Protein g1 phase. Medical search. Frequent questions

Diagnostic subsets of coexpressed genes reflected signaling activity, cross talk, and overlap of multiple mitogen-activated protein kinase (MAPK) pathways. (nih.gov)
PTEN encodes a protein kinase of the same name and functions as a tumor suppressor through regulation of cell proliferation. (medscape.com)
and protein kinase activity. (nih.gov)
Orthologous to human MAPK1 (mitogen-activated protein kinase 1). (nih.gov)
Transient activation of AMP-activated protein kinase at G1/S phase transition is required for control of S phase in NIH3T3 cells. (nih.gov)
Entry into the S phase in animal cells is regulated to a large extent by the cyclin E-CDK2 kinase complex. (news-medical.net)
This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. (cancerindex.org)
The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. (cancerindex.org)
This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb. (cancerindex.org)
This complex inhibits mammalian target of rapamycin (mTOR) kinase, a key protein in cells that regulate the gene translation responsible for cell-cycle regulation. (medscape.com)
CDK4 is a member of the Ser/Thr protein kinase family. (thermofisher.com)
The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). (thermofisher.com)
However, recent studies have suggested that BRAFi/MEKi and ERK1/2i resistance can arise through activation of a parallel signalling pathway leading to activation of ERK5, an unusual protein kinase that contains both a kinase domain and a transcriptional transactivation domain. (babraham.ac.uk)
Among them, the sirtuin, AMP-activated protein kinase, mammalian target of rapamycin, p53, and insulin/insulin-like growth factor-1 signaling pathways are most widely studied. (frontiersin.org)
Cyclin-dependent kinase 4 is a key regulator of G1 PHASE of the CELL CYCLE. (bvsalud.org)

This proadifen-MTX synergism was also mediated by the inhibition of various cellular proteins engaged in apoptosis, including Mc-1, Bcl-xL, survivin and activation of procaspase-3. (spandidos-publications.com)
Silencing RPL29 by RNA interference in cancer cells induces the cell cycle arrest at G0/G1 phase and promotes its apoptosis. (okayama-u.ac.jp)
Our simulations show that, if HMGB1 is overexpressed, then the oncoproteins CyclinD/E, which regulate cell proliferation, are overexpressed, while tumor suppressor proteins that regulate cell apoptosis (programmed cell death), such as p53, are repressed. (biomedcentral.com)
The HMGB1 signal transduction can influence the cell's fate by two important processes - apoptosis and cell proliferation - which are regulated respectively by the proteins p53 and CyclinE, acting in two different signaling pathways. (biomedcentral.com)
The protein p53 is one of the most important tumor suppressor proteins: its activation can lead to cell cycle arrest, DNA repair, or apoptosis. (biomedcentral.com)
In this paper, we ask the following questions: How do these proteins and their mutations change the cell's fate - apoptosis or survival - when HMGB1 signal transduction is activated? (biomedcentral.com)
Moreover, it induced cell cycle arrest in the G0/G1 phase, apoptosis, and ROS generation in these cells. (jcancer.org)
STAT3 protein belongs to a group of intracellular transcription factors that mediate a variety of functions such as cellular differentiation, proliferation, and apoptosis. (biolegend.com)
Effect of cadmium on P53 and mitogen-activated protein kinases in a murine macrophage cell line: relation to apoptosis. (cdc.gov)

What pathways are this gene/protein implicaed in? (cancerindex.org)
In particular, we will discuss the modifications in intrinsic and extrinsic apoptotic pathways caused by proteins encoded by HPV early genes. (mdpi.com)
The cell cycle is strictly regulated and controlled by a complex network of signaling pathways [ 1 ], comprised of hundreds of proteins. (biomedcentral.com)
Moreover, a number of extracellular proteins can bind to their receptors and activate signaling pathways that promote the proliferation of cancer cells. (biomedcentral.com)
Numerous E3 ubiquitin ligases, which facilitate the ubiquitination of specific substrates, have been shown to control G1/S. In this chapter, we will discuss components in the ubiquitin proteasome system that are implicated in G1/S control, how these enzymes are interconnected, gaps in our current knowledge, and the potential role of these pathways in the cancer cycle and disease proliferation. (intechopen.com)

