that cell- cell and cell-pathogen contacts occur, a fact that highlights the importance of glycobiology. (neb.com)
The non-specific adsorption of blood proteins on nanorobot surfaces could lead to clinical difficulties such as thrombosis and unwanted protein-mediated recognition interactions such as cell-nanorobot and nanorobot-nanorobot adhesion (aggregation). (nanomedicine.com)
The analysis of these results, in terms of a statistical-mechanical model that incorporates polymer flexibility as well as the excluded volume of the protein, shows that the dramatic enhancement of bovine pancreatic trypsin inhibitor self-association can be quantitatively rationalized in terms of hard repulsive interactions. (lu.se)

Whereas theoretical predictions of macromolec- use of nonadsorbing polymers, like polyethylene glycol, for ular crowding effects abound, there are remarkably few protein separation (Albertsson, 1986) and crystallization experimental studies of this universal phenomenon. (lu.se)

Studies reveal, for the highest biological activity, all polysaccharides should be present. (slideshare.net)
Proteomics, the systematic study of proteins in biological systems, has expanded the knowledge of protein expression, modification, interaction and function. (neb.com)
Further determination of the mechanisms of these anti-cancer, immunostimulating and biological response modifying effects of PSK as well as of other protein-bound polysaccharides is certainly warranted. (nih.gov)
A variety of local and systemic cellular processes may be triggered depending upon which proteins are adsorbed to the surface (e.g., as opsonins) and their biological activity. (nanomedicine.com)
Cell adhesion, thrombogenicity, foreign body response and other reactions to implanted materials are related to the amount of adsorbed proteins, hence as an implanted object shrinks to smaller sizes (i.e., to micron-scale) the biological signal to local cell populations can increase enormously because the total amount of protein adsorbed on the implant mass is much greater. (nanomedicine.com)
provided a biological motivation for studying the effects of This task is further complicated by the background of abun- nominally inert background macromolecules on protein as- dant macromolecular crowding agent. (lu.se)

Conformational insights into recognition mechanism of O-antigen polysaccharides by tailspike protein. (mpg.de)
With many hundreds of plasma proteins (the predominant plasma protein is albumin) to choose from, unmodified implanted devices may quickly adsorb a monolayer containing many proteins in a distribution of conformational and orientational states. (nanomedicine.com)

Study strongly suggests that goji's distinct polysaccharides work in the body as directors and carriers of cell details and for that reason command and control numerous of the body's biochemical defense systems. (slideshare.net)
We also found that midi-GAGR strongly bound to fibroblast growth factor receptor 1 (FGFR1), a known neurotrophic receptor. (neurodegenerationresearch.eu)
In the presence of high concentrations of inert macromolecules, the self-association of proteins is strongly enhanced through an entropic, excluded-volume effect variously called macromolecular crowding or depletion attraction. (lu.se)

Much of the research that has been done on PSK is outlined in this paper and may serve as a foundation toward determining the mechanisms of action of this and other protein-bound polysaccharides in the treatment of cancer. (nih.gov)
Mechanisms for sugar recognition have evolved independently in diverse protein structural frameworks, but share some key features. (embl.de)

N -linked glycosylation occurs when glycans are attached to asparagine residues on the protein. (neb.com)

Note also that the amount of serum protein adsorbed on a nanorobot surface [ 24 ] varies inversely with nanorobot size for a constant mass, volume, or dosage of implanted medical nanomachinery. (nanomedicine.com)
One early strategy to try to accomplish this in implants was to coat the artificial surface with an adsorbed protein, usually bovine serum albumin (BSA) or high-density lipoproteins, to serve as cell adhesion inhibiting proteins that would resist the adsorption of other proteins. (nanomedicine.com)
Neisseria meningitidis employs polysaccharides and outer membrane proteins to cope with human serum complement attack. (uni-wuerzburg.de)

PNGase F hydrolyzes nearly all types of N-glycan chains from glycopeptides/ proteins. (neb.com)

secondarily, we assayed their adjuvant effect in combination with a known furin inhibitor, CMK, which avoids the SARS-CoV-2 S protein cleavage by means of that inhibition. (bvsalud.org)

