• Metabolism of carbohydrates, lipids, amino acids nucleotides and vitamins. (syllabusguru.com)
  • This is an unstable conformation leading to reactions with adjacent molecules: proteins, lipids and nucleic acids. (wellbeingphd.com)
  • It can be used to measure the intramolecular stability of a broad spectrum of biomolecules, including proteins, nucleic acids, lipids and detergent micellar systems. (lu.se)
  • DynaMut: predicting the impact of mutations on protein conformation, flexibility and stability. (trdizin.gov.tr)
  • Using molecular dynamics (MD) simulations, we investigated how the position of charge-changing point mutations influences the structure and conformational stability of the E protein for a set of variants of a single TBEV strain. (bvsalud.org)
  • Stability of protein and nucleic acid structures. (pathfinderacademy.in)
  • The VP-DSC provides fast, accurate transition midpoint (Tm) determination, as well as a thermodynamic profile that can provide insight into the factors that affect conformation and stability. (lu.se)
  • NMR spectroscopy or X-ray crystallography, but important width measurements at a single resonance frequency (or questions remain concerning the energetics, stability, and magnetic field strength), making it difficult to separate dynamics of this structurally diverse nucleic acid class. (lu.se)
  • In a startling new study, scientists have shown for the first time that abnormal prions - fragments of infectious protein that can cause fatal neurodegenerative diseases such as Creutzfeldt-Jakob disease - can erupt from healthy brain tissue. (scienceagogo.com)
  • Infectious prions, which are composed solely of protein, are classified by distinct strains, originally characterized by their incubation time and the disease they cause. (scienceagogo.com)
  • These toxic prions have the ability to reproduce, despite the fact that they contain no nucleic acid genome. (scienceagogo.com)
  • Prions are infectious proteins that cause fatal, incurable neurodegenerative diseases of humans and animals, which include Creutzfeldt-Jakob disease (CJD), sheep scrapie, bovine spongiform encephalopathy, and chronic wasting disease (CWD) of cervids. (cdc.gov)
  • The replicative properties of prions stem from the capacity of PrP Sc to template its conformation on PrP C in a cyclical process resulting in exponential accumulation of prion infectivity ( 8 - 11 ). (cdc.gov)
  • Although they lack nucleic acids, prions exhibit heritable strain properties that influence disease outcomes, including the time between infection and disease onset (incubation period), clinical signs, patterns of neuronal degeneration and PrP Sc deposition in the central nervous system (CNS), and the ability to replicate in non-CNS tissues such as the lymphoreticular system and musculature ( 12 ). (cdc.gov)
  • Prusiner demonstrated that the agents responsible for their transmission, which are called prions, were composed only of protein and were devoid of nucleic acid. (wolffund.org.il)
  • After purifying prions from the brain, he discovered that they are composed of a special type of protein encoded by a chromosomal gene. (wolffund.org.il)
  • The replication of prions involves the recruitment of the normally expressed prion protein, which has mainly an alpha-helical structure, into a disease-specific conformation that is rich in beta-sheet. (medscape.com)
  • Highly divergent hypotheses have been put forward regarding the makeup of the prions, including that they consist of nucleic acid only or protein only, are lacking both protein and nucleic acid, or are a polysaccharide. (medscape.com)
  • This hypothesis suggests that prions contain no nucleic acid and are referred to as PrP Sc . (medscape.com)
  • This concept is well exemplified by natural photosynthetic proteins, and can also be achieved in synthetic nucleic acid nanostructures. (uni-wuerzburg.de)
  • The purpose of this Notice of Funding Opportunity (NOFO) is to advance synthetic nucleic acid platforms for the rapid development and iterative testing of active and passive immunization strategies for HIV prevention, treatment, and cure. (nih.gov)
