AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsInformation ScienceHealth Care
LymphomaLymphoma, Non-HodgkinLymphoma, B-CellLymphoma, Large B-Cell, DiffuseLymphoma, T-CellLymphoma, FollicularLymphoma, Large-Cell, ImmunoblasticBurkitt LymphomaVincristinePrednisoneVindesineLymphoma, B-Cell, Marginal ZoneCyclophosphamideDoxorubicinLymphoma, Mantle-CellCarcinoma, Large CellAntineoplastic Combined Chemotherapy ProtocolsLymphoma, T-Cell, CutaneousLymphoma, T-Cell, PeripheralBleomycinLymphoma, AIDS-RelatedAntibodies, Monoclonal, Murine-DerivedLymphoma, Large-Cell, AnaplasticHodgkin DiseaseInfusions, SpinalEtoposideAntigens, CD30Transplantation, AutologousRemission InductionCytarabinePrognosisSurvival AnalysisCombined Modality TherapyTreatment OutcomeMethotrexateSurvival RatePrednisoloneNeoplasm StagingDisease-Free SurvivalCarcinoma, NeuroendocrineTranslocation, GeneticSalvage TherapyAntibodies, MonoclonalAntigens, CD20Follow-Up StudiesRetrospective StudiesRecurrenceImmunohistochemistryImmunophenotypingReed-Sternberg CellsFluorodeoxyglucose F18Lymphoma, Extranodal NK-T-CellFatal OutcomeProto-Oncogene Proteins c-bcl-6Receptor Protein-Tyrosine KinasesStem Cell TransplantationHerpesvirus 4, HumanDrug Administration ScheduleChromosomes, Human, Pair 14Hematopoietic Stem Cell TransplantationB-LymphocytesLymphoma, Primary Cutaneous Anaplastic Large CellChromosomes, Human, Pair 18Gene RearrangementLymph NodesMycosis FungoidesDisease ProgressionSkin NeoplasmsChromosomes, Human, Pair 2Thymus NeoplasmsTumor Markers, BiologicalTime FactorsEye NeoplasmsLung NeoplasmsNose NeoplasmsLeukemia, Lymphocytic, Chronic, B-CellDNA, NeoplasmLymphoproliferative DisordersEpstein-Barr Virus InfectionsCentral Nervous System NeoplasmsProtein-Tyrosine KinasesBiopsyIn Situ Hybridization, FluorescenceLymphomatoid PapulosisImmunoglobulin Heavy ChainsTumor Cells, CulturedAntineoplastic AgentsPolymerase Chain ReactionCell Line, TumorProspective StudiesNeoplasm ProteinsChromosomes, Human, Pair 5Flow CytometryPseudolymphomaGene Expression Regulation, NeoplasticImmunoenzyme TechniquesGenes, mycLeukemiaT-LymphocytesProto-Oncogene Proteins c-bcl-2
KinaseHodgkinCutaneous T-cell lFollicular lymphomaTumorsALCLSubtypesDiffuseLymphMalignant lymphomasMycosis fungoidesPeripheral T-cell lympSystemicSmall lymphocyTumor cellsRefractoryTranslocationCD30BiopsyReceptorMarginal ZoneBone marrowPrognosisClinicalBurkittPTCLTypes of lymphomaNodalDifferentiationCancerDLBCLSymptoms of lymphomaChimericIncidenceProliferationRelapseAntigensDiagnosisLymphoid cellsTissuesMedulloblastomaAutologousReceptorsOncogenicLymphocyteOccursInvolvementMutationsWorld Health OrganPrimaryCD20NeoplasmsClonalTransmembrane
Kinase16
  • ALK, i.e. anaplastic lymphoma kinase, is a protein product of the ALK gene located on chromosome 2. (wikipedia.org)
  • ALK is a serine/threonine-specific protein kinase that activities PI3K/AKT/mTOR, Ras-activated ERKs, Janus kinase-activated STAT proteins, and other cell signaling pathways as well as the expression of various genes by epigenetic mechanisms. (wikipedia.org)
  • CIRComa : Deciphering the role of circular RNAs in the pathogenesis and therapeutic resistance of anaplastic large cell lymphomas associated with the oncogenic tyrosine kinase ALK. (crct-inserm.fr)
  • 85% of ALK+ ALCLs are associated with a translocation between the NPM (nucleophosmin) gene and the ALK (Anaplastic Lymphoma Kinase) gene resulting in a constitutively activated, oncogenic fusion protein. (crct-inserm.fr)
  • ALCLs frequently carry a chromosomal translocation that results in expression of the oncoprotein nucleophosmin-anaplastic lymphoma kinase (NPM-ALK). (unito.it)
  • Anaplastic lymphoma kinase (ALK) protein may be detected in most cases (60-70%) of systemic ALCL by immunohistochemistry. (medscape.com)
  • This gene is also a translocation partner in anaplastic large cell lymphoma and inflammatory myofibroblastic tumor cases, where a t(2;17)(p23;q25) translocation has been identified with the anaplastic lymphoma kinase (ALK) gene on chromosome 2, and a t(8;17)(q24;q25) translocation has been identified with the MYC gene on chromosome 8. (cancerindex.org)
  • Further sequencing of that region identified mutations in the anaplastic lymphoma kinase (ALK) gene in eight families with familial neuroblastoma. (clpmag.com)
  • In the nodal T cell lymphomas, the major subtypes are PTCL, not otherwise specified (PTCL-NOS), angioimmunoblastic T cell lymphoma (AITL), anaplastic lymphoma kinase (ALK)-positive anaplastic large cell lymphoma (ALCL) and ALK-negative ALCL. (biomedcentral.com)
  • Whether IMT is reactive or neoplastic in nature has been controversial, but recently it is considered as a true tumor because of the identification of anaplastic lymphoma kinase (ALK) gene rearrangement [ 2 ]. (hindawi.com)
  • Which medications in the drug class Antineoplastic Agents, mTOR Kinase Inhibitors are used in the treatment of Non-Hodgkin Lymphoma (NHL)? (medscape.com)
  • This complex inhibits mammalian target of rapamycin (mTOR) kinase, a key protein in cells that regulate the gene translation responsible for cell-cycle regulation. (medscape.com)
  • This lymphoma is caused by chromosomal translocations involving the anaplastic lymphoma kinase gene (ALK). (biomedcentral.com)
