Protein receptor hyperlipidemias. Medical search. Frequent questions

Effect of hyperglycemia and hyperlipidemia on atherosclerosis in LDL receptor-deficient mice: establishment of a combined model and association with heat shock protein 65 immunity. (diabetesjournals.org)
In the current study, we established a model combining hyperglycemia with hyperlipidemia in LDL receptor-deficient (LDL-RD) mice and assessed its possible influences on lipid profile, HSP60/65, and atherogenesis. (diabetesjournals.org)
In conclusion, we have established a mouse model that combines hyperglycemia with diet-induced hyperlipidemia in LDL-RD mice and studied its effect on atherosclerosis progression. (diabetesjournals.org)
Hyperglycemia, hyperlipidemia, and insulin resistance are major inducers of the chronic low-grade inflammatory state that characterizes the diabetic heart. (hindawi.com)
These findings show that CIG can improve the hyperglycemia and hyperlipidemia of HFD-STZ-induced diabetic mice through the PI3K-Akt/PKB signaling pathway, and CIG might be a potential medicine or functional food for type 2 diabetes mellitus remedies. (rsc.org)
The incidence of diabetes mellitus or atherosclerotic cardiovascular disease is increased secondary to hyperglycemia (from insulin resistance) or hyperlipidemia, respectively. (medscape.com)

However, metabolic dysregulated factors such as peroxisome proliferator-activated receptors and sirtuins may serve as therapeutic targets to control this response by mitigating both Toll-like receptors and inflammasome signaling. (hindawi.com)
Moreover, YSY inhibited adipocyte differentiation by suppressing peroxisome proliferator-activated receptor gamma (PPAR-γ) and CCAAT/enhancer-binding proteins (C/EBPs). (tmu.edu.tw)
In recent posts we have looked at PPARα ( Peroxisome proliferator-activated receptor alpha) and PEA ( Palmitoylethanolamide) , which activates it. (epiphanyasd.com)
Peroxisome Profilerator-Activated Receptors (PPARs) are nuclear hormone receptors that belong to the steroid/ thyroid /retinoid superfamily of receptors (Keller et al. (bodybuilding.com)
The protein encoded by this gene is a nuclear transcriptional co-activator for peroxisome proliferator activated receptor alpha. (utsouthwestern.edu)
The encoded protein contains a zinc finger and is a helicase that appears to be part of the peroxisome proliferator activated receptor alpha interacting complex. (utsouthwestern.edu)

PIs also have a high affinity for the catalytic site of HIV-1 protease, which shares a 60% sequence homology with 2 proteins involved in lipid metabolism, cytoplasmic retinoic acid-binding protein type 1 (CRABP-1), and low-density lipoprotein receptor-related protein (LDLR-RP). (medscape.com)
In particular, her research focuses on the signaling pathways induced by low-density lipoprotein receptor-related protein 1 (LRP1) and bone morphogenetic protein (BMP), to develop treatments for vascular-associated conditions. (bcm.edu)

Familial combined hyperlipidemia (FCHL) is a common, atherogenic lipid disorder characterized by a variable phenotypic expression of hyperlipidemia. (univaq.it)
Mateo-Gallego R, Calmarza P, Jarauta E, Burillo E, Cenarro A and Civeira F (2010) Serum ferritin is a major determinant of lipid phenotype in familial combined hyperlipidemia and familial hypertriglyceridemia. (scielo.br)

His research uses animal models of disease in which molecules of interest have been ablated in specific tissues/cells, as well as human subjects and tissues, to evaluate the effects of hyperlipidemia and obesity on monocyte/macrophage phenotypes and their contributions to atherosclerosis and inflammation, with the goal of determining causal links between inflammation and metabolic dysfunctions, to identify novel therapeutic targets for patients with insulin resistance, diabetes, and atherosclerosis. (bcm.edu)

