Protein paired box transcription factors. Medical search. Frequent questions

The motif is very similar in sequence and structure in a wide range of DNA-binding proteins (e.g., cro and repressor proteins, homeotic proteins, etc. (embl.de)
One of the principal differences between HTH motifs in these different proteins arises from the stereo-chemical requirement for glycine in the turn which is needed to avoid steric interference of the beta-carbon with the main chain: for cro and repressor proteins the glycine appears to be mandatory, while for many of the homeotic and other DNA-binding proteins the requirement is relaxed. (embl.de)
It transduces regulatory information from activator and repressor proteins to RNA polymerase II. (nih.gov)

Paired box transcription factor 5 ( PAX5 ) plays a major role in B cell differentiation from pro B cell to mature B cell, the point at which the expression of non-B-lineage genes is permanently blocked. (wikidoc.org)
This translocation brings the potent E-mu enhancer of the IgH gene into close proximity of the PAX5 promoter, suggesting that the deregulation of transcription of this gene contributes to the pathogenesis of these lymphomas. (newmarketscientific.com)
PAX5 (NP_057953, 192 a.a. ~ 301 a.a) partial recombinant protein with GST tag. (scientificlabs.co.uk)
The PAX5 gene encodes the B-cell lineage specific activator protein (BSAP) that is expressed at early, but not late stages of B-cell differentiation. (enquirebio.com)
Pax5, or BSAP (B-cell lineage-specific activator protein), is a member of the paired box (Pax) family of transcription factors, it is an important transcription factor that is significant for B-cell differentiation and progression of B-cell development beyond the early pro-B (pre-B1) cell stage. (biogenex.com)

Members of this gene family typically encode proteins which contain a paired box domain, an octapeptide, and a paired-type homeodomain. (wikipedia.org)
Members of the Pax family typically contain a paired box domain and a paired-type homeodomain. (novusbio.com)

Sine oculis-related homeobox 3 (SIX3) and SIX6, 2 closely related homeodomain transcription factors, are involved in development of the mammalian neuroendocrine system and mutations of Six6 adversely affect fertility in mice. (nih.gov)

The central feature of this gene family is a novel, highly conserved DNA-binding motif, known as the paired box. (newmarketscientific.com)

Paired box gene 8, also known as PAX8, is a protein which in humans is encoded by the PAX8 gene. (wikipedia.org)
PAX8 and other transcription factors play a role in binding to DNA and regulating the genes that drive thyroid hormone synthesis (Tg, TPO, Slc5a5 and Tshr). (wikipedia.org)
A fusion protein, PAX8-PPAR-γ, is implicated in some follicular thyroid carcinomas and follicular-variant papillary thyroid carcinoma. (wikipedia.org)
3. Determination of functional domains of the human transcription factor PAX8 responsible for its nuclear localization and transactivating potential. (nih.gov)
6. The paired-domain transcription factor Pax8 binds to the upstream enhancer of the rat sodium/iodide symporter gene and participates in both thyroid-specific and cyclic-AMP-dependent transcription. (nih.gov)
8. Effects of Pax8 and TTF-1 thyroid transcription factor gene transfer in hepatoma cells: imaging of functional protein-protein interaction and iodide uptake. (nih.gov)
9. Comparative in situ hybridization analysis of PAX2, PAX8, and WT1 gene transcription in human fetal kidney and Wilms' tumors. (nih.gov)
11. The functional interaction between the paired domain transcription factor Pax8 and Smad3 is involved in transforming growth factor-beta repression of the sodium/iodide symporter gene. (nih.gov)
14. Possible regulation of Wilms' tumour gene 1 (WT1) expression by the paired box genes PAX2 and PAX8 and by the haematopoietic transcription factor GATA-1 in human acute myeloid leukaemias. (nih.gov)
17. Distinct functional properties of three human paired-box-protein, PAX8, isoforms generated by alternative splicing in thyroid, kidney and Wilms' tumors. (nih.gov)
Within anaplastic foci, thyroid specific transcription factor Paired box gene-8 (PAX8) expression was virtually lost. (nih.gov)
We found that elevated MYC protein had an inverse association with PAX8 and thyroid transcription factor-1 expression. (nih.gov)
PAX8 (Paired box gene 8) is a specialized protein called a transcription factor. (mypathologyreport.ca)
The PAX8 protein is required for the normal development and function of various organs including the thyroid gland, kidneys, ovaries, fallopian tubes, uterus, and vagina. (mypathologyreport.ca)
Pathologists use a test called immunohistochemistry to 'see' PAX8 protein inside cells. (mypathologyreport.ca)
The PAX8 protein is normally found in a part of the cell called the nucleus . (mypathologyreport.ca)
Positive for PAX8 means that the PAX8 protein was seen inside the cells of interest in the tissue sample. (mypathologyreport.ca)
Background: The Pax8 transcription factor genes have a role in cell differentiation and cell growth, and silencing of Pax8 in cell cultures results in cell death. (elsevierpure.com)
The aims of this study were to determine the expression and correlation of Pax8 protein with several clinicopathological variables in patients with endometrial cancer. (elsevierpure.com)
Conclusion: Overexpression of Pax8 protein by endometrial cancer is associated with poor disease outcomes. (elsevierpure.com)

