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MyocardiumHeart FailureHeartGene ExpressionGene Expression RegulationGene Transfer TechniquesGene Expression ProfilingGenetic TherapyGenetic Vectorsbeta-GalactosidaseAdenoviridaeHeart RateRNA, MessengerCardiac Output, LowHeart Failure, SystolicOligonucleotide Array Sequence AnalysisHeart Failure, DiastolicStroke VolumeHeart DiseasesHeart TransplantationCardiomyopathy, DilatedNatriuretic Peptide, BrainVentricular Function, LeftTime FactorsVentricular Dysfunction, LeftHemodynamicsTreatment FailureChronic DiseaseGene Expression Regulation, DevelopmentalAdrenergic beta-AntagonistsVentricular RemodelingReverse Transcriptase Polymerase Chain ReactionTreatment OutcomeTranscription, GeneticHeart Defects, CongenitalEchocardiographyCardiotonic AgentsMyocardial ContractionPromoter Regions, GeneticTranscription FactorsCardiomegalyBase SequenceCardiac Pacing, ArtificialPrognosisMolecular Sequence DataMyocytes, CardiacHeart Function TestsGene Expression Regulation, NeoplasticDisease Models, AnimalCardiomyopathiesFollow-Up StudiesProspective StudiesGene Expression Regulation, EnzymologicMyocardial InfarctionSignal TransductionDiureticsRisk FactorsBiological MarkersHeart AtriaCells, CulturedAngiotensin-Converting Enzyme InhibitorsHeart-Assist DevicesGene Expression Regulation, PlantHospitalizationFetal HeartMyocardial IschemiaPropanolaminesExercise TestHeart VentriclesGene Expression Regulation, BacterialSystoleDogsPredictive Value of TestsRats, Sprague-DawleySeverity of Illness IndexAtrial Natriuretic FactorHeart ValvesRetrospective StudiesDiastoleDNA-Binding ProteinsCell LineGene Expression Regulation, ViralMice, Inbred C57BLKidney Failure, ChronicDigoxinExercise ToleranceCarbazolesUp-RegulationVentricular DysfunctionOxygen ConsumptionSympathetic Nervous SystemCluster AnalysisRats, WistarRisk AssessmentVentricular PressurePatient ReadmissionProportional Hazards ModelsSurvival AnalysisEchocardiography, DopplerMutation
InfarctionApoptosisHypertrophy and heart failureAcuteCongestive heart fIschemiaRegulationContractilityMutationsCoronaryRegulateTissueMyocardiumDysfunctionIschemic heart dAtherosclerosisLeft ventricularMiRNAsVentricularHypoxiaProgressionMRNACardiovascular diseasesDilated cardiomyopathyVivoInflammationSevereMiceHypertensionDiseasesOverexpressionCellularKinasesCytokinesAtrialPerfusionEnzymesCardiomyocytesTherapeuticDegradationPathologicalStrokeChronicInhibitionMicroRNAEffectorHypertrophicOntologyPatientsInactivatePathwayKinase familySignal transductionInhibitorSubunitContractileMitochondrialPathwaysTissuesTranscriptionMechanismsPeripheralResponsesReceptorsRegenerative
Infarction21
Apoptosis11
  • CRT effects are related to alterations in genes and microRNAs (miRs) expression, which regulate cardiac processes involved in cardiac apoptosis, cardiac fibrosis, cardiac hypertrophy and angiogenesis, and membrane channel ionic currents. (hindawi.com)
  • Protein expression of ER stress and apoptosis factors was analyzed using Western Blot analysis. (karger.com)
  • Res effectively suppress the cardiomyocytes hypertrophy and apoptosis induced by ISO, characterized by the reduction of the myocardial cell surface area, the ANP gene expression, the LDH and MDA leakage amount and the rate of cell apoptosis, while decrease of the protein expression of GRP78, GRP94 and CHOP, and reverse the expression of Bcl-2 and Bax. (karger.com)
  • In summary, Res treatment effectively suppressed myocardial hypertrophy and apoptosis at least partially via inhibiting ER stress. (karger.com)
  • The present study aimed to investigate the effects of S/V on the expression of metastasis‑associated lung adenocarcinoma transcript 1 (MALAT1), inflammation and apoptosis in human umbilical vein endothelial cells (HUVECs) induced by oxidized low‑density lipoprotein (ox‑LDL) and to elucidate its possible mechanism. (spandidos-publications.com)
  • Overall, the findings suggested that S/V could downregulate the expression of MALAT1, inhibit inflammation and apoptosis and improve endothelial function in ox‑LDL‑induced HUVECs via inactivating the TLR4/NF‑κB signaling pathway. (spandidos-publications.com)
  • Although they cannot encode proteins, they are involved in many biological processes as regulators, such as proliferation, apoptosis, migration and invasion ( 9 ). (spandidos-publications.com)
  • Upregulated genes included a large proportion of transcription factors, genes related to cell growth/apoptosis/DNA repair, cell structure proteins, metabolism, and cell signaling/communication. (gsea-msigdb.org)
  • By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. (insulin-receptor.info)
  • What is the pathophysiologic significance of cardiomyocyte apoptosis in heart failure? (latestfashiontips.com)
  • A study by Hashem et al using induced pluripotent stem cell-derived cardiomyocytes indicated that LAMP2 protein deficiency in Danon disease results in autophagic flux impairment, which in turn causes excessive oxidative stress and, subsequently, cardiomyocyte apoptosis. (medscape.com)
Hypertrophy and heart failure2
Acute2
  • MCARD-mediated βARKct gene expression results in preservation of regional and global systolic function after acute MI without arresting progressive ventricular remodeling. (mssm.edu)
  • Serious' effects are those that evoke failure in a biological system and can lead to morbidity or mortality (e.g., acute respiratory distress or death). (cdc.gov)
Congestive heart f1
  • The most common cause of mortality worldwide is cerebrovascular disease (CVD), which includes coronary heart disease (CHD), congestive heart failure, CVD and stroke, peripheral artery diseases, carotid artery diseases, and aortoiliac disease. (medscape.com)
Ischemia3
  • Adult rats were subjected to myocardial ischemia/reperfusion (I/R) injury with or without ischemic preconditioning (IPC), and the level of miR‑133b‑5p in myocardium was measured. (spandidos-publications.com)
