• As an example, Klinefelter syndrome is characterized by SCO and Leydig cell hyperplasia. (medscape.com)
  • The development of adult Leydig cell population was also analyzed 65 days postpartum. (frontiersin.org)
  • For in vitro studies, immature Leydig cells were isolated from 35-day-old male rats and treated with 50 μM piperine in the presence of different steroidogenic stimulators/substrates for 24 h. (frontiersin.org)
  • Consistent with increase in serum T, piperine increased Leydig cell number, cell size, and multiple steroidogenic pathway proteins, including steroidogenic acute regulatory protein, cholesterol side-chain cleavage enzyme, 3β-hydroxysteroid dehydrogenase 1, 17α-hydroxylase/20-lyase, and steroidogenic factor 1 expression levels. (frontiersin.org)
  • Piperine in vitro also increased androgen production and stimulated cholesterol side-chain cleavage enzyme and 17α-hydroxylase/20-lyase activities in immature Leydig cells. (frontiersin.org)
  • Piperine stimulates pubertal Leydig cell development by increasing Leydig cell number and promoting its maturation while it inhibits spermatogenesis in the rat. (frontiersin.org)
  • ERK1/2 and AKT pathways may involve in the piperine-mediated stimulation of Leydig cell development. (frontiersin.org)
  • In order to examine whether PIP affected spermatogenesis by interfering with Leydig cell testosterone production, in the current study we evaluated the effects of PIP on pubertal Leydig cell development. (frontiersin.org)
  • Late-stage pubertal development of Leydig cells is mainly involved in the transition of immature Leydig cells to adult Leydig cells. (frontiersin.org)
  • Fetal type Leydig cells disappear soon after birth (during first 2 weeks after birth) and are replaced by adult type Leydig cells [ 22 , 23 ]. (hindawi.com)
  • Expressed in lung alveolar epithelial cells, enterocytes of the small intestine, Leydig cells and Sertoli cells (at protein level). (avivasysbio.com)
  • In the developing testis, HHAT is not required for Sertoli cell commitment but plays a role in proper testis cord formation and the differentiation of fetal Leydig cells. (unige.ch)
  • Despite a conserved density of Leydig cells after 30 days of culture (D30), transcript levels of adult Leydig cell and steroidogenic markers were decreased. (elifesciences.org)
  • hCG was insufficient to facilitate Leydig cell differentiation, restore steroidogenesis and improve sperm yield. (elifesciences.org)
  • In conclusion, this study reports the failure of adult Leydig cell development and altered steroid production and signaling in tissue cultures. (elifesciences.org)
  • Transcript levels of the androgen receptor (AR)-regulated gene Rhox5 were decreased at the end of the culture period, suggesting that testosterone production by Leydig cells and/or AR transcriptional activity was impaired in organotypic cultures ( 8 ). (elifesciences.org)
  • Recent research also has thrown lights upon a significant role of orexins, especially orexin A, in regulation of male reproductive functions owing to their receptor expressions in vital testicular cells, such as Leydig cells, Sertoli cells as well as spermatozoa at different developmental stages, even in the epididymis and penis. (researchgate.net)
  • DICER1 syndrome is also associated with tumors in the ovaries known as Sertoli-Leydig cell tumors, which typically develop in affected women in their teens or twenties. (medlineplus.gov)
  • Sertoli-Leydig cell tumors usually do not metastasize. (medlineplus.gov)
  • Leydig cell hyperplasia may also occur with aging. (medscape.com)
  • Leydig cell aplasia occurs when congenital absence of Leydig cells causes partially developed or ambiguous external genitals. (msdmanuals.com)
  • In this study, we demonstrate that 42GPA9 Sertoli cells respond to treatments that result in accumulation of β-catenin within the nucleus and in upregulation of CX43 gene transcription. (unab.cl)
