Protein phospholipids. Medical search. Frequent questions

The receptor is in liquid crystalline phospholipid bilayers, without modification of its amino acid sequence and under physiological conditions. (rcsb.org)
Permeability of phospholipid bilayers. (lynniezulu.com)
Phospholipid bilayers are critical components of cell membranes. (lynniezulu.com)
Specifically, our aim is to localize an iodine-labelled phenylalanine in the SARS E protein, incorporated in DMPC phospholipid bilayers, which are deposited in the form of thick multilamellar stacks on silicon surfaces. (huji.ac.il)
This molecular architecture allows phospholipids to assemble as lipid bilayers in which the hydrophobic chains face each other while the polar head groups face outward to the aqueous milieu ( Figure 1 ). (sigmaaldrich.com)
1 These integral membrane proteins (IMPs) ( Figure 2 ) are not soluble in aqueous solutions as they aggregate to protect their hydrophobic domains, but are soluble in detergent solutions as micelles formed by detergents are analogous to the bilayers of the biological membranes. (sigmaaldrich.com)
[22] A mitochondrion contains outer and inner membranes composed of phospholipid bilayers and proteins . (wikipedia.org)
Native membrane derived polymer-supported lipid bilayers (nSLBs) are poised to bridge the gap between live cell experiments and traditional model membrane architectures that by offering a combination of accessibility by surface sensitive analytical instrumentation and a composition which more closely resembles cellular membranes by displaying a diversity of endogenous membrane proteins, lipids, and carbohydrates. (lu.se)

What role do phospholipids and proteins play in cell membranes? (lynniezulu.com)
Phospholipids work to provide pathways for various substances across membranes. (lynniezulu.com)
Phospholipids are abundant in all biological membranes. (lynniezulu.com)
Phospholipids are essential structural components of all cellular membranes. (lynniezulu.com)
Igs, typical constitutively secreted proteins, which needed chemical cross-linking to serve as an aggregated protein control, pelleted membranes almost independently of pH. (silverchair.com)
We conclude that pancreatic zymogen aggregates, formed under the acidic conditions of the secretory pathway sorting compartments, have the capacity to bind firmly to membranes through their phospholipid constituents. (silverchair.com)
A procedure was developed to vary the cholesterol-to-phospholipid (Ch/PL) ratio of synaptic plasma membranes and synaptosomes using a nonspecific lipid transfer protein so that membrane lipid composition could be correlated with presynaptic function. (mcw.edu)
In synaptic plasma membranes, Ch/PL molar ratios from 0.21 to 1.19 were produced from a normal value of 0.52 +/- 0.01 by incubation with the transfer protein and an excess of either phosphatidylcholine or cholesterol/phosphatidylcholine liposomes for 60 min at 32 degrees C. In synaptosomes, Ch/PL ratios from 0.16 to 0.81 were similarly produced from a normal value of 0.38 +/- 0.04. (mcw.edu)
Cholesterol loading or depletion of the membranes was accompanied by a decrease or increase, respectively in the phospholipid-to-protein ratio. (mcw.edu)
The antagonistic action of the CKI gene product on SEC14p function revealed a previously unsuspected influence of biosynthetic activities of the CDP-choline pathway for PC biosynthesis on yeast Golgi function and indicated that SEC14p controls the phospholipid content of yeast Golgi membranes in vivo. (tamu.edu)
All-atom simulations of 4E10, PGZL1, 10E8 and LN01 docked onto HIV-like membranes consistently form phospholipid complexes at key complementarity-determining region loop sites, solidifying that stable and specific lipid interactions anchor bnAbs to membrane surfaces. (elifesciences.org)
Biological membranes consist of phospholipids that contain two hydrophobic groups connected to a polar head. (sigmaaldrich.com)
Mounting evidence suggests that the genetic disorders/mutation and diseases change not only the protein expression patterns but also membranes themselves. (lu.se)