Whether YSY is a potential adjuvant intervention for reducing hyperlipidaemia, atherogenesis, or obesity is unclear. (tmu.edu.tw)
This study evaluated the inhibitory effects and mechanisms of YSY for hyperlipidaemia, atherogenesis, and obesity. (tmu.edu.tw)
Our findings suggest that YSY is an adjuvant intervention for treating and preventing hyperlipidaemia, atherogenesis, and obesity. (tmu.edu.tw)
Her research uses multidisciplinary approaches to examine how risk factors such as inflammation, obesity, and hypertension modify the function of cardiac ion channels and calcium handling proteins via transcriptional or post-transcriptional mechanisms, with the goal of elucidating the mechanistic link between risk factors and the pathophysiology of cardiac arrhythmias, to develop novel therapeutic targets for arrhythmic patients. (bcm.edu)
Hyperlipidemia, characterized by the abnormal blood lipid profiles, is one of the dominant factors of many chronic diseases such as diabetes, obesity, and cardiovascular diseases (CVD). (hindawi.com)
Apart from CVD, hyperlipidemia is also closely associated with diabetes, insulin resistance, and obesity [ 10 ]. (hindawi.com)

6 There are also rare forms of FH that result from mutations in genes for apolipoprotein B-100 (ApoB), proprotein convertase subtilisin/kexin type 9 (PCSK9), 8 and the low-density lipoprotein receptor adaptor protein 1 (LDLRAP1), which causes a rare form of autosomal recessive FH. (acc.org)
Autosomal recessive hypercholesterolemia caused by mutations in a putative LDL receptor adaptor protein. (medscape.com)

3 Building on this work in 1973, Goldstein and Brown characterized the low-density lipoprotein receptor (LDLR) and related the phenotype of FH to defects in the LDLR. (acc.org)
This phenotype results from a point mutation in the gene specifying the very low density lipoprotein receptor (VLDLR), whose protein product normally mediates the massive oocytic uptake of egg yolk precursors from the circulation. (psu.edu)
Hyperlipidemia comprises a heterogeneous group of disorders, characterized by high levels in one or more lipids and/or lipoproteins [atherogenic free fatty acids (FA), triglycerides (TG) (hypertriglyceridemia), small dense low-density lipoprotein cholesterol (LDL-C) (hypercholesterolemia), and apolipoprotein (apo) B], and/or low level in antiatherogenic high density lipoprotein cholesterol (HDL-C), in the circulation [ 1 - 3 ]. (hindawi.com)
under these conditions, low-density lipoprotein (LDL) proteins can be oxidized (oxLDL). (biomedcentral.com)

We are now fully characterizing this protein and evaluating its utility as a drug target for diabetes, dyslipidemia, and fatty liver disease. (yale.edu)
Indeed, although targeted disruption of the muscle insulin receptor causes a marked defect of insulin action in this tissue, the phenotype of such animals is modest with a lack of diabetes ( 11 ). (diabetesjournals.org)
Currently, DKD diagnosis primarily relies on a patient's medical history of diabetes mellitus and laboratory tests, including urine glucose qualitative testing, blood glucose measurement and urine protein measurement. (spandidos-publications.com)
A lot of in vitro studies suggest that endothelial cell apoptosis might play a special role in the pathophysiology of micro- and macroangiopathy under certain conditions like diabetes or hyperlipidemia. (substack.com)

G protein-coupled receptors (GPCR) have recently been implicated in intracellular crosstalk pathways with IR. (mdpi.com)
Maintaining bile acid (BA) homeostasis is important and regulated by BA activated receptors and signaling pathways. (aspetjournals.org)
Research had proven that different signaling pathways get excited about VSMC dysfunction induced by hypertension in being pregnant, such as for example Ca2+, mitogen-activated proteins kinases (MAPKs) [13] and G-protein [14]. (cmerp.net)

The PCSK9 program also has the potential to treat patients with hyperlipidemia. (wikipedia.org)