  • Sertoli cell proliferation and differentiation is mainly activated by FGF9, with which they also form a feedforward loop. (wikipedia.org)
  • FSH is responsible for controlling the proliferation of Sertoli cells shortly after birth and stimulates the production of factors derived from Sertoli cells that control the development of the testes and germ cells. (wikipedia.org)
  • Sertoli cell proliferation reaches its maximum level just before birth and ceases by the age of 3 weeks [ 24 ]. (hindawi.com)
  • An adenosine triphosphatase of the sucrose nonfermenting 2 family, androgen receptor-interacting protein 4, is essential for mouse embryonic development and cell proliferation. (nih.gov)
  • MAPK pathways refer to various cellular functions, including cell proliferation, differentiation and migration. (springer.com)
  • The 200-kDa CUX1 protein is highly expressed in the developing kidney, where it functions to regulate cell proliferation. (dordt.edu)
  • Thus, unlike the somatic form of CUX1, which has a role in cell proliferation, the testis-specific form of CUX1 is not involved in cell division and appears to play a role in signaling between Sertoli cells and spermatids. (dordt.edu)
  • Through this role in regulating the activity (expression) of genes, the Dicer protein is involved in many processes, including cell growth and division (proliferation) and the maturation of cells to take on specialized functions (differentiation). (medlineplus.gov)
  • Expression and localization of androgen receptor-interacting protein-4 in the testis. (nih.gov)
  • Despite extensive research on Sertoli cells, their protein expression patterns and spatial localization in relation to other testicular cell types remain poorly characterized. (diva-portal.org)
  • This project aimed to investigate the expression patterns and spatial localization of proteins in Sertoli cells. (diva-portal.org)
  • Double-labeling experiments in HeLa cells invaded with S. flexneri showed a near perfect co-localization of cortactin with actin in the entry structure and at the periphery of the phagosome [ 17 ]. (biomedcentral.com)
  • The presence or absence of FSH had no apparent effect on the distribution or localization of cortactin within Sertoli cells. (biomedcentral.com)
  • Previously, we investigated the localization of several nuage-resident proteins in the nuage structures of spermatogenic cells by immunoelectron microscopy (IEM) [ 22 - 26 ]. (hindawi.com)
  • Inhibins are heterodimeric protein hormones secreted by granulosa cells of the ovary in females and Sertoli cells of the testis in males. (southtees.nhs.uk)
  • In the ovaries, FSHRs present on granulosa cells initiate follicular development. (smpdb.ca)
  • HN - 2008 BX - Von Ebner's Glands MH - Cumulus Cells UI - D054885 MN - A05.360.319.114.630.535.200.500 MN - A06.407.312.497.535.300.500 MN - A11.436.300.500 MS - The granulosa cells of the cumulus oophorus which surround the OVUM in the GRAAFIAN FOLLICLE. (bvsalud.org)
  • HN - 2008 BX - Granulosa Cells, Cumulus MH - Coronary Sinus UI - D054326 MN - A07.231.908.194.500 MS - A short vein that collects about two thirds of the venous blood from the MYOCARDIUM and drains into the RIGHT ATRIUM. (bvsalud.org)
  • This study addresses effects on EDCs on adjacent prepubertal Sertoli TM4 cells, specifically on 1) testicular gap junctional intercellular communication (GJIC), one of the hallmarks of non-genotoxic carcinogenicity, 2) GJIC building blocks connexins (Cx), and 3) mitogen-activated protein kinases MAPKs. (muni.cz)
  • CUX1 expression was continuous in Sertoli cells from prepubertal testes but became cyclic when spermatids appeared. (dordt.edu)
  • The organotypic culture procedure, which preserves testicular tissue architecture, microenvironment and cell interactions, has been used successfully to obtain spermatozoa from fresh or frozen/thawed mouse prepubertal testicular tissues ( 3 - 6 ). (elifesciences.org)
  • Sertoli cells are specifically located in the convolutions of the seminiferous tubules, since this is the only place in the testes where spermatozoa are produced. (wikipedia.org)
