Protein hepatitis e virus. Medical search. Frequent questions

The high hydrophobicity of the TM1 domain of L, but not of S, was shown to be essential for virus infection at a step downstream of receptor binding and virus internalization. (edu.au)
Persistent Hepatitis C virus (HCV) infection may result in liver cancer. (spandidos-publications.com)
Chronic infection of hepatitis virus B (HBV) is associated with an increased incidence of hepatocellular carcinoma (HCC). (figshare.com)
The prevalence of past or present infection with hepatitis B virus among adults aged 18 years or older declined from 5.7% in 1999-2002 to 4.3% in 2015-2018. (cdc.gov)
Kruszon-Moran D, Paulose-Ram R, Martin CB, Barker L, McQuillan G. Prevalence and trends in hepatitis B virus infection in the United States, 2015-2018. (cdc.gov)
Amantadine is an antiviral and antiparkinsonian drug that has been evaluated in combination therapies against hepatitis C virus (HCV) infection. (unifg.it)
There are about 350 million hepatitis B virus (HBV) carriers in worldwide and these chronic carriers are responsible for one to five percent of infection spreading [1]. (scielo.br)
Chronic hepatitis C virus (HCV) infection has been implicated in the induction and maintenance of B-cell lymphomas. (unipv.it)
In the present study, we evaluated the IFN-alpha-producing capacity of PDCs of patients with chronic hepatitis C virus (HCV) infection in treatment-naive, sustained responder, and nonresponder patients. (umassmed.edu)
Approved treatments for HBV infection include nucleos(t)ide analogs (NUCs) that inhibit the reverse transcription activity of P protein, but in most cases, discontinuing therapy leads to viral replication relapse and the emergence of drug-resistant strains. (ghuhlo.top)
Expression of the protein product (HBx) appears necessary for establishment of natural infection. (elsevierpure.com)
Context: Thyroiditis is one of the most common extrahepatic manifestations of hepatitis C virus (HCV) infection. (elsevierpure.com)
Studies have shown that different viral proteins may individually induce host responses to infection. (elsevierpure.com)
Hepatitis E is an enterically transmitted infection that is typically self-limited. (medscape.com)
Hepatitis E results from HEV infection and is spread by fecally contaminated water within endemic areas. (medscape.com)
Hepatitis B is a viral liver infection that can lead to acute or chronic conditions. (pasteur.fr)
Chronic infection with hepatitis B virus (HBV) affects more than 250 million people worldwide, putting them at high risk of developing serious liver conditions including liver cancer, an extremely severe form of cancer for which scientists have not yet found an effective treatment. (pasteur.fr)
Hepatitis B vaccination is the most effective measure to prevent hepatitis B virus (HBV) infection and its consequences, including cirrhosis of the liver, liver cancer, liver failure, and death. (cdc.gov)
This report, the second of a two-part statement from the Advisory Committee on Immunization Practices (ACIP), provides updated recommendations to increase hepatitis B vaccination of adults at risk for HBV infection. (cdc.gov)
In settings in which a high proportion of adults have risks for HBV infection (e.g., sexually transmitted disease/human immunodeficiency virus testing and treatment facilities, drug-abuse treatment and prevention settings, health-care settings targeting services to IDUs, health-care settings targeting services to MSM, and correctional facilities), ACIP recommends universal hepatitis B vaccination for all unvaccinated adults. (cdc.gov)
To promote vaccination in all settings, health-care providers should implement standing orders to identify adults recommended for hepatitis B vaccination and administer vaccination as part of routine clinical services, not require acknowledgment of an HBV infection risk factor for adults to receive vaccine, and use available reimbursement mechanisms to remove financial barriers to hepatitis B vaccination. (cdc.gov)
The acute and chronic consequences of hepatitis B virus (HBV) infection are major health problems in the United States. (cdc.gov)
Immunization with hepatitis B vaccine is the most effective means of preventing HBV infection and its consequences. (cdc.gov)
Integrating hepatitis B vaccine into childhood vaccination schedules in populations with high rates of childhood infection (e.g. (cdc.gov)
The risk of perinatal HBV infection among infants born to HBV-infected mothers ranges from 10% to 85%, depending on each mother's hepatitis B e antigen (HBeAg) status (3,7,8). (cdc.gov)
Hepatitis A virus (HAV) infection resolves in most patients uneventfully within weeks from the onset of the disease. (elsevier.es)
Here we present a case of a 36-year-old female patient who developed severe pruritus and jaundice three weeks after initially uncomplicated hepatitis A. A relapse of the infection was excluded. (elsevier.es)
Efficacy of early treatment with anti-SARS-CoV-2 spike protein monoclonal antibodies (mAbs) for nosocomial SARS-CoV-2 infection in hematologic patients is unknown. (bvsalud.org)
The primary treatment goals for patients with hepatitis B (HBV) infection are to prevent progression of the disease, particularly to cirrhosis, liver failure, and hepatocellular carcinoma (HCC). (medscape.com)
Detection of ongoing/recent dengue virus infection by both molecular (RT-PCR) and serological methods (IgM) was available in 15/19 participating laboratories. (who.int)
Dengue is a mosquito-borne viral infection associated with significant morbidity and mortality caused by any of four closely related virus serotypes (DENV-1,-2,-3 and -4), all of which circulate in the World Health Organization (WHO) Western Pacific Region. (who.int)