NFKB 105 subunit for example is a polypetide gene enhancer of genes in B cells.The activation of transcription factor subunits is the first step of gene expression, in which a particular segment of DNA is copied into RNA (mRNA) by the enzyme RNA polymerases. (homeodomains.com)
We determined that two separate morpholinos targeted against the proliferating cell nuclear antigen (PCNA) mRNA reduced PCNA protein levels. (zfin.org)
It transcribes protein-coding genes to produce precursor messenger RNA (pre-mRNA). (microbiologynote.com)
The pre-mRNA molecules produced by RNA Pol II undergo various modifications, such as splicing and capping, before they are transported out of the nucleus for translation into proteins. (microbiologynote.com)
A luciferase reporter assay, in A549 cells, identified allele-dependent mRNA transcription. (cdc.gov)

The highly conserved paired box sequence within the Pax genes encodes a paired DNA binding domain, indicating that the Pax proteins are transcription factors which bind and regulate downstream target genes. (brownwalker.com)

4] The 6 genes involved in WS are PAX3 (encoding the paired box 3 transcription factor), MITF (microphthalmia-associated transcription factor), EDN3 (endothelin 3), EDNRB (endothelin receptor type B), SOX10 (encoding the Sry bOX10 transcription factor), and SNAI2 (snail homolog 2), with different frequencies. (medscape.com)
8] Both mutations created stop codons leading to truncation of the PAX3 protein. (medscape.com)
A novel PAX3 heterozygous mutation of c.372-373delGA (p.N125fs) was found that gave rise to a frameshift and truncation of the PAX3 protein. (medscape.com)
PAX3 was a substrate of APC/C(Cdh1) in melanocytes, and APC/C(Cdh1)-mediated ubiquitylation marked PAX3 for proteolytic degradation in a manner dependent on the D-box motif in PAX3. (ox.ac.uk)
Either mutating the D-box in PAX3 or knocking down Cdh1 prevented the ubiquitylation and degradation of PAX3 and increased proliferation and melanin production in melanocytes. (ox.ac.uk)
Some members of the Pax family, which includes Pax3 and Pax7, encode a second DNA binding domain of the paired-type homeodomain (HD) class. (brownwalker.com)
Pax3 and Pax7 are closely related paired box family members specifically expressed in the dorsal neural tube and the developing somites and in proliferating and migrating neural crest cells where they are implicated in early neural and myogenic development, and are required for development of specific myogenic, neurogenic and neural crest cell lineages. (brownwalker.com)

The PAX genes give instructions for making proteins that attach themselves to certain areas of DNA. (wikipedia.org)
To carry out these roles, the PAX genes provide instructions for making proteins that attach to specific areas of DNA and help control the activity (expression) of particular genes. (nih.gov)

Finally, we observed that 5-AZA and Vitamin C led to an increased expression of Hepatocyte nuclear factor 4α (HNF4α) and E-Cadherin and a significant down regulation of Snail1 (SNAIL), the key transcriptional repressor of E-Cadherin. (cancerindex.org)
The sites identified are an E-box-like element, a consensus hepatocyte nuclear factor 1 site, a CCAAT box motif, and a novel site. (edu.au)

Its expression has also been detected in developing CNS and testis and so the encoded protein may also play a role in neural development and spermatogenesis. (newmarketscientific.com)