  • Reperfusion after cardiac ischemia increases cell death and infarct size (IS), called myocardial ischemia/reperfusion (I/R) injury, which is the main cause of myocardial injury during the cardiac surgery particularly in coronary artery bypass graft surgery ( 1 , 2 ). (spandidos-publications.com)
  • Myocardial ischemia results when the blood supply from the coronary arteries is unable to keep up with the increased oxygen demand of the myocardium due to cardiac hypertrophy. (alliedacademies.org)
Regulation9
  • Calcium/calmodulin-dependent protein kinase involved in the regulation of Ca(2+) homeostatis and excitation-contraction coupling (ECC) in heart by targeting ion channels, transporters and accessory proteins involved in Ca(2+) influx into the myocyte, Ca(2+) release from the sarcoplasmic reticulum (SR), SR Ca(2+) uptake and Na(+) and K(+) channel transport. (icr.ac.uk)
  • The CRT-induced "reverse molecular remodeling" in responders patients is related to an increase in the expression of genes involved in the regulation of excitation-contraction coupling and a reversal in the isoforms switching of the contractile genes [ 9 ] ultimately leading to remodeling effects and improving of myocardial performance. (hindawi.com)
  • In all cases tested, the qRT-PCR analyses confirmed the come to passs order sleepwell in australia of the Illumina analyses (Figure 8 ), namely lofty expression of gene sequences active in starch biosynthesis and sporamin accumulation, of the gene encoding CDK and of genes belonging to the class-I knotted-like homeobox protein family, and down-regulation of genes encoding enzymes of lignin biosynthesis in ISRs. (upb.ro)
  • Bbeta-adrenergic receptor kinase-1 levels in catecholamine-induced myocardial hypertrophy: regulation by beta- but not alpha1-adrenergic stimulation. (duke.edu)
  • beta2-Adrenergic receptor regulation by GIT1, a G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein. (duke.edu)
  • The study indicates that inducing the expression of LAV-BPIFB4 in aged mice improved cardiac function and regulation of blood flow to the heart. (medicalnewstoday.com)
  • They are encoded by separate but linked genes termed regulation of complement activation (RCA) genes, located on the q32 region of chromosome 1. (medscape.com)
  • In addition, the (pro)renin-PRR complex triggers a signal transduction cascade to mediate regulation of downstream genes independently of AngII. (mtu.edu)
  • We will further investigate the detailed mechanism of brain PRR on the regulation of inflammation and heart failure. (mtu.edu)
Contractility5
  • Cardiac hypertrophy primarily happens when the myocardium's total volume is increased and its contractility is strengthened due to prolonged myocardial pressure overload. (alliedacademies.org)
  • As a result, myocardial contractility eventually declined. (alliedacademies.org)
  • Through the network analysis, reduction of cardiac preload and myocardial contractility was shown to be the major effect of Schisandra components, which was further experimentally validated. (frontiersin.org)
  • In addition, the expression of NCOR2 and NFAT in myocyte were experimentally confirmed to be associated with Schisandra in the treatment of AMI, which may be responsible for the preservation effect of myocardial contractility. (frontiersin.org)
  • Another approach involves delivering genes that regulate myocardial contractility, aiming to improve the heart's pumping ability. (aliyuncs.com)
Mutations12
  • The discovery that mutations in sarcomere protein genes cause HCM has enabled the development of mouse models that recapitulate clinical manifestations of disease. (rupress.org)
  • New disease genes and pathogenic mutations often seem far afield from the overt manifestations of human pathology, in particular when the gene is expressed life long, but the disease emerges only after years or decades. (rupress.org)
  • The journey from defining genetic etiology to molecular understanding of disease mechanism can be frustratingly slow, requiring exploration of how mutations alter functions of the encoded protein and delineation of the responses that they trigger in relevant cells. (rupress.org)
  • Scope includes mutations and abnormal protein expression. (cancerindex.org)
  • Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene. (jax.org)
  • Clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) gene-editing technology is the ideal tool of the future for treating diseases by permanently correcting deleterious base mutations or disrupting disease-causing genes with great precision and efficiency. (bvsalud.org)
  • They are caused by mutations of the dystrophin gene, the largest known human gene, at the Xp21.2 locus. (msdmanuals.com)
  • In Duchenne dystrophy, these mutations result in the severe absence ( 5%) of dystrophin, a protein in the muscle cell membrane. (msdmanuals.com)
  • The most common cause of HCM is now known to be one of over 200 possible mutations in at least 10 genes that involve sarcomeric proteins. (medscape.com)
  • Forms of HCM without evidence of mutations in sarcomeric proteins have also been identified. (medscape.com)
  • [ 9 ] Genomic sequencing for the LAMP2 gene revealed mutations in 2 of 197 (1%) patients with HCM. (medscape.com)
  • We confirm that Brugada syndrome is the same entity as sudden night death, highly prevalent in Southeast Asian countries (Thailand, Philippines and Japan), both of which share mutations in the same gene: SCN5A. (bvsalud.org)
Coronary7
  • It is also widely known that cholesterol values are a biomarker and risk indicator for coronary and vascular disease, and that C-reactive protein (CRP) is a marker for inflammation. (wikipedia.org)
  • The functioning of the heart itself requires oxygen and nutrients that are supplied by the coronary arteries. (medicalnewstoday.com)