In this part of interphase, the cell synthesizes mRNA and proteins in preparation for subsequent steps leading to mitosis. (wikipedia.org)
G1 phase together with the S phase and G2 phase comprise the long growth period of the cell cycle cell division called interphase that takes place before cell division in mitosis (M phase). (wikipedia.org)
In human somatic cells, the cell cycle lasts about 10 hours, and the G1 However, in Xenopus embryos, sea urchin embryos, and Drosophila embryos, the G1 phase is barely existent and is defined as the gap, if one exists, between the end of mitosis and the S phase. (wikipedia.org)
Between the beginning of the G1 phase (which is also after mitosis has occurred) and R, the cell is known as being in the G1-pm subphase, or the post-mitotic phase. (wikipedia.org)
From late mitosis to the G1 phase of the cell cycle ORC CDC6 and Cdt1 form the machinery necessary to load MCM2-7 complexes onto DNA. (exposed-skin-care.net)
During the G1 phase of interphase, enzymes and proteins needed for mitosis are synthesized. (assignmentexpert.com)
Protein synthesis and the production of microtubules occurs during G2 phase, which is then followed by mitosis. (novusbio.com)
Mitosis is the briefest phase of the cell cycle, however is extremely important. (novusbio.com)
A fifth phase has been identified, G0, in which the cell is resting just after mitosis but still carrying out normal functions. (coursehero.com)
The M phase consists of mitosis, in which the cell divides, producing two new, identical cells. (coursehero.com)
Interphase is collectively the gap 1 (G1), synthesis (S), and gap 2 (G2) phases of mitosis, in which a cell grows, replicates its DNA, and grows again. (coursehero.com)

Abrogation by c-myc of G1 phase arrest induced by RB protein but not by p53. (wdv.com)
Escape from G1 arrest during acute MEK inhibition drives the acquisition of drug resistance. (babraham.ac.uk)
Selumetinib causes long-term G1 arrest accompanied by reduced expression of DNA replication and repair genes, but cells stochastically re-enter the cell cycle during treatment despite continued repression of pERK1/2. (babraham.ac.uk)
This suggests that DNA replication following escape from G1 arrest in drug is more error prone and provides a potential explanation for the DNA damage observed under long-term RAF-MEK-ERK1/2 pathway inhibition. (babraham.ac.uk)
To test the hypothesis that escape from G1 arrest in drug promotes amplification, we exploited the combination of palbociclib and selumetinib. (babraham.ac.uk)
Combined treatment with selumetinib and a dose of palbociclib sufficient to reinforce G1 arrest in selumetinib-sensitive cells, but not to impair proliferation of resistant cells, delays the emergence of resistant colonies, meaning that escape from G1 arrest is critical in the formation of resistant clones. (babraham.ac.uk)
The underphosphorylated, active form of Rb interacts directly with E2F1 , leading to cell cycle arrest, while the hyperphosphorylated form decouples from E2F1, thus promoting the transcription of genes promoting entry into the S phase. (biolegend.com)
ST caused G0/G1 cell cycle arrest which was accompanied by a decrease in CDK4 and cyclin D1, and an increase in p21/Cip1and p27/Kip1 protein levels. (biomedcentral.com)
Cd at 20 microM markedly increased cells in G2/M and hypodiploid sub-G1 phases of the cell cycle suggesting cycle arrest and cell death. (cdc.gov)

pRB functions as a negative regulatory transcription factor during the G1 to S phase cell cycle transition. (medscape.com)
It promotes the transition from G1 to S phase by phosphorylating and inactivating RB1. (rndsystems.com)
CyclinE is a cell cycle regulatory protein which regulates the G1-S phase transition during cell proliferation. (biomedcentral.com)
Furthermore, silibinin inhibited the migration and invasion abilities of YD10B and Ca9-22 cells by regulating the expression of proteins involved in the epithelial-mesenchymal transition. (jcancer.org)
Rb , or retinoblastoma protein, is a key regulator of the cell cycle, particularly during the transition from the G1 to S phases. (biolegend.com)