The protein acts as a transcription factor, which is a protein that attaches (binds) to specific regions of DNA and helps control the activity of particular genes. (medlineplus.gov)
Initiation marks the beginning of transcription, where RNA polymerase, the enzyme responsible for transcription, recognizes specific DNA sequences known as promoters and binds to them. (microbiologynote.com)
a "promoter region [juxtaposed to the core promoter that] binds transcription factors that modify the affinity of the core promoter for RNA polymerase. (wikiversity.org)

We show that SIX6 repression requires interaction with transducin-like enhancer of split corepressor proteins and competition for DNA-binding sites with the transcriptional activator pituitary homeobox 1. (nih.gov)
2. Transcriptional regulation of human sodium/iodide symporter gene: a role for redox factor-1. (nih.gov)
Such networks are composed of two types of components, or nodes: the gene targets that are subject to transcriptional control and the TF proteins that execute transcriptional control. (biomedcentral.com)
One explanation for transcriptional repression is the reduced accessibility of transcription factors. (rupress.org)

These mutations can affect different functions of the protein including DNA binding, gene activation, protein stability, and cooperation with the co-activator p300. (wikipedia.org)
This gene encodes the B-cell lineage specific activator protein that is expressed at early, but not late stages of B-cell differentiation. (newmarketscientific.com)

PAX2 Transcription Factor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (childrensmercy.org)
This graph shows the total number of publications written about "PAX2 Transcription Factor" by people in this website by year, and whether "PAX2 Transcription Factor" was a major or minor topic of these publications. (childrensmercy.org)
Below are the most recent publications written about "PAX2 Transcription Factor" by people in Profiles. (childrensmercy.org)

This nuclear protein is involved in thyroid follicular cell development and expression of thyroid-specific genes. (wikipedia.org)
Aplha, transcription related growth factors and stimulating factors or repressing nuclear factors are complex subunits of proteins involved in cell differentiation. (homeodomains.com)
Because these transcription factors are nuclear protein, as opposed to the cytoplasmic nature of other more traditional immunomarkers, they add an additional morphologic advantage to tumor immunodiagnosis. (medscape.com)
Electrophoretic mobility shift assays (EMSA) identified oligonucleotide-protein binding for risk and non-risk SNPs to nuclear extracts of A549, BEAS 2B, and IMR-90 lung cell lines. (cdc.gov)

A la I Conferència i Taller Internacional sobre diferenciació dels antígens leucocitaris humans , celebrada a París el 1982, fou aprovada la terminologia CD (cúmul o grup de diferenciació [18] o cluster of differentiation en anglès). (wikipedia.org)
B-lymphocyte antigen CD19 , also known as CD19 molecule ( C luster of D ifferentiation 19 ), B-Lymphocyte Surface Antigen B4 , T-Cell Surface Antigen Leu-12 and CVID3 is a transmembrane protein that in humans is encoded by the gene CD19 . (wikidoc.org)

A paired box transcription factor that is involved in EMBRYONIC DEVELOPMENT of the CENTRAL NERVOUS SYSTEM and SKELETAL MUSCLE . (bvsalud.org)
During embryonic development, the PAX6 protein is thought to turn on (activate) genes involved in the formation of the eyes, the brain and spinal cord (central nervous system), and the pancreas. (nih.gov)

5. A thyroid-specific far-upstream enhancer in the human sodium/iodide symporter gene requires Pax-8 binding and cyclic adenosine 3',5'-monophosphate response element-like sequence binding proteins for full activity and is differentially regulated in normal and thyroid cancer cells. (nih.gov)
The metal ion regulation of MTs is conferred by a short sequence element called the metal-responsive element (MRE [21]) or TGC box (31, 34), which functions as a metal ion-dependent enhancer. (wikiversity.org)
Mutagenesis demonstrated that each site contributed to enhancer activity, although there was a weaker contribution from the CCAAT box, and that no individual site was critical for responsiveness. (edu.au)
In keeping with the tissue-restricted expression of the CYP2H1 gene, gel shift experiments established that the proteins binding to these enhancer sites are enriched in chicken liver, kidney, and small intestine. (edu.au)
The proteins binding to the 240-bp fragment are different from those recently reported to be required for the activity of the phenobarbital responsive enhancer domains of rodent CYP2 genes. (edu.au)

At least two A1BG gene isoforms have their transcription initiated by an MRE. (wikiversity.org)

