• research focusing on prost
  • Though a significant amount of research focusing on prostaglandins is ongoing, much of the current understanding of the potent biochemicals was developed in the 1960s and 1970s by scientists Sune K. Bergstr m, Bengt Ingemar Samuelsson, and John Robert Vane, who were rewarded for their efforts with the Nobel Prize for Physiology or Medicine in 1982. (fsu.edu)
  • blood vessels
  • However, while COX-1 and COX-2 are both located in the blood vessels, stomach and the kidneys, prostaglandin levels are increased by COX-2 in scenarios of inflammation and growth. (wikipedia.org)
  • Anti-Inflammatory
  • M.J.H. Smith, A.W. Ford-Hutchinson and P.C. Elliott , Prostaglandins and the Anti-Inflammatory Activities of Aspirin and Sodium Salicylate , J. Pharm. (springer.com)
  • J.R. Walker, M.J.H. Smith and A.W. Ford-Hutchinson , Anti-Inflammatory Drugs, Prostaglandins and Leucocyte Migration , Agents and Actions 6 , 602-606 (1976). (springer.com)
  • E.L. Tolman and R. Patridge , Multiple Sites of Interaction between Prostaglandins and Non-Steroidal Anti-Inflammatory Agents , Prostaglandins 9 , 349-359 (1975). (springer.com)
  • B. Fjalland , Inhibition by Non-Steroidal Anti-Inflammatory Agents of the Release of Rabbit Aorta Contracting Substance and Prostaglandins from Chopped Guinea Pig Lungs , J. Pharm. (springer.com)
  • vivo
  • It is concluded that aspirin exerts two separate inhibitory effects on prostaglandin formation in vivo, a rapid action of the intact molecule on easily accessible tissues and a later action due to its metabolic conversion to salicylic acid. (springer.com)
  • structural
  • Due to these features, prostaglandins may contribute to virtually all the functional and structural alterations which characterize the different phases of diabetic nephropathy. (springer.com)
  • The structural differences between prostaglandins account for their different biological activities. (wikipedia.org)
  • 1977
  • A.W. Ford-Hutchinson, J.R. Walker, N.S. Connor and M.J.H. Smith , Prostaglandins and Leucocyte Migration in Inflammatory Reactions , Agents and Actions 7 , 469-472 (1977). (springer.com)
  • Up until the late 1970s prostaglandins were thought to raise IOP, but a paper published in 1977 showed that prostaglandin F2α lowered it, and subsequent studies found that this was due to increasing the outflow of aqueous humor, mainly by relaxing the ciliary muscle, and possibly also due to changes in extracellular matrix and to widening of spaces within the trabecular meshwork. (wikipedia.org)
  • Prostaglandin E2 was first made in 1970 and approved for medical use in the United States in 1977. (wikipedia.org)
  • aqueous
  • Degradation of prostaglandins in anhydrous or aqueous pharmaceutically acceptable, water-miscible alcohol solutions is prevented by adding a stabilizing amount of a pharmaceutically acceptable acetal. (google.com)
  • 1. A stable prostaglandin composition comprising a prostaglandin dissolved in an anhydrous or aqueous pharmaceutically acceptable, water-miscible alcohol solution containing a stabilizing amount of a pharmaceutically acceptable acetal having the general formula R 1 CH(OR 2 ) 2 wherein R 1 is an alkyl radical of 1 to 4 carbon atoms or phenyl and R 2 is an alkyl radical of 1 to 4 carbon atoms. (google.com)
  • Samuelsson
  • The biochemists Sune K. Bergström, Bengt I. Samuelsson and John R. Vane jointly received the 1982 Nobel Prize in Physiology or Medicine for their research on prostaglandins. (wikipedia.org)
  • phospholipase
  • Burch RH, Axelrod J, Dissociation of bradykinin-induced prostaglandin formation from phosphatidylinositol turnover in Swiss 3T3 fibroblasts: evidence for G protein regulation of phospholipase A 2 . (springer.com)
  • Craven PA, Patterson MC, DeRubertis FR, Role of enhanced arachidonate availability through the phospholipase A 2 pathway in the mediation of increased prostaglandin synthesis by glomeruli from diabetic rats. (springer.com)