During G1 phase, the G1/S cyclin activity rises significantly near the end of the G1 phase. (wikipedia.org)
Complexes of cyclin that are active during other phases of the cell cycle are kept inactivated to prevent any cell-cycle events from occurring out of order. (wikipedia.org)
At the G1/S checkpoint, formation of the G1/S cyclin with Cdk to form a complex commits the cell to a new division cycle. (wikipedia.org)
It further inhibited cell-cycle progression in the G1 phase by four different mechanisms: rapid downregulation of cyclin D1, induction of Chk2 with simultaneous downregulation of Cdc25A, induction of the Cdk-inhibitor p21 Cip/Waf and inhibition of ribonucleotide reductase activity resulting in reduced dCTP and dTTP levels. (nature.com)
Cyclin E-CDK2 is also needed for the DNA replication and centrosome duplication events in S phase. (news-medical.net)
The molecular consequence of translocation is overexpression of the protein cyclin D1 (coded by the PRAD1 gene located close to the breakpoint). (medscape.com)
The accumulation of both Cyclin and CKI proteins is tightly regulated at the level of transcription. (intechopen.com)
In addition, Cyclin and CKI proteins are controlled at the level of their destruction. (intechopen.com)
p27 is a protein that binds to and prevents the activation of different G1 and S phase cyclin-CDK complexes. (lu.se)

During G1 phase, the cell grows in size and synthesizes mRNA and protein that are required for DNA synthesis. (wikipedia.org)
In order for the cell to continue through the G1-pm, there must be a high amount of growth factors and a steady rate of protein synthesis, otherwise the cell will move into G0 phase. (wikipedia.org)
The S phase is characterized by DNA synthesis, and in the 1960s it was discovered that histone proteins are also synthesized during this phase. (news-medical.net)
This process is assumed to be under the control of the cell cycle, because of how closely linked to the S phase histone synthesis is. (news-medical.net)
A cell spends most of its time in interphase, during which it mostly performs its normal functions, such as protein synthesis. (coursehero.com)
Interphase comprises the gap 1 (G1), synthesis (S), and gap 2 (G2) phases, in which the cell grows and replicates its genetic material. (coursehero.com)
Cycloheximide, an inhibitor of protein synthesis, did not alter Cd-induced cytotoxicity indicating that J774A.1 cell death by Cd is independent of de novo protein synthesis including p53. (cdc.gov)
Ricin causes toxicity by inhibiting the formation (synthesis) of proteins in the cells of the exposed individual. (cdc.gov)
In the hemorrhagic diathesis that may follow, disseminated intravascular coagulation (DIC) involves decreased synthesis of coagulation factors, altered platelet function, and bleeding from the gastrointestinal (GI) mucosa and abdominal or pleural serosa. (medscape.com)
Tendon protein synthesis in otherwise healthy males and females scheduled for anterior cruciate ligament (ACL) surgery. (who.int)
Tendon tissue protein synthesis rate, expressed as fractional synthesis rate (FSR, %/d), will be measured for 7 days prior to surgery. (who.int)

DRAM2 overexpression also increased proteins CDK4, CyclinD3, and decreased p27 expression, all of which are cell cycle-related factors. (cancerindex.org)

This phosphorylation occurs in a cell cycle-dependent manner and peaks in the G1 phase. (aacrjournals.org)
Protein phosphorylation is the most common post-translation modification of proteins and regulates many biological processes. (lu.se)

These complexes then activate S-Cdk complexes that move forward with DNA replication in the S phase. (wikipedia.org)
Within this research the hypothesis was explored that SNF2H protein might are likely involved in the excitement of MCM launching onto mobile replication origins which the Cdt1-SNF2H conversation is usually important in this context. (exposed-skin-care.net)
However, most of the vertebrate histone genes are replication dependent and are therefore more highly expressed during the cell cycle's S phase. (news-medical.net)
Given that the replication dependent histone genes all activate upon entry into the S phase, it is speculated that there exists some further upstream regulatory element. (news-medical.net)
Cells increase in size during G1 phase, which is followed by DNA replication in S phase. (novusbio.com)
Interphase is characterized by cell growth and DNA replication , while M is the phase of the cell cycle in which the chromosomes of the cell prepare for the cell to divide into two new cells. (coursehero.com)
During the S phase, the replication of the cell's genetic material, DNA, occurs. (coursehero.com)
Cell cycle-specific with activity in the S-phase as single agent and has for many years been combined with biochemical modulator leucovorin.Has activity as single agent that inhibits DNA replication and transcription. (medscape.com)
Recent breakthroughs have uncovered more and more DNA replication licensing machinery proteins (ORC, Cdc6, Cdt1, geminin, etc.) functioning in other cell cycle events, including centrosome replication, mitotic events, transcription and so on. (intechopen.com)
Throughout the cell cycle, the chromosome progressively goes from being fully methylated to hemimethylated during DNA replication - this results in differential binding of regulatory proteins to activate or repress transcription. (kenyon.edu)