  • The utility and technical advantages of synthetic nucleic acid platforms (SNAP), including their efficacy, safety, speed of development, and ease of vaccine manufacture, were revealed during the COVID-19 pandemic, thus instilling hope that these technologies can be leveraged for the development of an effective HIV vaccine and broadly neutralizing antibody (bNAb) delivery. (nih.gov)
  • Here, we demonstrate that non-infectious SARS-CoV-2 VLPs can be successfully assembled by co-expressing three important viral proteins membrane (M), envelop (E) and nucleocapsid (N) in plants. (nature.com)
  • Over one hundred vaccines using varied approaches including protein subunit, viral vector, RNA, DNA, inactivated virus, attenuated virus, and virus like particles (VLPs) platforms are in clinical trials. (nature.com)
  • These protein subunits can assemble into virus particles without viral RNA genome in mammalian cells to study virus-cell entry 2 and to develop vaccines 3 . (nature.com)
  • VLPs self-assembled into empty shells can be used safely as vaccines without the risk of replication or infection due to the lack of viral nucleic acid. (nature.com)
  • VLPs are highly immunogenic and can induce elevated titers of neutralizing antibodies, even without adjuvants, thanks to the maintenance of the native conformation of viral proteins presenting repetitive epitopes to the host immune system cells. (nature.com)
  • Our results also point to relationships between E protein dynamics and viral neuroinvasiveness. (bvsalud.org)
  • 8-Br-dG should prove useful as a chemical probe for the conformation about glycosidic bonds in unusual nucleic acid structures. (caltech.edu)
  • Today's situation is very different: the rate at which structures are solved has greatly increased, with over 60,000 high-resolution protein structures now available in the consolidated Worldwide Protein Data Bank (wwPDB) 1 . (nature.com)
  • For example, many biochemists regularly view protein structures to gain insight into protein function ( Fig. 1 ). (nature.com)
  • Molecular biologists view RNA structures and complexes with proteins to gain insight into RNA signal and message processing. (nature.com)
  • i ) Superposition is commonly used to compare two or more related structures-for example, two distinct states of the same protein, or, as shown here, two separate proteins with similar structure (PDB 1QCF and 1FMK ) 98 . (nature.com)
  • The Chromosome Conformation Capture (3C) assay is a powerful technique to detect looping structures and assess the probability of interaction between distant genomic elements (1-3). (bath.ac.uk)
  • Our database now contains 95% of all available DNA-protein complexes, making our tools for analysis of these structures accessible to a broad community. (researchwithrutgers.com)
  • We proposed that a cell theoretically could in principle synthezise a big number of forms of [ 2 H]labeled macromolecules with somewhat different structures and conformations, so that a cell could easily select a preferable one from al these species in a course of adaptation to 2 H 2 O, that is the best suitable namely for that conditions. (o8ode.ru)
  • Although protein structures have been solved by experiments at an increasing rate, a flood of new sequences have been determined even more rapidly due to the advance of sequencing technologies[ 6 , 7 ]. (biomedcentral.com)
  • It was subsequently realised that proteins (or domains) with similar amino-acid sequences have similar overall 3D structures, and that the degree of this similarity (measured by the root-mean-square distance, or RMSD, between corresponding atoms in the two models) is correlated with the degree of sequence similarity. (embl.org)
  • In November 2020, more than 60 years after the first protein structures were determined experimentally, AlphaFold was recognised as the best-performing method for predicting 3D protein structure by the assessors of the 14th round of the biennial CASP experiment. (embl.org)
  • Thus, the AlphaFold predictions were consistently very similar to the experimentally determined structures of the proteins included in this round of CASP. (embl.org)
  • AlphaFold builds on this huge body of experimental information and generates its predictions by analysing the relationship between these known protein structures and huge amounts of protein-sequence data. (embl.org)
