Promoter transcription gene rearrangement. Medical search. Frequent questions

It is able to form homodimers with other MAX proteins and heterodimers with other transcription factors, including Mad, Mxl1 and Myc. (wikipedia.org)
NTRK (neurotrophic tyrosine receptor kinase) gene fusions that encode chimeric proteins exhibiting constitutive activity of tropomyosin receptor kinases (TRK), are oncogenic drivers in multiple cancer types. (bvsalud.org)
Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process. (lookformedical.com)
By contrast, the 10 downregulated genes were primarily associated with epithelial membrane proteins ( 11 ). (spandidos-publications.com)
The expression of the PCWDE-encoding genes has been so far primarily investigated on the level of transcriptional regulation by regulatory proteins, especially the transactivator Xyr1 and the repressor Cre1. (tuwien.at)
Otherwise, the impact of chromatin remodeling, i.e. the dynamic modification of chromatin architecture to allow the regulatory proteins access to genomic DNA, on gene expression in T. reesei has received hardly any attention so far. (tuwien.at)
Among CRE1 repressed transcripts, genes encoding unknown proteins and transport proteins were overrepresented. (biomedcentral.com)
Analysis of virulence related gene expression and computational simulations of pivotal proteins involved in pathogenesis demonstrate that myricetin downregulates the saeR global regulator and interacts with sortase A and α-hemolysin. (nature.com)
The initial domains of homeotic gene repression are set by the segmentation proteins, which also divide the embryo into segments. (nih.gov)
To reduce the risk of analyzing cell line- pathway can be divided into distinct stages based on the specific features, we used several representative cell lines for recombination status of the Ig genes and on the expression each of four major stages in B cell development: pro-B, pre-B, pattern of surface markers and the presence of intracellular proteins [1- 6]. (lu.se)
Specialized cell structures called ribosomes are the cellular organelles that actually synthesize the proteins (RNA transcription). (cdc.gov)

Mad:Max, Max:Myc) provides a system of transcriptional regulation with greater diversity of gene targets. (wikipedia.org)
The regulation of WUS transcription is crucial for meristem homeostasis, whereby high WUS expression leads to enlarged meristems and low expression leads to the formation of small meristems 3 , 14 . (nature.com)
These experiments indicated that Tα3-Tα4 collaborates with factors bound to Tα1-Tα2 for the strict developmental regulation of Tcra rearrangement. (aai.org)
Scholars@Duke publication: Regulation of T cell receptor-alpha gene recombination by transcription. (duke.edu)
Our results demonstrate two key functions for transcription in Tcra locus regulation. (duke.edu)
Although it is clear that switching among BESs does not involve DNA rearrangements and that regulation is probably epigenetic, it remains unknown why BESs are transcribed by Pol I and what roles are played by chromatin structure and histone modifications. (asm.org)
Regulation of nucleosome density is therefore an important mechanism to enable the transcription machinery to access the DNA. (asm.org)
Our in-silico review on the features present within GH17J043079 element in BRCA 1 helps to postulate an intricate transcription regulation. (fortuneonline.org)
Such candidate based analysis of features within cis regulatory element on a gene can help elucidate intricate genomic architecture, gene regulation and its impact on complex disorders. (fortuneonline.org)
Targets transcription factors involved in the regulation of inflammatory responses and in the immune response: suppresses NF-kappa-B activation, and activates AP-1 (By similarity). (proteopedia.org)
Induces up-regulation of FAS promoter activity, and thereby contributes to the increased triglyceride accumulation in hepatocytes (steatosis) (PubMed:14602201). (proteopedia.org)
Of the 31 genes, the 21 upregulated genes were primarily associated with cell paracrine and intracellular signaling, transcription regulation and cell adhesion and migration, and their transcriptional products included transforming growth factor-β2 (TGF-β2), insulin-like growth factor-binding protein 2 and transcriptional factor AP-2α/γ ( 11 ). (spandidos-publications.com)
We are driven by a desire to understand the molecular basis of organismal diversity, and the belief that many differences in physiology, morphology and behavior arise from changes in gene regulation. (berkeley.edu)
We are a hybrid computational and experimental lab who couple genome-scale computational and experimental analysis of gene regulation in Drosophila melanogaster and Saccharomyces cerevisiae with extensive analysis of comparative sequence data and experimental analysis of species closely related to these model systems. (berkeley.edu)
We focus on short evolutionary timescales where it is possible to couple specific changes in genome sequences with alterations in gene regulation and expression. (berkeley.edu)
To provide a solid experimental foundation for our evolutionary studies, we are working with several other labs in Berkeley to systematically dissect gene expression and regulation in the early D. melanogaster embryo. (berkeley.edu)
The detailed experimental data we are generating for D. melanogaster , and the genome sequences of 12 Drosophila species are a tremendous resource for studying the evolution of gene regulation. (berkeley.edu)
To take advantage of sequence diversity outside of the genus Drosophila, we are sequencing developmentally important loci from several non-Drosophilid fly families to provide insights into the underlying principles of gene regulation. (berkeley.edu)
There are transcribed sequences that are not translated into peptide products that can also be involved in gene expression regulation. (cd-genomics.com)
Today, a plethora of genes have been shown to be under control of CreA or CRE1 (reviewed in [ 7 ]) but the mechanisms triggering regulation by CreA/CRE1 are less well understood. (biomedcentral.com)
Chromosome aberrations can affect one or more genes in a complex manner, such as by changing the regulation of gene expression, by disrupting exons, and by creating fusion genes. (biomedcentral.com)

