Protein lipoproteins. Medical search. Frequent questions

Description: A sandwich ELISA kit for detection of High Density Lipoprotein Binding Protein from Rat in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (tuberculosistest.net)

The nonpolar lipids (ie, cholesterol ester, triglycerides [TGs]) reside in a core surrounded by more polar components (eg, free cholesterol, phospholipids, proteins). (medscape.com)
Disease activity (DAS28) and plasma lipoproteins concentrations (total, HDL and LDL-cholesterol, triglycerides, ApoA, ApoB) were assessed in 55 RA patients and 55 controls. (bmj.com)
The LDL:HDL ratio in humans is set mainly by CETP activity, which exchanges cholesteryl esters for triglycerides across lipoprotein fractions to raise LDL and lower HDL as CETP activity increases. (biomedcentral.com)
Hyperlipidemia comprises a heterogeneous group of disorders, characterized by high levels in one or more lipids and/or lipoproteins [atherogenic free fatty acids (FA), triglycerides (TG) (hypertriglyceridemia), small dense low-density lipoprotein cholesterol (LDL-C) (hypercholesterolemia), and apolipoprotein (apo) B], and/or low level in antiatherogenic high density lipoprotein cholesterol (HDL-C), in the circulation [ 1 - 3 ]. (hindawi.com)

Lipoprotein receptor-related proteins, low density lipoprotein receptor-related proteins (HGNC) or prolow-density lipoprotein receptor-related protein (UniProt), abbreviated LRP, are a group of proteins. (wikipedia.org)
They include: LRP1 LRP1B LRP2 (megalin) LRP3 LRP4 LRP5 LRP6 LRP8, apolipoprotein e receptor LRP10 LRP11 LRP12 LRPAP1 (low density lipoprotein receptor-related protein associated protein 1) Lipoprotein receptor-related proteins are co-receptors for Wnt signaling. (wikipedia.org)
This was supported by identification of an interaction with Low density lipoprotein receptor related protein 1 (LRP1), an endocytic regulator of PDGF-BB signalling and VSMC proliferation. (ox.ac.uk)
relationship between vitamin D and low-density lipoprotein receptor-related protein (LRP-1) has revealed that the two may work together to possibly clear amyloid-beta (Aβ), a deposition that is linked to the progression of neurological dysfunction. (todayspractitioner.com)
Among Aβ scavenger receptors, low density lipoprotein receptor related protein ( LRP-1 ) has been most extensively studied. (todayspractitioner.com)
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat Low Density Lipoprotein Receptor Related Protein 8 (LRP8) in serum, plasma and other biological fluids. (thescientistconnect.com)
Regional European differences in allele and genotype frequencies of low density lipoprotein receptor-related protein 1 polymorphism in Alzheimer's disease. (unifg.it)
The low density lipoprotein receptor-related protein 1 (LRP1 gene) is a candidate gene for Alzheimer's disease (AD), because it is a ligand for proteins involved in ADpathogenesis, such as apolipoprotein E (APOE), a2-macroglobulin (A2M), amyloid precursor protein (APP), and is located on chromosome 12, within a region linked with AD. (unifg.it)
A novel high-content imaging-based technique for measuring binding of Dickkopf-1 to low-density lipoprotein receptor-related protein 6. (ox.ac.uk)
INTRODUCTION: Dickkopf-related protein 1 (Dkk1) is a secreted protein ligand of low-density lipoprotein receptor-related protein 6 (LRP6), which antagonises canonical Wnt signalling. (ox.ac.uk)
The elimination of [ 125 I]hAβ(1-40) was significantly inhibited by human receptor-associated protein (RAP) and the elimination was attenuated in either anti-low-density lipoprotein receptor-related protein (LRP)1 antibody-treated or RAP-deficient mice, suggesting that a member(s) of the low-density lipoprotein receptor gene family is involved in the elimination of hAβ(1-40) from CSF. (elsevierpure.com)

When proteins and sugars are mixed together and heated, new chemical compounds are formed. (news-medical.net)