  • When DeepMind decided to predict the structures of a huge number of proteins and started to think about how to disseminate the 3D models freely and openly, an obvious partner to collaborate with was the European Bioinformatics Institute, EMBL-EBI, the European home of many biological data resources used by the AlphaFold team, including PDBe and UniProt. (embl.org)
  • Guanine quadruplexes are nucleic acid structures built ions in slow exchange with bulk ions. (lu.se)
  • Chemical modifications are powerful tools to probe nucleic acid structure and protein-nucleic acid interactions. (caltech.edu)
  • Impact of nucleic acid self-alignment in a strong magnetic field on the interpretation of indirect spin-spin interactions. (muni.cz)
  • The formation of biomolecular condensates can be driven by liquid-liquid phase separation, which arises from weak, multivalent interactions among proteins and nucleic acids. (duke.edu)
  • Interactions between nucleic acids and proteins form the foundation of the central dogma of molecular biology. (ku.edu)
  • By studying these dynamic structure-function relationships, we are able to identify the mechanisms that govern the biochemical processes arising from these nucleic acid-protein interactions. (ku.edu)
  • For example, assembly of the hepatitis C virus (HCV) nucleocapsid depends on interactions between the genomic RNA and numerous copies of the multifunctional core protein. (ku.edu)
  • Accordingly, our lab uses these single-molecule methods, in conjunction with conventional ensemble techniques, to study a variety of nucleic acid-protein interactions. (ku.edu)
  • Effective encoding of residue contact information is crucial for protein structure prediction since it has a unique role to capture long-range residue interactions compared to other commonly used scoring terms. (biomedcentral.com)
  • Among various structure-based terms, residue-residue contact potentials[ 21 - 23 ] are unique in that they capture long-range interactions in a protein structure[ 24 ]. (biomedcentral.com)
  • Shortly after SARS-CoV emerged at the turn of the 21st century, the spike (S) protein (particularly in its native conformation) was identified as the immunodominant antigen of the virus3. (who.int)
  • Amyloid plaques in the brains of animals and humans dying of prion diseases are composed of this abnormal protein. (wolffund.org.il)
  • He and his co-researchers in London found that when normal prion protein is coated onto steel wires and brought into contact with cultured cells, a small but significant proportion of the coated wires cause prion infection of the cells - and when transferred to mice, they continue to spawn the disease. (scienceagogo.com)
  • Pol II and Pol III are protein complexes consisting of 12 and 17 subunits. (cipsm.de)
  • DNAproDB (https://dnaprodb.usc.edu) is a web-based database and structural analysis tool that offers a combination of data visualization, data processing and search functionality that improves the speed and ease with which researchers can analyze, access and visualize structural data of DNA-protein complexes. (researchwithrutgers.com)
  • We have updated the structure of our data files to support complex DNA conformations, multiple DNA-protein complexes within a DNAproDB entry and model indexing for analysis of ensemble data. (researchwithrutgers.com)
  • On the basis of several successful reports for proteins and their complexes, the technique has become popular in structural biology, and the conformation survival becomes more and more taken for granted. (upf.edu)
  • For example, we have recently shown that Molecular Dynamics (MD) simulations, followed by quantum mechanics/molecular mechanics (QM/MM) calculation, provided detailed structural informations and binding energies of the complexes between nickel(II), copper(II), zinc(II) metallointercalators with nucleic acids in the canonical B conformation [1]. (unipa.it)
  • However, when the adaptive process goes continuously during the many generation, the population of cells can use a special genetic mechanisms for the adaptation to 2 H 2 O. For example, mutations of geens can be resulted in amino acid replacements in molecules of proteins, which in turn could cause a formation of a new isoenzymes, and in the special cases - even the anomal working enzymes of a newer structure type. (o8ode.ru)
