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InterferonsInterferon-gammaInterferon Type IReceptors, InterferonInterferon InducersInterferon-alphaRecombinant ProteinsCytokinesInterferon-betaInterferon Regulatory Factor-1Interferon Regulatory Factor-3Cells, CulturedInterferon Regulatory FactorsReceptor, Interferon alpha-betaSTAT1 Transcription FactorCell LineTumor Necrosis Factor-alphaMice, Inbred C57BLT-LymphocytesRNA, MessengerInterleukin-4Molecular Sequence DataAntiviral AgentsMice, Inbred BALB CInterferon Regulatory Factor-7Interleukin-12MacrophagesGene Expression RegulationInterleukin-2Poly I-CBase SequenceCD4-Positive T-LymphocytesSpleenGamma RaysKiller Cells, NaturalInterferon Regulatory Factor-2Newcastle disease virusLymphocyte ActivationTh1 CellsSignal TransductionInterleukinsInterleukin-10Mice, KnockoutLeukocytes, MononuclearFlow CytometryRibavirinGene ExpressionLipopolysaccharidesInterferon-gamma Release TestsAmino Acid SequenceMonocytesChemokine CXCL10Interferon-Stimulated Gene Factor 3Hepatitis C, ChronicImmunity, InnateTranscription, GeneticL Cells (Cell Line)Vesicular stomatitis Indiana virus2',5'-Oligoadenylate SynthetaseAntibodies, MonoclonalMacrophage ActivationCD8-Positive T-LymphocytesImmunity, CellularDNA-Binding ProteinsTime FactorsReceptors, ImmunologicT-Lymphocyte SubsetsKineticsVirus ReplicationInterleukin-1Tumor Cells, CulturedAntigens, CDEnzyme-Linked Immunosorbent AssayFibroblastsReverse Transcriptase Polymerase Chain ReactionCytotoxicity, ImmunologicLatent TuberculosisDose-Response Relationship, DrugInterleukin-5TuberculosisTrans-ActivatorsPolyethylene GlycolsMice, Inbred StrainsDendritic CellsTuberculin TestInterleukin-6Cell DivisionPromoter Regions, GeneticTh2 CellsTranscription FactorsT-Lymphocytes, Helper-InducerEncephalomyocarditis virusLymphocytesMycobacterium tuberculosisJanus Kinase 1Membrane GlycoproteinsInterferon-Stimulated Gene Factor 3, gamma SubunitSTAT2 Transcription FactorMice, Inbred C3HCell Differentiation
IFNGReceptorGeneManufactures the interferon gammaAntigensInducible proteinCytokinesInterleukinIGRASignal TransductionAntibodiesExtracellularGenesPeptidesMutationsBindsPurified protein deMycobacteriumEncoded protein is secretedInteractionsRecombinant proteinAntiviralELISACD119PathwayHumanQuantificationMembraneImmunityExpressionTranscriptionSequenceAmino acidsDetectionTypePathwaysCellularLymphocytesOmega
IFNG11
  • Interferon gamma receptor 1 (IFNGR1), along with IFNGR2, are type II cytokine receptors that combine to form a high affinity signaling complex with the type II interferon, IFNG. (rndsystems.com)
  • This assay has high sensitivity and excellent specificity for detection of Interferon Gamma (IFNg). (uscnk.com)
  • No significant cross-reactivity or interference between Interferon Gamma (IFNg) and analogues was observed. (uscnk.com)
  • Matrices listed below were spiked with certain level of recombinant Interferon Gamma (IFNg) and the recovery rates were calculated by comparing the measured value to the expected amount of Interferon Gamma (IFNg) in samples. (uscnk.com)
  • Intra-assay Precision (Precision within an assay): 3 samples with low, middle and high level Interferon Gamma (IFNg) were tested 20 times on one plate, respectively. (uscnk.com)
  • Inter-assay Precision (Precision between assays): 3 samples with low, middle and high level Interferon Gamma (IFNg) were tested on 3 different plates, 8 replicates in each plate. (uscnk.com)
  • The linearity of the kit was assayed by testing samples spiked with appropriate concentration of Interferon Gamma (IFNg) and their serial dilutions. (uscnk.com)
  • The microtiter plate provided in this kit has been pre-coated with an antibody specific to Interferon Gamma (IFNg). (uscnk.com)
  • Standards or samples are then added to the appropriate microtiter plate wells with a biotin-conjugated antibody specific to Interferon Gamma (IFNg). (uscnk.com)
  • After TMB substrate solution is added, only those wells that contain Interferon Gamma (IFNg), biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. (uscnk.com)
  • The concentration of Interferon Gamma (IFNg) in the samples is then determined by comparing the O.D. of the samples to the standard curve. (uscnk.com)
Receptor16
  • The active protein is a homodimer that binds to the interferon gamma receptor which triggers a cellular response to viral and microbial infections. (origene.com)