It has mass of 27 kDa and probably involved in process of intracellular membrane structure formation to allow virus replication. (wikipedia.org)
The recently developed HCV cell culture system, based on the JFH1 strain of HCV, has provided an opportunity to study the role of the viral proteins in the complete HCV replication cycle in human hepatoma cells. (monash.edu)
How the viral proteins functionally interact during replication of HCV in cell culture is not completely understood. (monash.edu)
Using this approach, the functional interactions of p7 and E2 with other viral proteins during HCV replication was investigated. (monash.edu)
Kakumani PK, Ponia SS, Sood V, Chinnappan M, Banerjea AC, Medigeshi GR, Malhotra P, Mukherjee SK, Bhatnagar RK (2013) Role of RNA interference (RNAi) in dengue virus replication and identification of NS4B as an RNAi suppressor. (virosin.org)
Although no enzymatic activity could be attributed yet to the HCV non-structural protein 5A (NS5A), it is indispensable for viral replication and particle assembly. (biomedcentral.com)
The Hepatitis B virus (HBV) core protein is an attractive target for preventing capsid assembly and viral replication. (ghuhlo.top)
By directly attaching to the core protein carboxyl-terminal domain, Ciclopirox derivatives may be able to suppress HBV virus assembly and subsequent viral replication inhibition. (ghuhlo.top)
In addition, viral particles empty of the genome are produced by S proteins, which can be active in modulating immune responses during replication. (ghuhlo.top)
Also, the presence of cccDNA in liver cells is a factor in persistent virus replication activity [3]. (ghuhlo.top)
Recent studies show that core proteins play an essential role in cccDNA formation and virus replication [4]. (ghuhlo.top)
Investigation of the role of XIP in hepatitis B virus replication in differentiated hepatocellular carcinoma cells revealed that XIP expression reduces wild-type hepatitis B virus replication to levels observed following transfection with an HBx-minus virus. (elsevierpure.com)
In contrast, the replication levels of the duck hepatitis B virus, a hepadnavirus that lacks the x open reading frame, were unchanged in the context of XIP expression. (elsevierpure.com)
We propose that one of the physiologic functions of the cellular protein XIP is to negatively regulate HBx activity and thus to alter the replication life cycle of the virus. (elsevierpure.com)
Melegari, M, Scaglioni, PP & Wands, JR 1998, ' Cloning and characterization of a novel hepatitis B virus x binding protein that inhibits viral replication ', Journal of virology , vol. 72, no. 3, pp. 1737-1743. (elsevierpure.com)
The largest, ORF-1, codes for the nonstructural proteins responsible for viral replication. (medscape.com)
Although several antiviral treatments can effectively inhibit HBV replication, they are not curative and do not fully eliminate the virus. (pasteur.fr)

