• gene
  • In this study, we show that a 170-nt region in the promoter of CYP19A1/aromatase, a key gene required for ovarian estrogen biosynthesis and feminization of chicken embryonic gonads, contains highly quantitative, nucleotide base-level epigenetic marks that reflect phenotypic gonadal sex differentiation. (biomedsearch.com)
  • The -1185 A/G and -1051 G/A dimorphisms in the von Willebrand factor gene promoter and risk of myocardial infarction. (biomedsearch.com)
  • Recently, four linked dimorphisms in the VWF gene promoter were demonstrated to influence plasma VWF level. (biomedsearch.com)
  • STUDY DESIGN: Variations in the exons and promoter of the NHE3 gene were analyzed with direct sequencing analysis and mini sequencing (SNaPshot analysis) in 251 cases of SIDS, plus 50 infant control subjects who had died of other causes, and 170 healthy adults. (biomedsearch.com)
  • CONCLUSIONS: Our findings suggest the involvement of polymorphisms in the NHE3 gene and promoter in cases of SIDS, which may result in an overexpression of NHE3 in the medulla oblongata and which possibly leads to a disturbance in breathing control. (biomedsearch.com)
  • Genetic engineers must first choose what gene they wish to insert into the organism. (wikipedia.org)
  • The gene must then be isolated and incorporated, along with other genetic elements, into a suitable vector. (wikipedia.org)
  • These genetic elements are generally a promoter and terminator region as well as a selectable marker gene. (wikipedia.org)
  • Knowledge of how the gene functions and interacts with other genetic elements is important. (wikipedia.org)
  • The gene then needs to be mapped by comparing the inheritance of the phenotype with other known genetic markers. (wikipedia.org)
  • As well as producing hormones, vaccines and other drugs genetic engineering has the potential to cure genetic diseases through gene therapy. (wikipedia.org)
  • Unlike traditionally animal and plant breeding, which involves doing multiple crosses and then selecting for the organism with the desired phenotype, genetic engineering takes the gene directly from one organism and inserts it in the other. (wikipedia.org)
  • Genetic engineering could potentially fix severe genetic disorders in humans by replacing the defective gene with a functioning one. (wikipedia.org)
  • First-tier Golden Gate assembly constructs the single-gene construct by adding in genetic elements such as promoter, open reading frames, and terminators. (wikipedia.org)
  • Chronic variable stress induces offspring hypothalamic gene expression modifications, including elevated methylation levels of the BDNF promoter in the hippocampus. (wikipedia.org)
  • Chromatin remodeling in rodent offspring and altered gene expression within the limbic brain regions that may contribute to depression, stress, and anxiety-related disorders in future generations. (wikipedia.org)
  • Here is the promoter for the FAM149A gene provided by ElDorado and the sequence extracted from the information. (wikipedia.org)
  • A study on Escherichia coli found that gene deletions spontaneously occur in plasmid regions containing Z-DNA-forming sequences. (wikipedia.org)
  • The ENO3 gene spans 6 kb and contains 12 exons, though the first exon is an untranslated region and, thus, non-coding. (wikipedia.org)
  • Advances in genetic testing, such as exome sequencing and specific gene panels, can provide greater access to diagnoses for muscle β-enolase deficiency and other rare disorders. (wikipedia.org)
  • TFG-TEC binds to the proximal promoter region of the ENO3 gene. (wikipedia.org)
  • The 3' coding region of mir-433 is also the promoter of the neighbouring miRNA gene: mir-127. (wikipedia.org)
  • No such association was found between mir-433 variation and Parkinson's disease despite the fact that variation in the region of the FGF20 gene which binds to mir-433, is associated with Parkinson's disease. (wikipedia.org)
  • Identified for the first time in the country and described the genetic, the biochemical and the clinical features of several structural defects of hemoglobins and thalassemia variants, including a point mutation in the promoter region of the gamma globin gene responsible for the Brazilian form of HbF persistence. (wikipedia.org)
  • Nucleic Acid
  • This relies on recombinant nucleic acid techniques to form new combinations of heritable genetic material followed by the incorporation of that material either indirectly through a vector system or directly through micro-injection, macro-injection or micro-encapsulation. (wikipedia.org)