  • Anaplastic large cell lymphoma with anaplastic lymphoma kinase gene translocations (ALK+ ALCL) is a mature T-cell lymphoma that primarily affects lymph nodes, but also gives rise to tumors in extranodal organs and occasional characteristic skin lesions. (biomedcentral.com)
  • Anaplastic Lymphoma Kinase. (lab-ally.com)
  • ALK is one of the receptor tyrosine kinase (RTK) family of enzymes, which have significant roles in the proliferation and differentiation of cells. (lab-ally.com)
Hodgkin39
Cutaneous T-cell l3
  • Case Report: primary cutaneous T-cell lymphoma with aberrant CD20 expression. (cusabio.com)
  • Cutaneous T-cell lymphoma is a general term from mycosis fungoides or occur spontane- to identify non-Hodgkin's T-cell lymphomas ously, although some authors now consider that primarily affect the skin. (bvsalud.org)
  • subtypes of cutaneous T-cell lymphoma, SS is a malignant neoplasm originating the most common of which are mycosis from T lymphocytes, which involves the fungoides and Sézary syndrome (SS). (bvsalud.org)
Follicular lymphoma7
  • Malignant blast cells (i.e. diffuse large B-cell lymphoma) are fast-growing and result in aggressive disease, whereas malignant mature lymphocytes (i.e. follicular lymphoma) behave indolently. (oncolink.org)
  • The t(14;18) translocation (characteristic for follicular lymphoma but also common in other types) results in activation of the BCL-2 gene and suppression of apoptosis. (oncolink.org)
  • Important types include follicular lymphoma and small lymphocytic lymphoma . (oncolink.org)
  • Follicular lymphoma (FL), a B-cell lymphoma, is the most common indolent (slow-growing) form of NHL, accounting for approximately 20 percent to 30 percent of all NHLs. (lymphomaindia.com)
  • Follicular lymphoma international prognostic index. (medscape.com)
  • or adults with relapsed or refractory (r/r) large B-cell lymphoma after two or more lines of systemic therapy including diffuse large B-cell lymphoma (DLBCL) not otherwise specified, high grade B-cell lymphoma and DLBCL arising from follicular lymphoma. (wikimili.com)
  • In May 2022, the indication in the US was updated to include the treatment of adults with relapsed or refractory follicular lymphoma (FL) after two or more lines of systemic therapy. (wikimili.com)
Tumors20
  • This targets and selectively kills cancer cells and shrinks tumors using radiation . (medicinenet.com)
  • A group of heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes. (lookformedical.com)
  • The only common feature among these tumors is the absence of giant REED-STERNBERG CELLS, a characteristic of Hodgkin's disease. (lookformedical.com)
  • B-cell lymphoid tumors that occur in association with AIDS. (lookformedical.com)
  • The differential diagnosis will include anaplastic ependymoma, atypical teratoid rhabdoid tumor (AT/RT), or other forms of highly proliferative malignant neuroectodermal tumors. (medscape.com)
  • My research interests comprise cutaneous tumors with emphasis in lymphomas and melanoma. (mdanderson.org)
  • In lymphomas I have conducted studies in rare aggressive primary cutaneous tumors such as gamma/delta T cell lymphoma (expanding the description of the epidermotropic variant) as well as more indolent entities such as lymphomatoid papulosis (type D) and CD4-positive small to medium size T cell lymphoproliferative disorders. (mdanderson.org)
  • MCPyV in tumor cell genomes, tumor-associated mutations search Ethics Board, Halifax, Nova Scotia, Canada, and in the large T-antigen (T-ag) gene, and large T-ag expres- by the Baylor College of Medicine Institutional Review sion in tumors suggest that MCPyV is not only associated Board, Houston. (cdc.gov)
  • Neuroblastoma is one of the most common solid tumors of childhood, arising from immature sympathetic nervous system cells. (biomedcentral.com)
  • NBs belong to the subgroup of small round blue cell tumors and can often pose a challenge to the pathologist because of their similarities with lymphomas, rhabdomyosarcomas, the Ewing family of tumors and desmoplastic round cell tumors. (biomedcentral.com)
  • Incidence of primary large bowel lymphomas comprises only 0.2-0.6% of large bowel malignant tumors ( 3 ). (frontiersin.org)
  • Overview of Lymphoma Lymphomas are a heterogeneous group of tumors arising in the reticuloendothelial and lymphatic systems. (msdmanuals.com)
  • reticulum cell sarcomas, cutaneous nodular amyloidosis) are relatively common cutaneous tumors. (merckvetmanual.com)
  • For recurrent, invasive tumors, more aggressive attempts at excision or electroporation may be required. (merckvetmanual.com)
  • The German high-grade non-Hodgkin's Lymphoma study group (DSHNHL) analyzed 343 patients with 289 having tumors that belonged to one of the four major subtypes of PTCL. (biomedcentral.com)
  • 1 The most frequent primary tumor types of anterior mediastinal masses are thymic tumors and lymphoma, with approximate proportions of 35% and 25% among mediastinal lesions, respectively. (allenpress.com)
  • Primary cutaneous anaplastic large cell lymphoma - This type of lymphoma presents as nodules or tumors on the skin and is typically slow-growing. (uhapo.co.in)
  • In the past decade, many clinical trials have been investigating anti-CTLA-4 as well as anti-programmed cell death protein 1 (PD-1) therapies in various solid tumors, including HCC. (stanford.edu)