Genetically elevated high-density lipoprotein cholesterol through the cholesteryl ester transfer protein gene does not associate with risk of Alzheimer's disease. (hjarta.is)
This narrative review focuses on the role of cholesteryl ester transfer protein (CETP) and peripheral lipoproteins in the vascular contributions to cognitive impairment and dementia (VCID). (biomedcentral.com)
Cholesteryl Ester Transfer Protein in Alzheimer's Disease. (biomedcentral.com)
and 3) describing the functions of cholesteryl ester transfer protein (CETP) in regulating the LDL:HDL ratio in humans, including therapeutic strategies targeting CETP. (biomedcentral.com)
Genetic variation in the cholesteryl ester transfer protein (CETP) locus is associated with altered HDL-C. We aimed to assess AD risk by genetically predicted HDL-C. Methods: Ten single nucleotide polymorphisms within the CETP locus predicting HDL-C were applied to the International Genomics of Alzheimer's Project (IGAP) exome chip stage 1 results in up 16,097 late onset AD cases and 18,077 cognitively normal elderly controls. (uai.cl)

Amino acids, peptides and proteins. (unibo.it)

Lipids and Lipoproteins in Disease. (mcgill.ca)
Biochemistry: Structure, function and metabolism of lipids and lipoproteins as they relate to lipid storage diseases, obesity, insulin resistance, diabetes, heart disease, Alzheimers disease and other neurological diseases. (mcgill.ca)

This receptor family includes seven family members that are closely related and include the LDL receptor, very low density lipoprotein (VLDL) receptor, apoE receptor 2, multiple epidermal growth factor-like domains 7 (MEGF7), glycoprotein 330 (gp330/megalin/LRP2), LRP1 and LRP1B. (todayspractitioner.com)
Apo B-450 is associated with chylomicrons and their remnants, and apo B-100 is associated with low-density lipoprotein (LDL), very low-density lipoprotein (VLDL), VLDL remnants, and intermediate-density lipoprotein. (medscape.com)

It's a member of the LDL receptor family, which plays various different roles related to enzyme activation, the entry of bacterial toxins and viruses into cells, and the metabolism of a proteins that transport and combine with fats in the blood . (todayspractitioner.com)
The proteins, termed apolipoproteins, play an important role in lipoprotein metabolism. (medscape.com)
The beta lipoproteins are structural, are never complexed with HDL, and remain throughout the metabolism of the lipoproteins with which they are associated. (medscape.com)
These effects on lipoprotein metabolism may be exerted through specific modulation of the expression of the LDL receptor and apolipoprotein B genes. (cambridge.org)
Akt pathways have effects on apoptosis, protein synthesis, metabolism and cell cycle. (springer.com)
MANNHEIM, Germany - A novel drug that targets production of a liver protein involved in lipid metabolism appears to markedly reduce low-density lipoprotein (LDL) cholesterol levels for patients with homozygous familial hypercholesterolemia (HoFH), suggest results from the phase 2 GATEWAY trial. (medscape.com)
ANGPTL3 regulates lipoprotein metabolism by inhibiting lipoprotein and endothelial lipases. (medscape.com)

Lipoprotein signal peptidase (Buchnera aphidicola str. (nih.gov)

The reduction of ADAMTS-5 was accompanied by accumulation of biglycan and versican, the major lipoprotein-binding proteoglycans, in atherosclerosis. (ox.ac.uk)
TS-containing diets did not increase the cholesterol content of any of the major lipoprotein fractions. (cambridge.org)
Unlike humans, wild-type mice do not express catalytically active CETP and have HDL as their major lipoprotein fraction. (biomedcentral.com)

The major apolipoproteins of high-density lipoprotein (HDL) are alpha lipoproteins (ie, apolipoprotein A-I [apo A-I], apo A-II, apo A-IV), which are soluble and can move between different classes of lipoproteins. (medscape.com)

100 mg/dL showed an increase in NCM, IL-1 beta, LPS-binding protein (LBP), and Castelli's atherogenic risk index as compared to controls (n = 65) with optimal LDL-C concentrations (≤100 mg/dL). (nih.gov)
Low levels of high-density lipoprotein cholesterol (HDL), or hypoalphalipoproteinemia (HA), includes a variety of conditions, ranging from mild to severe, in which concentrations of alpha lipoproteins or high-density lipoprotein (HDL) are reduced. (medscape.com)
While it is well established that the fatty acid composition of dietary fat is important in determining plasma lipoprotein cholesterol concentrations, the effects of changing the absolute quantities of the individual fatty acids are less clear. (cambridge.org)
1 Among the traditional cardiovascular risk factors, the lipid profile in RA has often been described as "pro-atherogenic", 2 based on decreased HDL-cholesterol (HDL-C) and increased LDL:HDL-C ratio and lipoprotein (a) plasma concentrations in both active and treated RA. (bmj.com)
Weight and body composition were determined and C-reactive protein and interluekin-6 concentrations were measured. (who.int)