Here we report a strategy for genetic transformation of lettuce plants (Lactuca sativa L.) using the surface antigen HBsAg of hepatitis B virus. (scielo.br)
Thus, striking improvements in recombinant antigen were achieved by alternative polyadenylation signals and fusion proteins containing targeting signals designed to enhance integration or retention of HBsAg in the endoplasmic reticulum (ER) of plant cells [6]. (scielo.br)
Testing to identify pregnant women who are hepatitis B surface antigen (HBsAg)-positive and providing their infants with immunoprophylaxis effec- tively prevents HBV transmission during the perinatal period (4,5). (cdc.gov)
The assay, which utilizes a truncated 56 kDa recombinant HEV capsid protein expressed in insect cells as antigen, was performed as described previously (1), with modifications (2). (cdc.gov)
[ 5 ] In addition, immunoglobulin and vaccination should be administered to newborns born to women positive for hepatitis B surface antigen (HBsAg). (medscape.com)

Abstract Objective To investigate the effect and molecular mechanism of interferon-α (INF-α) on the apoptosis of the mouse podocyte cell line MPC5 induced by hepatitis B virus X (HBx) protein. (zgddek.com)
abstract = "To further investigate the functions of proteins encoded by C open reading frame of hepatitis B virus (HBV) in HBV infectious cycle, cell lines expressing these proteins were established. (johnshopkins.edu)

HCV is one of the major causes of chronic hepatitis which can lead to liver cirrhosis and hepatocellular carcinoma. (monash.edu)
Hepatitis C computer virus (HCV) replicates preferentially in the liver, and in most instances, the HCV illness becomes chronic and often results in hepatocellular carcinoma. (careersfromscience.org)
The hepatitis C virus (HCV) is a major human pathogen that causes severe diseases such as chronic hepatitis, liver cirrhosis and finally hepatocellular carcinoma. (biomedcentral.com)
The Hepatitis B virus (HBV) is the cause of chronic hepatitis B (CHB), liver cirrhosis, and hepatocellular carcinoma (HCC). (ghuhlo.top)
To further address the possible functional role of HBx in the life cycle of hepatitis B virus, we performed an analysis using the yeast two-hybrid system to screen a cDNA library derived from a hepatocellular carcinoma cell line with a HBx fusion bait in an attempt to identify cellular partners that may bind to and alter the biologic properties of HBx. (elsevierpure.com)
This 9.6-kDa protein is capable of binding to HBx in vitro, and transient and stable expression in hepatocellular carcinoma cells abolishes the transactivation properties of HBx on luciferase constructs driven by AP-1 and endogenous hepatitis B virus enhancer/promoter elements. (elsevierpure.com)
Background: Hepatitis C virus (HCV) is a blood born virus that is considered a major cause of chronic liver disease and hepatocellular carcinoma (HCC) worldwide. (bvsalud.org)

Setting: Human thyroid cell lines ML-1 and human thyrocytes in primary cell culture were treated with HCV recombinant E2 protein. (elsevierpure.com)
Identification of the major, parenteral non-A, non-B hepatitis agent (hepatitis C virus) using a recombinant cDNA approach. (microbiologyresearch.org)
A successful recombinant hepatitis E vaccine has been developed. (medscape.com)

Nonstructural protein 4B (NS4B) is a viral protein found in the hepatitis C virus. (wikipedia.org)
Hepatitis C virus (HCV) nonstructural protein 5A (NS5A) modulates cellular apoptosis, which is involved in the occurrence and development of liver cancer. (spandidos-publications.com)