The integration of GPCR and receptor tyrosine kinase (RTK) signaling, including IR upon ligand stimulation, is eloquently reviewed. (mdpi.com)
Furthermore, to investigate the molecular mechanism of action, the phosphorylation and protein expression of phosphoinositide 3-kinase (PI3K) and its downstream proteins, such as insulin receptor (INSR), protein kinase B (Akt/PKB) and glucose transporter 4 (GLUT4) have been detected. (rsc.org)
In addition, YSY promoted lipid metabolism by inducing adiponectin secretion and activation (phosphorylation) of 5' adenosine monophosphate-activated protein kinase (AMPK) and by suppressing the activation of acetyl-CoA carboxylase (ACC) and HMG-CoA reductase (HMGCR). (tmu.edu.tw)
Next, the levels of glucose content, insulin receptor substrate1 (IRS1) Caspase Inhibitor web protein expression and phosphatidylinositol 3-kinase (PI3K) subunit p85 mRNA expression were measured. (ezh2inhibitor.com)

4 And in 1983, Russell and colleagues cloned the LDLR gene, which allowed for molecular-level analysis of receptor mutations. (acc.org)

The proximal events of TLR-mediated intracellular signaling are initiated by interactions with cytosolic adapters, mainly myeloid differentiation primary response protein 88 (MyD88) [ 25 ]. (hindawi.com)
Zukowska et al have shown that NPY stimulates Y1 and Y2 receptors and involved in multiple methods of atherogenesis, including EC attachment, migration, proliferation, and differentiation [4]. (cmerp.net)

The enantiomeric excesses (e.e.) in the solutions had been Adiponectin Receptor Agonist custom synthesis determined by HPLC evaluation applying chiral stationary phases. (ezh2inhibitor.com)
BACKGROUND Mirabegron is a β3-adrenergic receptor (β3-AR) agonist approved only for the treatment of overactive bladder. (jci.org)

An upregulation of IR expression and its activation is significantly associated with higher downstream G protein signaling cascades. (mdpi.com)
They work as pattern recognition receptors (PRRs) implicated in tailoring innate immune signaling [ 22 ]. (hindawi.com)
Furthermore, we the expression of fibrosis‑related proteins and NF‑κB signaling pathway proteins was determined using western blot analysis. (spandidos-publications.com)
The impact of exposures on bile acid (BA) signaling and Farnesoid X receptor-mediated gut-liver crosstalk is emerging. (aspetjournals.org)

Experimental results showed that YSY reduced body weight, hyperlipidaemia, fatty liver, and atherogenesis in hyperlipidaemic mice. (tmu.edu.tw)

Further mechanistic analysis revealed that the therapeutic effects of HPS on DKD mice may be mediated by inhibiting the high mobility group box 1/receptor for advanced glycation end‑products/toll‑like receptor 4 pathway. (spandidos-publications.com)

Although lipids are a distinct class of biomolecules, we shall see that they often occur combined, either covalently or through weak bonds, with members of other classes of bio-molecules to yield hybrid molecules such as glycolipids , which contain both carbohydrate and lipid groups, "and lipoproteins , which contain both lipids and proteins. (medmuv.com)

Cardiac Toll-like receptors and inflammasome complexes may be key inducers for inflammation probably through NF- B activation and ROS overproduction. (hindawi.com)
Activation of Toll-like receptors (TLRs) and the inflammasome complex has recently been proposed to be central in cardiac inflammation and likely in the pathogenesis of DCM. (hindawi.com)

Results of the present study revealed that supplementing CrPic and biotin alone or in a combination exerts anti-diabetic activities, probably through modulation of PPAR-γ, IRS-1 and NF-κB proteins. (cambridge.org)

Results: Our results revealed that FTZ attenuated glucose content and up-regulated the expression of PI3K p85 mRNA and IRS1 protein in insulin-resistant HepG2 cells in vitro. (ezh2inhibitor.com)
Might β3-adrenergic receptor agonists be useful in disorders of glucose homeostasis? (jci.org)