In this study we assessed the role of anionic lipids in the binding of the terminal complement proteins to the membrane and the efficiency of subsequent hemolysis. (psu.edu)
The principal components of the plasma membrane are lipids (phospholipids and cholesterol), proteins, and carbohydrate groups that are attached to some of the lipids and proteins. (lynniezulu.com)
What is the relationship between proteins and lipids? (lynniezulu.com)
For over 100 years experts have recognised the benefit of phospholipids for reducing symptoms of a number of conditions such as heart disease, cancer and inflammation, according to an article published in Lipids in Health and Disease. (lynniezulu.com)
Surfactant recovered by alveolar wash from most mammals contains 70-80% phospholipids, 8-10% protein, and 10% neutral lipids, primarily cholesterol. (medscape.com)
its primary translation product, 22 kd, is processed to an extremely hydrophobic 4-kd protein that is associated with lipids in lamellar bodies. (medscape.com)
Among subjects with normal lung function, phospholipid levels were elevated in current smokers , in comparison to no effect of smoking on these lipids at abnormal lung function. (bvsalud.org)
Smoking increased exhaled number of particles and the contents of lipids and surfactant protein A in the particles. (bvsalud.org)
Common applications include cell lysis, solubilization of membrane proteins and lipids, protein crystallization, and reduction of background staining in blotting experiments. (sigmaaldrich.com)
Proteins and lipids are embedded in this bilayer forming the fluid mosaic model ( Figure 2 ) which was first proposed by Singer and Nicolson in 1972. (sigmaaldrich.com)
Plasma lipoproteins are macromolecular complexes of lipids and proteins that are classified by density and electrophoretic mobility. (medscape.com)
The nonpolar lipids (ie, cholesterol ester, triglycerides [TGs]) reside in a core surrounded by more polar components (eg, free cholesterol, phospholipids, proteins). (medscape.com)
LNP include lipids, phospholipids, cholesterol and polyethylene glycol (PEG), which increases LNP stability. (cdc.gov)
Due to the lack of detergent solubilization and reconstitution steps, the nSLBs created using this approach contain essentially all of the native lipids, as well as the membrane-associated proteins and carbohydrates from the donor membrane. (lu.se)

Our previous nuclear magnetic resonance studies indicate that IL-8 binding to the N-terminal residues is mediated by the membrane, underscoring the importance of the phospholipid bilayer for physiological activity. (rcsb.org)
The Fluid Mosaic Model The model proposes that integral membrane proteins are embedded in the phospholipid bilayer, as seen in Figure above. (lynniezulu.com)
Some of these proteins extend all the way through the bilayer, and some only partially across it. (lynniezulu.com)
The phospholipids bound to the monomer surface should be part of the matrix leaflet of the phospholipid bilayer. (lynniezulu.com)
They form a mediating layer between the membrane-spanning part of the protein and help to position the complex vertically in the bilayer. (lynniezulu.com)
How do phospholipids and proteins interact in a lipid bilayer? (lynniezulu.com)
They contain multiple membrane-spanning regions that form a passage through the lipid bilayer, allowing polar or charged molecules to cross the membrane through a protein pore without interacting with the hydrophobic fatty acid chains of the membrane phospholipids. (lynniezulu.com)
The deleterious effects of Mla knockouts probably result from phospholipid accumulation in the OM outer leaflet, forming bilayer patches that are portals for entry of lipophilic small molecules 17 . (nature.com)
We report on an anomalous X-ray reflectivity study to locate a labelled residue of a membrane protein with respect to the lipid bilayer. (huji.ac.il)
Simulations estimating protein-membrane interaction strength for PGZL1 variants along an inferred maturation pathway show bilayer affinity is evolved and correlates with neutralization potency. (elifesciences.org)
Antibodies can target epitopes on integral membrane proteins very near to the lipid bilayer surface, even those partially embedded within the headgroup region. (elifesciences.org)
Proteins are held in the lipid bilayer by hydrophobic interactions between the lipid tails and hydrophobic protein domains. (sigmaaldrich.com)
Hydrophobic regions of membrane proteins, normally embedded in the membrane lipid bilayer, are now surrounded by a layer of detergent molecules and the hydrophilic regions are exposed to the aqueous medium. (sigmaaldrich.com)
At concentrations equal to, or higher than the detergent's CMC, the lipid bilayer becomes saturated with detergent molecules and breaks apart generating lipid-protein-detergent mixed micelles (c). 8 A detergent/protein ratio of around 1-2 (w/w) is believed to be sufficient to solubilize IMPs to form lipid-protein-detergent mixed micelles. (sigmaaldrich.com)
In addition, when platelets are activated, negatively charged phospholipids move from the inner to the outer leaflet of the membrane bilayer. (medscape.com)