In addition, NS5A significantly increases the expression of inducible nitric oxide synthase, cyclin D1 and nuclear factor-κB, but decreases p53 protein expression in HepG2 cells ( 6 ). (spandidos-publications.com)
SARS-CoV-2, the coronavirus causing the global COVID-19 pandemic, uses a protein called polymerase to replicate its genome inside infected human cells. (news-medical.net)
One of human HCC cell lines, HepG2 cells, was transfected to stably express HBx protein (HBx(+)-HepG2). (nih.gov)
Flow cytometry and western-blot further demonstrated that B7-H1 protein synthesis was enhanced in HBx(+)-HepG2 cells. (nih.gov)
We describe the first report of RNA sequencing of 5' capped (Pol II) RNAs isolated from acutely hepatitis C virus (HCV) infected Huh 7.5 cells that provides a general approach to identifying differentially expressed annotated and unannotated genes that participate in viral-host interactions. (mdpi.com)
In this study, we screened all the nonstructural proteins of HCV and found that HCV NS2 could suppress RNAi induced either by small hairpin RNAs (shRNAs) or small interfering RNAs (siRNAs) in mammalian cells. (virosin.org)
After 48 hours of intervention under different experimental conditions, flow cytometry was used to measure the apoptosis of MPC5 cells, and quantitative real-time PCR and Western blot were used to measure the mRNA and protein expression of slit diaphragm-related proteins (nephrin, CD2AP, and synaptopodin) and the cytoskeleton-related protein transient receptor potential cation channel 6 (TRPC6). (zgddek.com)
Results MPC5 cells transfected by pEX-HBx had the highest expression of HBx mRNA at 48 hours after transfection (P P P P Conclusions INF-α can inhibit the apoptosis of podocytes induced by HBx, possibly through improving the abnormal expression of slit diaphragm-related proteins (CD2AP, nephrin, and synaptopodin) and cytoskeleton-related protein (TRPC6) induced by HBx. (zgddek.com)
This protein is abundantly expressed in nearly all eukaryotic cells [26]. (pkc-inhibitor.com)
We conclude that most lymphomas of HCV-infected patients do not arise from B cells aimed at eliminating the virus. (unipv.it)
In agreement with previous reports, confocal immunofluorescence analysis of the subcellular localization of HCV structural proteins indicated that, in infected cells, the glycoprotein heterodimer is retained in the endoplasmic reticulum. (ox.ac.uk)
Surprisingly, no colocalization was observed between the glycoprotein heterodimer and the capsid protein in infected cells. (ox.ac.uk)
A) The HCV RNA genome is certainly proven with buy Laminin (925-933) buy Laminin (925-933) the 5- and 3-UTRs flanking the open up reading body (ORF) for the polyprotein, which, after developing, produces the pathogen structural protein and the nonstructural … The reality that HCV replicates preferentially in the liver organ suggests that the virus-like lifestyle routine is dependent on elements mainly portrayed in liver organ cells. (careersfromscience.org)
We hypothesized that HCV E2 protein binding to CD81 expressed on thyroid cells activates a cascade of inflammatory responses that can trigger autoimmune thyroiditis in susceptible individuals. (elsevierpure.com)
Here we show that the ion channel activity of HCV p7 expressed in mammalian cells can substitute for that of influenza virus M2 in a cell-based assay. (microbiologyresearch.org)
When viruses infect cells, they make use of cellular machinery, in other words the cell's built-in multiplication mechanisms. (pasteur.fr)
Red blood cells contain hemoglobin, a protein that enables them to carry oxygen from the lungs and deliver it to all parts. (msdmanuals.com)
140), proteins 136 g/dL, and 18 cells/ dren. (cdc.gov)

This 30 kb size virus has caused many difficulties for scientists in search of a vaccine. (news-medical.net)
As the death toll from the COVID-19 pandemic mounts, scientists worldwide continue their push to develop effective treatments and a vaccine for the highly contagious respiratory virus. (news-medical.net)
See U.S. Food and Drug Administration Influenza Virus Vaccine Safety & Availability . (hivguidelines.org)
Although there is a vaccine that offers protection against the virus, current treatments which prevent the virus from replicating are not curative for infected individuals. (pasteur.fr)
This prevention strategy includes making hepatitis B vaccine a part of routine vaccination schedules for all infants. (cdc.gov)
The recommendations for implementing this strategy include making hepatitis B vaccine a part of routine vaccination schedules for infants. (cdc.gov)
More than 90% of these infections can be prevented if HBsAg-positive mothers are identified so that their infants can receive hepatitis B vaccine and hepatitis B immune globulin (HBIG) soon after birth (4,5). (cdc.gov)

Nineteen national-level public health laboratories performed routine dengue diagnostic assays on a proficiency testing panel consisting of two modules: one containing commercial serum samples spiked with cultured dengue viruses for the detection of nucleic acid and non-structural protein 1 (NS1) (Module A) and one containing human serum samples for the detection of anti-dengue virus antibodies (Module B). A review of logistics arrangements was also conducted. (who.int)