  • Variation
  • The authors concluded that "our findings, taken in context with previous work, suggest that genetic variation in each of these regions contributes to development of the important psychological trait of male sexual orientation. (wikipedia.org)
  • Transcriptional
  • SNF2 chromatin-remodeling ATPases play an important role in ensuring proper development in higher eukaryotes by controlling accessibility of cis-regulatory DNA regions to transcription factors and to the transcriptional machinery. (mendeley.com)
  • We present evidence that SYD is recruited to the WUS promoter and that it is involved in regulation of the stem cell pool maintenance via direct transcriptional control of this master regulator. (mendeley.com)
  • Upstream of the first exon lies a TATA-like box and CpG-rich region, which contains recognition motifs for binding transcriptional regulatory factors such as Sp1, activator protein 1 and 2, CCAAT box transcription factor/nuclear factor I, and cyclic AMP. (wikipedia.org)
  • regulatory
  • This first intron, along with the 5'-flanking region, contains a consensus sequence for muscle-specific regulatory factors that includes a CC(A + T-rich)6GG box, a M-CAT-box CAATCCT, and two myocyte-specific enhancer-binding factor 1 boxes. (wikipedia.org)
  • molecular
  • Using genetic and molecular analyses we have identified WUSCHEL (WUS) as a biologically important target of the SNF2-class ATPase SPLAYED (SYD) in the shoot apical meristem of Arabidopsis. (mendeley.com)
  • A decade later molecular genetic tools have improved methods for protein identification. (wikipedia.org)
  • Molecular drive is a term coined by Gabriel Dover in 1982 to describe evolutionary processes that change the genetic composition of a population through DNA turnover mechanisms. (wikipedia.org)
  • Molecular drive operates independently of natural selection and genetic drift. (wikipedia.org)
  • After his post-doctoral training at the Oxford University, in the laboratories of Professor Sir David J. Wetherall, whose group was at the time establishing the molecular bases of the thalassemias, he returned to Brazil and started a research group with a major scientific interest in the genetic bases of hematological diseases. (wikipedia.org)
  • Differences
  • These results indicate the impact of this OXTR genetic variant on individual differences in social affective neural processing. (scirp.org)
  • Proteins
  • The first company to focus on genetic engineering, Genentech, was founded in 1976 and started the production of human proteins. (wikipedia.org)
  • functional
  • According to Dover, TRAM is a genetic system that has features of Non-mendelian inheritance Turnover, copy number and functional Redundancy And Modulatory. (wikipedia.org)
  • diseases
  • These data demonstrated that this Black population is significantly different from its U.S. or Caribbean counterparts, with implications for the medical genetic studies that compare these populations and for the understanding of the hereditary diseases. (wikipedia.org)
  • organism
  • Genetic engineering is a process that alters the genetic make-up of an organism by either removing or introducing DNA. (wikipedia.org)
  • The sexual organism could henceforth pass on some of its genetic material to produce new individuals and could itself become disposable with respect to the survival of its species. (wikipedia.org)
  • Male
  • Although the mechanisms of avian sex determination remains unknown, the genetic sex is experimentally reversible by in ovo exposure to exogenous estrogens (ZZ-male feminization) or aromatase inhibitors (ZW-female masculinization). (biomedsearch.com)
  • Subsequently, a genomewide scan by Hamerʻs group revealed additional regions on autosomes that were moderately linked to male sexual orientation. (wikipedia.org)
  • Hamer's results were robustly replicated in 2012 in a large, comprehensive multi-center genetic linkage study of male sexual orientation conducted by several independent groups of researchers. (wikipedia.org)
  • material
  • Polymerase chain reaction (PCR), developed by Kary Mullis in 1983, allowed small sections of DNA to be amplified and aided identification and isolation of genetic material. (wikipedia.org)
  • New DNA is obtained by either isolating and copying the genetic material of interest using recombinant DNA methods or by artificially synthesising the DNA. (wikipedia.org)
  • research
  • Genetic engineering has been applied in numerous fields including research, medicine, industrial biotechnology and agriculture. (wikipedia.org)