  • The amino acid sequence of human rhodopsin, deduced from the nucleotide sequence of its gene, is 348 residues long and is 93.4% homologous to that of bovine rhodopsin. (nih.gov)
  • AlphaFold is an Artificial Intelligence (AI) system developed by DeepMind that predicts a protein's three-dimensional (3D) structure from its amino-acid sequence. (embl.org)
  • A subclass of nonhistone chromatin proteins from rat liver, previously shown to exhibit high affinity for DNA, has been fractionated by single-stranded DNA-agarose affinity chromatography. (tamu.edu)
  • The native Gene 32 Protein from bacteriophage T4 (T4gp32) is a single-stranded DNA binding protein that is required for T4 DNA replication, recombination and repair. (qiagen.com)
  • The T4 Gene 32 Protein also stimulates the rate of synthesis of T4 DNA Polymerase on primed-single-stranded substrates showing a 5-10-fold increase in synthesis rate. (qiagen.com)
  • The T4 Gene 32 Protein is a single-stranded nucleic acid binding protein that has the function of stabilizing single-stranded regions of DNA. (qiagen.com)
  • DNA binding of single stranded DNA by T4 Gene 32 Protein was measured using a gel shift assay with a single-stranded, fluorescently labeled oligonucleotide. (qiagen.com)
  • In the case of threading, alignment accuracy strongly influences the fraction of common contacts identified among proteins of the same fold, which eventually affects the fold recognition accuracy. (biomedcentral.com)
  • In this study, nuclease was used to find the association of certain oncogenic sequences with chromatin and nuclear proteins. (wikipedia.org)
  • 5) Designing MisFolded Protein Sequences by Energy Landscaping. (jnu.ac.in)
  • Cascade will release crRNAs that will bind with foreign nucleic acid sequences - via base pair matching to a "seed" sequence of nucleotides - and silence or otherwise inactivate them. (lbl.gov)
  • This binding puts these ssDNA sequences into optimal conformations for interacting with DNA polymerases and other replication proteins. (qiagen.com)
  • This means that for every known sequence in the UniProt data resource there will be either an experimentally determined structure (in the Protein Data Bank, PDB), or a predicted structure in AlphaFold DB, or the structure can be readily modeled using traditional structure-prediction techniques based on models for similar sequences in PDB or AlphaFold DB. (embl.org)
  • As a result, AlphaFold is able to produce accurate structure predictions even for amino-acid sequences that it has never encountered before. (embl.org)
  • Following prion infection, the abnormal or misfolded prion protein (PrPSc) converts PrPC into a likeness of itself, by causing it to change its conformation or shape. (scienceagogo.com)
  • Prusiner showed that in lesions in animals with the neuro-degenerative disease scrapie, there is an abnormal form of this protein. (wolffund.org.il)
  • The infectious agent in the prion disease is composed mainly or entirely of an abnormal conformation of a host-encoded glycoprotein called the prion protein. (medscape.com)
  • Mitochondrial trifunctional protein deficiency due to HADHB gene mutation in a Chinese family. (trdizin.gov.tr)
  • Using reconstitution and knock-in models, we report that mutation of key amino acids involved in Z-DNA/RNA binding in ZBP1's ZBDs prevented necroptosis upon infection with mouse cytomegalovirus. (ox.ac.uk)
  • Briefly, this technique relies on the use of the non-specific endo-exonuclease micrococcal nuclease, an enzyme derived from the bacteria Staphylococcus aureus, to bind and cleave protein-unbound regions of DNA on chromatin. (wikipedia.org)
  • DNA bound to histones or other chromatin-bound proteins (e.g. transcription factors) may remain undigested. (wikipedia.org)
  • While MNase-seq is primarily used to sequence regions of DNA bound by histones or other chromatin-bound proteins, the other three are commonly used for: mapping Deoxyribonuclease I hypersensitive sites (DHSs), sequencing the DNA unbound by chromatin proteins, or sequencing regions of loosely packaged chromatin through transposition of markers, respectively. (wikipedia.org)