  • Aging is associated with an increase in the risk of cardiovascular conditions, including heart attack , heart failure , and coronary artery disease . (medicalnewstoday.com)
  • These cardiovascular conditions are caused by alterations in the structure and function of the heart and blood vessels, including the coronary arteries. (medicalnewstoday.com)
  • Life-threatening disorders like coronary heart disease, cerebrovascular, peripheral arterial, rheumatic heart, congenital heart diseases, deep-vein thrombosis, and pulmonary embolism are caused due to impairment of heart and blood vessels, and they are collectively known as cardiovascular diseases (CVDs). (walshmedicalmedia.com)
  • Statins are the most effective drugs in the treatment of lowering low-density lipoproteins and coronary heart disease. (walshmedicalmedia.com)
  • Coronary sinus, normally located between the LEFT ATRIUM and LEFT VENTRICLE on the posterior surface of the heart, can serve as an anatomical reference for cardiac procedures. (bvsalud.org)
Regulate4
  • Targets also transcription factors and signaling molecules to regulate heart function. (icr.ac.uk)
  • In pathological myocardial remodeling acts downstream of the beta adrenergic receptor signaling cascade to regulate key proteins involved in ECC. (icr.ac.uk)
  • In addition to Ca(2+) channels, can target and regulate the cardiac sarcolemmal Na(+) channel Nav1.5/SCN5A and the K+ channel Kv4.3/KCND3, which contribute to arrhythmogenesis in heart failure. (icr.ac.uk)
  • Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. (cancerindex.org)
Tissue7
  • Finally, we found a significant upregulation of MST1 and downregulation of SIRT3 levels in human myocardial tissue of cancer patients treated with DOX. (bvsalud.org)
  • Tissue or organ-specific genes were predicted by BioGPS. (researchsquare.com)
  • Furthermore, this group investigated the knockdown efficacy of several other antagomirs and showed for the very first time which the cholesterol-based chemistry was also in a position to knockdown miRNA expression in cardiac tissue after intravenous injection (Krutzfeldt et al, 2005). (bioxorio.com)
  • In these analyses we isolated a variety of inflammatory specific cell types within adipose tissue and have taken extensive use of RNAseq technology to characterize the expression profiles of these various cell subsets. (einsteinmed.edu)
  • Our results demonstrate that miR-146a transcript levels were sharply increased in cardiac ventricular tissue of transgenic mice with specific overexpression of TNF-α in the heart, and also in a cardiomyocyte cell line of human origin (AC16) exposed to TNF-α. (jefferson.edu)
  • By enhancing blood supply to the damaged heart tissue, these therapeutic genes can potentially improve cardiac function and reduce symptoms such as shortness of breath and fatigue. (aliyuncs.com)
  • Downregulated adipose tissue expression of browning genes with increased environmental temperatures. (medscape.com)
Myocardium2
Dysfunction7
  • The pathophysiology of sepsis includes inflammation, immune dysfunction, and dysfunction of coagulation, while sepsis-induced cardiomyopathy ( SIC ), defined as a global but reversible dysfunction of both sides of the heart induced by sepsis, plays a significant role in all of the aspects above in the pathogenesis of sepsis. (frontiersin.org)
  • The endotoxin-induced myocardial dysfunction probably depends on the toll-like receptor (TLR) 4-induced cytokines release as a delay in onset of myocardial depression after endotoxin administration ( 10 ). (frontiersin.org)
  • Other TLR-related genes (TLR2, 3, and 9) were demonstrated to be involved in sepsis-induced cardiac dysfunction from recent studies. (frontiersin.org)
  • Another change associated with aging involves the dysfunction of endothelial cells , which form the inner lining of blood vessels and the heart. (medicalnewstoday.com)
  • Given that MMP-9 is an AP-1 target gene involved in cardiac remodeling, myocardial dysfunction and progression of heart failure, these findings suggest that miR-146a might be a new and promising therapeutic tool for treating cardiac disorders associated with enhanced inflammation in the heart. (jefferson.edu)
  • Gene expression of PGC-1α was 2.5-fold higher in GAMT-/- hearts while downstream genes were not activated, implicating a dysfunction in mitochondrial biogenesis signaling. (ox.ac.uk)
  • Executive dysfunction in Klinefelter syndrome: associations with brain activation and testicular failure. (medscape.com)
Ischemic heart d1
  • According to the World Health Organization, an estimated 17.5 million people died of cardiovascular disease in 2012, of which 7.4 million died of ischemic heart disease and 6.7 million died of stroke ( 1 ). (spandidos-publications.com)
Atherosclerosis1
Left ventricular1
  • The thickening of the left ventricle, known as left ventricular hypertrophy , can result in complications such as heart failure, which is the inability of the heart to pump sufficient quantities of blood to the body. (medicalnewstoday.com)
MiRNAs6
  • MicroRNAs (miRNAs/miRs) are endogenous, single-stranded, small (approximately 22 nucleotides in length) noncoding RNA molecules that play an important and ubiquitous role in regulating genes expression. (spandidos-publications.com)
  • MiRNAs typically bind to the 3′ untranslated region (UTR) of their mRNA targets and downregulate gene expression via mRNA degradation or translational inhibition ( 8 - 10 ). (spandidos-publications.com)
  • MiRNAs are non-protein-coding, small RNAs of 20C23 nucleotides (nt) which exist in practically all organisms and so are highly evolutionary conserved (Ambros, 2001) suggesting an excellent role in essential biological processes. (bioxorio.com)