This gene is a member of the paired box (PAX) family of transcription factors. (wikipedia.org)
Pax4 is a member of the paired box family of transcription factors. (novusbio.com)
[ 11-28 ] PAX-2 is a member of the paired box family of transcription factors, which is required for development and proliferation of renal tubules from blastema. (medscape.com)

Six3 is expressed in an immature gonadotrope cell line and represses transcription of the early lineage-specific pituitary genes, GnRH receptor (GnRHR) and the common α-subunit (Cga), whereas Six6 is expressed in a mature gonadotrope cell line and represses the specific β-subunits of LH and FSH (LHb and FSHb) that are expressed later in development. (nih.gov)
Complex subunit associated factors are involved in hybridoma growth, Eosinohils, eritroid proliferation and derived from promotor binding stimulating subunits on the DNA binding complex. (homeodomains.com)

The SOX4 gene encodes a protein of 474 amino acids with three distinguishable domains, including an HMG box, a glycine-rich region, and a serine-rich region. (spandidos-publications.com)

Homeodomain Proteins SIX3 and SIX6 Regulate Gonadotrope-specific Genes During Pituitary Development. (nih.gov)
As a result, there is less PAX6 protein to regulate the activity of other genes. (nih.gov)
The combinatorial nature of gene transcription provides an exquisite level of flexibility to regulate genome expression. (biomedcentral.com)
Transcription regulatory networks are composed of two types of components, or nodes: the genes involved in the system and the TFs that regulate their expression. (biomedcentral.com)

The methylation status of CpG islands and surrounding regions (CpG island shores) is an important factor in regulating chromatin structure and gene expression during development and differentiation (Deaton and Bird 2011 ). (springer.com)

A complete RNA polymerase II transcription system has been derived by the fractionation of yeast and mammalian cell extracts. (nih.gov)
Structural studies of the RNA polymerase II transcription machinery began with electron microscope analysis of two-dimensional protein crystals formed on lipid layers. (nih.gov)

Nine base pairs of DNA-RNA hybrid could be seen extending from the active center at nearly right angles to the entering DNA. (nih.gov)
Based on a previous GWAS study, 14 DA associated loci and flanking regions were selected for NGS (6,996,180 base pairs). (cdc.gov)
The nucleosome, comprising 147 base pairs of DNA and 2 copies each of histones H2A, H2B, H3 and H4, is the fundamental organizing principle of chromatin. (nih.gov)

Unlike the mutations that cause Liebenberg syndrome (described above), these genetic changes reduce the amount of functional PITX1 protein, which disrupts normal development of the lower limbs. (medlineplus.gov)
These mutations lead to a shortage of functional PAX6 protein, which disrupts the formation of the eyes during development. (nih.gov)
The homology modeling of protein domains and a phylogenetic analysis of ParDAM5 suggest its functional integrity. (frontiersin.org)
While C. elegans gene predictions have undergone continuous refinement, this is not true for the annotation of functional transcription factors. (biomedcentral.com)
We discuss how transcription factor splice variants and dimer formation may affect the total number of functional transcription factors. (biomedcentral.com)
In summary, eukaryotic transcription is a vital process that enables cells to convert DNA information into functional RNA molecules. (microbiologynote.com)
The central domain containing the glycine-rich region located between the HMG box and serine-rich domains serves as a novel functional region for promoting apoptotic cell death ( 7 ). (spandidos-publications.com)

The structures of the Drosophila Paired homodimer and the yeast a1/alpha2 heterodimer bound to DNA, along with a high-resolution study of a Drosophila eve-DNA complex, have deepened our understanding of how homeodomains locate their DNA targets. (embl.de)

What is Eukaryotic Transcription? (microbiologynote.com)
Eukaryotic transcription is a complex process that allows eukaryotic cells to convert genetic information stored in DNA into RNA molecules, which can be transported and used for various cellular functions. (microbiologynote.com)
Eukaryotic transcription produces different types of RNA molecules with diverse functions. (microbiologynote.com)
Understanding the intricacies of eukaryotic transcription provides insights into gene expression regulation and the complexity of the eukaryotic genome. (microbiologynote.com)
Eukaryotic transcription, a crucial process for gene expression, involves the activity of multiple enzymes. (microbiologynote.com)
Let's delve into the functions and characteristics of these enzymes involved in eukaryotic transcription. (microbiologynote.com)
Operating within the nucleoplasm, RNA Pol II takes on a central role in eukaryotic transcription. (microbiologynote.com)