  • Main Outcome(s) and Measure(s): The primary study outcome was to determine the prognostic value of p53 Abs from a large population of patients with solid tumors, as determined before data collection. (stanford.edu)
  • Murine tumors displayed the phenotypic diversity observed in ALK+ ALCL patients, including CD4+ and CD8+ lymphomas. (biomedcentral.com)
ALCL16
  • Considered as a single entity, ALCL is the most common type of peripheral lymphoma and represents ~10% of all peripheral lymphomas in children. (wikipedia.org)
  • ALCL is defined based on microscopic histopathological examination of involved tissues which shows the presence of at least some ALCL-defining pleomorphic cells. (wikipedia.org)
  • ALK-positive and ALK-negative ALCL are aggressive systemic lymphomas. (wikipedia.org)
  • pcALCL and BIA-ALCL are far less aggressive lymphomas that tend to be localized to one or a very few sites. (wikipedia.org)
  • Its neoplastic cells may contain some gene translocations including, in very rare cases, ones with the ALK gene that are similar to those in ALK-positive ALCL. (wikipedia.org)
  • These tissues have lymphoma-like infiltrates that have variable numbers of ALCL "hallmark" cells, i.e. cells with kidney- or horseshoe-shaped nuclei that strongly express CD30 as detected by immunohistochemistry and an ALK fusion protein as detected by fluorescence in situ hybridization. (wikipedia.org)
  • Anaplastic large cell lymphoma (ALCL) is an aggressive, predominantly paediatric T-cell lymphoma. (crct-inserm.fr)
  • Anaplastic large cell lymphoma (ALCL) is an aggressive non-Hodgkin's lymphoma found in children and young adults. (unito.it)
  • ALCL was recognized in 1985, when tumor cells consistently demonstrated labeling by the monoclonal antibody Ki-1, a marker later shown to recognize the CD30 antigen. (medscape.com)
  • In 1988, ALCL was added as a distinct entity to the revised Kiel classification, and in 1994, it was included in the Revised European-American Lymphoma (REAL) classification. (medscape.com)
  • PC-ALCL is one of the primary cutaneous CD30 + T-cell lymphoproliferative disorders, a wide spectrum of disease, with lymphomatoid papulosis (LyP) at the benign end of the spectrum and PC-ALCL at the malignant end. (medscape.com)
  • Histologically, ALCL is characterized by sheets of large pleomorphic cells with abundant cytoplasm, horseshoe- or wreath-shaped nuclei, and multiple prominent nucleoli. (medscape.com)
  • Anaplastic Large-Cell Lymphoma (ALCL) ALCL is an aggressive peripheral T-cell neoplasm representing two of all nonHodgkin lymphomas in adults and 105 inside the pediatric population [51]. (esiservizi.com)
  • Specifically, we found that the WNT signaling cell surface receptor ROR2 represented a robust and genuine marker of all ALK+ ALCL patient tumor samples. (biomedcentral.com)
  • The majority of ALK+ ALCL tumor cells have been shown to express at least one T-cell specific marker. (biomedcentral.com)
  • Between 60 and 80% of ALK+ ALCL cases harbor the NPM-ALK chromosomal translocation, which leads to constitutive activation of the ALK protein. (biomedcentral.com)
Subtypes5
  • Histologic subtypes of medulloblastoma include: (1) desmoplastic/nodular type, (2) medulloblastoma with extensive nodularity, and (3) large-cell/anaplastic medulloblastoma. (medscape.com)
  • 1] Several subtypes of medulloblastoma have been recognized including: (1) desmoplastic/nodular type, (2) medulloblastoma with extensive nodularity, (3) large-cell variant, and (4) anaplastic medulloblastoma. (medscape.com)
  • Some types of the disease strike infants but spontaneously disappear with minimal treatment, while other subtypes in older children may be relentlessly aggressive. (clpmag.com)
  • The International PTCL project that collected 1314 cases of T/NK-cell lymphomas from 22 institutions worldwide revealed that the most common subtypes worldwide are the nodal T cell lymphomas [ 2 ]. (biomedcentral.com)
  • PurposePrevious studies indicate that breast cancer molecular subtypes differ with respect to their dependency on autophagy, but our knowledge of the differential expression and prognostic significance of autophagy-related biomarkers in breast cancer is limited.Methods Immunohistochemistry (IHC) was performed on tissue microarrays from a large popu. (researchgate.net)
Diffuse8
  • In search for subgroups of diffuse large B-cell lymphoma (DLBCL) with different histogenetic origin and prognosis, as has been described by gene expression profiling, we examined tumor specimens from 125 patients with DLBCL, uniformly treated by either cyclophosphamideAdriamycin-vincristine-prednisone or methotrexate, doxorubicin, cyclophosphamide, vincristine, prednisone, and bleomycin in a multicenter trial set by the Nordic Lymphoma Group 1989-1994. (aacrjournals.org)
  • Diffuse large B-cell lymphoma (DLBCL) is the most common form of NHL, accounting for more than 30 percent of newly diagnosed cases. (lymphomaindia.com)
  • Approximately 30-40 % of patients with FL will eventually transform to a more aggressive form of lymphoma like Diffuse Large B Cell Lymphoma and may require intensive chemotherapy followed by autologous stem cell transplantation. (lymphomaindia.com)
  • Diffuse large B-cell lymphoma is the most common histologic subtype of NHL, with ENKTL of the large bowel being less frequent ( 4 ). (frontiersin.org)
  • [6] Serious infections occur in around three in ten diffuse large B-cell lymphoma (DLBCL) patients. (wikimili.com)