This guideline on pretreatment assessment of patients with chronic hepatitis C virus (HCV) was developed by the New York State Department of Health AIDS Institute (NYSDOH AI) to guide primary care providers and other practitioners in New York State in all aspects of treating and curing patients with chronic HCV. (hivguidelines.org)

The compounds from G.glabra showed good docking scores for both Hepatitis B and C. This study will be useful in future for designing novel drugs for the treatment of liver diseases. (simulations-plus.com)
Hepatitis A (formerly known as ''infectious hepatitis'') is an acute infectious disease of the liver caused by the hepatitis A virus (HAV), which is most commonly transmitted by the fecal-oral route via contaminated food or drinking water. (news-medical.net)
HMGB1 is closely related to many inflammatory diseases, such as ischemia of liver and kidney, hepatitis, arthritis, stroke, ischemia buy ICG-001 of liver buy ICG-001 and kidney, sepsis, and systemic lupus erythematosus [21C25]. (pkc-inhibitor.com)
Scientists at the Institut Pasteur postulated that a protein mainly produced in several organs, including the liver, could take on the role of a restriction factor. (pasteur.fr)
This document provides the rationale for a comprehensive strategy to eliminate transmission of HBV and ultimately reduce the incidence of hepatitis B and hepatitis B-associated chronic liver disease in the United States. (cdc.gov)
Patients with hepatitis B disease and fulminant hepatic failure should be hospitalized in the intensive care unit (ICU) and be considered as liver transplant candidates in the event that they do not recover. (medscape.com)

HBsAg is the abundantly expressed envelope protein as a dimmer of two identical polypeptides encoded by the same gene. (scielo.br)

The hepatitis E virus (HEV) genome contains three open reading frames (ORFs). (medscape.com)
It is a hepatotropic, approximately 7.2 kb single-stranded positive-sense RNA virus whose genome contains three open reading frames (ORF1, ORF2, and ORF3), 5′ and 3′ untranslated regions (UTRs), and a poly(A) tract at the 3′ end. (nature.com)

Erdtmann L, Franck N, Lerat H, Le Seyec J, Gilot D, Cannie I, Gripon P, Hibner U, Guguen-Guillouzo C (2003) The hepatitis C virus NS2 protein is an inhibitor of CIDE-B-induced apoptosis. (virosin.org)
Hepatitis B virus X protein modulates apoptosis in primary rat hepatocytes by regulating both NF-kappaB and the mitochondrial permeability transition pore[J]. J Virol, 2009, 83(10):4718-4731. (zgddek.com)
In conclusion, our results suggest that HCV interferes with antiviral immunity through TLR2-mediated monocyte activation triggered by the HCV core protein to induce cytokines that in turn lead to PDC apoptosis and inhibit IFN-alpha production. (umassmed.edu)
New EMBO members' review: viral and bacterial proteins regulating apoptosis at the mitochondrial level. (microbiologyresearch.org)

Expression of precore and core proteins of hepatitis B virus in human hepatoma cell line. (johnshopkins.edu)
The DNA fragments encoding 25 000, 22 000 precore-core and 21 000 core protein respectively were amplified from plasmid pCP10 which contained HBV genome, and inserted into a eukaryotic expression vector pcDNA-3, and then transfected into hepatoma cell line HepG2. (johnshopkins.edu)
Dive into the research topics of 'Expression of precore and core proteins of hepatitis B virus in human hepatoma cell line. (johnshopkins.edu)

Ji J, Glaser A, Wernli M, Berke JM, Moradpour D, Erb P (2008) Suppression of short interfering RNA-mediated gene silencing by the structural proteins of hepatitis C virus. (virosin.org)
Subcellular localization of hepatitis C virus structural proteins in a cell culture system that efficiently replicates the virus. (ox.ac.uk)
This allowed us to reinvestigate the subcellular localization of HCV structural proteins in the context of an infectious cycle. (ox.ac.uk)
In conclusion, the cell culture system for HCV allowed us for the first time to characterize the subcellular localization of HCV structural proteins in the context an infectious cycle. (ox.ac.uk)

Hepatitis C virus (HCV) is a medically important human pathogen that causes acute and chronic hepatitis. (virosin.org)