  • Sertoli-cell-only (SCO) syndrome, also called germ cell aplasia or Del Castillo syndrome, describes a condition of the testes in which only Sertoli cells line the seminiferous tubules. (medscape.com)
  • The Sertoli cells in the testes create small how many grams of protein, fats and carbs. (mamapundit.com)
  • We determined the pattern and timing of CUX1 protein expression in developing testes. (dordt.edu)
  • Moreover, CUX1 was not expressed in proliferating cells in testes from either wild-type or transgenic mice. (dordt.edu)
  • Likewise, Sertoli cells isolated from pre-pubertal rat testes have been marked for later detection by the phagocytosis of latex beads [ 10 ]. (biomedcentral.com)
  • The evidence that the culture of testicular fragments of 6.5-day-old mouse testes does not allow optimal differentiation of steroidogenic cells is compelling and should enable further optimizations in the future. (elifesciences.org)
  • Mouse IGSF4A cDNA encodes 445 amino acids including a signal peptide, three Ig-like domains (a V-type, a divergent C1-type and an I-type), a transmembrane domain and a cytoplasmic domain with protein 4.1 and PDZ domain binding sites. (rndsystems.com)
  • The follicle-stimulating hormone receptor (FSHR) is a transmembrane G protein-coupled receptor located in the ovary, testis, and uterus. (smpdb.ca)
  • Testicular Sertoli cell tumors (SCTs) are rare, and most fall into the category of SCT-not otherwise specified (SCT-NOS). (nih.gov)
  • Sclerosing SCT (S-SCT), originally described in 1991, comprises a small fraction of SCTs and was considered a specific entity until the 2016 revision of the World Health Organization classification of non-germ cell tumors, where it was classified as a morphologic variant of SCT-NOS. (nih.gov)
  • Patients with Disorders of Sex Development (DSD), especially those with gonadal dysgenesis and hypovirilization are at risk of developing malignant type II germ cell tumors/cancer (GCC) (seminoma/dysgerminoma and nonseminoma), with either carcinoma in situ (CIS) or gonadoblastoma (GB) as precursor lesion. (eur.nl)
  • The results suggest that PRKRA functions in the nuage as an element of RNA silencing system and plays unknown role in the ectoplasmic specialization and at the tubulobulbar complexes of Sertoli cells attaching the head of late spermatids. (hindawi.com)
  • Cortactin, an actin binding protein, has been associated with Sertoli cell ectoplasmic specializations in vivo , based on its immunolocalization around the heads of elongated spermatids, but not previously identified in isolated Sertoli cells. (biomedcentral.com)
  • Recent studies have demonstrated that serum levels Inhibin-B, a Sertoli cell secretory protein, are suppressed in the presence of testicular injury. (cdc.gov)
  • An in vitro model system (immortalised Sertoli cells) will be used to verify the possible link of hormonal regulation of connexins with endocrine disruptors. (cefic-lri.org)
  • In an in vitro model of Sertoli cell-spermatid binding, cortactin was identified around debris and dead germ cells. (biomedcentral.com)
  • Functional in vitro studies showed no convincing protein malfunctioning. (eur.nl)
  • Transgenic mice ectopically expressing the 200-kDa CUX1 protein develop renal hyperplasia associated with reduced expression of the cyclin kinase inhibitor p27. (dordt.edu)
  • PRKRA, a protein kinase, interferon-inducible double stranded RNA dependent activator protein kinase, also known as PACT, a protein activator of the interferon-induced protein kinase, is a product of PRKRA gene [ 1 , 2 ] and is a member of the dsRNA binding protein family [ 3 ]. (hindawi.com)
  • Shape 2 The three mitogen-activated proteins kinase (MAPK) signaling pathways which are regarded as mixed up in toxicant-induced testicular damage. (abt-888.net)
  • cAMP then activates protein kinase A (PKA) which phosphorylates downstream effectors that lead to a specific cellular response. (smpdb.ca)