  • Finally, miRNAs are incorporated into RNA-induced silencing complexes (RISC) to silence gene expression on the post-transcriptional level by targeting messenger RNAs (mRNAs) with the consequence of mRNA degradation or by translational inhibition finally resulting in target protein repression. (bioxorio.com)
  • Regardless of the existence of ribonucleases, miRNAs remain stable in serum as well as other body fluids because of loading from the 2-Hydroxysaclofen supplier miRNAs into proteins, lipids or lipoprotein complexes such as for example exosomes or microvesicles. (bioxorio.com)
  • The involvement of miRNAs in cancer research emerged from studies demonstrating their aberrant expression in neoplastic tissues. (genengnews.com)
Ventricular7
  • Chronic unloading of the failing heart with a left ventricular assist device (LVAD) can decrease cardiac mass and myocyte size and has the potential to improve contractile function. (gsea-msigdb.org)
  • To study the effect of chronic ventricular unloading on myocardial gene expression, a microarray (U133A, Affymetrix) profiling gene expression was compared before and after LVAD support in seven patients with idiopathic dilated cardiomyopathy and end-stage heart failure. (gsea-msigdb.org)
  • Advanced patients' disease is characterised by severe myocardial fibrosis and impaired ventricular systolic function [ 3 ]. (alliedacademies.org)
  • Due to cellular heterogeneity in the heart, the activation of gene programs representing specific atrial and ventricular cardiomyocyte subtypes would be highly desirable. (biomedcentral.com)
  • Transcription factor GATA4-targeted compounds that have previously shown in vivo efficacy in cardiac injury models were tested for stage-specific activation of atrial and ventricular reporter genes in differentiating pluripotent stem cells using a dual reporter assay. (biomedcentral.com)
  • GATA4-targeted compounds 3i-1000 and 3i-1103 were identified as differential modulators of atrial and ventricular gene expression. (biomedcentral.com)
  • Furthermore, it is unknown whether endogenous progenitors/stromal cells in the adult human heart could be chemically induced to generate functional atrial or ventricular heart muscle to treat adult heart diseases. (biomedcentral.com)
Hypoxia3
  • Hypoxia/reoxygenation (H/R) as well as hypoxic preconditioning (HPC) is widely used for simulating in vivo myocardial I/R and ischemic preconditioning (IPC) in a cell culture model. (spandidos-publications.com)
  • In their studies on genetically modified mice, the Bad Nauheim researchers also found that in animals in which miR-1/133a was switched off, the heart muscle cells coped much better with hypoxia conditions (oxygen depletion), such as those that exist after a heart attack. (mpg.de)
  • In the experiment, the heart muscle cells from miR-1/133a knockout animals showed higher viability and survival in hypoxia,' Valussi said. (mpg.de)
Progression3
  • More specifically, a biomarker indicates a change in expression or state of a protein that correlates with the risk or progression of a disease, or with the susceptibility of the disease to a given treatment. (wikipedia.org)
  • Mice null for cardiac PRMT1 exhibit a rapid progression to dilated cardiomyopathy and heart failure within 2 months, accompanied by cardiomyocyte hypertrophy and fibrosis. (korea.ac.kr)
  • Adenoviral vectors have shown promise in gene therapy for chronic heart failure by targeting key cellular mechanisms involved in the progression of this condition. (aliyuncs.com)
MRNA3
  • According to Dr. Marcusson, an important aspect of these studies was the demonstration of miR-21 knockdown using genome-wide mRNA expression studies. (genengnews.com)
  • Among all the in silico predicted miR-146a target genes, Fos mRNA and protein levels notably decreased after TNF-α treatment or miR-146a overexpression. (jefferson.edu)
  • Challenge of rGMCs with 1 or 10 μM HgCl 2 or Pb 2 acetate increased HSPA5 mRNA and protein levels. (bioone.org)
Cardiovascular diseases3
Dilated cardiomyopathy2
  • In its activated form, is involved in the pathogenesis of dilated cardiomyopathy and heart failure. (icr.ac.uk)
  • Idiopathic-dilated cardiomyopathy (IDC) is a common primary myocardial disease of unknown etiology characterized by progressive biventricular failure, cardiac dilatation, and premature mortality. (nih.gov)
Vivo4
  • This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag. (cusabio.com)
  • Additionally, we've made progress in hepatocyte-targeted in vivo gene silencing by modifying the siRNAs. (genengnews.com)
  • RESULTS: In vivo LV catheterization revealed lower heart rate and developed pressure in aging GAMT-/- but normal lung weight and survival versus age-matched controls. (ox.ac.uk)
  • Assaying fibroblast activation protein (FAP) expression in vivo and in vitro for possible targeting with chimeric antigen receptor (CAR) T cells. (cdc.gov)
Inflammation5
  • There is growing evidence that a specific class of diabetes drugs may help fight heart disease by also fighting inflammation. (natap.org)
  • In recent years research has pointed to inflammation as a possible cause of heart disease. (natap.org)
  • And early studies have hinted that the type 2 diabetes drugs Actos and Avandia may help fight heart disease not only by improving blood sugar but also by battling inflammation. (natap.org)
  • But Actos also improved several heart disease risk factors, including cholesterol and markers of inflammation, such as C-reactive protein. (natap.org)
  • And less inflammation may mean less heart disease and stroke. (natap.org)
Severe4
  • Interestingly, the neurodegeneration is fully rescued in hEGFR KI/KI mice, however, they develop a severe heart hypertrophy with semilunar valve abnormalities. (silverchair.com)
  • Cardiac beta ARK1 inhibition prolongs survival and augments beta blocker therapy in a mouse model of severe heart failure. (duke.edu)
