- These types of prostate cancer comprise true neuroendocrine cancers, such as small cell carcinoma, carcinoid and carcinoid-like tumors, as well as prostatic adenocarcinoma exhibiting focal neuroendocrine phenotype. (wikipedia.org)
- Two morphologic types have been described: the open type, extending slender apical processes to the ductal or acinar lumen, and the closed type cells, which lack lumenal protrusions but display dendrite-like processes that extend between adjacent epithelial cells. (wikipedia.org)
- Neuroendocrine tumor cells express cytokeratins that are typically expressed by luminal secretory type cells, but lack basal cell markers such as high molecular weight cytokeratin and p63. (wikipedia.org)
- High risk of acute pulmonary toxicity with both myeloablative and non-myeloablative total body irradiation-based conditioning for allogeneic stem cell transplantation. (dukecancerinstitute.org)
- These types of prostate cancer comprise true neuroendocrine cancers, such as small cell carcinoma, carcinoid and carcinoid-like tumors, as well as prostatic adenocarcinoma exhibiting focal neuroendocrine phenotype. (wikipedia.org)
- As opposed to the focal type of neuroendocrine differentiation seen in prostatic adenocarcinoma, small cell carcinoma of the prostate, in turn, exhibit a universal type in that virtually all the constituent tumor cells display neuroendocrine features. (wikipedia.org)
- Immunohistochemically, prostatic small cell carcinoma are positive for thyroid transcription factor 1 (TTF-1), CD56, chromogranin A, synaptophysin, neuron-specific enolase, calcitonin and bombesin/gastrin-releasing peptide, while lacking, or rarely and weakly expressing, androgen receptor and prostate-specific antigen. (wikipedia.org)
- Extrapulmonary small cell carcinoma is an aggressive neoplasm that enlarges rapidly and disseminates early in the course of illness. (medscape.com)
- Due to the multiplicity of sites where it can arise, there are no symptoms or signs specifically attributable to extrapulmonary small cell carcinoma. (medscape.com)
- As with pulmonary small cell carcinoma, paraneoplastic syndromes have been described with extrapulmonary small cell carcinoma. (medscape.com)
- The pathology of extrapulmonary small cell carcinoma. (medscape.com)
- Xu JL, Guo Y. Clinical characteristics and survival of extrapulmonary small cell carcinoma in 11 different primary tumor sites in the United States, 1975-2016. (medscape.com)
- Patterns of relapse in extrapulmonary small cell carcinoma: retrospective analysis of outcomes from two cancer centres. (medscape.com)
- Extrapulmonary small cell carcinoma: imaging features with radiologic-pathologic correlation. (medscape.com)
- Extrapulmonary small-cell carcinoma: a single-institution experience. (medscape.com)
- Small cell carcinoma of the pyriform sinus successfully treated with concurrent chemo-radiotherapy: A case report. (medscape.com)
- Extrapulmonary small cell carcinoma: multimodality treatment results. (medscape.com)
- Naidoo J, Teo MY, Deady S, Comber H, Calvert P. Should patients with extrapulmonary small-cell carcinoma receive prophylactic cranial irradiation? (medscape.com)
- The most heavily studied aspect of neuroendocrine differentiation in prostate cancer (but not the only one, as mentioned above) is the focal type, which refers to a conventional prostatic adenocarcinoma that exhibits neuroendocrine foci at histopathological examination. (wikipedia.org)
- 9. Characterization of neuroendocrine differentiation in human benign prostate and prostatic adenocarcinoma. (nih.gov)
- 16. Endocrine-paracrine cell types in the prostate and prostatic adenocarcinoma are postmitotic cells. (nih.gov)
- Two morphologic types have been described: the open type, extending slender apical processes to the ductal or acinar lumen, and the closed type cells, which lack lumenal protrusions but display dendrite-like processes that extend between adjacent epithelial cells. (wikipedia.org)
- They are thought to arise from a different precursor than other epithelial prostatic cells, possibly through a neurogenic lineage of their own, which is therefore distinct from the secretory and basal cells that derive from urogenital sinus. (wikipedia.org)
- 20. Multidirectional differentiation in the normal, hyperplastic, and neoplastic human prostate: simultaneous demonstration of cell-specific epithelial markers. (nih.gov)
- Chromogranin A, which is the most abundant product of prostatic neuroendocrine cells and neuroendocrine tumor cells, is widely recognized as a reliable marker for neuroendocrine differentiation. (wikipedia.org)
- The most frequently encountered products in neuroendocrine tumor cells across prostate cancer samples appear to be calcitonin (in more than one third of cases), neurotensin, serotonin, human chorionic gonadotropin, vasoactive intestinal peptide (VIP) and bombesin/gastrin-releasing peptide. (wikipedia.org)
- Neuroendocrine tumor cells express cytokeratins that are typically expressed by luminal secretory type cells, but lack basal cell markers such as high molecular weight cytokeratin and p63. (wikipedia.org)
- however, adjacent non-neuroendocrine tumor cells appear to display an increased expression of Ki-67. (wikipedia.org)
- 18. Acquisition of neuroendocrine characteristics by prostate tumor cells is reversible: implications for prostate cancer progression. (nih.gov)
- Prostatic neuroendocrine cells, also known as endocrine-paracrine cells, are part of a larger regulatory cell population scattered throughout the whole organism, collectively known as diffuse neuroendocrine system or APUD cells. (wikipedia.org)
- Regulatory cues might come through endocrine, paracrine (from neighboring neuroendocrine cells), autocrine or neurocrine routes. (wikipedia.org)
- As opposed to their normal neuroendocrine counterparts, tumor neuroendocrine cells express the beta-oxidative enzyme alpha-methylacyl-CoA racemase, which is a recently described marker for prostate cancer. (wikipedia.org)
- 4. Neuroendocrine cells of the prostate and neuroendocrine differentiation in prostatic carcinoma: a review of morphologic aspects. (nih.gov)
- 11. [Role of neuroendocrine cells in prostate cancer progression]. (nih.gov)
- 12. Endocrine-paracrine (APUD, neuroendocrine) cells in the normal and pathologic prostate. (nih.gov)
- The open type cells may in addition receive regulatory signals from luminal molecules The developmental origin of these cells is as yet unknown. (wikipedia.org)
- 3. The prostatic endocrine-paracrine (neuroendocrine) regulatory system and neuroendocrine differentiation in prostatic carcinoma: a review and future directions in basic research. (nih.gov)
- Pryor JG, Simon RA, Bourne PA, Spaulding BO, Scott GA, Xu H. Merkel cell carcinoma expresses K homology domain-containing protein overexpressed in cancer similar to other high-grade neuroendocrine carcinomas. (medscape.com)
- Extrapulmonary Small Cell Cancer: A New Insight into a Rare Disease. (medscape.com)
- Neuroendocrine differentiation is a term primarily used in relation to prostate cancers that display a significant neuroendocrine cell population on histopathological examination. (wikipedia.org)
- 19. Plasma neuroendocrine markers in patients with benign prostatic hyperplasia and prostatic carcinoma. (nih.gov)
- Patients may present with symptoms and signs of excess calcium, hyponatremia, or corticosteroid excess, depending upon the severity and rate of development of endocrine abnormality. (medscape.com)
- Grossman RA, Pedroso FE, Byrne MM, Koniaris LG, Misra S. Does surgery or radiation therapy impact survival for patients with extrapulmonary small cell cancers? (medscape.com)
- TTF-1 positive small cell cancers: Don't think they're always primary pulmonary! (medscape.com)
- 2. Neuroendocrine differentiation in human prostatic carcinoma. (nih.gov)