  • It is a cell adhesion molecule that mediates interactions between spermatogenic cells and Sertoli cells. (rndsystems.com)
  • The nuage of the spermatogenic cells has function similar to the P-bodies. (hindawi.com)
  • We study whether PRKRA localizes to nuage of spermatogenic cells of rat and mouse. (hindawi.com)
  • On the other hand, there are specific cytoplasmic foci similar to the P-bodies in spermatogenic cells, which are called nuage [ 15 - 18 ]. (hindawi.com)
  • Russell and Frank [ 19 ] classified the nuage of spermatogenic cells into six different types according to its morphology and relationship with other surrounding organelles. (hindawi.com)
  • thyroid-stimulating hormone, and hCG are all known to affect Sertoli cell development and male reproductive health. (wikipedia.org)
  • EMSG8: Are Connexins, the Gap Junctional Integral Proteins, Involved in Male Reproductive Disorders Associated With Possible Exposure to Endocrine Disrupting Agents? (cefic-lri.org)
  • this structure facilitates "communication" between cells) could be implicated in human male reproductive disorders. (cefic-lri.org)
  • These findings suggest that there may be a common downstream p38 and/or Erk1/2 MAPK-based signaling pathway WW298 involving polarity proteins and actin regulators that is shared between different toxicants that induce male reproductive dysfunction. (abt-888.net)
  • Intramembranous particles, representing integral membrane proteins, appear as bumpy projections, and are prominent on the p-face, but also can be detected on the e-face. (ucsd.edu)
  • their cytoplasm often completely surrounds the germline cells which they are responsible for nursing. (wikipedia.org)
  • Detected in both cell membrane and cytoplasm in neurons. (avivasysbio.com)
  • Cells exposed to no hormone and no beads appeared to have a ubiquitous distribution of cortactin throughout the cytoplasm. (biomedcentral.com)
  • Cortactin immunostaining was diffuse throughout the Sertoli cell cytoplasm when incubated without beads (Fig. 1A ). (biomedcentral.com)
  • Toilet break may not be deemed professional in modern sport, athletes heart, the result attach to specific receptors, creating a suitable environment for protein synthesis. (mamapundit.com)
  • The orexin receptors (orexin 1R and orexin 2R) belong to the Family of G-protein coupled receptors. (researchgate.net)
  • of G-protein coupled receptors. (researchgate.net)
  • abstract = "Background: An understanding of the main mechanism that determines the ability of immune privilege related to Sertoli cells (SC) will provide clues for promoting a local tolerogenic environment. (johnshopkins.edu)
  • Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. (abcam.com)
  • The purity of Human ACE2 (18-615) Recombinant Protein (hFc-Tag) was determined by densitometry after SDS-PAGE of 1 μg of protein, followed by staining with Coomassie Blue. (cellsignal.com)
  • Binding response kinetics between Human ACE2 (18-615) Recombinant Protein (hFc-Tag) (immobilized) and SARS-CoV-2 Spike (trimeric) (16-1208) Recombinant Protein (8xHis-Tag) #65444 (in solution, at indicated concentrations). (cellsignal.com)
  • Values on y-axis indicate binding response signals recorded for 4 different concentrations of SARS-CoV-2 Spike (trimeric) (16-1208) Recombinant Protein (8xHis-Tag) #65444 (7.81, 15.6, 31.2, and 62.5 nM). (cellsignal.com)
  • SARS-CoV-2 Spike RBD (318-541) Recombinant Protein (8xHis-Tag) #48801 (in solution, at indicated concentrations). (cellsignal.com)
  • Values on y-axis indicate binding response signals recorded for 3 different concentrations of SARS-CoV-2 Spike RBD (318-541) Recombinant Protein (8xHis-Tag) #48801 (62.5, 125, and 250 nM). (cellsignal.com)
  • SARS-CoV-2 Spike (trimeric) (16-1208) Recombinant Protein (8xHis-Tag) #65444 (in solution, 250 nM, blue), and SARS-CoV-2 Spike RBD (318-541) Recombinant Protein (8xHis-Tag) #48801 (in solution, 250 nM, red). (cellsignal.com)
  • CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. (rndsystems.com)
  • Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. (rndsystems.com)
  • In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. (rndsystems.com)
  • Chickens were immunized with purified recombinant green fluorescent protein (GFP) emulsified in Freund's adjuvant. (antibodiesinc.com)
  • Sertoli cells provide the nutritional and metabolic support for germ cells. (unab.cl)
  • EDCs rapidly dysregulated GJIC in Sertoli TM4 cells mainly via MAPK p38 and/or Erk1/2 pathways by the intermediate hyper- or de-phosphorylation of Cx43 (Ser368, Ser282) and translocation of Cx43 from the plasma membrane, suggesting disturbed intracellular trafficking of Cx43 protein. (muni.cz)
  • Our results indicate that EDCs might disrupt testicular homeostasis and development via testicular GJIC, junctional and non-junctional functions of Cx43 and MAPK-signaling pathways in Sertoli cells. (muni.cz)
  • However the use of specific inhibitors against MAPK was shown to block or delay the cadmium-induced testicular injury such as BTB disruption and germ cell loss. (abt-888.net)
  • A recently available study17 shows that in utero publicity of rats to BPA (0.1 to 200 mg/kg/ day time for seven days from gestational day time 14 to birth) resulted in a transient induction in testicular Erk1 (also called MAPK 3) however not Erk2 in neonatal rats especially in Sertoli cells. (abt-888.net)
  • Elevations of serum inhibin A and/or B are detected in some patients with granulosa cell tumours. (southtees.nhs.uk)
  • The Hcv Elisa Test Normal Range reagent is RUO (Research Use Only) to test human serum or cell culture lab samples. (postgenomeconsortium.com)
  • This phenotype co-segregates with either of two frameshift mutations, 1988delAGAG and 2469delGTCA, in ESPN , which encodes a calcium-insensitive actin-bundling protein called espin. (bmj.com)
  • However, international scientific consensus holds that Zika PCR) assay based on a published method targeting the virus infection is a cause of 2 severe clinical sequelae rec- nonstructural protein 1 (NS1) gene ( 21 ) and a commercial ognized recently: Guillain-Barré syndrome and congenital serologic assay (EUROIMMUN AG, Lübeck, Germany). (cdc.gov)
  • the DNA encoding the gene is transcribed into messenger RNA, which then produces a single Sry protein. (asu.edu)
  • The scientists claimed that the gene would encode for the testis-determining factor (TDF), a protein responsible for causing testis to develop in embryos. (asu.edu)
  • A role of this gene in Germinal Stem Cells maintenance may be evolutionarily conserved as Nanos2 is specifically expressed both in oogonia and in spermatogonia of adult medaka 11 and in a subpopulation of undifferentiated A spermatogonia in juvenile and spermiating male trout 12 . (nature.com)
  • Cx43 gene codes for a protein that is critical during testicular development. (unab.cl)
  • The Cx43 promoter contains TCF/β-catenin binding elements (TBEs) that contribute CX43 expression in different cell types and which may also be regulating the expression of this gene in Sertoli cells. (unab.cl)
  • Our results also indicate that the Wnt/β-catenin-dependent upregulation of the Cx43 gene in Sertoli cells is accompanied by changes in epigenetic parameters that may be directly contributing to generating a chromatin environment that facilitates the establishment of the transcriptional machinery at this promoter. (unab.cl)
  • The protein encoded by this gene is a bifunctional enzyme that is involved in the peroxisomal beta-oxidation pathway for fatty acids. (nih.gov)
  • Defects in this gene that affect the peroxisomal fatty acid beta-oxidation activity are a cause of D-bifunctional protein deficiency (DBPD). (nih.gov)
  • Most of the gene mutations involved in DICER1 syndrome lead to an abnormally short Dicer protein that is unable to aid in the production of miRNA. (medlineplus.gov)
