Von Hippel-Lindau Tumor Suppressor Proteinvon Hippel-Lindau DiseasePancreatic CystHypoxia-Inducible Factor 1, alpha SubunitKidney NeoplasmsCarcinoma, Renal CellProcollagen-Proline DioxygenaseTumor Suppressor Protein p53Ubiquitin-Protein LigasesProteasome Endopeptidase ComplexNobel PrizeTumor Suppressor ProteinsGenes, Tumor SuppressorHemangioblastomaUbiquitinUbiquitinationRho FactorCell Line, TumorProto-Oncogene Proteins c-mdm2ProteolysisTumor Suppressor Protein p14ARFRetinoblastoma ProteinProtein BindingCell LineCysteine EndopeptidasesMutationMolecular Sequence DataMultienzyme ComplexesNuclear ProteinsProteasome InhibitorsApoptosisvon Willebrand FactorSignal TransductionTransfectionAmino Acid SequenceDNA-Binding ProteinsTranscription FactorsProtein Structure, TertiaryLeupeptinsUbiquitinsGene Expression Regulation, NeoplasticPhosphorylationPolyubiquitinCell Cycle ProteinsCell CycleGenes, p53Tumor Cells, CulturedDown-RegulationProtein StabilityProto-Oncogene ProteinsNeurofibromin 2Blotting, WesternHeLa CellsCyclin-Dependent Kinase Inhibitor p21Base SequenceAdenomatous Polyposis Coli ProteinLigasesTranscription, GeneticCell ProliferationRNA, MessengerRepressor ProteinsPromoter Regions, GeneticProteinsCarrier ProteinsDNA DamageRNA, Small InterferingProtein Processing, Post-TranslationalCyclin-Dependent Kinase Inhibitor p16Cells, CulturedCell Transformation, NeoplasticRNA InterferenceGenes, SuppressorNeoplasm ProteinsPTEN PhosphohydrolaseGene Expression RegulationCell NucleusImmunoprecipitationNeoplasmsRecombinant Fusion ProteinsCysteine Proteinase InhibitorsTranscriptional ActivationCyclinsCell DivisionBinding SitesHEK293 CellsCullin ProteinsModels, BiologicalProtein-Serine-Threonine KinasesSuppressor of Cytokine Signaling ProteinsFibroblastsGene SilencingCell HypoxiaReverse Transcriptase Polymerase Chain ReactionImmunoblottingMembrane ProteinsTrans-ActivatorsE2F Transcription FactorsCOS Cellsvon Willebrand DiseasesF-Box Proteins