These mutations delete a large part of the PITX1 gene or the whole gene, or change a single protein building block (amino acid) in the PITX1 protein. (medlineplus.gov)
Feeding with amino acids can stimulate protein synthesis in all tissues, especially in skeletal muscle as reviewed by Davis et al. (nature.com)
The mutations that cause Peters anomaly change single protein building blocks (amino acids) in the PAX6 protein. (nih.gov)
Most of these mutations change single amino acids in the PAX6 protein. (nih.gov)
It synthesizes transfer RNA (tRNA), which plays a vital role in protein synthesis by bringing specific amino acids to the ribosome. (microbiologynote.com)

For inferences concerning the evolutionary conservation versus plasticity of transcription factor expression patterns and their putative roles, a broad comparative approach is imperative. (biomedcentral.com)

A complement factor H homolog, heparan sulfation, and syndecan maintain inversin compartment boundaries in C. elegans cilia. (nih.gov)

The recent structural determinations and biochemical analysis of several multimeric complexes have provided a better understanding of how protein interactions influence the DNA-binding activity of homeodomain proteins. (embl.de)
Crystal structure of a paired domain-DNA complex at 2.5 A resolution reveals structural basis for Pax developmental mutations. (embl.de)

To achieve these results, the scientists combined plant genetics experiments, bioinformatics analyses, but also used protein imaging by cryo-electron microscopy, allowing them to see these two proteins in action. (ibs.fr)

This sequence appears to contain regulatory sequences that are conserved in all three genes and thus it seems probable that transcription factors and/or spliceosomess that bind to this region would act similarly on all three genes. (brownwalker.com)
Transcription regulatory networks are composed of interactions between transcription factors and their target genes. (biomedcentral.com)
Whereas unicellular networks have been studied extensively, metazoan transcription regulatory networks remain largely unexplored. (biomedcentral.com)
The comprehensive identification of transcription factors is essential for the systematic mapping of transcription regulatory networks because it enables the creation of physical transcription factor resources that can be used in assays to map interactions between transcription factors and their target genes. (biomedcentral.com)
Finally, we discuss how wTF2.0 can be used together with physical transcription factor clone resources to facilitate the systematic mapping of C. elegans transcription regulatory networks. (biomedcentral.com)
wTF2.0 provides a starting point to decipher the transcription regulatory networks that control metazoan development and function. (biomedcentral.com)
Transcription of each gene can be up- or down-regulated by TFs that bind to cis -regulatory DNA elements. (biomedcentral.com)
Frequently, the expression level of a gene is the result of a balance between transcription activation and repression governed by multiple cis -regulatory elements and, hence, multiple TFs. (biomedcentral.com)
Transcription regulatory networks provide models to understand differential gene expression at a systems level. (biomedcentral.com)
Protein-protein interactions between TFs and protein-DNA interactions between TFs and their target genes can be visualized in transcription regulatory networks. (biomedcentral.com)
Termination can occur in different ways, depending on the specific gene and regulatory factors involved. (microbiologynote.com)
Learning Objective: 11-02 Design experiments that can identify cis-acting regulatory elements and trans-acting transcription factors. (testbank.ltd)

It acts as an adaptor protein to recruit cytoplasmic signaling proteins to the membrane and it works within the CD19/CD21 complex to decrease the threshold for B cell receptor signaling pathways. (wikidoc.org)

During transcription, a DNA sequence is read by an RNA polymerase, which produces a complementary, anti-parallel RNA strand called a primary transcript. (homeodomains.com)
Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence. (ucsc.edu)
AK132404 - Mus musculus 14 days embryo liver cDNA, RIKEN full-length enriched library, clone:4432412B16 product:paired box gene 9, full insert sequence. (ucsc.edu)
99% concordance between SNP genotypes and sequence-based single-nucleotide variation (SNV) at the same sites in all 86 pairs with both data, attesting to the accuracy of the sequence calls. (nature.com)