Furthermore, Max required BRG1 to activate neuroendocrine transcriptional programs and to up-regulate Myc targets, such as glycolytic-related genes. (wikipedia.org)
Transcriptional blockade also derepressed cryptic J(alpha) promoters. (duke.edu)
Transcription increases the recombination of J(alpha) segments located within several kilobases of a promoter and prevents the activation of downstream promoters through transcriptional interference. (duke.edu)
This is reminiscent of the structural topology of transcription factors and led to the hypothesis that the PS-DBD fusions form aberrant transcriptional condensates through phase separation, which was supported through transcriptomic data analysis and cellular condensate assays. (bvsalud.org)
Genomic cis regulatory elements support the gene transcriptional landscape which fine tune spatiotemporal gene expression via interaction with different transcription factors and co modulators during development. (fortuneonline.org)
A total of 7 possible genetic alterations and epigenetic changes in CAFs are discussed, including gene differential expression, karyotype analysis, gene copy number variation, loss of heterozygosis, allelic imbalance, microsatellite instability, post‑transcriptional control and DNA methylation. (spandidos-publications.com)
Assays in transgenes in Drosophila previously identified cis -acting transcriptional regulatory elements from homeotic genes. (nih.gov)
The transcriptional silencers are clustered in the two regions whose interactions are required for the maintenance of silencing in the endogenous genes. (nih.gov)
On the other hand, since the eukaryotes are not separated from the transcription and transcription process in the nuclear structure, the transcriptional enzyme is not limited by the mobile factor, but by other genes pass trans. (techintroduce.com)
However, the transcriptional activity of TBP (TATA box-binding protein) and its promoter binding factor (TBPF), Calcitriol (Rocaltrol) RNA polymerase II, remain unaffected during differentiation. (globaltechbiz.com)
In line with this, RBPJL is able to fully reconstitute transcriptional repression at Notch target genes in cells lacking RBPJ. (uni-ulm.de)

