• Clozapine
  • To minimize the side effects of the aforementioned drugs, clozapine (Figure 1(c) ), the structural analogue of loxapine, was synthesized, where the chlorine on C-2 is shifted to C-8 atom and the oxygen at position 5 of tricyclic ring is replaced with nitrogen [ 10 ]. (hindawi.com)
  • drugs
  • Loxapine (Figure 1(a) ) and clothiapine (Figure 1(b) ) are well known antipsychotic agents prescribed in schizophrenia, but they have major extrapyramidal side effects (EPSE) and motor side effects, which can be attributed mainly to the electronegative chlorine atom on carbon number 2 (C-2) of their tricyclic ring, which is responsible for greater affinity of these drugs towards D 2 receptors. (hindawi.com)