Complex carbohydrate recognition by proteins: fundamental insights from bacteriophage cell adhesion systems. (mpg.de)

Researchers tested goji berry samples searching for polysaccharide material. (slideshare.net)

LBP polysaccharides showed to have exceptional sources of the necessary cell sugars (glycoconjugates), rhamnose, xylose, sugar, mannose, arabinose and galactose- that are necessary for appropriate immune function and cells to interact. (slideshare.net)

Research on the interaction between a whey protein, one of the major milk proteins, and sugar beet pectin, one of the most versatile polysaccharides, demonstrated that pre-heating the protein and pectin separately before combining is a good way to facilitate binding between the two biopolymers. (usda.gov)
This study helped to advance our understanding of the interaction between milk proteins and pectin, which can be beneficial to improve foods and beverages and design new ones. (usda.gov)

The screening used a genetically modified sequence type (ST)-41/44 clonal complex (cc) strain lacking LPS sialylation, polysaccharide capsule, the factor H binding protein (fHbp) and MutS, a protein of the DNA repair mechanism. (uni-wuerzburg.de)

Solvent networks tune thermodynamics of oligosaccharide complex formation in an extended protein binding site. (mpg.de)
Opc expression was associated with vitronectin binding and reduced membrane attack complex deposition confirming recent observations. (uni-wuerzburg.de)

Addition of inert macromolecules to a protein solution quantitatively the self-association of bovine pancreatic shifts equilibria toward the more compact state because this trypsin inhibitor (BPTI) (Gottschalk et al. (lu.se)

Cantonnés aux rôles structural et de soutien, les polysaccharides ont gagné depuis peu leur place dans le concert des acteurs biomoléculaires (protéines, acides nucléiques) du Vivant, soulevant toutes une séries de questions sur les bases structurales et les mécanismes moléculaires à l'origine de leurs propriétés fonctionnelles. (hal.science)
AXE STRUCTURAL**- Le progrès des connaissances dans ce domaine nécessite de lever des verrous analytiques en particulier pour la caractérisation structurale et le séquençage de séquences glucidiques bioactives, dont les méthodes font aujourd'hui encore défaut. (hal.science)
When examined from the viewpoint of the bound sugar, the structural information accumulated so far on lectins and other proteins that are specific to galactose and glucose (or mannose), provides suggestive evidence for distinct ligand-dependent distribution of hydrogen-bond partners in the combining site. (embl.de)

The approximate molecular weight of PSK is 100,000 Da, and the protein component is reported at the β-1,6 side chain. (wikipedia.org)
Coarse-grained molecular model for the glycosylphosphatidylinositol anchor with and without protein. (mpg.de)

Maitake is a rich source of polysaccharides - compounds found in some plants that are increasingly recognized for their ability to support the body's immune defenses. (vitacart.com)

More recently, the realization that macro- principal experimental challenge is to resolve and quantify molecules occupy 20-30% of the intracellular volume has populations of protein oligomers in dynamic equilibrium. (lu.se)

A transformation study confirmed that penicillin-binding protein (PBP) 2b was the primary meropenem resistance determinant, and PBP1a was essential for high-level resistance. (cdc.gov)

Each of the 4 main polysaccharides has their own unique benefit. (slideshare.net)
Goji Berries And Starch Each of the 4 main polysaccharides has their own unique benefit. (slideshare.net)
Sea vegetables also contain a unique group of polysaccharides called fucoidans. (naturalnews.com)

As originally described by Lancefield, beta-hemolytic streptococci can be divided into many groups based on the antigenic differences in group-specific polysaccharides located in the bacterial cell wall. (medscape.com)
An AMC is a legally-binding agreement for an amount of funds to subsidize the purchase, at a given price, of an as yet unavailable vaccine against a specific disease causing high morbidity and mortality in low-income countries. (who.int)

Meropenem resistance seen in the S. pneumoniae 15A-ST63 clone in Japan was thought to be due to acquisition of penicillin-binding protein (PBP) 1a (type 13) via recombination with a formerly predominant global serotype 19A-ST320 vaccine strain ( 3 ). (cdc.gov)