A high lipoprotein (a) level may mean you have a high risk for heart and blood vessel disease, even if your cholesterol levels are normal and you are healthy. (medlineplus.gov)
The prevalence of type 2 diabetes among 25,000 patients with familial hypercholesterolemia (a genetic disorder characterized by high low-density lipoprotein [LDL] cholesterol levels) was significantly lower than among unaffected relatives, with the prevalence varying by the type of gene mutation, according to a study in the March 10 issue of JAMA. (news-medical.net)
To help answer that question, researchers at Western University's Robarts Research Institute have identified that an estrogen receptor, previously shown to regulate blood pressure in women, also plays an important role in regulating low-density lipoprotein (LDL) cholesterol levels. (news-medical.net)

If the gene encoding a protein is duplicated in the genome, which often happens in evolution, original and copy will interact with the same partners in the protein network. (medindia.net)
LDL receptor-related protein 1: unique tissue-specific functions revealed by selective gene knockout studies. (todayspractitioner.com)
Placental lipoprotein lipase (LPL) gene expression in a placentotrophic lizard, Pseudemoia entrecasteauxii. (cipps.org.au)
The drug, ARO-ANG3 (Arrowhead Pharmaceuticals), is a hepatocyte-targeted small interfering ribonucleic acid (siRNA) designed to silence expression of the angiopoietin-like protein 3 (ANGPTL3) gene. (medscape.com)
METHODS: Human peripheral blood mononuclear cells (PBMCs) were stimulated in vitro with HDI-albumin conjugates or control antigen, and changes in phenotype, gene and protein expression were characterized by flow cytometry, microarray, Western blot and ELISA. (cdc.gov)
RESULTS: Human monocytes take up HDI-albumin conjugates and undergo marked changes in morphology and gene/protein expression in vitro. (cdc.gov)

Low-density lipoprotein (LDL) receptor-related protein-1 (LRP1) is expressed in retinal Müller glial cells (MGCs) and regulates intracellular translocation to the plasma membrane (PM) of the membrane proteins involved in cellular motility and activity. (sdu.dk)
Next, we observed that LRP1 translocation to the PM was promoted by insulin-regulated exocytosis through intracellular activation of the IR/PI 3 K/Akt axis and Rab-GTPase proteins such as Rab8A and Rab10. (sdu.dk)
In addition, these Rab-GTPases regulated both the constitutive and insulin-induced LRP1 translocation to the PM. Finally, we found that dominant-negative Rab8A and Rab10 mutants impaired insulin-induced intracellular signaling of the IR/PI3K/Akt axis, suggesting that these GTPase proteins as well as the LRP1 level at the cell surface are involved in insulin-induced IR activation. (sdu.dk)

Background: Bacillus subtilis is a favorable host for the production of industrially relevant proteins because of its capacity of secreting proteins into the medium to high levels, its GRAS (Generally Recognized As Safe) status, its genetic accessibility and its capacity to grow in large fermentations. (rug.nl)
4O4A: 2.75 Angstrom Crystal Structure of Putative Lipoprotein from Bacillus anthracis. (rcsb.org)

C reactive protein (CRP), an important serum marker of atherosclerotic vascular disease, has recently been reported to be active inside human atherosclerotic plaques. (bmj.com)
Although most peripheral lipoproteins cannot enter the brain parenchyma due to the BBB, it is increasingly appreciated that direct access to the vascular endothelium may enable peripheral lipoproteins to have indirect effects on brain health. (biomedcentral.com)

Regulation of lipoprotein lipase in the diabetic rat. (jci.org)
Diabetes mellitus is associated with a reduction of lipoprotein lipase (LPL) activity and development of hypertriglyceridemia. (jci.org)

Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human High Density Lipoprotein Binding Protein (HDLBP) in samples from tissue homogenates, cell lysates, cell culture supernates and other biological fluids with no significant corss-reactivity with analogues from other species. (tuberculosistest.net)
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat High Density Lipoprotein Binding Protein (HDLBP) in tissue homogenates, cell lysates, cell culture supernates and other biological fluids. (tuberculosistest.net)
Known also as Glycosylphosphatidylinositol Anchored High Density Lipoprotein Binding Protein 1 elisa. (phosphatidylinositol.com)

Novel role of ADAMTS-5 protein in proteoglycan turnover and lipoprotein retention in atherosclerosis. (ox.ac.uk)
Atherosclerosis is initiated by the retention of lipoproteins on proteoglycans in the arterial intima. (ox.ac.uk)
This study provides the first evidence implicating ADAMTS-5 in the regulation of proteoglycan turnover and lipoprotein retention in atherosclerosis. (ox.ac.uk)
A low HDL cholesterol level is thought to accelerate the development of atherosclerosis because of impaired reverse cholesterol transport and possibly because of the absence of other protective effects of HDL, such as decreased oxidation of other lipoproteins. (medscape.com)