12. Analysis of human sodium/iodide symporter, thyroid transcription factor-1, and paired-box-protein-8 gene expression in benign thyroid diseases. (nih.gov)
We stress the importance of adopting the conceptual framework of "geroscience", which starts from the observation that advanced age is the major risk factor for several of these pathologies and aims at identifying the mechanistic links between aging and age-related diseases. (springer.com)

While the basic process of transcription is similar in prokaryotes and eukaryotes, there are notable differences due to the presence of a membrane-bound nucleus and organelles in eukaryotic cells . (microbiologynote.com)

This investigation demonstrates the presence and binding of the protein LC8 (described as "protein inhibitor of nNOS" or PIN in some reports) to different components of neuronal nitric oxide synthase (nNOS) in nitrergic varicosities of mice gut. (embl-heidelberg.de)

Some studies have suggested that the renal PAX genes act as pro-survival factors and allow tumor cells to resist apoptosis. (wikipedia.org)
Such is the case for colonic carcinoma (CDX-2), Wilms tumor (WT-1), and lung tumor (thyroid transcription factor-1). (medscape.com)
Renal cell carcinoma (RCC) is a comprehensive concept, which includes a variety of tumor entities with independent driving factors, histological patterns and clinical prognosis. (biomedcentral.com)
It is well-known that epigenetics is strongly modified in tumor cells and that epigenetic regulators influence the expression and function of Cytochrome P450 (CYP) enzymes through altering crucial transcription factors responsible for drug-metabolizing enzymes. (cancerindex.org)
Paired esophageal cancer and adjacent non-tumor tissues were obtained from 42 patients who underwent primary surgical resection for esophageal cancer. (spandidos-publications.com)

Within the brain, the PAX6 protein is involved in the development of a specialized group of brain cells that process smell (the olfactory bulb). (nih.gov)
Additionally, researchers believe that the PAX6 protein controls many aspects of eye development before birth. (nih.gov)
After birth, the PAX6 protein likely regulates the expression of various genes in many structures of the eyes. (nih.gov)
Most of these mutations create a premature stop signal in the instructions for making the PAX6 protein and lead to the production of an abnormally short, nonfunctional protein. (nih.gov)
The mutations that cause Peters anomaly reduce the PAX6 protein's ability to bind to DNA, disrupting its role as a transcription factor. (nih.gov)
These genetic changes reduce but do not eliminate PAX6 protein function. (nih.gov)
As a result, the PAX6 protein is less able to control the activity of certain genes involved in eye development. (nih.gov)

The PITX1 gene provides instructions for making a protein that plays a critical role in development of the lower limbs. (medlineplus.gov)
The PITX1 protein is found primarily in the developing legs and feet. (medlineplus.gov)
The PITX1 protein is also found in the developing pituitary gland, which is a hormone-producing gland located at the base of the brain, and in an embryonic structure called the branchial arch. (medlineplus.gov)
The PITX1 protein may play a role in formation of the pituitary gland and tissues derived from the branchial arch, such as the roof of the mouth, the jaw, and parts of the inner ear. (medlineplus.gov)
Because the PITX1 protein normally directs lower limb structure, bones, muscles, and tendons in the arms and hands develop more like those in the legs and feet, leading to the features of Liebenberg syndrome. (medlineplus.gov)

15. Role of insulin and serum on thyrotropin regulation of thyroid transcription factor-1 and pax-8 genes expression in FRTL-5 thyroid cells. (nih.gov)
16. A novel thyroid transcription factor is essential for thyrotropin-induced up-regulation of Na+/I- symporter gene expression. (nih.gov)
It regulates the expression of genes involved in thyroid development, such as TTF-1 (Thyroid Transcription Factor-1) and TTF-2. (mypathologyreport.ca)

A mitjans de la dècada de 1980 es crearen els primers sistemes parcialment automatitzats d'ús específic en immunohistoquímica [23] i el 1990 fou dissenyat un aparell automàtic amb capacitat d'efectuar alhora immunohistoquímica i hibridació in situ per fluorescència (FISH, de l'anglès fluorescence in situ hybridization ). (wikipedia.org)

Homeodomain proteins play key roles in development and gene regulation in eukaryotes. (embl.de)
Previous studies have demonstrated that transcription factors such as Pax genes play important roles during their development. (biomedcentral.com)
Learning Objective: 11-03 Diagram and explain the roles of transcription factors (e.g., basal factors, activators, and repressors) in the regulation of eukaryotic gene expression. (testbank.ltd)