  • In April 2017, tisagenlecleucel received breakthrough therapy designation by the U.S. Food and Drug Administration (FDA) for the treatment of relapsed or refractory diffuse large B-cell lymphoma . (wikimili.com)
  • [19] In March 2019, NICE issued guidance approving Kymriah for treatment of relapsed or refractory diffuse large B-cell lymphoma in adults after 2 or more systemic therapies. (wikimili.com)
  • Bone scintigraphy, lumbar spine and pelvic MRI revealed disseminated, diffuse infiltration of the bone marrow which primarily raised the suspicion of lymphoma (Fig. 1a ). (biomedcentral.com)
Lymph5
  • Another example is "primary mediastinal B-cell lymphoma" which often occurs in younger patients and grows rapidly in the chest (mediastinum) Often, the first sign of DLBCL is a painless rapid swelling in the neck, armpit, or groin, which is caused by enlarged lymph nodes. (lymphomaindia.com)
  • Malignant lymphoma in which the lymphomatous cells are clustered into identifiable nodules within the LYMPH NODES. (lookformedical.com)
  • A group of malignant lymphomas thought to derive from peripheral T-lymphocytes in lymph nodes and other nonlymphoid sites. (lookformedical.com)
  • In this study, we investigated the presence of Merkel cell polyomavirus (MCPyV) was fi rst described MCPyV in benign lymph nodes and malignant lymphomas in 2008 ( 1 ) as a new human virus associated with in patients from Canada. (cdc.gov)
  • Sezary syndrome - This is a more aggressive form of mycosis fungoides that can affect the blood and lymph nodes as well as the skin. (uhapo.co.in)
Malignant lymphomas1
  • The area of research for our group is malignant lymphomas - all possible aspects, aiming for the improvement of the quality of life and survival of these patients. (lu.se)
Mycosis fungoides2
Peripheral T-cell lymp1
  • Seattle Genetics, Inc. and Millennium: The Takeda Oncology Company, a wholly owned subsidiary of Takeda Pharmaceutical Company Limited (TSE:4502), today announced the initiation of a global phase III clinical trial evaluating ADCETRIS (brentuximab vedotin) in combination with chemotherapy for the treatment of newly diagnosed CD30-positive mature T-cell lymphoma (MTCL) patients, including patients with systemic anaplastic large cell lymphoma (sALCL) and other types of peripheral T-cell lymphomas. (news-medical.net)
Systemic1
  • Allos Therapeutics, Inc. today announced that it has submitted a request to the European Medicines Agency (EMA) for a re-examination of the negative opinion issued in January by the EMA's Committee For Medicinal Products for Human Use (CHMP) for conditional approval of FOLOTYN (pralatrexate injection) for the treatment of patients with peripheral T-cell lymphoma (PTCL) whose disease has progressed after at least one prior systemic therapy. (news-medical.net)
Small lymphocy1
  • Chronic Lymphocytic Leukemia (CLL) is also considered a subtype of NHL as it is essentially the same disease as Small Lymphocytic Lymphoma . (lymphoma.org.au)
Tumor cells7
  • Tumor cells are found in the bone marrow in up to 40% of the cases when immunohistochemical analysis is performed. (wikipedia.org)
  • Most patients, including up to 90% of young children and adolescents, have circulating autoantibodies directed against the ALK fusion protein expressed by their tumor cells. (wikipedia.org)
  • Background: Ectopic production of amylase by tumor cells is known since 1951. (bvsalud.org)
  • Furthermore to tumor cells and tumor DNA, standard cells and their components which might be present within the tumor microenvironment are also released within the blood. (esiservizi.com)
  • this RNA could function as a communicator between the tumor cells and their microenvironment or distant metastases [479]. (esiservizi.com)
  • Moreover, increasing data have shown that peripheral T-cell tolerance is an essential property of the specific immune response to tumor cells. (biomedcentral.com)
  • Agents in this class halt the cell cycle at the G1 phase in tumor cells. (medscape.com)
Refractory5
  • Allogeneic stem cell transplantation should be considered for refractory disease or for very early relapsing disease. (lymphomaindia.com)
  • Though salvage price is higher in comparison to other T-cell lymphomas, relapsed/refractory sufferers possess a 5-year OS of 500 [51,53,54]. (esiservizi.com)
  • Leukemia, particularly aggressive refractory hematological malignancies unresponsive to upfront therapy, remains a difficult condition to treat. (biomedcentral.com)
  • INO has been approved for treatment of relapsed /refractory B cell precursor ALL. (biomedcentral.com)
  • Multiple ongoing trials are evaluating its role in the relapsed /refractory B cell NHL. (biomedcentral.com)
Translocation3
  • It has been postulated that translocation of chromosome 1, where amylase gene is situated, is responsible for ectopic production from the malignant plasma cells. (bvsalud.org)
  • The majority of mantle-cell lymphomas are associated with a t(11;14) translocation resulting in overexpression of the CYCLIN D1 gene (GENES, BCL-1). (lookformedical.com)
  • We were the first to identify mutations in ALK," said Mossé, adding that in lymphoma and lung cancer, ALK acts through translocation, a different mechanism that involves an exchange of DNA between chromosomes to produce a new cancer-causing fusion gene. (clpmag.com)