Various hydrophilic adsorbed coatings have been attached to artificial surfaces to make them more protein-resistant, in effect "passivating" them against protein adsorption and greatly reducing or preventing cell adhesion to biomedical implants [ 754 ]. (nanomedicine.com)

Lectins are a diverse group of proteins, both in terms of structure and activity. (embl.de)
Carbohydrate binding ability may have evolved independently and sporadically in numerous unrelated families, where each evolved a structure that was conserved to fulfil some other activity and function. (embl.de)

Pneumococci are classified into serotypes depending on their capsular polysaccharide, which is a main virulence factor for pneumococcus ( 4 ). (cdc.gov)

American Cancer Society's page for Trametes versicolor and Polysaccharide-K. Memorial Sloan-Kettering Cancer Center's page for Trametes versicolor and Polysaccharide-K. A "Detailed Scientific Review of Trametes versicolor and Polysaccharide-K" by the MD Anderson Cancer Center. (wikipedia.org)

When we consume plants that are rich in polysaccharides, these protective results are bestowed upon us. (slideshare.net)

Selectins are glycoproteins (sugar-protein molecules) that are often used to signal inflammatory processes in the body. (naturalnews.com)
There are proteins with modules similar in overall structure to CRDs that serve functions other than sugar binding. (embl.de)

4 primary bioactive polysaccharides were discovered in Lycium Barbarum (Latin name for goji) named LBP (Lycium Barbarum polysaccharides). (slideshare.net)
it enhanced neurite outgrowth and increased phosphorylated cAMP-responsive element binding protein (pCREB) in the nuclei of primary cortical neurons. (neurodegenerationresearch.eu)

Here, we introduce a powerful new technique, fast field-cycling magnetic relaxation dispersion, for investigating crowding effects on protein self-association equilibria. (lu.se)

Structure binding relationship of human surfactant protein D and various lipopolysaccharide inner core structures. (mpg.de)

Trametes versicolor and Polysaccharide-K information from Drugs.com. (wikipedia.org)
M. Sprintz notes that the binding of plasma proteins has relevance to the displacement of other highly protein-bound drugs, such as phenytoin (Dilantin), barbiturates, propranolol, and benzodiazepines. (nanomedicine.com)

These sulfated polysaccharides are also revered for their powerful ability to reduce blood clots. (naturalnews.com)

The complete taxonomic breakdown of all proteins with CLECT domain is also avaliable . (embl.de)

These sulfated polysaccharides have also been shown to block the typical binding sites for many viruses such as Herpes. (naturalnews.com)
By blocking binding sites the virus is unable to replicate. (naturalnews.com)

Taxonomic distribution of proteins containing CLECT domain. (embl.de)

Celle que nous développons avec le marquage résolu en temps par rayonnement synchrotron et analyse MS permet de cartographier finement la surface protéique exposée au solvant et d'identifier sur la protéine en solution les domaines impliqués dans la liaison du ligand oligosaccharidique \[*[J. Synchr. (hal.science)

There are 74207 CLECT domains in 53821 proteins in SMART's nrdb database. (embl.de)

Anatomy7

Organisms41

Diseases6

Chemicals and Drugs116

Analytical, Diagnostic and Therapeutic Techniques and Equipment37

Phenomena and Processes45

Disciplines and Occupations3

Technology, Industry, Agriculture1

Information Science4

Health Care3

Beta-glucan2

Krestin2

Coriolus1

Anticancer1

Peptide3

Oligosaccharides2

Antigens2

Affinity4

Carbohydrates3

Oxidative1

Carbohydrate binding2

Interactions3

Polymers1

Biological6

Conformational2

Strongly3

Mechanisms2

Glycans1

Serum3

Chains1

Cleavage1

Recognition1

Researchers1

Sugars1

Interaction2

Mechanism1

Complex2

Bovine1

Structural3

Molecular2

Found1

Populations1

Study1

Unique3

Specific2

Strain1

Surfaces1

Activity2

Main1

Cancer1

Rich1

Sugar2

Primary2

Effects1

Human1

Drugs2

Ability1

Complete1

Sites2

Distribution1

Solution1

Database1