CXCR1 is a class A, rhodopsin-like G-protein-coupled receptor (GPCR), the largest class of integral membrane proteins responsible for cellular signal transduction and targeted as drug receptors. (rcsb.org)

Phospholipid transfer protein is a protein that in humans is encoded by the PLTP gene. (wikipedia.org)
Binding of phospholipid transfer protein (PLTP) to apolipoproteins A-I and A-II: location of a PLTP binding domain in the amino terminal region of apoA-I". J. Lipid Res. (wikipedia.org)
PhosphoLipid transfer protein (PLTP) exerts a direct pro-inflammatory effect on rheumatoid arthritis (RA) fibroblasts-like-synoviocytes (FLS) independently of its lipid transfer activity. (nih.gov)
Description: Quantitativesandwich ELISA kit for measuring Human phospholipid transfer protein(PLTP) in samples from serum, plasma, tissue homogenates. (elisareagents.com)
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Phospholipid Transfer Protein (PLTP) in serum, plasma, tissue homogenates and other biological fluids. (elisareagents.com)
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Phospholipid Transfer Protein (PLTP) in samples from Serum, plasma, tissue homogenates and other biological fluids with no significant corss-reactivity with analogues from other species. (elisareagents.com)

Recent structural determination of GPCRs has advanced by modifying the receptors with stabilizing mutations, insertion of the protein T4 lysozyme and truncations of their amino acid sequences, as well as addition of stabilizing antibodies and small molecules that facilitate crystallization in cubic phase monoolein mixtures. (rcsb.org)
Overactivation of NMDA receptors is believed to induce neuronal death by increasing phospholipid hydrolysis and subsequent degradation. (jneurosci.org)
Excessive Ca 2 + entry through glutamate receptors activates a large array of potential neurotoxic mechanisms, which include activation of enzymes such as phospholipases, calpains and other proteases, protein kinases, nitric oxide synthetase, endonucleases, as well as reactive oxygen species (for review, see Sattler and Tymianski, 2000 ). (jneurosci.org)
These membrane proteins act as transport proteins and receptors proteins. (lynniezulu.com)
This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors that play a key role in the maintenance of cholesterol balance in the body. (nih.gov)

In addition to regulating the size of HDL particles, this protein may be involved in cholesterol metabolism. (wikipedia.org)
Alteration of synaptic membrane cholesterol/phospholipid ratio using a lipid transfer protein. (mcw.edu)
As reported earlier, the helical arrangement of the protein component of the vesicles facilitates image averaging and enables us to determine how cholesterol and phospho-lipid molecules are distributed in the surrounding matrix, using headgroup size as a means to discriminate between the two kinds of lipid. (iucr.org)
Bile is isosmotic with plasma and consists primarily of water and electrolytes but also organic compounds: bile salts, phospholipids (mostly lecithin), cholesterol, bilirubin, and other endogenously produced or ingested compounds, such as proteins that regulate gastrointestinal function and drugs or their metabolites. (msdmanuals.com)

Engineered mutations to the 10E8 paratope at light-chain solvent-exposed residues that add positive charge or hydrophobic sidechains proved to increase antibody association to anionic phospholipid vesicles in vitro and also boosted neutralization potency 27 . (elifesciences.org)
membrane phospholipids, and other anionic phospholipid-containing moieties. (bvsalud.org)

CCT is a key enzyme that maintains a balanced composition of cell membrane phospholipids. (asbmb.org)

The effects of aging and of liposome treatment on the lateral mobility of phospholipids and proteins in the plasma membrane of cultured rat heart myocytes were studied by fluorescence photobleaching recovery. (tau.ac.il)
MlaC probably accepts a phospholipid from MlaA and shuttles it to the ABC transporter for ATP-dependent plasma membrane insertion 5 . (nature.com)

