• oocytes
  • The ability of Fzr1 Δ/Δ oocytes to remain prophase I/germinal vesicle (GV) arrested in vitro was also compromised, despite the addition of the phosphodiesterase milrinone. (biologists.org)
  • Thus, APC/C FZR1 activity is required to repress cyclin B1 levels in oocytes during prophase I arrest in the ovary, thereby maintaining meiotic quiescence until hormonal cues trigger resumption. (biologists.org)
  • Mammalian oocytes are arrested in prophase of the first meiotic division. (rupress.org)
  • In mouse oocytes, we find that early mitotic inhibitor 1 (Emi1), an inhibitor of the anaphase-promoting complex (APC) that is responsible for cyclin B destruction and inactivation of MPF, is present at prophase I and undergoes Skp1-Cul1-F-box/βTrCP-mediated destruction immediately after germinal vesicle breakdown (GVBD). (rupress.org)
  • Exogenous Emi1 or the inhibition of Emi1 destruction in prophase-arrested oocytes leads to a stabilization of cyclin B1-GFP that is sufficient to trigger GVBD. (rupress.org)
  • Labs
  • ProPhase Labs on Tuesday launched the Cold-Eeze oral spray, which is formulated with zinc gluconate to help reduce the severity and duration of the common cold. (drugstorenews.com)
  • ProPhase Labs Inc. (wsj.com)
  • ProPhase Labs is a diversified natural health medical science company. (marketwired.com)
  • ProPhase Labs has several wholly owned subsidiaries including a manufacturing unit, which consists of an FDA registered facility to manufacture Cold-EEZE ® Cold Remedy lozenges and fulfill other contract manufacturing opportunities. (marketwired.com)
  • cyclin
  • The abrupt onset of M-Cdk in late prophase I depends on the positive transcription regulation feedback loop consisting of Ime2, Ndt80 and Cdk/cyclin complex. (wikipedia.org)
  • organization
  • WIRB-Copernicus Group (WCG), a provider of solutions that measurably improve the quality and efficiency of clinical research, has acquired MedAvante and ProPhase , and has named Dr. Jeffrey Litwin as the CEO of the combined organization. (centerwatch.com)
  • early
  • Wee1 activity is high in early prophase I and the accumulation of Cdc25 activates M-Cdk by direct phosphorylation and marking Wee1 to be degraded. (wikipedia.org)
  • distinct
  • During prophase itself, the chromatids condense and thicken to form distinct bodies. (dictionary.com)
  • It precedes prophase and is characterized by two distinct events: The formation of the preprophase band, a dense microtubule ring underneath the plasma membrane. (wikipedia.org)
  • ready
  • That's one reason that compelled Sofija Jovic , chief executive officer of ProPhase , to apply to participate in the inaugural Women in Bio Boardroom Ready program. (biospace.com)