• anticoagulant
  • The main form of C4BP in human blood is composed of 7 identical alpha-chains and one unique beta-chain, which in turn binds anticoagulant, vitamin K-dependent protein S. C4BP is a large glycoprotein (500 kDa) with an estimated plasma concentration of 200 micrograms/mL synthesized mainly in the liver. (wikipedia.org)
  • regulatory
  • X-ray crystallography of Sterol Regulatory Element Binding Protein 1A with polydeoxyribonucleotide. (wikipedia.org)
  • These activated SREBPs then bind to specific sterol regulatory element DNA sequences, thus upregulating the synthesis of enzymes involved in sterol biosynthesis. (wikipedia.org)
  • These proteins work with asymmetric sterol regulatory element (StRE). (wikipedia.org)
  • Once in the nucleus, SREBP can bind to specific DNA sequences (the sterol regulatory elements or SREs) that are found in the control regions of the genes that encode enzymes needed to make lipids. (wikipedia.org)
  • regulation
  • Current research suggests that the protein is associated with regulation of the GH supply in the circulatory system as well as GH receptor function. (wikipedia.org)
  • Regions
  • The CREB protein carries out its function by activating transcription, where interaction with transcription factors is managed by one or more CREB domains: the nuclear receptor interaction domain (RID), the KIX domain (CREB and MYB interaction domain), the cysteine/histidine regions (TAZ1/CH1 and TAZ2/CH3) and the interferon response binding domain (IBiD). (wikipedia.org)
  • fatty
  • SREB proteins are indirectly required for cholesterol biosynthesis and for uptake and fatty acid biosynthesis. (wikipedia.org)
  • structures
  • This book is a passionate account of the scientific breakthroughs that led to the solution of the first protein structures and to the understanding of their function at atomic resolution. (wisepress.com)
  • where it "could be employed during the hit-to-lead optimization stages of drug discovery to refine lead compound structures to meet the desired plasma protein binding and pharmacokinetics profile," the team declared. (separationsnow.com)
  • drugs
  • Basic drugs will bind to the acidic alpha-1 acid glycoprotein. (wikipedia.org)
  • For example, assume that Drug A and Drug B are both protein-bound drugs. (wikipedia.org)
  • When two, highly protein-bound drugs (A and B) are added into the same biological system it will lead to an initial small increase in the concentration of free drug A (as drug B ejects some of the drug A from its proteins). (wikipedia.org)
  • complexes
  • He produced crystals of concanavalin A complexes with methyl-glucoside and with methyl-mannoside and participated in solving the structure of this protein binding-site for saccharides. (wisepress.com)
  • In mammalian cells, some ORPs function as sterol sensors that regulate the assembly of protein complexes in response to changes in cholesterol levels. (wikipedia.org)
  • In mammalian, ORPs participate as sterol sensors.This sensors regulate the assembly of protein complexes when cholesterol levels fluctuate. (wikipedia.org)
  • TIN2, RAP1, TPP1 are adaptor proteins influencing signalling complexes. (wikipedia.org)
  • molecular
  • Due to the extremely small cross section of the conductive path (50 nm x 50 nm), changes close to the surface significantly affect the apparent conduction in the semicircle and can be monitored electronically to determine the occurrence of molecular binding events. (nsti.org)
  • complex
  • This region modulates the DNA binding activity of the C-terminus, and modulation of DNA-binding affects the rate of transcription complex formation and initiation of transcription. (wikipedia.org)
  • TFIID is the first protein to bind to DNA during the formation of the pre-initiation transcription complex of RNA polymerase II (RNA Pol II). (wikipedia.org)
  • complement
  • The interaction with apoptotic and necrotic cells is mediated by the Gla domain of protein S and does not affect the ability of C4BP to inhibit complement. (wikipedia.org)
  • residues
  • The mature protein comprises around 165 residues, and contains a number of potential N-glycosylation sites. (wikipedia.org)
  • TBP binds with the negatively charged phosphates in the DNA backbone through positively charged lysine and arginine amino acid residues. (wikipedia.org)
  • sequences
  • There include: TRF1 TRF2 POT1 TIN2 RAP1 TPP1 Both TRF1 and TRF2 bind the telomeric repeat sequences in the duplex region of the genome in vivo. (wikipedia.org)
  • amino
  • Reference amino acid composition of globular proteins. (plos.org)
  • When the cysteine amino acids in GHBP are mutated and the disulfide bridges are disrupted, the stability of the ligand to bind to the active site of the GHBP is significantly lessened. (wikipedia.org)
  • When TBP binds to a TATA box within the DNA, it distorts the DNA by inserting amino acid side-chains between base pairs, partially unwinding the helix, and doubly kinking it. (wikipedia.org)
  • concentration
  • The initial ligand concentration also determines the probability of binding since it allows for more ligand to be bound to the protein binding sites. (physicsforums.com)
  • The scatchard equation is (r/c) = Ka*n - Ka*r, where r is the ratio of the concentration of bound ligand to total available binding sites, c is the concentration of free ligand, Ka is the association constant, and n is the number of binding sites per protein, right? (physicsforums.com)
  • So through this I could find the ratio of bound ligand to total available binding sites under the given ligand concentration and Kd (the inverse would be Ka). (physicsforums.com)
  • These findings reveal the binding partners for ertapenem but do not show which proteins are the major factors that trap the antibiotic and reduce the free drug concentration. (separationsnow.com)
  • Most of the individual proteins were responsible for a 2-4-fold rise in the minimum inhibitory concentration (MIC) of ertapenem. (separationsnow.com)