Choline kinase alpha (ChoKalpha) is an enzyme involved in the metabolism of phospholipids recently found to play a relevant role in the regulation of cell proliferation, oncogenic transformation and human carcinogenesis. (nih.gov)
The molecular basis to understand the connection between phospholipids metabolism and cell cycle regulation through choline kinase is reported. (nih.gov)
Ontogenetic aspects of phospholipid-sensitive calcium-dependent protein kinase in guinea pig tissues. (wikidata.org)

These results show that membrane damage by NMDA is preceded by inhibition of phospholipid synthesis and not by phospholipid degradation in the early stages of the excitotoxic process, and that NMDA receptor overactivation decreases phosphatidylcholine and phosphatidylethanolamine synthesis by inhibiting choline-ethanolaminophosphotransferase activity. (jneurosci.org)
Essential phospholipids (EPL substance - an active ingredient in Essentiale medications) is a complex of substances of natural origin (ethers of cholinephosphoric acid (phosphatidylcholine) and unsaturated fatty acids (linoleic, linolenic, olein). (lynniezulu.com)
Dipalmitoyl phosphatidylcholine (DPPC), or lecithin, is functionally the principle phospholipid. (medscape.com)
The contents of surfactant protein A and albumin in exhaled particles was quantified with immunoassays and the contents of the phospholipids dipalmitoyl- and palmitoyl-oleoyl- phosphatidylcholine with mass spectrometry . (bvsalud.org)
SEC14p is the yeast phosphatidylinositol (PI)/phosphatidylcholine (PC) transfer protein, and it effects an essential stimulation of yeast Golgi secretory function. (tamu.edu)
The radiolabelled protein showed strong binding to purified phosphatidylcholine and phosphatidylserine and weak binding to purified sphingomyelin, lysophosphatidylcholine and phosphatidylethanolamine, but did not interact with phosphatidic acid, lysophosphatidic acid or phosphatidylinositol. (tmu.edu.tw)
Interacting proteins dictate function of the minimal START domain phosphatidylcholine transfer protein/StarD2. (wikipedia.org)

Time scales of water dynamics at biological interfaces: peptides, proteins and cells. (lu.se)

We now investigated the effect of NMDA receptor overactivation on synthesis and degradation of major membrane phospholipids in the early stages of the excitotoxic process. (jneurosci.org)
c ) The 5.8 Å density map and superimposed 2.7 Å structure of the Torpedo receptor (PDB entry 6uwz ) obtained from detergent-solubilized protein complexed with α -bungarotoxin. (iucr.org)

This asymmetry is maintained by the Mla pathway, a six-component system that is widespread in Gram-negative bacteria and is thought to mediate retrograde transport of misplaced phospholipids from the outer leaflet of the OM to the cytoplasmic membrane 4 . (nature.com)
Here we show, using X-ray crystallography, molecular dynamics simulations and in vitro and in vivo functional assays, that MlaA is a monomeric α-helical OM protein that functions as a phospholipid translocation channel, forming a ~20-Å-thick doughnut embedded in the inner leaflet of the OM with a central, amphipathic pore. (nature.com)
This architecture prevents access of inner leaflet phospholipids to the pore, but allows outer leaflet phospholipids to bind to a pronounced ridge surrounding the channel, followed by diffusion towards the periplasmic space. (nature.com)
MlaA represents a lipid transport protein that selectively removes outer leaflet phospholipids to help maintain the essential barrier function of the bacterial OM. (nature.com)
Only the Mla system maintains asymmetry directly via phospholipid extraction, while PldA and PagP both generate lysophospholipids in the outer leaflet that still require removal. (nature.com)
MlaA is the most enigmatic Mla component, particularly since its identity as a periplasmically exposed lipoprotein appears hard to reconcile with its proposed activity on outer leaflet phospholipids. (nature.com)