A group of proteins and polyamino acids with positively charged domains were shown to inhibit the binding of 125 I-LDL to its receptor on the surface of human fibroblasts. (elsevierpure.com)

Lipoproteins are particles made of protein and fats (lipids). (medlineplus.gov)
Impairment of chylomicron and lipoprotein absorption results in malabsorption of fats and protein. (msdmanuals.com)

genetic disruptions of lipid regulatory proteins such as cell surface receptors leading to human disease. (mcgill.ca)

To investigate the simultaneous presence of macrophages, CRP, membrane attack complex C5b-9 (MAC), and oxidised low density lipoprotein (oxLDL) in atherectomy specimens from patients with different coronary syndromes. (bmj.com)
Increasing evidence has demonstrated that oxidized low-density lipoproteins (oxLDL) and lipopolysaccharide (LPS) enhance accumulation of interleukin (IL)-1 beta-producing macrophages in atherosclerotic lesions. (nih.gov)

Diagnostic subsets of coexpressed genes reflected signaling activity, cross talk, and overlap of multiple mitogen-activated protein kinase (MAPK) pathways. (nih.gov)
AMPK pathways inhibit biosynthetic pathways with energy consumption, such as protein, fatty acid and glycogen synthesis. (springer.com)
The present study used targeted proteomics to establish cardiometabolic proteins related to all MetS components, thereby providing new hypotheses regarding pathways involved in the pathogenesis of MetS. (lu.se)

Plasma lipoproteins are macromolecular complexes of lipids and proteins that are classified by density and electrophoretic mobility. (medscape.com)

Chemokines that regulate monocyte/macrophage trafficking (MIF, MCP-1) and pattern-recognition receptors that bind chitin (chitinases) and oxidized low-density lipoprotein (CD68) were also increased following isocyanate -albumin exposure. (cdc.gov)
These antibodies react with epitopes on the muscle protein titin and ryanodine receptors (RyR). (medscape.com)

In vivo, human HDI exposure was performed via a specific inhalation challenge, and subsequent changes in PBMCs and serum proteins were measured by flow cytometry and ELISA. (cdc.gov)

and ykrL (encoding an HtpX homologue) specifically under membrane proteins overproduction. (rug.nl)
Annexin VI has been identified as a major membrane-associated protein capable of directly binding α 2 M* at acidic pH. (tmu.edu.tw)
Lipoprotein-related protein 4 is present on the postsynaptic membrane and is a receptor for agrin and is essential for neuromuscular junction formation. (medscape.com)

Elevated Dkk1 levels have been linked to Alzheimer's disease (AD), with protein blockade protective in pre-clinical AD models, suggesting inhibitors of Dkk1-LRP6 binding may have therapeutic utility against AD. (ox.ac.uk)
Introduction: There is conflicting evidence whether high-density lipoprotein cholesterol (HDL-C) is a risk factor for Alzheimer's disease (AD) and dementia. (uai.cl)

At 12 months, low-density lipoprotein cholesterol, total cholesterol, and number of metabolic syndrome markers were significantly higher in the comparison group than in the intervention group. (cdc.gov)
An elevated low-density lipoprotein cholesterol (LDL-C) is associated with coronary heart disease (CHD) and frequently coexists with metabolic syndrome. (cdc.gov)

The effect of different dietary fatty acids on lipoprotein. (cambridge.org)
C-reactive protein level had a significant association with body mass index ( r = 0.18), adiposity ( r = 0.23), smoking ( r = 0.20), carbohydrate intake ( r = 0.19) and saturated fatty acid ( r = 0.20). (who.int)

Humans have a peripheral lipoprotein profile where low-density lipoproteins (LDL) represent the dominant lipoprotein fraction and high-density lipoproteins (HDL) represent a minor lipoprotein fraction. (biomedcentral.com)

Diabetes decreased adipose tissue LPL activity partially by decreasing immunoreactive LPL protein and the steady-state levels of LPL mRNA, but primarily by reducing the catalytic activity of LPL. (jci.org)
In the heart, LPL activity tended to be elevated with diabetes in parallel to an increase in immunoreactive LPL protein even though levels of LPL mRNA declined. (jci.org)
Both chronic and acute insulin normalized LPL activity and immunoreactive LPL protein, while only chronic insulin corrected the levels of LPL mRNA. (jci.org)