  • Because Actos and Avandia can cause fluid retention, they are not recommended for people with moderate to severe heart failure. (natap.org)
  • [ 4 ] The excessive intrasarcomeric glycogen is mostly responsible for the severe myocardial hypertrophy and is possibly responsible for pre-excitation. (medscape.com)
Mice9
  • SN degeneration was also observed in muscles of MLC/SOD1G93A mice, with muscle specific expression of the SOD1G93A mutant gene. (bvsalud.org)
  • Expression of a beta-adrenergic receptor kinase 1 inhibitor prevents the development of myocardial failure in gene-targeted mice. (duke.edu)
  • Mice develop tumors resembling those seen in humans, including expression of high levels of miR-21. (genengnews.com)
  • In the new study, inducing the expression of LAV-BPIFB4 in aged mice led to improvements in cardiac function that, translated to the human context, would be equivalent to a reduction in the heart's biological age by 10 years. (medicalnewstoday.com)
  • This study demonstrates that it is also possible to make human cardiac cells younger and older mice hearts by transferring a gene expressed by centenarians. (medicalnewstoday.com)
  • Short-term Cr deficiency is metabolically well tolerated as GAMT-/- mice exhibit normal exercise capacity and response to ischemic heart failure. (ox.ac.uk)
  • This is associated with hemodynamic changes without evidence of heart failure, which may represent an acceptable functional compromise in return for reduced energy demand in aging mice. (ox.ac.uk)
  • If these molecules are switched off, the heart was less damaged after a heart attack in experiments with mice. (mpg.de)
  • Scientists from Thomas Braun's department at the Max Planck Institute for Heart and Lung Research in Bad Nauheim have now been able to show in mice that one such mechanism involves two so-called micro-RNAs, miR-1 and miR-133a. (mpg.de)
Hypertension4
  • Valsartan is an angiotensin receptor blocker, and used to treat hypertension and heart failure . (walshmedicalmedia.com)
  • Post-transcriptional gene, Cardiovascular disease, Pulmonary hypertension. (alliedacademies.org)
  • A clinical syndrome known as hypertension is characterised by elevated systemic arterial blood pressure (systolic blood pressure of at least 140 mmHg and diastolic blood pressure of at least 90 mmHg), which can result in damage to the kidney, heart, brain, and other organs. (alliedacademies.org)
  • Research in the MPL focuses on the role of the brain's (pro)renin receptor (PRR) and other members of the renin angiotensin system in the development of hypertension, metabolic syndrome, and heart failure. (mtu.edu)
Diseases5
  • Several biomarkers have been identified for many diseases such as serum LDL for cholesterol, blood pressure, and P53 gene and MMPs as tumor markers for cancer. (wikipedia.org)
  • Heart failure (HF) and type 2 diabetes mellitus (T2DM) are two growing and related diseases in general population and particularly in elderly people. (hindawi.com)
  • The available therapies for degenerative diseases can only alleviate the symptoms of patients, while siRNA therapy drugs can upregulate gene expression, modify epigenetic changes, and stop the disease. (bvsalud.org)
  • Defects in the expression of complement or complement receptors may result in loss of tolerance to self-proteins and the development of immune complex-mediated autoimmune diseases such as systemic lupus erythematosus (SLE). (medscape.com)
  • These diseases are a result of storage in cellular vacuoles and include Danon disease, Pompe disease, Fabry disease , and a form of HCM related to a mutation in the adenosine monophosphate (AMP)-activated, gamma-2 noncatalytic subunit of protein kinase ( PRKG2 ). (medscape.com)
Overexpression5
  • PRMT1 depletion in isolated cardiomyocytes evokes hypertrophic responses with elevated remodeling gene expression, while PRMT1 overexpression protects against pathological responses to neurohormones. (korea.ac.kr)
  • Overexpression of this gene is associated with tumor cell proliferation and metastasis. (cancerindex.org)
  • Additionally, DRAM2 overexpression promoted cell metastasis and proliferation in vitro, while knockdown of DRAM2 expression yielded opposite result. (cancerindex.org)
  • DRAM2 overexpression also increased proteins CDK4, CyclinD3, and decreased p27 expression, all of which are cell cycle-related factors. (cancerindex.org)
  • HER2 overexpression or HER2 gene amplification as determined by an accurate and validated assay (see sections 4.4 and 5.1). (who.int)
Cellular3
  • Molecular chaperones are known to play a role in stabilizing protein structure and function during events of cellular stress. (bioone.org)
  • By harnessing these viral vectors' ability to efficiently infect both dividing and non-dividing cells, scientists can introduce specific genes into diseased tissues and initiate targeted cellular responses aimed at restoring normal physiological functions. (aliyuncs.com)
  • They are single-chain molecules present on host cellular membranes and belong to the complement control protein family. (medscape.com)
Kinases5
  • We have previously shown that second-messenger-dependent kinases (cAMP-dependent kinase, protein kinase C) in the olfactory system are essential in terminating second-messenger signaling in response to odorants. (duke.edu)
  • G protein-coupled receptor activation leads to the membrane recruitment and activation of G protein-coupled receptor kinases, which phosphorylate receptors and lead to their inactivation. (duke.edu)
  • Stimulation of Gi-coupled receptors leads to the activation of mitogen-activated protein kinases (MAP kinases). (duke.edu)
  • Protein kinases are enzymes that transfer a phosphate group from a phosphate donor onto an acceptor amino acid in a substrate protein. (insulin-receptor.info)