The protein encoded by this gene is one of at least two lipid transfer proteins found in human plasma. (wikipedia.org)
It is associated with a mutation of the ABCB4 gene which codes for protein MDR3, a biliary carrier. (nih.gov)
The SP-B gene is on human chromosome 2, and its primary translation product is 40 kd, which is clipped to become an 8-kd protein in the type II cells before entering lamellar bodies to be cosecreted with phospholipids. (medscape.com)
This gene encodes the protein FIC1, also known as ATP8B1. (medscape.com)
This suggests that in most patients with PFIC-2, the gene defect is sufficiently severe to produce no product or a protein that cannot be inserted into the canalicular membrane. (medscape.com)
Heterologous gene expression confirmed that proteins from the ISC and CDP-DAG pathways retain mitochondrial targeting sequences that are recognized by yeast mitochondria. (lu.se)

Some of these phospholipids, such as phosphatidylserine, are vital in other protist endoparasites that invade their host through apoptotic mimicry. (lu.se)

Vesicles composed of single classes of phospholipids were also pelleted, but with various efficacies. (silverchair.com)
Here, cryo-EM is used to examine the protein-lipid architecture of this membrane in tubular vesicles obtained from the (muscle-derived) electric organ of the Torpedo ray. (iucr.org)
Here, we analyse by cryo-EM the architecture of this membrane in vesicles isolated from the (muscle-derived) electric organ of the Torpedo ray, with view to defining the protein-lipid interplay required to achieve an optimal neurotransmitter response. (iucr.org)

Oxidized phospholipids are thought to market atherogenesis by rousing endothelial cells (ECs) to create inflammatory cytokines such as for example IL-8. (careersfromscience.org)

Cleavage of the anchor by PIPLC removes the hydrophobic diacylglycerol or alkylacylglycerol and generates a hydrophilic protein that retains the glycan portion of the anchor. (elsevierpure.com)
Among the four surfactant apoproteins identified, surfactant protein B (SP-B) and SP-C are two small hydrophobic proteins that make up 2-4% of the surfactant mass and are present in commercially available surfactant preparations. (medscape.com)
2 Proteins are incorporated into these micelles via hydrophobic interactions. (sigmaaldrich.com)
Complete removal of detergent could result in aggregation due to the clustering of hydrophobic regions and, hence, may cause precipitation of membrane proteins. (sigmaaldrich.com)

Low-Phospholipid Associated Cholelithiasis (LPAC) is a genetic disease responsible for the development of intrahepatic lithiasis. (nih.gov)
Using the genetic code of the SARS-CoV-2 virus, vaccine manufacturers developed mRNA that instructs ribosomes to produce the spike protein of the SARS-CoV-2 virus. (cdc.gov)
In comparison, mRNA vaccines can be more quickly generated in the laboratory using the genetic sequences for selected pathogen proteins. (cdc.gov)
Genetic and nongenetic sources of variation in phospholipid transfer protein activity. (cdc.gov)

Therefore, condensates are mixtures of proteins, nucleic acids and specific metabolites. (nature.com)

Click on genes, proteins and metabolites below to link to respective articles. (wikipedia.org)
Expression array evaluation of Ercalcidiol aortic EC ethnicities derived from 12 individuals revealed that >1 0 genes were regulated by oxidized phospholipids. (careersfromscience.org)
We display that several recognized modules are significantly enriched in genes for known pathways and confirm a module enriched for unfolded protein response (UPR) genes using siRNA and the UPR inducer tunicamycin. (careersfromscience.org)
The SFTPB and SFTPC genes provide instructions for making surfactant protein-B (SP-B) and surfactant protein-C (SP-C), respectively, two of the four proteins in surfactant. (medlineplus.gov)

Egg yolks, liver, wheat germ and peanuts contain the phospholipid lecithin. (lynniezulu.com)

We find that these condensates have a unique chemical microenvironment that enriches amphipathic metabolites such as phospholipids. (nature.com)
The presence of phospholipids and other amphipathic metabolites might enable condensates to facilitate specific metabolic reactions. (nature.com)