  • Interferon gamma receptor 2 also known as IFN-γR2 is a protein which in humans is encoded by the IFNGR2 gene. (wikipedia.org)
  • This gene (IFNGR2) encodes the non-ligand-binding beta chain of the gamma interferon receptor. (wikipedia.org)
  • Human interferon-gamma receptor is a multimer of two IFN-γR1 chains (encoded by IFNGR1) and two IFN-γR2 chains. (wikipedia.org)
  • Interferon gamma receptor 1 ( IFNGR1 ) also known as CD119 ( C luster of D ifferentiation 119 ), is a protein that in humans is encoded by the IFNGR1 gene . (wikidoc.org)
  • The gene IFNGR1 encodes IFN-γR1, which is the ligand-binding chain (alpha) of the heterodimeric gamma interferon receptor, which is found on macrophages . (wikidoc.org)
  • Interferon gamma receptor 1 has been shown to interact with Interferon-gamma . (wikidoc.org)
  • The human interferon-gamma receptor. (wikidoc.org)
  • Unusual susceptibility to mycobacterial infections can be caused by deleterious mutations in genes that encode the interferon-γ receptor 1 chain. (eur.nl)
  • We here report two patients with unusual mycobacterial infections, both diagnosed with homozygous deleterious interferon-γ receptor 1 gene mutations. (eur.nl)
  • She carried a homozygous C71Y mutation in the extracellular part of the mature interferon-γ receptor 1 protein, resulting in the lack of detectable protein expression and absence of interferon-γ dependent signaling. (eur.nl)
  • A homozygous splice-site mutation in intron 3 was identified, resulting in the deletion of exon 3 at the mRNA level and consequently a truncated interferon-γ receptor 1 protein with absence of the transmembrane domain. (eur.nl)
  • The osteoclast vitronectin receptor is found in the cell membrane and may be involved in the binding to this protein. (origene.com)
  • STAT3 belongs to the family of STAT (signal transducers and activators of transcription) proteins which are phosphorylated by receptor associated kinases, translocate to the nucleus, and act as transcription factors in response to cytokines and growth factors. (thermofisher.com)
  • NMR structure of the interferon-binding ectodomain of the human interferon receptor. (wikidoc.org)
  • The interferon-α/β receptor (IFNAR) is a virtually ubiquitous membrane receptor which binds endogenous type I interferon (IFN) cytokines. (wikidoc.org)
Gene8
  • This gene encodes a soluble cytokine that is a member of the type II interferon class. (origene.com)
  • The expression of this gene is regulated by interferon-gamma and lipopolysaccharide. (cancerindex.org)
  • What does this gene/protein do? (cancerindex.org)
  • What pathways are this gene/protein implicaed in? (cancerindex.org)
  • The protein encoded by this gene is involved in the attachment of osteoclasts to the mineralized bone matrix. (origene.com)
  • When intravenously injected into mice with metastatic melanoma , it was able to deliver signaling molecules, called cyclic dinucleotides, across the cell membranes of their liver macrophages, where they stimulated the production of immune-related proteins called type 1 interferons via a stimulator of an interferon gene (STING) pathway. (news-medical.net)
  • 1995. Transcriptional induction of pim-1 protein kinase gene expression by interferon gamma and posttranscriptional effects on costimulation with steel factor. . (oregonstate.edu)
  • [9] For example, type I IFNs induce interferon-stimulated gene ( ISG ) expression, classically resulting in a robust anti-viral immune response. (wikidoc.org)
Manufactures the interferon gamma2
  • Gamma Assay Laboratories manufactures the interferon gamma release assay (igra) reagents distributed by Genprice. (ifn-a.com)
  • Gamma Elisa Laboratories manufactures the interferon gamma elisa protocol reagents distributed by Genprice. (plant-gem.org)
Antigens4
  • We compared the frequencies of gamma interferon (IFN-gamma)-secreting T cells specific for five region of difference 1 (RD1)-encoded antigens and one DosR-encoded antigen in 205 individuals either with active disease (n = 167), whose immune responses had failed to contain the bacillus, or with remotely acquired latent infection (n = 38), who had successfully achieved immune control, and a further 149 individuals with recently acquired asymptomatic infection. (birmingham.ac.uk)