However, it is unclear how HCV core protein modulates TNF-α-induced NK-κB activation. (ewha.ac.kr)

doi: 10.1002/hep.31712. (phoenixbio.co.jp)

In this thesis, a chimeric JFH1 genome that encodes the p7 protein of genotype (GT) 1b strain J4 was generated. (monash.edu)

It interacts with other proteins and has a crucial role in hepatocarcinogenesis ( 3 ). (spandidos-publications.com)
Bakowska JC, Jenkins R, Pendleton J, Blackstone C. The Troyer syndrome (SPG20) protein spartin interacts with Eps15. (medlineplus.gov)
To fulfil its function NS5A interacts with a large number of different proteins including both viral and human ones. (biomedcentral.com)

HCV NS4B: From Obscurity to Central Stage in "Hepatitis C Viruses: Genomes and Molecular Biology. (wikipedia.org)
The hepatitis B virus and the mammalian hepadnavirus genomes encode for a short open reading frame called x. (elsevierpure.com)

Although dedicated studies in large cohorts of patients are needed to confirm this observation, we speculate that patients carrying procholestatic hepatobiliary transporter variants may benefit from vaccination against hepatitis A. (elsevier.es)

NS5A upregulates Beclin 1 mRNA and protein expression in a HCV NS5A-transactivated protein 9 (NS5ATP9)-dependent manner ( 15 ). (spandidos-publications.com)

A hydrophobic domain in the large envelope protein is essential for fusion of duck hepatitis B virus. (edu.au)
The duck hepatitis B virus (DHBV) envelope is comprised of two transmembrane (TM) proteins, the large (L) and the small (S), that assemble into virions and subviral particles. (edu.au)

TDF is a non-selective RT inhibitor with demonstrated in vitro activity against both wild-type and mutant strains of HIV [ 4 - 6 ] and is also effective for treating chronic hepatitis B (CHB) [ 7 - 10 ]. (biomedcentral.com)
This study used a fragment-based drug discovery (FBDD) approach to reconstruct a repurposed core protein inhibitor to some novel antiviral derivatives. (ghuhlo.top)

Since the protein plays a critical role in the virus life cycle, chemical compounds that block p7 function are potential candidates for anti-viral therapy. (monash.edu)

iGEM dock software tool is used for docking analysis to screen potent inhibitors of target proteins. (simulations-plus.com)

Results: HCV envelope protein E2 induced strong inflammatory responses in human thyrocytes, resulting in production of interleukin (IL)-8, IL-6, and tumor necrosis factor-a. (elsevierpure.com)
Furthermore, the E2 protein induced production of several heat shock proteins including HSP60, HSP70p12A, and HSP10, in human primary thyrocytes. (elsevierpure.com)
Mitochondrial alterations induced by the p13II protein of human T-cell leukemia virus type 1. (microbiologyresearch.org)
Hepatitis E has many similarities with hepatitis A . Hepatitis E has been associated with chronic hepatitis in solid-organ transplant recipients, patients infected by human immunodeficiency virus (HIV), and in an individual on rituximab treatment for non-Hodgkin lymphoma. (medscape.com)
He was veillance and reporting are needed to human calicivirus in the Sapporo virus admitted to a local hospital in Nicara- shed some more light on this poorly clade, associated with an outbreak of gas- gua, at which time routine results of understood virus. (cdc.gov)

Brazilian National Immunization Program presents a good schedule viewing hepatitis B immunization for infants, adolescents, and adults. (scielo.br)

We expressed the lymphoma B-cell receptors as soluble immunoglobulin Gs and membrane IgMs, and analyzed their reactivity with HCV proteins and with HCV virions. (unipv.it)

During our research, we demonstrated that a cellular protein capable of degrading DNA could be incorporated into the viral particle and induce degradation of the hepatitis B virus genome," explains Jean-Pierre Vartanian from the Institut Pasteur's Molecular Retrovirology Unit. (pasteur.fr)
HCV is thought to induce HCC either indirectly or directly by the effect of its viral proteins on different host cell proteins and signaling pathways. (bvsalud.org)

Thermo Fisher Scientific, the world leader in serving science, today announced the availability of the Thermo Scientific MAS Omni Infectious Disease quality control sets for monitoring serological assays for analytes such as HIV 1&2, Hepatitis B & C virus, Syphilis and HTLV I/II. (news-medical.net)