CD305
  • These "hallmark" cells have abnormal kidney-shaped or horseshoe-shaped nuclei, prominent Golgi, and express the CD30 tumor marker protein on their surface membranes. (wikipedia.org)
  • Anaplastic large cell lymphomas (ALCLs) are distinguished from other lymphomas by their anaplastic cytology and constant membrane expression of the CD30 antigen (an activation marker for B or T cells). (medscape.com)
  • CD20, CD22, and CD30 are also targeted antigens of CAR T cells in ALL and lymphoma trials [ 26 ]. (biomedcentral.com)
  • 11. A first time report on the coocurrence of sarcoidosis and ALK(-) CD30(+) anaplastic large cell lymphoma that is highly responsive to brentuximab vedotin treatment.Afacan Öztürk HB, Albayrak M, Pala Öztürk Ç, Yıldız A,Maral S, Önder E. J Oncol Pharm Pract. (medipol.com.tr)
  • The Reed Sterberg cells also have with a specific protein called CD15 or CD30 on them. (lymphoma.org.au)
Biopsy4
  • Fine-needle aspirate is sufficient for lymphoma diagnosis but rarely adequate for subtyping, thus excisional or incisional biopsy is considered mandatory[5]. (oncolink.org)
  • A biopsy of the affected skin may be necessary to diagnose lymphoma of the skin. (uhapo.co.in)
  • Biopsy - A biopsy is a procedure where a small sample of skin is removed and examined under a microscope to determine if cancer cells are present. (uhapo.co.in)
  • Hence, there is a need for noninvasive in vivo clinical imaging tools that can study perfusion in the entire tumor, can be used to assess much larger volumes than small biopsy samples, and can probably guide biopsy and excision sites for better results. (ajnr.org)
Receptor15
  • Here we show that the activator protein 1 family members JUN and JUNB promote lymphoma development and tumor dissemination through transcriptional regulation of platelet-derived growth factor receptor-β (PDGFRB) in a mouse model of NPM-ALK-triggered lymphomagenesis. (unito.it)
  • Translocations are thought to occur during normal gene rearrangements (Ig, T-cell receptor). (oncolink.org)
  • The protein encoded by this gene is a receptor for C-C type chemokines. (cancerindex.org)
  • This receptor may contribute to the accumulation and activation of eosinophils and other inflammatory cells in the allergic airway. (cancerindex.org)
  • Such immune dysfunction may be due to a disorder in thymic output function (in particular in young patients), which results in a lower level of naive T-cells in the peripheral blood available for an immune response to the proliferation and abnormal expression of the T cell receptor (TCR) repertoire. (biomedcentral.com)
  • The IL-2 portion of the molecule targets the lymphoma cells by binding to the IL-2 receptor on the plasma membrane, and upon endocytosis, the diphtheria toxin is delivered to the lymphoma cells. (lymphomation.org)
  • Functions as a store-operated calcium (SOC) channel component promoting calcium influx after activation by the B-cell receptor/BCR. (cusabio.com)
  • What do toxins need in a cell receptor? (childrenshospital.org)
  • This was not possible previously, because the receptor for the toxin isn't found in most cell types," says Dong. (childrenshospital.org)
  • It is specifically required for cells to make Gb3, the receptor used by Shiga toxin. (childrenshospital.org)
  • T cells from a person with cancer are removed, genetically engineered to make a specific chimeric cell surface receptor with components from both a T-cell receptor and an antibody specific to a protein on the cancer cell, and transferred back to the person. (wikimili.com)
  • A chimeric T cell receptor (" CAR-T ") is expressed on the surface of the T cell. (wikimili.com)
  • The gene encodes a chimaeric antigen receptor (CAR) that targets leukaemia cells. (wikimili.com)
  • Immunotherapeutic agents including antibodies and chimeric antigen receptor T cells are widely studied in clinical trials. (biomedcentral.com)
  • It regulates the receptor for cholesterol, takes it out of the blood stream and puts it into the cells. (cdc.gov)
Marginal Zone1
  • Primary cutaneous marginal zone B-cell lymphoma - This is a slow-growing lymphoma that typically presents as a single nodule or a small number of nodules on the skin. (uhapo.co.in)
Bone marrow8
  • Bone marrow examination showed the proliferation of hematopoietic cells were active, mainly granulocytes, and immature granulocytes increased. (frontiersin.org)
  • a type of cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell). (massivebio.com)
  • Acute lymphocytic leukemia (ALL) is a type of cancer of the blood and bone marrow - the spongy tissue inside bones where blood cells are made. (massivebio.com)
  • Most lymphomas are nodal with variable involvement of the bone marrow and peripheral blood. (msdmanuals.com)
  • A bone marrow smear was performed, in which 'cerebriform' cells were identified, confirming the diagnosis of Sézary syndrome. (bvsalud.org)
  • Anaplastic Anemia is an uncommon disease resulting in deficiencies of blood cell production by bone marrow. (lab-ally.com)
  • Too many immature white blood cells are present in the blood and bone marrow. (lab-ally.com)
  • This is a form of AML in which excess amounts of promyelocytes (immature white blood cells) are found in bone marrow. (lab-ally.com)
Prognosis5