  • When subjects with an IFN-gamma enzyme-linked immunospot (ELISpot) assay response to one or more RD1-encoded antigens were analyzed, T cells from subjects with active disease recognized more pools of peptides from these antigens than T cells from subjects with nonrecent latent infection (P = 0.002). (birmingham.ac.uk)
  • released from sensitized lymphocytes in whole blood incubated overnight with purified protein derivative (PPD) from M. tuberculosis and control antigens. (cdc.gov)
  • APLISOL® is one of two purified-protein derivative (PPD) tuberculin antigens that are licensed by the United States Food and Drug Administration (FDA) for use in performing tuberculin skin tests. (cdc.gov)
Inducible protein1
  • We have previously shown that Interferon-γ inducible protein 16 (IFI16), a host nuclear innate immune DNA sensor, plays an important role in the maintenance of KSHV latency [J Virol. (technologynetworks.com)
Cytokines1
  • Cytokines are small proteins that are secreted by immune cells and help ensure a rapid response to restrict a virus. (freerepublic.com)
Interleukin3
  • Detailed immunological assessment revealed the presence of common variable immunodeficiency, complicated by a severe impairment of the capacity of T-cells to produce both gamma-interferon and interleukin-17. (biomedcentral.com)
  • This protein is also a cytokine that upregulates expression of interferon-gamma and interleukin-12. (origene.com)
  • Significant elevations in interferon (IFN)-gamma but not interleukin (IL)-4 protein were also observed in stimulated lymph node cells. (cdc.gov)
IGRA5
  • Two kinds of immunologic methods are used for detecting Mycobacterium tuberculosis infection: tuberculin skin tests (TSTs) and interferon-γ release assay (IGRA) blood tests. (cdc.gov)
  • Blood samples were drawn for interferon-gamma release assay (IGRA) and antibody determination six (+/- 2) weeks after the second vaccine dose. (ecco-ibd.eu)
  • The specific T cell response to SARS-CoV-2 was determined by IGRA using Qiagen® QuantiFERON® SARS-CoV-2 RUO tubes with a patented Spike protein combination. (ecco-ibd.eu)
  • The Interferon Gamma Release Assay (Igra) reagent is RUO (Research Use Only) to test human serum or cell culture lab samples. (ifn-a.com)
  • Two types of immunological methods are used for detecting Mycobacterium tuberculosis infection: tuberculin skin tests (TSTs) and interferon-gamma release assay (IGRA) blood tests. (cdc.gov)
Signal Transduction1
Antibodies2
  • For this study, the researchers engineered the extracellular vesicles to express the CD64 protein on their surface, which serves as a docking mechanism to load both anti-CD71 and anti-PD-L1 antibodies. (mdanderson.org)
  • Antibodies to the Spike (S) SARS-CoV-2 protein were analyzed by CLIA. (ecco-ibd.eu)
Extracellular1
Genes1
  • Complex formation then triggers a signaling cascade that culminates in the transcription of the interferon stimulated genes (ISGs) and additional transcription factors. (rndsystems.com)
Peptides1
  • Expression of TAP1 is down-regulated by human Epstein-Barr virus vil-10 protein, thereby affecting the transport of peptides into the endoplasmic reticulum and subsequent peptide loading by MHC class I molecules. (lu.se)
Mutations1
  • Scope includes mutations and abnormal protein expression. (cancerindex.org)
Binds2
  • When Recombinan human IFN-gamma (Catalog # 285-IF/CF) is immobilized at 2.00 µg/mL (100 µL/well), In the presence of Recombinant Human IFN-gamma R2, Biotinylated Recombinant Human IFN-gamma R1/CD119 Avi-tag His-tag binds with an ED 50 of 0.750-4.50 µg/mL. (rndsystems.com)
  • The encoded protein is secreted and binds hydroxyapatite with high affinity. (origene.com)
Purified protein de3
  • However, in vitro stimulation of peripheral blood mononuclear cells (PBMCs) from patients with newly diagnosed, relapsed and chronic TB with purified protein derivative (PPD) or heat killed M. tuberculosis (H37Ra) enhanced production of granulysin by PBMCs. (nih.gov)
  • manufactured by Cellestis Limited, Carnegie, Victoria, Australia) that measures the release of interferon-gamma in whole blood in response to stimulation by purified protein derivative was approved by the Food and Drug Administration. (cdc.gov)
  • Tubersol is one of two purified-protein derivative (PPD) tuberculin products licensed by the Food and Drug Administration (FDA). (cdc.gov)
Mycobacterium2
Encoded protein is secreted1