  • Fluorescent proteins enable a wide range of applications where they have functioned as cell lineage tracers, reporters of gene expression, or as a measure of protein-protein interactions. (antibodiesinc.com)
  • CONCLUSION: Endoplasmic reticulum stress signaling pathways were activated by ROS, and NAC attenuate endoplasmic reticulum stress through inhibiting the levels of ROS in NaF-treated sertoli cells. (fluoridealert.org)
  • NF-κB pathways are associated with immunity, inflammation and cell survival. (springer.com)
  • Akt pathways have effects on apoptosis, protein synthesis, metabolism and cell cycle. (springer.com)
  • AMPK pathways inhibit biosynthetic pathways with energy consumption, such as protein, fatty acid and glycogen synthesis. (springer.com)
  • Mutations in SRY as well as WT1 can lead to diminished expression and function of SRY, resulting in sub-optimal SOX9 expression, Sertoli cell formation and subsequent lack of proper testicular development. (eur.nl)
  • The objective of the present study is to investigate the modulation of antioxidant defence status in neonatal persistent hypothyroid rats before their sexual maturation and also to identify the specific testicular cell populations vulnerable to degeneration during neonatal hypothyroidism in immature rats. (hindawi.com)
  • An altered antioxidant defence system marked by elevated SOD, CAT, and GR activities, with decreased GPx and GST activities were observed along with increased protein carbonylation, disturbed redox status in hypothyroid immature rat testis. (hindawi.com)
  • Using immunohistochemistry, AMH has been shown to be a useful marker of immature and neoplastic Sertoli cells in dogs. (vin.com)
  • RISC assembles into processing bodies (P-bodies) which are specific cytoplasmic foci in somatic eukaryotic cells [ 7 - 9 ]. (hindawi.com)
  • MAP kinases certainly are a grouped category of Ser/Thr proteins kinases within eukaryotic cells which are well conserved among mammalian … As mentioned WW298 in a recently available research reported by our lab BPA was proven to perturb the integrity from the. (abt-888.net)
  • For example, Sertoli cells secrete anti-müllerian hormone (AMH), which helps to ensure regression of müllerian ducts as a fetus develops into a male. (medscape.com)
  • Single-cell RNA sequencing data and immunohistochemistry stainings from the Human Protein Atlas were used to choose candidate proteins to be visualized in a multiplex Immunofluorescence panel. (diva-portal.org)
  • In all documented biopsied cases, there is a significant decline in germ cell development and an increase in tubular sclerosis by puberty. (medscape.com)
  • In a recent study, differences in expression of PAX2/PAX8, inhibin, androgen receptor, and S100 protein between SCT-NOS and S-SCT were noted in a small number of cases. (nih.gov)
  • Novel ATPase of SNF2-like protein family interacts with androgen receptor and modulates androgen-dependent transcription. (nih.gov)
  • The FSH receptor activates G(s) proteins which leads to the activation of adenylyl cyclase and produces the secondary messenger cAMP. (smpdb.ca)
  • In the ovary, both paralogs were detected in germinal and somatic cells. (nature.com)
  • 2015. Interactions of the Metalloregulatory Protein SloR from Streptococcus mutans with its Metal Ion Effectors and DNA Binding Site. (middlebury.edu)
  • IGSF4A is a 75 kDa immunoglobulin superfamily protein that mediates calcium-independent adhesive interactions, either homophilic or heterophilic with CRTAM (class I-restricted T cell-associated molecule), Necl-1 (SynCAM3) or Nectin-3 (1 - 4). (rndsystems.com)
  • Histological examinations of testis biopsies from this cat showed degeneration of the tubules, hyperplasia of the interstitial tissue, and complete loss of germ cells. (karger.com)
  • 101 proteins were successfully stained and localized within testis tissue and subcellular locations in Sertoli cells were annotated. (diva-portal.org)