These lipoproteins carry cholesterol to the cells in your arteries. (medlineplus.gov)

It combines with proteins to travel through the bloodstream. (kidshealth.org)
LDL (low-density lipoprotein) cholesterol , or "bad cholesterol," carries cholesterol from the liver into the bloodstream, where it can stick to the blood vessels. (kidshealth.org)

Preparations for a lipoprotein (a) test depend on the lab doing the test. (medlineplus.gov)

A study published in the January/February 2015 issue of the Journal of Clinical Lipidology indicates corn oil significantly reduces cholesterol more than extra virgin olive oil with favorable changes in both total and low-density lipoprotein (LDL) cholesterol. (news-medical.net)
Twenty-two proteins were significantly related to all 5 MetS components, and of those, 20 were with MetS as a binary outcome (n = 600, 24% of the sample) following adjustment for age, sex, fat mass, and lifestyle factors (alcohol intake, smoking, education, and exercise habits). (lu.se)

Conclusions: The results give better insights into B. subtilis responses to protein overproduction stress and provide potential targets for genetic engineering in order to further improve B. subtilis as a protein production host. (rug.nl)

How has the prevalence of high total cholesterol and low levels of high-density lipoprotein (HDL) in U.S. changed since 1999-2000 to 2015-2016? (cdc.gov)
As a result, high levels of lipoprotein (a) may mean you have a very high risk for heart disease, stroke, and other serious conditions related to blockages and blood clots in your arteries. (medlineplus.gov)
Researchers are still studying how lipoprotein (a) levels affect health and when the test should be used. (medlineplus.gov)
Lipoprotein (a) levels usually don't change much over time. (medlineplus.gov)

The Low Density Lipoprotein Cholesterol (direct) test is used to evaluate a person's risk for heart disease . (requestatest.com)
A high level of lipoprotein (a) may mean you have a high risk for heart disease and stroke . (medlineplus.gov)
That's because a routine cholesterol test may show that your LDL cholesterol level is "healthy," but if a large percentage of your LDL cholesterol is carried by lipoprotein (a) particles, your risk for heart disease and stroke could still be high. (medlineplus.gov)
A lipoprotein (a) test is used to get a better understanding of your risk for heart disease, stroke, and other blood vessel diseases. (medlineplus.gov)
To calculate cost-effectiveness, we used direct employer costs of the program divided by either the relative reduction in low-density lipoprotein cholesterol or the absolute change in coronary heart disease risk. (cdc.gov)
10.17 per percentage-point reduction of low-density lipoprotein cholesterol and $454.23 per point reduction in coronary heart disease risk. (cdc.gov)
This study demonstrated the cost-effectiveness in a small organization of a worksite health promotion that improved low-density lipoproteins and coronary heart disease risk in participating employees. (cdc.gov)

new roles in pathogenesis due to similarities with and affinity for the high-density lipoprotein (HDL)? (bvsalud.org)

Digestion of proteins. (unibo.it)

3 Moreover, inflammatory markers, such as C reactive protein (CRP), are strong independent predictors of future cardiovascular risk. (bmj.com)

The two main groups of lipoproteins are called HDL ( high-density lipoprotein ) or "good" cholesterol and LDL ( low-density lipoprotein ) or "bad" cholesterol. (medlineplus.gov)
High and low density proteins are supplied by Cloud Clone Corp in volumes of 1. (phosphatidylinositol.com)
Here we report a novel immunocytochemical-based assay utilising high-content imaging (HCI) and automated data analysis suitable for the screening of protein and small-molecule inhibitors of Dkk1-LRP6 binding. (ox.ac.uk)
HDL (high-density lipoprotein) cholesterol, or "good cholesterol," carries the cholesterol in the blood back to the liver, where it is broken down. (kidshealth.org)
Supportive treatment of intestinal lymphangiectasia includes a low-fat ( 30 g/day), high-protein diet containing medium-chain triglyceride supplements. (msdmanuals.com)

Anatomy17

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ELISA Kit1

Triglycerides4

Density lipoprotein receptor11

Chemical compounds1

Cholesteryl ester t5

Peptides1

Lipids and lipoproteins2

VLDL2

Metabolism7

Signal peptidase1

Major lipoprotein3

Apolipoprotein1

Concentrations5

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Bacillus2

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Lipase2

BINDING PROTEIN3

Atherosclerosis4

Group of proteins1

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Cell surface r1

OxLDL2

Pathways3

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Receptors2

Serum1

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