Protein-nucleic acid contacts help explain DNA and RNA strand separation, the specificity of RNA synthesis, and RNA and DNA translocation during transcription elongation. (nih.gov)
The SRP is involved in the translocation of proteins across the endoplasmic reticulum membrane, an essential process for protein targeting. (microbiologynote.com)

Metazoan genomes contain thousands of predicted protein-coding genes. (biomedcentral.com)

[17] CD19 signaling involves the recruitment and activation of phosphoinositide 3-kinase (PI3K ) and later downstream, the activation of protein kinase B ( Akt ). (wikidoc.org)
The diagram shows an overview of the four core promoter elements B recognition element (BRE), TATA box , initiator element (Inr), and downstream promoter element (DPE), with their respective consensus sequences and their distance from the transcription start site . (wikiversity.org)

There are 130113 HOX domains in 120724 proteins in SMART's nrdb database. (embl.de)
Par DAM5 also contained all characteristic domains of the type II (MIKC C ) subfamily of MADS-box transcription factors. (frontiersin.org)

RNA polymerase II is responsible for transcribing protein-coding genes, producing messenger RNAs (mRNAs) that carry the genetic information to the site of protein synthesis . (microbiologynote.com)
Through its activity, RNA Pol I ensures the synthesis of crucial components of the ribosome, the cellular machinery responsible for protein synthesis. (microbiologynote.com)
MT genes specify the synthesis of low-molecular-weight metal-binding proteins. (wikiversity.org)

The general transcription factors are responsible for promoter recognition and for melting the DNA template for the initiation of transcription. (nih.gov)
The results have been assembled in a preliminary picture of a complete transcription initiation complex. (nih.gov)
From this picture, principles of both the initiation of transcription. (nih.gov)
The transcription process in eukaryotes can be divided into three stages: initiation, elongation, and termination. (microbiologynote.com)
An initiation box contains which of the following pairs of bases? (testbank.ltd)

Taxonomic distribution of proteins containing HOX domain. (embl.de)
The complete taxonomic breakdown of all proteins with HOX domain is also avaliable . (embl.de)
Click on the protein counts, or double click on taxonomic names to display all proteins containing HOX domain in the selected taxonomic class. (embl.de)
The U box is a modified RING finger - a common domain in ubiquitination. (embl.de)
The 2.5 A resolution structure of a cocrystal containing the paired domain from the Drosophila paired (prd) protein and a 15 bp site shows structurally independent N-terminal and C-terminal subdomains. (embl.de)
Contains 1 paired domain. (ucsc.edu)
The HMG box serves as a DNA-binding region, whereas the serine-rich domain serves as a transactivation domain ( 6 ). (spandidos-publications.com)

We identify candidate redundant worm transcription factor genes and orthologous worm and human transcription factor pairs. (biomedcentral.com)

A paired box transcription factor that is involved in ODONTOGENESIS . (nih.gov)

Protein interactions of homeodomain proteins. (embl.de)

Anatomy17

Organisms8

Chemicals and Drugs135

Analytical, Diagnostic and Therapeutic Techniques and Equipment23

Phenomena and Processes72

Disciplines and Occupations1

Information Science4

Repressor Proteins3

PAX55

Contain a paired box domain2

Homeodomain transcription1

Known as the paired box1

PAX820

MRNA5

Highly conserved1

PAX37

Instructions for making proteins that2

Hepatocyte Nuclear Factor2

Role in neural development and spermatogenesis1

Binds3

Transcriptional4

Activator2

PAX23

Nuclear4

Humans2

EMBRYONIC DEVELOPMENT2

Enhancer5

Isoforms1

Family of transcription factors3

Subunit2

Encodes a protein1

Regulate4

Chromatin structure1

Polymerase II transcription2

Base pairs3

Functional7

Homodimer1

Eukaryotic transcription7

Amino5

Putative1

Homolog1

Structural2

Genetics1

Regulatory12

Cytoplasmic1

Sequence4

Diseases2

Prokaryotes and eukaryotes1

Mice1

Tumor5

Pax67

PITX15

Thyroid3

Situ Hybridization1

Roles3

Translocation2

Predicted protein-codin1

Downstream2

Domains2

Synthesis3

Initiation5

Domain7

Human transcription factor1

ODONTOGENESIS1

Interactions1