These data suggest that mutations within E1 or E2 can compensate for the reduction in infectivity observed for HVR1 deleted viruses. (monash.edu)
In summary, this thesis demonstrates the importance of functional interactions between HCV proteins during virus morphogenesis and infectivity. (monash.edu)

Fabozzi G, Nabel CS, Dolan MA, Sullivan NJ (2011) Ebolavirus proteins suppress the effects of small interfering RNA by direct interaction with the mammalian RNA interference pathway. (virosin.org)

Mohebbi A, Ghorbanzadeh T, Naderifar S, Khalaj F, Askari FS, Sammak AS (2023) A fragment-based drug discovery developed on ciclopirox for inhibition of Hepatitis B virus core protein: An in silico study. (ghuhlo.top)

p7 is a highly hydrophobic, integral membrane protein and is classified in the viroporin family. (monash.edu)
Induction of membrane proliferation by poliovirus proteins 2C and 2BC. (microbiologyresearch.org)

We developed genomic locus proteomics (GLoPro), in which we combine CRISPR-based genome targeting, proximity labeling, and quantitative proteomics to discover proteins associated with a specific genomic locus in native cellular contexts. (nature.com)
microRNAs (miRNAs) are little RNAs that work in post-transcriptional gene control.9 Mature miRNAs are incorporated in microRNA-protein (miRNP) processes, including Argonaute (Ago), and usually help the miRNP complicated to focus on sequences in the 3-UTRs of cellular mRNAs. (careersfromscience.org)
Demonstration of p7 ion channel activity in cellular membranes and its inhibition by amantadine affirm the protein as a target for future anti-viral chemotherapy. (microbiologyresearch.org)
Thus, these observations indicate that HCV core protein may play an important role in the regulation of the cellular inflammatory and immune responses through NF-κB. (ewha.ac.kr)
Scientists at the Institut Pasteur working in collaboration with the CNRS have demonstrated that a cellular protein is capable of acting as a restriction factor for the hepatitis B virus by degrading the viral DNA. (pasteur.fr)
To combat viruses, some cellular proteins are capable of interfering with these mechanisms. (pasteur.fr)

Molecular elucidation of drug-induced abnormal assemblies of the hepatitis B virus capsid protein by solid-state NMR. (pasteur.fr)

The role of electrostatic interactions in the viral capsid assembly process was studied by comparing the assembly process of a truncated hepatitis B virus capsid protein Cp149 with its mutant protein D2N/D4N, which has the same conformational structure but four fewer charges per dimer. (uky.edu)
Hepatitis B virus (HBV) capsid assembly modulators (CAMs) represent a recent class of anti-HBV antivirals. (pasteur.fr)

Among the seven HBV-encoded proteins, we identified HBx as the sole viral factor that inhibits resection. (figshare.com)
Expression of dominant negative form of TRAF2 inhibits the synergistic effects of HCV core protein on NF-κB activation, suggesting that HCV core protein potentiates NF-κB activation through TRAF2. (ewha.ac.kr)

Here, we show that hepatitis C virus (HCV) co-opts the host protein CypA to aid evasion of antiviral responses dependent on the effector protein kinase R (PKR). (nih.gov)

Herein, the predicted atomic structures of five representative sequence variants of the reverse transcriptase protein (RT) of hepatitis B virus (HBV), sampled from patients with rapid or slow response to tenofovir disoproxil fumarate (TDF) treatment, have been examined to identify structural variations between them in order to assess structural and functional properties of HBV-RT variants associated with the differential responses to TDF treatment. (biomedcentral.com)
Inhibition of this protein may be an effective new treatment for patients with immune-inflammatory eye disease. (pkc-inhibitor.com)
HCV core protein, which was detectable in the plasma of infected patients, reduced TLR9-triggered IFN-alpha and increased TNF-alpha and IL-10 production in PBMCs but not in isolated PDCs, suggesting HCV core induced PDC defects. (umassmed.edu)
Triple therapy with amantadine in treatment-naive patients with chronic hepatitis C: a placebo-controlled trial. (microbiologyresearch.org)
DNase I, considered as a new antiviral restriction factor, is expressed in vitro in a hypoxic (oxygen-depleted) environment and also in patients infected with hepatitis B virus. (pasteur.fr)
Patients with acute hepatitis should be monitored with blood tests in order to document biochemical improvement (see Workup). (medscape.com)
Patients with acute or chronic hepatitis without cirrhosis have no dietary restrictions. (medscape.com)