  • It is becoming increasingly apparent that chromatin is not randomly folded into the nucleus, but instead is highly organized into specific conformations within the nucleus. (bath.ac.uk)
  • DNA unwinding component of the nonhistone chromatin proteins. (tamu.edu)
  • In our present view, these areas are found for systems where several types of macromolecules (proteins, polysaccharides or polyelectrolytes) and/or amphiphiles interact to form a functional or destructive unit. (lu.se)
  • We found that overall the residue contact pattern can distinguish protein folds best when contacts are defined for residue pairs whose Cβ atoms are at 7.0 Å or closer to each other. (biomedcentral.com)
  • Mammalian cells normally produce harmless cellular prion protein (PrPC). (scienceagogo.com)
  • Our previous studies using gene-targeted mouse models of chronic wasting disease (CWD) demonstrated that Norway and North America cervids are infected with distinct prion strains that respond differently to naturally occurring amino acid variation at residue 226 of the prion protein. (cdc.gov)
  • The extraordinary biology and transmissibility of these disorders stems from the protean conformational properties of the prion protein (PrP). (cdc.gov)
  • These amyloid plaques are immunoreactive with antibodies to the prion protein and do not immunoreact with antibodies to other amyloidogenic proteins, such as the amyloid-beta (which is deposited in Alzheimer disease). (medscape.com)
  • A new inhibited conformation of the KD is observed in a DFG-out conformation and with the glycine-rich loop adopting a structure that blocks ATP binding to the active site. (rcsb.org)
  • 4) Exploring protein-peptide binding specificity through computational peptide screening. (jnu.ac.in)
  • Structural biology is rapidly accumulating a wealth of detailed information about protein function, binding sites, RNA, large assemblies and molecular motions. (nature.com)
  • a - d , f ) A simple way to gain insight into function is to use ribbon representation colored by sequence features: for example, domains ( a ), SNPs ( b ), exons ( c ), protein binding sites ( d ) and sequence conservation ( f ). ( e ) An effective way to show overall shape is with nonphotorealistic rendering using flat colors and outlines. (nature.com)
  • The protein fraction that bound to DNA-agarose in 0.19 M NaCl-buffer and was eluted with 2 M NaCl-buffer is enriched for a protein component of approximately 20,000 daltons and exhibits preferential binding to denatured DNA. (tamu.edu)
  • TY - JOUR T1 - Structural characterization of Escherichia coli ribosomal protein S8 and its binding site in 16S ribosomal RNA. (unboundmedicine.com)
  • Z-DNA/RNA is recognised by Z-binding domains (ZBDs), which are present in proteins implicated in antiviral immunity. (ox.ac.uk)
  • Improved yields and quality of templates may be achieved with the use of DNA-binding proteins in amplification and sequencing reactions. (qiagen.com)
  • In one data set, mutants of a protein involved in RNA biogenesis and processing, human TAR DNA binding protein 43 (TDP-43), were expressed in S. cerevisiae . (frontiersin.org)
  • The functional importance of these biomolecules hinges on their ability to sample multiple conformations. (ku.edu)
  • Experimental methods of multi-dimensional NMR spectroscopy, dynamics and theoretical description of spin system evolution, multiple resonance NMR technique for structural studies of proteins and nucleic acids by NMR spectroscopy, contemporary methods of structural biology, studies of complex biomolecular systems. (muni.cz)
  • Protein structural biology. (embl.org)
  • Heritable strain information appears to be enciphered by distinct PrP Sc conformations that are faithfully propagated during prion replication ( 14 , 15 ). (cdc.gov)
  • The ability of T4 Gene 32 Protein to enhance the performance of several DNA synthesis-related activities is based on its essential function in the replication of bacteriophage T4. (qiagen.com)
  • The tertiary structure of proteins provides crucial information for understanding molecular mechanisms of biological functions. (biomedcentral.com)
  • A proper encoding of residue contact information is crucial for structure prediction because in principle, a full distance map or a residue contact map has sufficient information for reconstructing the tertiary structure of a protein[ 25 ]. (biomedcentral.com)