  • In this way, caspases recruit and activate proteins involved in the apoptotic process (eg, caspase-dependent endonuclease), inactivate survival proteins (eg, the extracellularly responsive kinases and the DNA repair enzyme poly-ADP-ribosyl polymerase), and act directly on cytoskeletal proteins, resulting in plasma membrane changes. (latestfashiontips.com)
Cytokines3
  • LVAD support resulted in downregulation of genes for a group of cytokines. (gsea-msigdb.org)
  • One potential application is the delivery of genes encoding growth factors or cytokines that promote angiogenesis, the formation of new blood vessels. (aliyuncs.com)
  • Previously, we have shown in a mouse model that exposure to hog dust extract (HDE) collected from a CAFO results in the activation of protein kinase C (PKC), elevated lavage fluid cytokines/chemokines including interleukin-6 (IL-6), and the development of significant lung pathology. (cdc.gov)
Atrial2
  • Hypertrophy was estimated by measuring the cell surface area and the atrial natriuretic peptide (ANP) gene expression. (karger.com)
  • HN - 2008 BX - Lateral Sinus MH - Atrial Septum UI - D054087 MN - A07.541.459.249 MS - The thin membrane-like muscular structure separating the right and the left upper chambers (HEART ATRIA) of a heart. (bvsalud.org)
Perfusion2
  • For example, rubidium chloride is used in isotopic labeling to evaluate perfusion of heart muscle. (wikipedia.org)
  • Heart failure is the inability of the cardiac systolic and/or diastolic functions to completely empty the veins of the heart's blood, which ultimately results in venous system blood stasis and inadequate arterial blood perfusion. (alliedacademies.org)
Enzymes1
  • Furthermore, myocardial energy stores and key ATP homeostatic enzymes were barely altered, while pathology was unrelated to oxidative stress since superoxide production and protein carbonylation were unaffected. (ox.ac.uk)
Cardiomyocytes3
  • The level of active CaMKII is significantly elevated in PRMT1-deficient hearts or cardiomyocytes. (korea.ac.kr)
  • Collectively, these results indicate the potential for therapeutic alteration of cell fate decisions and pathological gene regulatory networks by GATA4-targeted compounds modulating chamber-specific transcriptional programs in multipotent cardiac progenitor cells and cardiomyocytes. (biomedcentral.com)
  • Ectopic expression of SARS-CoV-2 S and ORF-9B proteins alters metabolic profiles and impairs contractile function in cardiomyocytes. (cdc.gov)
Therapeutic4
  • One particularly influential approach in this regard is the use of adenoviral vectors, which hold great potential for unlocking the therapeutic benefits of gene therapy. (aliyuncs.com)
  • Adenoviruses are DNA viruses that can be genetically modified to deliver therapeutic genes into target cells, offering a means to correct or replace defective genes responsible for disease pathogenesis. (aliyuncs.com)
  • In addition, the inclusion of features such as codon optimization and promoters providing long-term expression have improved the expression characteristics of therapeutic transgenes. (bvsalud.org)
  • Early approaches were based on gene addition, where a new DNA copy of a gene is introduced to complement a genetic mutation: however, the advent of RNA-based products that can directly express a therapeutic protein or manipulate gene expression, together with the expanding range of tools for gene editing, has stimulated the development of alternative approaches. (bvsalud.org)
Degradation2
  • Environmental injury has been associated with endoplasmic reticulum (ER) stress, a response characterized by activation of the unfolded protein response, proteasomal degradation of proteins, and induction of HSPA5, also known as GRP78 or BiP. (bioone.org)
  • Ultimately, the caspase cascade leads to the cleavage of target intracellular proteins resulting in their activation or degradation. (latestfashiontips.com)
Pathological1
  • Pathological and physiological changes resulting from disease onset are expected to serve as identifying factors for targeted delivery or targets for gene editing. (bvsalud.org)
Stroke2
  • Heart disease and stroke are the leading causes of death among people with diabetes, with two out of three diabetes patients eventually dying from one of these conditions. (natap.org)
  • According to one the new study's researchers, it makes sense that the TZDs would protect against heart attack and stroke because insulin is active in the lining of the blood vessels. (natap.org)
Chronic7
  • Chronic kidney disease and anaemia are common in heart failure (HF) and are associated with a worse prognosis in these patients. (revistanefrologia.com)
  • The medical treatment of chronic heart failure has undergone a dramatic transition in the past decade. (duke.edu)
  • Chronic human heart failure is characterized by abnormalities in beta-adrenergic receptor (betaAR) signaling, including increased levels of betaAR kinase 1 (betaARK1), which seems critical to the pathogenesis of the disease. (duke.edu)
  • Although the cardiac hypertrophy is an adaptive response of the heart that responds to a variety of extrinsic and intrinsic stimuli, prolonged hypertrophy typically culminates in chronic heart failure or sudden cardiac death. (karger.com)
  • To illustrate this potential, consider the hypothetical case study of John, a 45-year-old patient suffering from chronic heart failure due to impaired cardiac function. (aliyuncs.com)
  • Specifically, it will delve into their potential applications in treating chronic heart failure and the challenges that need to be addressed for successful implementation. (aliyuncs.com)
  • In conclusion, adenoviral vectors hold immense potential for revolutionizing regenerative biomedicine and offering new treatment options for chronic conditions such as heart failure. (aliyuncs.com)
Inhibition4
  • Inhibition of GRK2 via expression of a peptide βARKct transferred by molecular cardiac surgery with recirculating delivery (MCARD) may be a promising intervention. (mssm.edu)