Surfactant is a complex lipoprotein (see the image below) composed of six phospholipids and four apoproteins. (medscape.com)
Current smoking alters phospholipid- and surfactant protein A levels in small airway lining fluid: An explorative study on exhaled breath. (bvsalud.org)
Current smokers , compared to never smokers , had higher number exhaled particles and more surfactant protein A in the particles. (bvsalud.org)
This condition results from abnormalities in the composition or function of surfactant, a mixture of certain fats (called phospholipids) and proteins that lines the lung tissue and makes breathing easy. (medlineplus.gov)
The phospholipids and proteins that make up surfactant are packaged in cellular structures known as lamellar bodies. (medlineplus.gov)
These structures are also important for some processing of surfactant proteins, which is necessary for the proteins to mature and become functional. (medlineplus.gov)
These two proteins help spread the surfactant across the surface of the lung tissue, aiding in the surface tension-lowering property of surfactant. (medlineplus.gov)
Proteins enriched in HDL from patients with ESRD (ESRD-HDL) included surfactant protein B (SP-B), apolipoprotein C-II, serum amyloid A (SAA), and α-1-microglobulin/bikunin precursor. (lww.com)

Mutations in the CDP-choline pathway for phospholipid biosynthesis bypass the requirement for an essential phospholipid transfer protein. (tamu.edu)
It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor arachidonic acid. (nih.gov)

Most fats, oils and fat-containing foods contain phospholipids as well. (lynniezulu.com)

The intracellular loops of GPCRs are crucial for G-protein interactions, and activation of CXCR1 involves both amino-terminal residues and extracellular loops. (rcsb.org)
Therefore, we designed a protein-free dispersion media containing phospholipids and amino acids in an isotonic balanced electrolyte solution, a solution for nasal and olfactory transport (SNOT). (cdc.gov)

We investigated a phospholipid-protein complex (PPC) from krill that is hypothesized to influence lipid metabolism, inflammation, and redox status. (uib.no)

Examination of the blue module exposed the presence of a large number of molecular chaperones (DNAJA1 DNAJA4 DNAJB1 DNAJB6 and DNAJB9) and warmth shock proteins (HSPA1A HSPA1B and HSPH1) many of which are known to be induced by ER stress as part of the UPR pathway (Table 1) (18). (careersfromscience.org)
Molecular function GO terms and their p-values for co-expressed proteins. (lu.se)

In contrast, the two acidic phospholipids, DPPS and DPPA, caused a dose- dependent increase in both lysis and C5b-7 uptake. (psu.edu)
Some regulated secretory proteins are thought to be targeted to secretory granules through an acidic-dependent aggregation in the trans -Golgi network. (silverchair.com)

Rather than defective bile acid export, patients with PFIC3 have deficient hepatocellular phospholipid export. (medscape.com)
The lack of phospholipids produces unstable micelles that have a toxic effect on the bile ducts, leading to bile duct plugs and biliary obstruction. (medscape.com)
The mechanism whereby the loss of FIC1 activity results in defective bile salts excretion is unknown, but it has been hypothesized that a mutation in this protein causes phospholipid membrane instability leading to reduced function of bile acid transporters. (medscape.com)
While the PFIC1 and PFIC2 involve a defect in bile acid secretion, PFIC3 involves a defect in phospholipid secretion. (medscape.com)

Furthermore, its protein-lipid composition, organization and size are subject to modification by physiological events, making it an important mediator of neuronal plasticity. (iucr.org)

These are polar interactions between phospholipid head groups and hydrophilic portions of proteins (leading to some specificity of the phospholipids surrounding some proteins). (lynniezulu.com)
The specificity of interaction between 125 I-SVA and phospholipids was studied by TLC overlay techniques. (tmu.edu.tw)

This new approach has been shown to preserve mobility and enzymatic activity of transmembrane proteins in the resulting nSLB. (lu.se)

The proteins, termed apolipoproteins, play an important role in lipoprotein metabolism. (medscape.com)

Channel proteins span the membrane and make hydrophilic tunnels across it, allowing their target molecules to pass through by diffusion. (lynniezulu.com)