  • The T4 Gene 32 Protein has exhibited an ability to enhance the performance of several DNA synthesis-related activities in secondary-structure rich regions, including PCR amplification and DNA sequencing. (qiagen.com)
  • Molecular genetic tests for detecting drug-resistance are, in general, just a variation of nucleic acid amplification (NAA) tests and can reliably provide information on the presence of mutations associated with drug resistance in 1 to 2 days. (cdc.gov)
  • This study demonstrated that it is necessary to gain insight into protein dynamics under external electric field stress, in order to develop the novel food processing techniques that can be potentially used to reduce or eradicate food allergens. (mdpi.com)
  • 1) Searching target sites on DNA by proteins: Role of DNA dynamics under confinement. (jnu.ac.in)
  • The effect of DNA conformation on the dynamics of multidomain proteins. (jnu.ac.in)
  • The latter is a non-canonical conformation recently observed in human cells [2], and it has been proposed as a target for a novel class of anticancer drugs. (unipa.it)
  • The latter represents a conformationally modified form of a normal cellular PrP C , which is a normal host protein found on the surface of many cells, in particular neurons. (medscape.com)
  • Mitochondrial trifunctional protein deficiency (MTPD), a rare condition that leads to failure of converting certain fats to energy is characterized by decreased activity of three enzymes in the enzyme complex. (trdizin.gov.tr)
  • SARS-CoV-2 is composed of four essential structural proteins: the spike (S) glycoprotein, membrane (M) protein, envelope (E) protein, and nucleocapsid (N) protein, as well as multiple accessory and non-structural proteins 1 . (nature.com)
  • Flavonoids bind to nucleic acids and proteins. (horiba.com)
  • Many flavonoids, like proteins, are fluorescent, thus setting thestage for experiments involving Förster resonance energy-transfer (FRET) between the two types of compounds when they bind together. (horiba.com)
  • This notion is also perfectly applicable to viruses, which can be crudely approximated as infectious sub-micrometer particles consisting of genetic material encapsulated by proteins, forming a so-called nucleocapsid. (ku.edu)
  • Before the work of Professor Stanley B. Prusiner, infectious diseases were regarded as exclusively caused by nucleic acid-containing agents such as viruses, bacteria and parasites. (wolffund.org.il)
  • A molecular dynamic (MD) modeling approach was applied to evaluate the effect of external electric field on gliadin protein structure and surface properties. (mdpi.com)
  • Intrinsically disordered regions (IDRs) lacking a fixed three-dimensional protein structure are widespread and play a central role in cell regulation. (iucr.org)
  • Through a combination of cryo-electron microscopy and three-dimensional image reconstruction, they have determined the structure of a protein complex called "Cascade," that acts as a surveillance system for detecting and inactivating the nucleic acid of invading pathogens. (lbl.gov)
  • From left, Blake Wiedenheft, Eva Nogales, Gabriel Lander and Jennifer Doudna, used a combination of cryo-electron microscopy and 3-D image reconstruction to determine the structure of Cascade, a protein complex that detects and inactivates invading pathogens. (lbl.gov)
  • Identified phosphosites were mapped on the Pol II structure which provided indications that they might play a role in regulating the conformation of the clamp region and, as a consequence, interaction of Pol II with nucleic acids. (cipsm.de)
  • Membrane structure and function: Structure of model membrane, lipid bilayer and membrane protein diffusion, osmosis, ion channels, active transport, ion pumps, mechanism of sorting and regulation of intracellular transport, electrical properties of membranes. (pathfinderacademy.in)
  • To seek the most effective definition of residue contacts for template-based protein structure prediction, we evaluated 45 different contact definitions, varying bases of contacts and distance cutoffs, in terms of their ability to identify proteins of the same fold. (biomedcentral.com)