Based on its molecular genetic characteristics, the virus has been classified into the Hepacivirus genus of the family Flaviviridae. (monash.edu)
Molecular virology of hepatitis C virus. (microbiologyresearch.org)
Thus, this molecular approach will add incrementally to our current knowledge of the HEV-genome organization and pathogenesis in chronic hepatitis E. (nature.com)

Dyneins are large microtubule motor proteins required for mitosis intracellular transport and ciliary and flagellar motility1 2 They generate force through a powerstroke mechanism which is an ATP-consuming cycle of pre- and post-powerstroke conformational changes that cause relative motion between different dynein domains3-5. (researchensemble.com)
However, in contrast to previous reports, the capsid protein was not found in the nucleus or in association with mitochondria or other well-defined intracellular compartments. (ox.ac.uk)

Regulation of gene expression is primarily controlled by changes in the proteins that occupy genes' regulatory elements. (nature.com)
The expression of major proinflammatory cytokines was measured at the messenger RNA and protein levels. (elsevierpure.com)

The transformants were selected with neomycin, and three isolated colonies expressing precore or core proteins were obtained stably, which were demonstrated by immunohistochemistry and Western blotting analysis. (johnshopkins.edu)
Drug repurposing strategies have introduced several drugs targeting HBV core protein. (ghuhlo.top)
Auto Core Fragment in silico Screening (ACFIS) server was used for deconstruction-reconstruction of Ciclopirox in complex with HBV core protein. (ghuhlo.top)
Previous work has implicated that the core protein of hepatitis C virus (HCV) may play a modulatory effect on NF-κB activation induced by TNF-α. (ewha.ac.kr)
Here we show that overexpression of HCV core protein potentiates NF-κB activation induced by TNF-α. (ewha.ac.kr)
Moreover, we demonstrate that HCV core protein potentiates TRAF2-mediated NF-κB activation via IKKβ. (ewha.ac.kr)
In addition, HCV core protein associates with TNF-R1-TRADD-TRAF2 signaling complex, resulting in synergistically activation of NF-κB induced by TNF-α. (ewha.ac.kr)

Together, our findings uncovered that HCV NS2 can act as a VSR in vitro, thereby providing novel insights into the life cycle and virus-host interactions of HCV. (virosin.org)
We previously identified the function of the hepatitis C virus (HCV) p7 protein as an ion channel in artificial lipid bilayers and demonstrated that this in vitro activity is inhibited by amantadine. (microbiologyresearch.org)

Serum protein electrophoresis only showed hypoalbuminaemia, and bone marrow and splenic aspirates showed no abnormal cell clones. (who.int)

Anatomy5

Organisms17

Diseases22

Chemicals and Drugs25

Analytical, Diagnostic and Therapeutic Techniques and Equipment7

Phenomena and Processes12

Disciplines and Occupations1

Anthropology, Education, Sociology and Social Phenomena1

Technology, Industry, Agriculture2

Information Science5

Named Groups1

Health Care5

Geographicals5

Infection31

Replication17

Antigen5

Abstract2

Hepatocellular7

Recombinant3

Nonstructural protein2

Cells18

Vaccine7

Antibodies1

Chronic hepatitis C vir1

Liver6

HBsAg1

Genome contains three open readin2

Apoptosis4

Hepatoma3

Structural proteins4

Acute and chronic1

Modulates1

10.10021

Genotype1

Interacts3

Genomes2

Vaccination1

MRNA1

Duck hepat2

Inhibitor2

Chemical compounds1

Potent inhibitors1

Human5

Adults1

Reactivity1

Induce2

Syphilis1

Infectivity2

Suppress1

20231

Membrane2

Cellular6

Drug-induced1

Capsid assembly2

Inhibits2

Kinase1

Patients7

Molecular3

Intracellular2

Expression2

Core7

Vitro2

Serum1