5 A further increase of detergent concentration causes progressive delipidation of the lipid-protein-detergent mixed micelles. (sigmaaldrich.com)
This leads to the formation of lipid/detergent and protein/detergent mixed micelles (d). 8 A solubilized IMP in a complex with a bound detergent is called a protein-detergent complex, PDC. (sigmaaldrich.com)
Excess detergent is normally employed in solubilization of membrane proteins to ensure complete dissolution of the membrane and provide a large number of single protein molecule containing micelles. (sigmaaldrich.com)

FIC1 is a P-type ATPase responsible for maintaining a high concentration of phospholipids in the inner hepatocyte membrane. (medscape.com)

Protein-lipid interactions are responsible for preserving the functional integrity of integral proteins. (lynniezulu.com)
MSLBs are a useful model to evaluate protein-membrane interactions because of their cell-like dual aspect fluidity, their addressability and compositional versatility. (rsc.org)

How proteins modify water dynamics. (lu.se)
Analysis of protein dynamics simulations by a stochastic point process approach. (lu.se)
Hydration dynamics of a halophilic protein in folded and unfolded states. (lu.se)
Slow internal protein dynamics from water 1 H magnetic relaxation dispersion. (lu.se)
Does the dynamic Stokes shift report on slow protein hydration dynamics? (lu.se)
Dynamics at the protein-water interface from 17 O spin relaxation in deeply supercooled solutions. (lu.se)
Nanosecond to microsecond protein dynamics probed by magnetic relaxation dispersion of buried water molecules. (lu.se)
While many studies have been focused on the membrane structure, the dynamics of such systems are crucial for the function of the membrane including membrane bound proteins. (lu.se)

A phospholipid molecule is constructed from four components: fatty acids, a platform to which the fatty acids are attached, a phosphate, and an alcohol attached to the phosphate (Figure 12.3). (lynniezulu.com)

It is generally assumed that enzymatic hydrolysis of phospholipids leads to phospholipid degradation and membrane damage. (jneurosci.org)

Enzymatic hydrolysis of membrane phospholipids by phospholipases produces these lipid second messengers, as well as soluble second messengers such as inositol 1,4,5-trisphosphate, and also other molecules such as choline (Cho) that are released to the extracellular medium. (jneurosci.org)

There are a variety of different techniques to clean up biological samples for LC analysis, ranging from non-specific such as protein precipitation, to the very specific such as solid-phase extraction. (kemomind.com)
Even though studying membrane proteins is a major challenge in protein biochemistry, they remain an important area of study due to their significant biological and pharmacological relevance. (sigmaaldrich.com)

C. neoformans is equipped with enzymes known as proteases, which degrade proteins, as well as enzymes that destroy phospholipids. (encyclopedia.com)

However, the mechanisms by which phospholipases switch from physiological second-messenger production to phospholipid degradation remain unclear. (jneurosci.org)

However, corticosteroids are thought to act by the induction of phospholipase A2inhibitory proteins, collectively called lipocortins. (nih.gov)
Arachidonic acid is released from membrane phospholipids by phospholipase A2. (nih.gov)

In contrast, NMDA strongly reduced the incorporation of [ 3 H]choline and [ 3 H]ethanolamine into their respective phospholipids. (jneurosci.org)

This represents a unique combination of metabolic pathways in an MRO, including the first reported case of a mitosome-like organelle able to synthesize phospholipids de novo. (lu.se)

Unfortunately, protein and some elements in existing dispersion media are suboptimal for potential nose-to-brain transport of nanomaterial s because olfactory transport has size- and ion-composition requirements. (cdc.gov)

Whey Protein Phospholipid Concentrate (WPPC), a low-value coproduct, is currently being examined as a source of nutritional and functional ingredients. (dairyfoods.com)

Alternatively, research suggests that abnormally processed SP-C proteins form the wrong three-dimensional shape and accumulate inside the lung cells. (medlineplus.gov)

Plasma Phospholipid Transfer Protein Promotes Platelet Aggregation. (nih.gov)
Phospholipid transfer protein: its impact on lipoprotein homeostasis and atherosclerosis. (nih.gov)
ORP5 and ORP8: Sterol Sensors and Phospholipid Transfer Proteins at Membrane Contact Sites? (nih.gov)

Anatomy13

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Phenomena and Processes34

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