SPC-4955 inhibits the protein that is necessary for the formation of plasma LDL cholesterol particles. (wikipedia.org)
It inhibits the protein that controls the number of receptors responsible for removing LDL cholesterol particles from the blood. (wikipedia.org)
The characterization of this protein in vivo has shown that it widely expressed in different tissues and circulates in the blood, its levels rise after food intake in humans and stimulates insulin secretion and sensitivity and inhibits platelet aggregation. (yale.edu)

We found that an upstream calcium-dependent PKC isozyme PKC alpha that modulates the downstream ERK/NF-kappaB pathway through an influx of extracellular Ca2+ is induced by the spike protein of SARS-CoV. (substack.com)

the promoter of the LDL receptor gene contains a thyroid hormone responsive element (TRE) which allows the triiodothyronine (T3) to upregulate the gene expression of the LDL receptor 8 . (hormones.gr)

PHENOTYPE: Mice homozygous for a knock-out allele exhibit slower weight gain, hyperleptinemia, increased oxygen consumption, decreased respiratory quotient, decreased liver triglyceride level and ameliorated hyperlipidemia and hepatosteatosis when fed a high-fat diet. (utsouthwestern.edu)

The Y1 receptor post-synaptically mediates vasoconstriction and increases the blood pressure, by potentiating norepinephrine induced contraction and VSMC proliferation [5, 8]. (cmerp.net)

The expression levels of fibrosis‑related proteins fibronectin, α‑smooth muscle actin and TGF‑β1 were observed to be decreased in kidney tissues of DKD mice following HPS treatment. (spandidos-publications.com)

Hyperlipidemia (ie, elevated plasma cholesterol or triglyceride levels or both) is present in all hyperlipoproteinemias. (medscape.com)
The data will be used to monitor the status of hyperlipidemia and the success of the National Cholesterol Education Program. (cdc.gov)
Apo B is necessary for the reaction with LDL receptors in the liver and on cell walls, and is thus involved in transporting cholesterol from the liver to the vessel cell. (cdc.gov)

The underlying mechanism was attenuation of the decreased expression of PI3K p85 mRNA and IRS1 protein in both insulin-resistant HepG2 cells and MS rats. (ezh2inhibitor.com)

The goal of this minireview is to provide an update on the regulation of bile acid (BA) homeostasis by the nuclear receptor Farnesoid X receptor (FXR) and the effects on this regulation by exposure to environmental or therapeutic agents. (aspetjournals.org)

A common incriminated antigen in both disorders is the heat shock protein (HSP)-60/65. (diabetesjournals.org)
In 2009, we had a seminal moment when you published a manuscript in The New England Journal of Medicine describing PLA2R, phospholipase A2 receptor, as the antigen that was responsible for a majority of the cases of MN. (medscape.com)

Farnesoid X receptor (FXR) and its regulated target networks in both the liver and the intestines are critical in suppressing BA synthesis and promoting BA transport and enterohepatic circulation. (aspetjournals.org)
The increased levels of this protein in the serum may be due to a variety of physiological situations or previously diagnosed comorbidities that may be directly or indirectly related to liver dysfunction. (scielo.br)

Moreover, thyroid hormones stimulate the cholesteryl ester transfer protein (CETP), an enzyme which transports cholesteryl esters from HDL2 to the very low density lipoproteins (VLDL) and triglycerides in the opposite direction 9 (figure). (hormones.gr)

abstract = "Upon photostimulation, restricted ovulator (RO) female chickens exhibit endogenous hyperlipidemia, develop atherosclerotic lesions, and generally fail to lay eggs. (psu.edu)

It has been reported that NPY, like a potent peripheral regulatory peptide, is definitely participated in immune reactions, stimulates hyperlipidemia, induces vasoconstriction, as well as regulates the proliferation of various cell types including ECs and vascular clean muscle mass cells (VSMCs) through its related receptors [5, 6]. (cmerp.net)

Despite the importance of TCM herbs and formulations, there is no comprehensive review summarizing their scientific findings on handling hyperlipidemia. (hindawi.com)