  • Reporter gene assays were conducted to examine combinatorial effects of GATA-targeted compounds and bromodomain and extraterminal domain (BET) inhibition on chamber-specific gene expression. (biomedcentral.com)
  • The Bcl-2 proteins influence cell survival primarily by controlling the mitochondrial response to apoptotic signals, although direct inhibition of caspase activity may occur. (latestfashiontips.com)
  • Tak1 inhibition abolished the Wnta1-induced expression of TCF3, TCF4, and LEF1 and Wnta1-mediated ANP secretion and changes in mechanical dynamics. (kjpp.net)
MicroRNA1
  • miR-146a is a microRNA whose transcript levels are induced in the heart upon activation of NF-κB, a transcription factor induced by pro-inflammatory molecules (such as TNF-α) that is strongly related to the pathogenesis of cardiac disorders. (jefferson.edu)
Effector2
  • Acts by specifically binding and stimulating NPR1 to produce cGMP, which in turn activates effector proteins that drive various biological responses. (cusabio.com)
  • Effector proteins interacting with the Fc portion of immunoglobulin M (IgM) include complement and complement receptors. (medscape.com)
Hypertrophic2
  • In the nucleus, phosphorylates the MEF2 repressor HDAC4, promoting its nuclear export and binding to 14-3-3 protein, and expression of MEF2 and genes involved in the hypertrophic program. (icr.ac.uk)
  • Hypertrophic cardiomyopathy (HCM) is a common inherited heart disease with serious adverse outcomes, including heart failure, arrhythmias, and sudden cardiac death. (rupress.org)
Ontology6
  • Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways were used to conduct enrichment analysis. (researchsquare.com)
  • In order to solve this problem, a comprehensive network analysis method was established based-on "component-gene ontology-effect" interactions. (frontiersin.org)
  • In conclusion, the three-mode gene ontology network can be an effective network analysis workflow to evaluate the pharmacological effects of a multi-drug complex system. (frontiersin.org)
  • In contrast to protein interaction networks, enriched gene ontology (GO) terms of AMI related genes were used to construct a gene ontology interaction (GOI) network, which can be used to simulate the functional interactions between differential expressed genes of disease. (frontiersin.org)
  • For the construction of a "component-gene ontology" network of Schisandra in the treatment of AMI, the HPLC-Q-TOF-MS was used to analyze the Schisandra extract. (frontiersin.org)
  • Targets of Schisandra ingredients were further screened to enrich and construct the "component-gene ontology" network, which was a component for the integration of a three-mode network. (frontiersin.org)
Patients9
  • Heart failure is a major side effect of doxorubicin (DOX) treatment in patients with cancer. (bvsalud.org)
  • The effect of reverse remodeling was evaluated on long-term survival in mildly symptomatic patients with heart failure submitted to CRT [ 10 ]. (hindawi.com)
  • Studies in these models have provided unexpected insights into the biophysical and biochemical properties of mutated contractile proteins and may help to improve clinical diagnosis and management of patients with HCM. (rupress.org)
  • Consistently, PRMT1 is downregulated in heart failure patients. (korea.ac.kr)
  • These patients also have organ enlargement and serious functional disorders such as high blood pressure, diabetes and heart disease. (iccv2013.org)
  • In a study reported in September of 2003, University of Texas researchers identified six cases of congestive heart failureamong diabetes patients taking the drugs. (natap.org)
  • Systematic identification of ACE2 expression modulators reveals cardiomyopathy as a risk factor for mortality in COVID-19 patients. (cdc.gov)
  • Clinical variants of myocardial involvement in COVID-19-positive patients: a cumulative experience of 2020. (cdc.gov)
  • La présente analyse récapitule les facteurs pathologiques majeurs liant l'obésité au diabète, en se concentrant sur les données épidémiologiques actuelles relatives aux patients diabétiques obèses dans le monde arabe, l'étiologie de la maladie et les déterminants génétiques du diabète et de l'obésité. (who.int)
Inactivate1
  • Scientists from the Max Planck Institute for Heart and Lung Research in Bad Nauheim have now discovered that the two micro RNA molecules miR-1 and miR-133 in the adult heart inactivate two genes that normally force cell division. (mpg.de)
Pathway5
  • This study aims to test whether the serine/threonine kinase MST1, a major Hippo pathway component, contributes to the development of DOX-induced myocardial injury. (bvsalud.org)
  • Here they show the LOTUS domain protein eggd-1 organizes germ granules, and reveal a germ line-to-soma communication pathway activated upon perturbation of germ granules. (nature.com)
  • However, n the fed state, CDK8/CycC proteins are rapidly down regulated through a mTORC1 dependent pathway leading to increased SREBP-1c stability and increased lipogenic gene expression and lipogenesis. (einsteinmed.edu)
  • Further study showed that the phosphoinositide-3-kinase-forkhead protein pathway and proteins related to nitric oxide synthesis, including eNOS and dimethylarginine dimethylaminohydrolase isoform 1 (DDAH1, an enzyme regulating endogenous nitric oxide synthase activity), were significantly increased during the cardiac remodeling process. (gsea-msigdb.org)
  • In the canonical WNT pathway, activated WNT phosphorylates the dishevelled (DVL) protein leading to dissociation of β-catenin from its destruction complex. (kjpp.net)
Kinase family1
  • The protein kinase family is one of the largest families of proteins in eukaryotes, classified in 8 major groups based on sequence comparison of their tyrosine ,PTK) or serine/threonine ,STK) kinase catalytic domains. (insulin-receptor.info)