  • The initial release of the resource provides structure predictions for most of the proteins in the human proteome as well as for the proteomes of 20 other species of significant biological or medical interest. (embl.org)
  • He discovered that PrpSc was derived from Prpc but differs in its three-dimensional conformation. (wolffund.org.il)
  • Recently we have performed MD simulation to have an insight into the molecular recognition process of small organic ligands and other biological targets, such as mRNA and proteins [3]. (unipa.it)
  • Double-stranded DNA and RNA adopt different helical conformations, including the unusual Z-conformation. (ox.ac.uk)
  • The T4 Gene 32 Protein is intended for molecular biology applications. (qiagen.com)
  • Instructions for using T4 Gene 32 Protein are provided in the corresponding kit protocol in the resources below. (qiagen.com)
  • Protein concentration (OD 280 ) of T4 Gene 32 Protein was determined by OD 280 absorbance. (qiagen.com)
  • This movie shows the conformation of Cascade's subunits - CasA (purple), CasB (yellow) and CasE (magenta) - being rearranged while the helical spine of the complex remains relatively undisturbed. (lbl.gov)
  • AMP-activated protein kinase (AMPK) is a master metabolic regulator for controlling cellular energy homeostasis. (rcsb.org)
  • Static electric field strengths of 0.001 V/nm and 0.002 V/nm induced conformational changes in the protein but had no significant effect on its surface properties. (mdpi.com)
  • The mitochondrial trifunctional protein (MTP) is a multienzyme complex of the fatty acid beta- oxidation cycle. (trdizin.gov.tr)
  • On the background of chronic polyneuropathy and acute relapsing episodes triggered by fasting or illnesses and rhabdomyolysis physicians should suspect disorders of the fatty acid beta-oxidation cycle. (trdizin.gov.tr)
  • 1. Morris AAM, Spiekerkoetter U. Disorders of mitochondrial fatty acid oxidation and riboflavin metabolism. (trdizin.gov.tr)
  • Mitochondrial trifunctional protein deficiency: a severe fatty acid oxidation disorder with cardiac and neurologic involvement. (trdizin.gov.tr)
  • 16 this range (primarily cytochrome P-450 mediated oxidation to fatty acids and alcohols) is slow, while the aromatics are metabolized faster (oxidation of alkyl site and/or ring, sometimes with formation of reactive intermediates, and conjugation with glutathione, glucuronic acid, or glycine) (ATSDR 1999). (cdc.gov)
  • CRISPRs are transcribed and the long primary transcript is processed into a library of short CRISPR-derived RNAs (crRNAs), each of which contains a unique sequence that is complementary to a foreign nucleic acid challenger. (lbl.gov)
  • This development represents a step-change for molecular biology - for the first time in history, for almost every protein of known sequence, a high-quality 3D model will be readily available. (embl.org)
  • This protein-sequence information has also been generated by scientists all over the world, mainly through genome sequencing, and is made available through public resources, such as UniProt and Mgnify hosted at EMBL-EBI. (embl.org)
  • Nucleic acids are potent triggers for innate immunity. (ox.ac.uk)
  • Cell signaling: Hormones and their receptors, cell surface receptor, signaling through G-protein coupled receptors, signal transduction pathways, second messengers, regulation of signaling pathways, bacterial and plant two-component signaling systems, bacterial chemotaxis and quorum sensing. (pathfinderacademy.in)
  • In this case it is not excluded, that during the adaptation on the minimal medium, containing 2 Н 2 О there are formed the forms of bacteria, auxotrophic on a certain growth factors (for example amino acids et) and thereof bacterial growth is inhibited while grown on these media. (o8ode.ru)
  • The uncut DNA is then purified from the proteins and sequenced through one or more of the various Next-Generation sequencing methods. (wikipedia.org)
  • The largest deterioration of the fold recognition was observed for β-class proteins when the threading methods were used because the average alignment accuracy was worst for this fold class. (biomedcentral.com)
  • The spike protein of SARS-CoV--a target for vaccine and therapeutic development. (who.int)