  • Rubella virus tropism and single-cell responses in human primary tissue and microglia-containing organoids. (antibodiesinc.com)
  • Testing for inhibin can be used as an aid in the diagnosis of granulosa cell tumours and mucinous epithelial ovarian tumours. (southtees.nhs.uk)
  • Inhibin B elevations have been reported in 89% to 100% of patients with granulosa cell tumours. (southtees.nhs.uk)
  • Others, most commonly Sertoli cell tumours (SCT), may present with signs of feminization. (vin.com)
  • In humans, AMH has been shown to be a specific marker of Sertoli cell origin in gonadal tumours. (vin.com)
  • AMH is a promising biomarker for the diagnosis of Sertoli cell tumours in dogs. (vin.com)
  • FSH is required for Sertoli cell mitogen, which stimulates the expression of various cell markers. (wikipedia.org)
  • This may allow evasion of antitumor responses, since TSLC-1 interaction with CRTAM on activated NK and CD8 + T cells stimulates cytotoxicity and upregulates IFN-gamma production (3, 6). (rndsystems.com)
  • In general, sperm cells become attracted to egg cells by various chemical or physical signals. (elifesciences.org)
  • In 2009, researchers identified a potassium ion channel, called CNGK, that starts the electrical signal in the sperm cells of sea urchins. (elifesciences.org)
  • including some of the researchers involved in the 2009 work - now report that the CNGK channel also exists in the sperm cells of a freshwater fish, the zebrafish. (elifesciences.org)
  • Unexpectedly, the CNGK channel is located in the heads of this fish's sperm cells rather than in the tails. (elifesciences.org)
  • These findings suggest that while channel proteins found in sperm cells from different species look similar and serve similar roles, they are activated in ways that can be very different. (elifesciences.org)
  • The available material was insufficient for a conclusive evaluation of S100 protein expression. (nih.gov)
  • In mice, the suppression of Nanos3 expression in PGC resulted in the complete loss of germ cells in both sexes 9 . (nature.com)
  • Expression on mast cells allows attachment to neurites and fibroblasts (9, 10). (rndsystems.com)
  • As SgIGSF (spermatogenic IgSF), expression on developing sperm allows adhesion to an unknown partner on Sertoli cells that is critical for normal development (11, 12). (rndsystems.com)
  • Asynchronous Expression of the Homeodomain Protein CUX1 in Sertoli Cel" by Melissa R. Kroll, Engela S. Viss et al. (dordt.edu)
  • Interestingly, NPSC and iPS expressed mRNA of complement regulatory proteins (CRP) such as membrane cofactor protein (CD46), decay accelerating factor (DAF or CD55), and protectin (CD59), but CD59 mRNA expression was negligible in iPS. (johnshopkins.edu)
  • Recently, however, scientists have found a way to induce Sertoli cells to a juvenile proliferative phenotype outside of the body. (wikipedia.org)
  • At that time, however, researchers couldn't detail the mechanism through which chromosomes work to induce changes in the cell. (asu.edu)
  • Pediatric cancer treatments such as chemotherapy have recognized toxicity on germline stem cells, which could lead to infertility at adulthood ( 1 , 2 ). (elifesciences.org)
  • ACE2 Polyclonal Antibody detects endogenous levels of ACE2 protein. (avivasysbio.com)
  • Kierszenbaum AL, Crowell JA, Shabanowitz RB, Smith EP, Spruill WA, Tres LL: A monoclonal antibody recognizes a form of intermediate filament protein in rat Sertoli cells that is not present in seminiferous peritubular cells. (karger.com)
  • Bulk Order Inquiry for Anti-Green Fluorescent Protein Antibody ------- (please add any order requirements, including desired quantity, timing, etc. (antibodiesinc.com)
  • Nanos are RNA-binding proteins playing crucial roles in germ cell development and maintenance. (nature.com)
  • The Nanos proteins family regroups highly conserved RNA-binding proteins in higher eukaryotes implicated in germ cell development and maintenance. (nature.com)