Some authors will say that the restriction point and the G1/S checkpoint are one and the same, but more recent studies have argued that there are two different points in the G1 phase that check the progression of the cell. (wikipedia.org)
The G1/S checkpoint is the point between G1 phase and the S phase in which the cell is cleared for progression into the S phase. (wikipedia.org)
Microinjection of Rb in G1 phase reversibly arrests cell-cycle progression. (wdv.com)
It was found that the C . crescentus genome encodes for more two-component signal transduction proteins that assist in cell cycle progression than any other bacterial genome sequenced so far. (kenyon.edu)
Several two-component signal transduction proteins are involved in the cell cycle progression by accumulating at one or both poles "in a spatial and temporal pattern that is reproduced during each cycle" (Jacobs-Wagner 2003). (kenyon.edu)

One of the critical factors for the control of the protein levels during the cell cycle is the Anaphase Promoting Complex/Cyclosome (APC/C). This complex recognises proteins with specific signatures (or degrons) and targets them for degradation via the protein destruction machinery called the proteasome. (europa.eu)

Briefly, miRNAs are expected to account for 1-5% of the human genome and to interfere with at least 30% of the protein-coding genes ( 4 , 5 ). (frontiersin.org)
Tumor suppressor genes encode proteins that normally provide negative control of cell proliferation. (medscape.com)
This mechanism is hypothesized to transduce a shared signal that activates the transcription of histone genes when the G1/S phase boundary is reached. (news-medical.net)
Therefore, NPAT could be the link between cell cycle machinery and shared heightened transcription of histone genes during S phase. (news-medical.net)
This study aimed to evaluate the expression levels of miR-34a and 11 of its bioinformatically selected target genes and proteins to test their potential dysregulation in RCC. (hindawi.com)
The genetic study showed promising results in "silencing" the genes that translate into tau protein, the primary component behind dementia. (medicaldaily.com)
Forkhead box protein M1 (FOXM1) is a key transcription factor (TF) that regulates a common set of genes related to the cell cycle in various cell types. (mdpi.com)
Transcription factors are proteins that regulate the transcription of genes, or the production of mRNA from DNA. (biolegend.com)
The JAK2 , MPL , and THPO genes provide instructions for making proteins that promote the growth and division (proliferation) of blood cells. (medlineplus.gov)
The proteins produced from the JAK2 , MPL , and THPO genes are part of a signaling pathway called the JAK/STAT pathway, which transmits chemical signals from outside the cell to the cell's nucleus. (medlineplus.gov)

Mechanistically, both peptides caused a significant reduction at G0/G1 phase, in correlation with an augmented expression of the cell cycle inhibitory proteins p53, p27, p21, necrosis, exacerbated generation of reactive oxygen species and diminished mitochondrial membrane potential, all hallmarks of cellular stress. (nature.com)
Dr. Yasuhiro Miyake (Assistant Professor of Okayama University Hospital) with his colleagues have found the presence of anti-60S ribosomal protein L29 (RPL29) antibody in sera, and showed that the anti- recRPL29-peptides polyclonal antibody inhibited the proliferation of human pancreatic cancer Panc-1 cells via the down-regulation of Wnt/β-Catenin signaling pathway in a dose dependent manner. (okayama-u.ac.jp)

G1 phase ends when the cell moves into the S phase of interphase. (wikipedia.org)
The G1, S, and G2 phases of the cell cycle are collectively known as interphase. (coursehero.com)
Interphase, the part of the cell cycle between division events, includes the G1, S, and G2 phases, during which the cell grows, replicates its DNA, and undergoes its usual functions. (coursehero.com)