His research focuses on the molecular mechanisms by which prolyl hydroxylase domain proteins regulate calcium cycling and cardiac contractile function, and how their dysregulation contributes to the pathophysiological development of heart diseases such as cardiac hypertrophy and arrhythmia. (bcm.edu)

Within the pancreas, physiological concentrations of secretagogues bind to G-protein-linked cell-surface receptors on acinar cells, evoking short, oscillatory spikes of acinar cytosolic-free ionised calcium ([Ca2+]i), an ubiquitous intracellular messenger. (nih.gov)

The Y2 receptor functions only or works together with the Y5 receptor to potentiate angiogenesis, stimulate proliferation, migration, and capillary tube formation of ECs [9]. (cmerp.net)

TLR ligands include high-mobility group B1 (HMGB1), heat shock proteins (HSP60, HSP70), endotoxins, and extracellular matrix components [ 23 ]. (hindawi.com)
The Spike Protein alone causes an influx of extracellular Ca2+. (substack.com)

This has the potential to be used as a treatment for patients with hyperlipidemia. (wikipedia.org)

In addition, CIG can significantly enhance the expression level of the PI3K-Akt/PKB pathway related proteins in skeletal muscle, which is the key pathway of insulin metabolism. (rsc.org)

The expression levels of Gα subunits influence the biased profiling of β-agonists and antagonists in that they determine both their activity and efficacy by affecting different membrane distribution of receptor-G protein populations. (mdpi.com)
In the naïve state, the level of Gα expression influences the partitioning of not only Gα but also the co-expressed receptor in different membrane domains. (mdpi.com)

Decreased activity of LDL-receptors' resulting in decreased receptor-mediated catabolism of LDL and IDL is the main cause of the hypercholesterolemia observed in hypothyroidism 13-15 . (hormones.gr)

All these researches exposed that NPY and its receptors, including Y1, Y2 and Y5, paly important functions in practical rules of cardiovascular system. (cmerp.net)

Fatty acid-binding protein 3 (FABP3) located in renal mesangial and distal tubular cells, and had been shown to be a sensitive marker of renal injury, potentially be a mediator in pathogenesis of chronic kidney disease (CKD). (medsci.org)

G protein stoichiometry can dictate biased agonism through distinct receptor-G protein partitioning. (mdpi.com)

These changes include hyperlipidemia and increased gluconeogenesis. (lww.com)

These different isoforms vary in their affinity to ligands, distribution throughout the body, and cofactors proteins they bind to. (bodybuilding.com)

Thus, prevention and treatment of hyperlipidemia are effective approaches to reduce the incident rate of chronic diseases. (hindawi.com)

The efficacy (remission rate, 24 h urinary protein, and serum albumin and creatinine) and safety (adverse events) profiles of administered regimens were evaluated at 12, 24 and 48 weeks. (revistanefrologia.com)

Diseases1

Chemicals and Drugs17

Analytical, Diagnostic and Therapeutic Techniques and Equipment1

Phenomena and Processes2

Hyperglycemia6

Peroxisome6

Lipoprotein receptor-related protein2

Familial2

Atherosclerosis1

Obesity6

Adaptor protein2

Density lipoprotein4

Diabetes4

Pathways3

PCSK91

Kinase4

Mutations1

Differentiation2

Agonist2

Signaling4

Atherogenesis1

Advanced glycation1

Lipids1

Inflammation2

PPAR1

Glucose2

Inhibits3

Downstream1

Gene1

Phenotype1

Mediates1

Mice1

Cholesterol3

IRS11

Nuclear1

Antigen2

Liver2

Thyroid1

Abstract1

Immune1

Findings1

Mechanisms1

Concentrations1

Stimulate1

Extracellular2

Patients1

Pathway1

Expression2

Hypercholesterolemia1

Cardiovascular1

Renal1

Distinct1

Include1

Bind1

Chronic1

Urinary1