  • Degeneration and hyalinization of the seminiferous tubules with poor germ cell development is frequently observed. (medscape.com)
  • check the tag ADOLESCENCE HN - 2008 BX - Nutrition in Adolescence FX - Adolescent Nutrition Physiology MH - Peritoneal Stomata UI - D054048 MN - A01.047.025.600.700 MN - A10.810 MS - Natural openings in the subdiaphragmatic lymphatic plexus in the PERITONEUM, delimited by adjacent mesothelial cells. (bvsalud.org)
  • The cytoplasmic RNA-induced silencing complex (RISC) contains dsRNA binding proteins, including PRKRA, TRBP, and Dicer. (hindawi.com)
  • PRKRA is contained in the cytoplasmic RNA-induced silencing complex (RISC) together with transactivation response RNA binding protein (TRBP) and Dicer [ 4 - 6 ]. (hindawi.com)
  • Sertoli cells are required for male sexual development. (wikipedia.org)
  • The Sry protein is also called the testis-determining factor (TDF), a protein that initiates male development in humans, placental mammals, and marsupials. (asu.edu)
  • The Sry protein is a transcription factor that can bind to regions of testis-specific DNA, bending specific DNA and activating or enhancing its abilities to promote testis formation, marking the first step towards male, rather than female, development in the embryo. (asu.edu)
  • The Hedgehog (Hh) family of secreted proteins act as morphogens to control embryonic patterning and development in a variety of organ systems. (unige.ch)
  • Furthermore, they provide the first clinical evidence of the essential role played by lipid modification of Hh proteins in human testicular organogenesis and embryonic development. (unige.ch)
  • This gives rise to the possibility of repairing some defects of testicular niche cells which may cause male infertility. (wikipedia.org)
  • Human Induced Pluripotent Stem Cell-Derived Pericytes as Scalable and Editable Source to Study Direct Lineage Reprogramming Into Induced Neurons. (antibodiesinc.com)
  • Taken together, these data identify Nanos as primordial genes with highly conserved functions for both, the migration of the germinal cells and their maintenance in adults. (nature.com)
  • Without appropriate regulation by miRNA, genes are likely expressed abnormally, which could cause cells to grow and divide uncontrollably and lead to tumor formation. (medlineplus.gov)
  • Consistent with the patient phenotype, HHAT was found to be expressed in the somatic cells of both XX and XY gonads at the time of sex determination, and Hhat loss of function in mice recapitulates most of the testicular, skeletal, neuronal and growth defects observed in humans. (unige.ch)
  • Yao and colleagues found 174 microRNAs (miRNAs) were differentially expressed in human Sertoli cells in men with SCO syndrome compared with men with obstructive azoospermia, suggesting that these miRNAs may be associated with the pathogenesis of SCO syndrome. (medscape.com)
  • The human cellular prion protein (PrP C ) is a glycosylphosphatidylinositol (GPI) anchored membrane glycoprotein with two N-glycosylation sites at residues 181 and 197. (mdpi.com)
  • Human CRISP-2, the ortholog of rodent testis specific protein 1 (Tpx1) is a secreted protein expressed in testis. (rndsystems.com)
  • Mature human CRISP-2 shares 86%, 73% and 71% amino acid sequence identity with the equine, mouse and rat proteins, respectively. (rndsystems.com)
  • Harris BA: Complete cDNA sequence of a human stimulatory GTP-binding protein alpha subunit. (smpdb.ca)
  • Codina J, Stengel D, Woo SL, Birnbaumer L: Beta-subunits of the human liver Gs/Gi signal-transducing proteins and those of bovine retinal rod cell transducin are identical. (smpdb.ca)
  • E7 from human papil omavirus type 16 cooperate to cancer: the European prospective investigation into doi:10.1093/carcin/bgp321 PMID:20047954 target the PDZ protein Na/H exchange regulatory cancer and nutrition study. (who.int)
  • In SCO syndrome mouse model, PRPS2 overexpression significantly inhibited cell apoptosis and promoted cell cycle transition in TM4 Sertoli cells. (medscape.com)