  • Although BTZ has improved the prognosis of MM patients, MM remains incurable in most patients, mainly because MM cells become resistant to BTZ. (bvsalud.org)
  • The belief that T-cell lymphomas have a worse prognosis than B-cell lymphomas remains controversial. (oncolink.org)
  • Although the outcome for children with cancer has improved considerably during the past decades, the prognosis of children with aggressive neuroblastoma remains dismal. (biomedcentral.com)
  • Vitamin D insufficiency and prognosis in non-Hodgkin's lymphoma. (medscape.com)
  • 2. Clinical epidemiology - using data from the Swedish Lymphoma Registry to provide clinically useful real world data on treatment and prognosis, in many cases in collaboration with Nordic colleagues. (lu.se)
Clinical3
  • Several pharmaceutical companies are currently developing ALK inhibitors in the laboratory, and one ALK inhibitor is already in early-phase adult clinical trials against lung cancer and lymphoma. (clpmag.com)
  • The diagnosis of skin lymphoma can be challenging, as it may present various clinical features that may resemble other skin conditions. (uhapo.co.in)
  • Initial management consisted of en una paciente con topical corticosteroids and oral antihistamines with little clinical response. (bvsalud.org)
Burkitt1
PTCL3
Types of lymphoma1
Nodal1
  • The Non-Hodgkin's lymphomas (NHL) comprise a diverse collection of lymphoreticular neoplasms, usually but not necessarily arising in nodal tissue. (oncolink.org)
Differentiation6
  • The nature of disease (indolent vs. aggressive) is correlated to the stage of lymphocytic differentiation of the malignant cells. (oncolink.org)
  • Most of these lymphomas represent the malignant counterpart of B-lymphocytes at midstage in the process of differentiation. (lookformedical.com)
  • A group of lymphomas exhibiting clonal expansion of malignant T-lymphocytes arrested at varying stages of differentiation as well as malignant infiltration of the skin. (lookformedical.com)
  • Based on their functional outcome, co-signaling molecules can be divided as co-stimulators and co-inhibitors, which positively and negatively control the priming, growth, differentiation and functional maturation of a T-cell response. (biomedcentral.com)
  • B-lymphocyte-specific membrane protein that plays a role in the regulation of cellular calcium influx necessary for the development, differentiation, and activation of B-lymphocytes. (cusabio.com)
  • A type of clonal malignancy characterized by excess accumulation of lymphoblasts that phenotypically resemble the early stages of normal B-cell differentiation. (lab-ally.com)
Cancer33
  • Most important aspect of therapy is anti CD20 antibody, the Rituximab, which is a kind of immunotherapy or targeted therapy and attacks the CD20 antigen on the cancer cells. (lymphomaindia.com)
  • Rituximab should be combined with the chemotherapy for more efficient cancer cell kill. (lymphomaindia.com)
  • Thyroid cancer arises from the cells of the thyroid gland. (medicinenet.com)
  • Thyroid cancer is classified on the basis of the type of cells present in the tumor. (medicinenet.com)
  • Hurthle cell cancer is a rare variant of follicular thyroid cancer and is more aggressive. (medicinenet.com)
  • Anaplastic thyroid cancer is a rare type of thyroid cancer that usually occurs in older patients over the age of 60. (medicinenet.com)
  • Anaplastic thyroid cancer typically occurs in adults who are 60 years of age and older. (medicinenet.com)
  • Medullary thyroid cancer arises in the C cells in the thyroid gland. (medicinenet.com)
  • Though extremely rare, some types of cancer can arise in the thyroid, such as thyroid lymphoma (arises from the immune cells of the thyroid) or thyroid sarcoma (arises from the connective tissue cells in the thyroid). (medicinenet.com)
  • Chemotherapy is a drug treatment given intravenously (IV) that uses chemicals to kill cancer cells. (medicinenet.com)
  • Targeted drug treatments focus on specific abnormal proteins in cancer cells. (medicinenet.com)
  • The drugs block the abnormalities and can cause death of the cancer cells. (medicinenet.com)
  • Xtracellular vesicles, ranging from 30 to 120 nm in diameter, that can be released into the extracellular space by eukaryotic cells, including cancer cells. (esiservizi.com)
  • These cells may include significant data about the tumor and as a result have the prospective to be employed as cancer biomarkers. (esiservizi.com)
  • Mesenchymal stem cells up-regulate the invasive potential of prostate cancer cells via the eotaxin-3/CCR3 axis. (cancerindex.org)
  • This study aimed to clarify the role of mesenchymal stem cells (MSCs) as a component of the cancer microenvironment. (cancerindex.org)
  • We investigated the homing-related chemokine expression levels of MSCs treated with a prostate cancer cell line (PC-3) -conditioned medium. (cancerindex.org)
  • Merkel cell carcinoma (MCC), an uncommon but aggressive form of skin cancer. (cdc.gov)
  • It accounts for 7 percent of all childhood cancers, but due to its often aggressive nature, causes 15 percent of all childhood cancer deaths. (clpmag.com)
  • John M Maris, MD, senior author of the current study and director of the Center for Childhood Cancer Research at Children's Hospital, leads a laboratory with the world's largest collection of neuroblastoma tissue samples, gathered through the multicenter Children's Oncology Group in the US and through multiple international collaborations. (clpmag.com)