Signal transduction1
  • This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. (cancerindex.org)
Inhibitor1
  • In this line, reporter gene assays with combinatorial treatment of 3i-1000 and the BET bromodomain inhibitor (+)-JQ1 demonstrated the cooperative role of GATA4 and BRD4 in the modulation of chamber-specific cardiac gene expression. (biomedcentral.com)
Subunit1
  • The diagnostic level of natriuretic peptide A (NPPA), haemoglobin subunit beta (HBB), and hyaluronan and proteoglycan link protein 1(HAPLN1) were validated by a GSE116250 dataset. (researchsquare.com)
Contractile1
  • This strategy holds promise for restoring normal contractile function and preventing further deterioration of heart function. (aliyuncs.com)
Mitochondrial2
  • Apoptotic cell death follows well-defined time-depend-ent processes, which result in changes in the plasma membrane, proteolysis of intracellular proteins, loss of mitochondrial function, and characteristic DNA cleavage. (latestfashiontips.com)
  • Proapoptotic Bcl-2 proteins contribute to this process by disrupting the function of the mitochondrial membranes and their associated proteins. (latestfashiontips.com)
Pathways2
  • Thus, in order to research the multi-mechanism complex system in TCM, network pharmacology has been commonly used in recent years to predict the major target proteins or signal pathways of TCM. (frontiersin.org)
  • In addition, it inhibits the activation of the inflammatory mediator NF-κB, inhibits p38 MAPK, ERK1/2 and JNK signaling pathways, and inhibits the expression of the LPS receptor TLR4, suggesting that Ramalin has an excellent anti-inflammatory effect. (justia.com)
Tissues3
  • DRAM2 was preferentially upregulated in NSCLC tissues and higher expression of DRAM2 in NSCLC correlated with tumor node metastases stage and lymph node metastasis. (cancerindex.org)
  • Gene therapy has attracted much attention because of its unique mechanism of action, non-toxicity, and good tolerance, which can kill cancer cells without damaging healthy tissues. (bvsalud.org)
  • siRNA-based gene therapy can downregulate, enhance, or correct gene expression by introducing some nucleic acid into patient tissues. (bvsalud.org)
Transcription2
  • Reverse transcription‑quantitative PCR was performed to detect the MALAT1 expression. (spandidos-publications.com)
  • Ramalin of the invention is a compound derived from natural material, has no toxicity or side effects, and inhibits the expression of inducible nitric oxide synthase (iNOS) in the transcription stage to significantly inhibit the production of nitric oxide (NO) that is a key mediator of inflammatory responses. (justia.com)
Mechanisms3
  • However, the mechanisms underlying the development of DOX-induced heart failure need to be addressed. (bvsalud.org)
  • Small Indels in the Androgen Receptor Gene: Phenotype Implications and Mechanisms of Mutagenesis. (medscape.com)
  • A bioinformatics approach for identifying potential molecular mechanisms and key genes involved in COVID-19 associated cardiac remodeling. (cdc.gov)
Peripheral2
  • The purpose of the new initiative is to support the next phase of this research program by adding investigative teams to form a consortium with the biorepository serving as the Coordinating Center (CC). CaRe-T1D is currently collecting hearts, kidneys, carotid and peripheral arteries, and blood from organ donors with T1D, T2D and without diabetes. (nih.gov)
  • Synthetic androgens in humans that is enough for testosterone, total testosterone, and androgen binding protein in the peripheral serum of male rats during sexual maturation. (iccv2013.org)
Responses1
  • Although biochemical and biophysical assays and cell biology experiments advance these insights, full elucidation of the pathophysiology caused by human disease requires a broader approach, including assessment of the impact that cells with a pathogenic mutation have on neighboring cells that do not express the mutant protein and consideration of system-wide responses to a diseased organ. (rupress.org)
Receptors7
  • Pathogen-associated molecular patterns released by infecting organisms not only bind immune receptors on inflammatory cells but also bind receptors on cells in the heart ( 8 ). (frontiersin.org)
  • The beta-adrenergic receptor kinase 1 (beta ARK1) is a member of the G protein-coupled receptor kinase (GRK) family that mediates the agonist-dependent phosphorylation and desensitization of G protein-coupled receptors. (duke.edu)
  • Heart failure is accompanied by severely impaired beta-adrenergic receptor (betaAR) function, which includes loss of betaAR density and functional uncoupling of remaining receptors. (duke.edu)
  • We found that miR-1/133a suppresses two receptors on heart muscle cells. (mpg.de)
  • In this case, the heart muscle cells lost the ability to contract due to the unchecked activity of the two receptors and the animals suffered heart failure. (mpg.de)
  • Partial or complete deficiencies of the components of the complement system, including its receptors and regulatory proteins, are now described in humans and may be of a genetic or familial origin or acquired. (medscape.com)
  • Among healthy individuals, the number of CR1 receptors on the red blood cells varies widely, yet the phenotypic expression, regulated by 2 codominant alleles, is stable. (medscape.com)
Regenerative3
  • The compound scaffolds described within this study could be used to develop regenerative strategies for myocardial regeneration. (biomedcentral.com)
  • Accordingly, in contrast to organs with a high regenerative capacity, no divisible, regenerative stem cells are found in the heart. (mpg.de)
  • In recent years, the field of regenerative biomedicine has witnessed a paradigm shift with the emergence of gene therapy as a promising treatment modality. (aliyuncs.com)