Although some mechanisms through which TP inhibits NSCLC are well understood, those that involve ribosomal proteins remain yet to be understood. (techscience.com)
RPL29 is one of approximately 80 structural ribosomal proteins, and is highly expressed on the surface of a cancer cell. (okayama-u.ac.jp)

the post-mitotic and pre-mitotic phases. (wikipedia.org)
Browse our antibodies, ELISA kits and proteins related to mitotic G1-G1/S phases. (antibodies-online.com)

Since NCBI phased out the GI numbers, our service is not working properly anymore, and we are working on a solution. (lu.se)

Multidrug resistance caused by the overexpression of ABC transporter proteins in cancer cells remains a major obstacle limiting chemotherapy efficacy. (spandidos-publications.com)
A number of mechanisms involved in the occurrence of MDR have been described, including the overexpression of one or more ATP binding cassette (ABC) transporter proteins that mediate the efflux of many clinically relevant drugs. (spandidos-publications.com)
Recent studies have found that overexpression of the High-mobility group box-1 (HMGB1) protein, in conjunction with its receptors for advanced glycation end products (RAGEs) and toll-like receptors (TLRs), is associated with proliferation of various cancer types, including that of the breast and pancreatic. (biomedcentral.com)

The activity of CDKs is controlled by their binding to coactivator subunits termed Cyclins, as well as by CDK inhibitory proteins termed CKIs. (intechopen.com)

Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. (thermofisher.com)

We used the autologous uterine tissue transfer mouse model and studied the mRNA and protein expression of ERα, ERβ, GPER1, and PR in ectopic lesions at 2, 4, and 8 weeks of induction of endometriosis. (springer.com)

HMGB1 can activate a series of signaling components, including mitogen-activated protein kinases (MAPKs) and AKT, which play an important role in tumor growth and inflammation, through binding to different surface receptors, such as RAGE and TLR2/4. (biomedcentral.com)

The protein encoded by this gene is a member of the CMGC family of serine/threonine protein kinases. (cancerindex.org)

RB1 encodes the protein pRB and was the first tumor suppressor gene to be molecularly defined. (medscape.com)
TP53 encodes the protein p53, which is known as the "guardian of the genome. (medscape.com)
This was studied by using the CtrA gene, which encodes for an important cell cycle regulatory protein. (kenyon.edu)

Generally chromatin-remodeling proteins histone chaperones and histone acetylation enzymes are believed to do something synergistically to stimulate transcription on chromatin web templates (26). (exposed-skin-care.net)

The duration of each phase, including the G1 phase, is different in many different types of cells. (wikipedia.org)
Most nonproliferating vertebrate cells will enter the G0 phase. (wikipedia.org)
The cellular cycle of eukaryotic cells consists of four phases: G1 phase, S phase, G2 phase and M phase. (novusbio.com)
When cells are not actively dividing they are considered to be in a state of quiescence, known as the G0 phase. (novusbio.com)
Replacement of wild-type RB can suppress the tumorigenicity of some of these cells, suggesting that the RB protein (Rb) may negatively regulate cell growth. (wdv.com)
However, in cells that are still dividing, G0 is a brief period and can be considered part of G1. (coursehero.com)
During the G2 phase, a structure in the cytoplasm of animal cells that coordinates the formation of microtubules, called a centrosome , allows cell division to proceed during reproduction. (coursehero.com)
Agents in this class halt the cell cycle at the G1 phase in tumor cells. (medscape.com)
The relationship between lysate protein concentration from paclitaxel-treated and hydroxyurea-treated HeLa cells and the absorbance at 450 nm using the PathScan ® RP Phospho-Aurora A (Thr288) Sandwich ELISA Kit #41333 is shown in the upper figure. (cellsignal.com)
Within the brain, the protein is involved in the development of specialized cells that process smell. (biolegend.com)
Notably, the G1/S boundary represents a major barrier to cell proliferation and is universally dysfunctional in cancer cells, allowing for the unbridled proliferation observed in malignancy. (intechopen.com)
The CALR gene provides instructions for making a protein with multiple functions, including ensuring the proper folding of newly formed proteins and maintaining the correct levels of stored calcium in cells. (medlineplus.gov)
These proteins work together to turn on (activate) the JAK/STAT pathway, which promotes the proliferation of blood cells, particularly platelets and their precursor cells, megakaryocytes. (medlineplus.gov)

Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. (cancerindex.org)

11. Amsel, A. & Roussel, J. Motivational properties of ences in post-transcriptional processes spark interest in the development of frustration: I. Effect on a running response of the (protein redistribution, degradation), pharmacotherapies that selectively reg- addition of frustration to the motivational com- plex. (lu.se)

Protein activation and expression were analysed by western blotting, deoxyribonucleoside triphosphate levels by HPLC, ribonucleotide reductase activity by 14 C-cytidine incorporation into nascent DNA and cell-cycle distribution by FACS. (nature.com)

Specifically, the boundary between G1 and S-phase is tightly regulated by the ubiquitin proteasome system. (intechopen.com)

The G1 phase, gap 1 phase, or growth 1 phase, is the first of four phases of the cell cycle that takes place in eukaryotic cell division. (wikipedia.org)

These include G types G1, G2, G3, and G4 and P types P[4] and P[8] (on the basis of variability in the outer capsid proteins VP7 and VP4, respectively). (cdc.gov)
The single RNA is complexed with a capsid protein. (medscape.com)

The passage of a cell through the cell cycle is controlled by various cytoplasmic proteins in order to assure quality control. (novusbio.com)
The platinum complex also can bind to nucleus and cytoplasmic protein. (medscape.com)

The c-myc protein is localized in the nucleus and can physically associate with RB protein in vitro, hence c-myc may functionally antagonize RB function. (wdv.com)

Scope includes mutations and abnormal protein expression. (cancerindex.org)

The crosstalk is regulated by tumor suppressor proteins, including ARF, P21 and FBXW7, which are also frequently mutated in many cancers. (biomedcentral.com)

The rapid protocol (RP) PathScan ® RP Phospho-Aurora A (Thr288) Sandwich ELISA Kit is a solid phase sandwich enzyme-linked immunosorbent assay (ELISA) that detects endogenous levels of Aurora A protein phosphorylated at Thr288 in a reduced assay time of 1.5 hours. (cellsignal.com)

Binds to protein and other compounds containing SH group. (medscape.com)
It binds with high affinity to immunophilin FKBP (FK506-binding protein). (medscape.com)

p53 is a transcription factor whose expression is increased by DNA damage and blocks cell division at the G1 phase of the cell cycle to allow DNA repair. (medscape.com)

The cell cycle consists of four phases (G1, S, G2 and M), all of which are characterized by different factors. (news-medical.net)
The envelope consists of a lipid bilayer containing an envelope glycoprotein and a matrix protein. (medscape.com)

The ISWI-type nucleosome-remodeling aspect SNF2H and Williams symptoms transcription aspect (WSTF) were determined previously as book individual Cdt1-binding proteins (12). (exposed-skin-care.net)

Conversely, our data suggest that 14-3-3 stabilizes PTOV1 protein by sequestering PTOV1 in the cytosol and inhibiting its interaction with HUWE1. (aacrjournals.org)

A collection of microtubules (structural proteins) called a centrosome also replicates. (coursehero.com)

and a high concentration of Cdk inhibitors is found during G1 phase. (wikipedia.org)

Anatomy3

Organisms10

Diseases1

Chemicals and Drugs39

Analytical, Diagnostic and Therapeutic Techniques and Equipment22

Phenomena and Processes30

Information Science6

Health Care1

Kinase15

Apoptosis9

Pathways5

Mitosis11

Arrest9

Transition5

Cyclin9

Synthesis11

CDK41

Phosphorylation2

Replication10

Progression5

Anaphase-promoti1

Genes10

Peptides2

Interphase3

Ribosomal proteins2

Mitotic2

NCBI1

Overexpression3

Inhibitory1

Including D-type cyclins1

MRNA and protein1

Mitogen-Activat1

Kinases1

Encodes3

Enzymes1

Cells13

Regulate cell1

Degradation1

Activation1

Boundary1

Eukaryotic1

Capsid2

Cytoplasmic2

Vitro1

Mutations1

Tumor suppressor1

ELISA1

Binds2

Transcription factor1

Consists2

Cdt11

Cytosol1

Microtubules1

Inhibitors1