  • Although the normal role of the ALK gene is not well understood, other researchers had previously found that abnormalities in ALK raise a patient's risk for lymphoma and lung cancer. (clpmag.com)
  • Songhai screened many different cell lines without much success, until he talked to our neighbor, Dr. Rosalyn Adam in the Department of Urology, who happens to have a few bladder cancer cell lines. (childrenshospital.org)
  • Lymphoma is a type of cancer that affects the lymphatic system, which is a part of the body's immune system. (uhapo.co.in)
  • Lymphoma of the skin is a type of cancer that affects the lymphocytes, a type of white blood cell, in the skin. (uhapo.co.in)
  • Tisagenlecleucel , sold under the brand name Kymriah , is a CAR T cells medication for the treatment of B-cell acute lymphoblastic leukemia (ALL) which uses the body's own T cells to fight cancer ( adoptive cell transfer ). (wikimili.com)
  • and finally, radiosurgery in combination with immunotherapy for non-small cell lung cancer and melanoma. (pennmedicine.org)
  • Cancer cells that proliferate quickly and unlike normal cells. (lab-ally.com)
  • This is a cancer that usually affects the skeletal cells in the trunk, arms, and legs. (lab-ally.com)
  • This is a very aggressive thyroid cancer. (lab-ally.com)
  • BCC is a type of skin cancer that creates lesions and uncontrolled growth in the basal cells of the epidermis. (lab-ally.com)
  • Lymphoma is The most common cancer in adolescents and young adults, the 3rd most common in children less than 14 years, and the 6th most common cancer of all people of all ages. (lymphoma.org.au)
  • Lymphoma is a type of cancer that affects your blood cells called lymphocytes. (lymphoma.org.au)
  • Lymphomas have been called cancer of the blood, cancer of the lymphatic system and cancer of the immune system. (lymphoma.org.au)
DLBCL3
  • DLBCL is an aggressive (fast-growing) lymphoma. (lymphomaindia.com)
  • For example, DLBCL that only affects the brain is called "primary central nervous system lymphoma" and is treated differently than DLBCL that affects areas outside of the brain. (lymphomaindia.com)
  • Most patients with DLBCL are adults, although this lymphoma is sometimes seen in children. (lymphomaindia.com)
Symptoms of lymphoma1
Chimeric2
  • This chimeric gene overproduces a fusion protein with excessive ALK activity. (wikipedia.org)
  • Malignant transformation is usually the result of chromosomal translocations that activate proto-oncogenes or create a chimeric fusion protein. (oncolink.org)
Incidence1
Proliferation2
  • Activations of these signaling pathways and genes may stimulate cell growth, proliferation, survival, and/or other behaviors that promote malignancy. (wikipedia.org)
  • Previously, IMT was also described as inflammatory pseudotumor, plasma cell granuloma, and inflammatory myofibrohistiocytic proliferation. (hindawi.com)
Relapse2
  • In addition, PD-1/PD-L1 interactions contribute to functional T-cell impairment, which fails to elicit minimal residual disease and may be related to leukemia relapse. (biomedcentral.com)
  • With few exceptions, stem cell transplantation is usually reserved for patients with aggressive lymphomas after incomplete remission or relapse. (msdmanuals.com)
Antigens2
Diagnosis4
  • The surgical samples underwent pathological analysis, and a diagnosis of extranodal NK/T cell lymphoma nasal type was confirmed. (frontiersin.org)
  • Early diagnosis of primary intestinal NK/T cell lymphoma is frequently difficult. (frontiersin.org)
  • A diagnosis of skin lymphoma is typically made by a dermatologist or a hematologist/oncologist. (uhapo.co.in)
  • A dermatology work-up was initiated, and the síndrome de Sézary initial diagnosis of malignant T-cell neoplasm was confirmed. (bvsalud.org)
Lymphoid cells3
  • Differentiating between low-grade lymphoma and reactive lymphocytes is often difficult by morphology alone as reactive lymphoid cells may acquire activation morphology from being exposed to different cytokines within the body fluid. (cytojournal.com)
  • Lymphoid cells concerned with humoral immunity. (lookformedical.com)
  • Malignant lymphoma composed of large B lymphoid cells whose nuclear size can exceed normal macrophage nuclei, or more than twice the size of a normal lymphocyte. (lookformedical.com)
Tissues4
  • This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth. (lookformedical.com)
  • These fi ndings suggest that in human lymphoid tissues, blood cells, and lymphomas the lymphoid system plays a role in MCPyV infection and ( 17 - 20 ). (cdc.gov)
  • Once inside our tissues, Shiga and ricin toxins work similarly, disrupting cells' ability to make proteins. (childrenshospital.org)
  • The pituitary gland produces thyroid stimulating hormone (TSH) that goes into the blood stream to activate thyroid cells, which then secrete T3 and T4 into the peripheral tissues. (cdc.gov)
Medulloblastoma1
  • Medulloblastoma is defined by the World Health Organization (WHO) as "an embryonal neuroepithelial tumor arising in the cerebellum or dorsal brainstem, presenting mainly in childhood and consisting of densely packed small round undifferentiated cells with mild to moderate nuclear pleomorphism and high mitotic count. (medscape.com)
Autologous3