  • The encoded protein is secreted by cells of both the innate and adaptive immune systems. (origene.com)
Interactions1
  • No yeast two-hybrid interactions found for this protein. (yeastrc.org)
Recombinant protein3
  • Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. (origene.com)
  • Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. (rndsystems.com)
  • In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. (rndsystems.com)
Antiviral2
  • Interferons produce antiviral and antiproliferative responses in cells. (embl.de)
  • Interferons [ ( PUBMED:3022999 ) ] are proteins which produce antiviral and antiproliferative responses in cells. (embl.de)
ELISA2
  • Sandwich ELISA analysis of mouse IFN-γ protein using GTX02927 Interferon gamma antibody [AN18] as coating antibody and GTX02943-02 Interferon gamma antibody [R4-6A2] (Biotin) as detecting antibody. (genetex.com)
  • There are currently no references for Interferon gamma ELISA pair [AN18/R4-6A2] (GTX03106) . (genetex.com)
CD1191
  • 2 μg/lane of Biotinylated Recombinant Human IFN‑ gamma R1/CD119 Avi-tag His-tag Protein (Catalog # AVI11030) was resolved with SDS-PAGE under reducing (R) and non-reducing (NR) conditions and visualized by Coomassie® Blue staining, showing bands at 42‑55 kDa. (rndsystems.com)
Pathway2
  • The proteasome pathway is an enzyme complex existing in all cells, which degrades ubiquitinated proteins that control the cell cycle and cellular processes and maintains cellular homeostasis. (medscape.com)
  • [7] [8] Upon binding of type I interferons, IFNAR activates the JAK-STAT signalling pathway , along with MAPK , PI3K , and Akt signaling pathways. (wikidoc.org)
Human1
  • Subsequently, we screened all known human H3K9-MTase and identified two proteins that interact with IFI16 and is recruited by IFI16 at KSHV promoters. (technologynetworks.com)
Quantification1
  • L'objectif de la présente étude conduite en Égypte était d'évaluer l'utilité d'un test de quantification de la libération d'interféron gamma (IFN‑γ) pour le dépistage des infections tuberculeuses latentes chez les contacts de patients atteints de tuberculose active. (who.int)
Membrane1
  • Integral membrane protein. (lu.se)
Immunity1
  • Our results suggest that RD1-specific IFN-gamma-secreting T-cell frequencies correlate with the presence of disease rather than with protective immunity in M. tuberculosis-infected individuals and do not distinguish recently acquired asymptomatic infection from remotely acquired latent infection. (birmingham.ac.uk)
Expression2
Transcription1
Sequence1
  • On the basis of their sequence interferons are classified into five groups: alpha, alpha-II (or omega), beta, delta (or trophoblast) and gamma. (embl.de)
Amino acids1
  • Therefore, we designed a protein-free dispersion media containing phospholipids and amino acids in an isotonic balanced electrolyte solution, a solution for nasal and olfactory transport (SNOT). (cdc.gov)
Detection1
  • The aim of this study in Egypt was to estimate the usefulness of an interferon-gamma release assay (IFN-γ) assay for the detection of latent TB infection in contacts of active TB cases. (who.int)
Type3
  • It is structurally different from type I interferon and its major activity is immunoregulation. (iwai-chem.net)
  • These were released into the blood, activating another type of immune cell called natural killer cells in the spleen and lung, which produced interferon-gamma inside the lung metastases. (news-medical.net)
  • Type I interferons (alpha, beta) belong to the larger helical cytokine superfamily, which includes growth hormones, interleukins, several colony-stimulating factors and several other regulatory molecules. (embl.de)
Pathways2
  • KSHV hijacks multiple cellular proteins and pathways to establish lifelong latency in infected hosts, and latency is associated with KSHV malignancies. (technologynetworks.com)
  • Please note that proteins can be included in multiple pathways, ie. (embl.de)
Cellular1
  • Vincristine inhibits cellular mitosis by inhibition of intracellular tubulin function, binding to microtubules, and synthesis of spindle proteins in the S phase. (medscape.com)
Lymphocytes2
Omega2
  • The main conserved structural feature of interferons is a disulphide bond that, except in mouse beta interferon, occurs in all alpha, beta and omega sequences. (embl.de)
  • This entry also includes also interferon omega and tau. (embl.de)