  • This may be secondary to a germinal center origin or attributable to increased apoptosis via induction of bax and/or enhanced T-cell interaction, resulting in improved autologous tumor response. (aacrjournals.org)
  • Although localized disease can be treated by surgery alone, the standard therapy for patients with metastatic disease usually comprises intensive induction chemotherapy, local surgery and myeloablative chemotherapy followed by autologous stem cell transplant, external radiotherapy and retinoic acid treatment. (biomedcentral.com)
  • 18. An acute transverse myelitis attack after autologous stem cell transplantation: A rare case. (medipol.com.tr)
Receptors4
  • Exosomes can bring about changes in cellular processes by acting as messengers and transferring facts for the target cells by numerous mechanisms, including by fusing with the plasma membrane or by interacting together with the protein receptors present on target cells [43]. (esiservizi.com)
  • It belongs to family 1 of the G protein-coupled receptors. (cancerindex.org)
  • T-cell activation and dysfunction relies on direct and modulated receptors. (biomedcentral.com)
  • The iodine hormone exerts its action on receptors on the nucleus in cells. (cdc.gov)
Oncogenic2
  • Alveolar RMS can be characterized by a recurrent cytogenetic alteration involving FOXO-1 and PAX3 or PAX7 genes, and the consecutive translocations (t(2;13) or t(1;13) respectively) lead to the excess synthesis of fusion proteins with oncogenic effects [ 5 , 6 ]. (biomedcentral.com)
  • The oncogenic potential of the NPM-ALK fusion gene was first demonstrated in vitro using murine cell lines and primary cells. (biomedcentral.com)
Lymphocyte2
  • Immunotherapeutic options have elicited a promising approach in some malignancies with Food and Drug Administration (FDA) approving the first checkpoint inhibitor anti-cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) ipilimumab for the treatment of melanoma ten years ago. (stanford.edu)
  • Some rare lymphomas are Natural Killer cell (NK) lymphomas - NK cells are a type of T-cell lymphocyte. (lymphoma.org.au)
Occurs3
  • Involvement of the central nervous system or a leukemia-like circulation of malignant cells in the blood occurs only very rarely. (wikipedia.org)
  • One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). (lookformedical.com)
  • Lymphoma occurs when lymphocytes, a type of white blood cell that helps to fight infection and disease, become abnormal and begin to multiply out of control. (uhapo.co.in)
Involvement1
Mutations4
  • Scope includes mutations and abnormal protein expression. (cancerindex.org)
  • After detecting ALK mutations in familial neuroblastoma, the researchers then focused on the more common sporadic (non-familial) cases of neuroblastoma, and found that ALK mutations occurred in 12 percent of 194 tumor samples from the aggressive, high-risk form of the disease. (clpmag.com)
  • Since the mutations discovered by Mossé trigger an "on" signal for neuroblastoma cells, the abnormality is an outstanding target for therapies that inhibit the ALK protein's activity. (clpmag.com)
  • Genetic mutations - Some genetic mutations may increase a person's risk of developing cutaneous lymphoma. (uhapo.co.in)
World Health Organ1
  • The various types have little similarity to each other, and are categorized by the World Health Organization according to cell origin (B cell, T cell/NK cell). (oncolink.org)
Primary5
  • This ulcerated nodule of localized primary cutaneous CD30+ anaplastic large cell lymphoma is relatively nonspecific in appearance. (medscape.com)
  • We present a case of primary intestinal NK/T cell lymphoma with diagnostic challenge, which eventually developed into multiple intestinal perforations. (frontiersin.org)
  • Although their derivation was long debated, neoplastic cells characteristically express cytoplasmic immunoglobulin and may produce primary amyloid, leaving little doubt as to their lymphoplasmacytic origin. (merckvetmanual.com)
  • Primary CNS lymphoma in children and adolescents: a descriptive analysis from the international primary CNS lymphoma collaborative group (IPCG). (medscape.com)
  • Primary cutaneous gamma/delta T-cell lymphoma with simultaneous JAK2 and TP63 rearrangements: a new double-hit? (elsevierpure.com)
CD202
  • We conclude that the relationship between complement-regulatory proteins CFHR1 and CFHR3 and response to anti-CD20 mAb therapy varies based on the specific anti-CD20 mAb used. (cusabio.com)
  • B cell ALL and NHL frequently express CD19, CD20 and CD22 on the cell surfaces. (biomedcentral.com)
Neoplasms1
  • POEMS syndrome is a rare monoclonal plasma cell disorder with unique symptoms distinct from other plasma cell neoplasms. (bvsalud.org)
Clonal1
  • Although rare, malignant transformation of nevi to melanoma involves the clonal expansion of cells that acquire a selective growth advantage. (medscape.com)
Transmembrane3
  • PD-1 is a 50-55 kDa type I transmembrane protein with a single IgV domain in the extracellular region. (biomedcentral.com)
  • When the team compared the two screens, they found two factors that both Shiga and ricin toxins require to penetrate cells: the transmembrane proteins TMEM165 and TM9SF2. (childrenshospital.org)
  • CD22 molecule is a transmembrane protein from SIGLEC (Sialic acid-binding immunoglobulin-type lectins) family. (biomedcentral.com)