Unlike sequence-specific transcription factors, epigenetic regulators do not necessarily bind DNA at consensus sequences, but still achieve reproducible target binding in a manner that is cell and maturation-type specific. (frontiersin.org)
Since mutations at splicing donor sites of the transcripts reduce CSR,21),22) not only transcription but also splicing of transcripts appears to be important, which gives rise to germline transcripts comprising the I and CH exon sequences. (roma2024.com)
Foreign gene sequences could be inserted into deletion mutants, which may alter the infectious characteristics of the virus. (i-sis.org.uk)
The ETS-domain transcription factors divide into subfamilies based on protein similarities, DNA-binding sequences, and interaction with cofactors. (ox.ac.uk)
DNA sequences which are recognized (directly or indirectly) and bound by a DNA-dependent RNA polymerase during the initiation of transcription. (lookformedical.com)
Highly conserved sequences within the promoter include the Pribnow box in bacteria and the TATA BOX in eukaryotes. (lookformedical.com)
Nucleic acid sequences involved in regulating the expression of genes. (lookformedical.com)
Cis-acting DNA sequences which can increase transcription of genes. (lookformedical.com)
My lab studies how the genomic sequences that control gene expression function and evolve. (berkeley.edu)
For each of the approximately 40 transcription factors critical in shaping anterior-posterior and dorsal-ventral patterns, our goals are to: 1) measure the factor s in vitro affinity to each of its potential target sequences, 2) identify the genomic regions bound by each factor in living embryos, 3) determine the expression pattern of the factor and its targets in three-dimensions at cellular resolution. (berkeley.edu)
We now have extensive comparative sequence data for fruitflies (12 Drosophila genomes) and yeasts (many fungal genomes), and are using these data to characterize how the individual building blocks of regulatory sequences (transcription factor binding sites) and higher order structures (e.g. developmental enhancers) evolve. (berkeley.edu)
We are particularly interested in understanding how selection to maintain transcription factor binding sites affects the evolution of target sequences, and how the extensive plasticity seen in the organization of developmental enhancers is related to their function. (berkeley.edu)
We are particularly interested in regulatory sequences that have undergone extensive rearrangements in their binding site repertoires without altering their function. (berkeley.edu)
Although extensive rearrangements are observed among Drosophla regulatory sequences, there must be limits to this plasticity. (berkeley.edu)
Each genomic rearrangement is mediated by a common V(D)J recombinase that recognizes sequences flanking all antigen receptor gene segments. (wustl.edu)
These ACE-mediated alterations are critical for activation of gene segment transcription and for opening chromatin associated with recombinase target sequences. (wustl.edu)
The first type of non-coding sequences is the regulatory elements that control gene expression. (cd-genomics.com)
The changes provide powerful assays for identifying the trans -acting factors that regulate the homeotic genes and the cis -acting sequences through which they act. (nih.gov)
According to the structure: a long-end repeating structure (LIT) similar to the reverse transcription virus, containing GAG and POL genes, but the film-free protein gene ENU does not have LTR but has 3'Polya, with Cardiocodecodes containing GAG and POL Similar sequences, 5 'is often truncated. (techintroduce.com)
TY factor is often located in the TRNA gene, The 5SrRNA gene and the gene of the U6 are adjacent or upstream, showing the promoters or related sequences of these transposons to transcribed by RNA polymerase III. (techintroduce.com)
Insertion sequences flanking the stx region suggest that gene rearrangements occurred and resulted in a defective phage. (cdc.gov)

During thymocyte maturation, enhancers of genes encoding for TCRδ ( Tcrd ) and TCRα ( Tcra ), Eδ 8 , and Eα, work as a developmental switch controlling transition from Tcrd to Tcra activity at the Tcrad locus. (aai.org)
Various hybrid or combination promoters have been constructed from the CaMV 35S promoter which led to improved expression of transgenes: double 35S promoters (10), a hybrid containing the core 19S promoter from CaMV and the 35S upstream enhancers (11), and combination of CaMV 35S with mannopine synthase elements (12), or with Adh1 - and ocs- promoter elements for expression in monocotyledons (13). (i-sis.org.uk)
Enhancers can usually function in either orientation and at various distances from a promoter. (lookformedical.com)
The chromatin configuration of antigen receptor loci is governed by the concerted action of enhancers and promoters, which function as accessibility control elements (ACEs). (wustl.edu)
Non-coding elements include cis-regulatory regions such as promoters, enhancers, insulators, and silencers, as well as non-coding RNAs. (cd-genomics.com)
As mentioned, these cis-regulatory elements may act as enhancers, promoters, or silencers of gene expression when bound by trans-regulatory elements, such as TFs or transcription factors. (cd-genomics.com)

Using PCR generated, site-specific probes corresponding to the non-coding exons 1 and 2 and intron 2 of CHOP, rearrangements in five of seven tumors mapped to the 2.4 and 1.6 kbp PstI fragments that contain the first two exons and introns of the gene and the upstream promoter region. (lu.se)
The CaMV promoter is a sequence of about 350 basepairs upstream of the 35S transcript (-343 to +8, with Cap site at +1), about 250 basepairs of which overlap with the 3' end of gene Vl, the last of the six large open reading frames. (i-sis.org.uk)
A 712-bp nucleotide sequence upstream of the first exons of both of the duplicated MBP genes of shi(mld) was completely consistent with that of the control. (elsevierpure.com)
The chromosomal aberrations identified an imaginal leg enhancer about 35 kb upstream of the Scr promoter. (nih.gov)

Loss of expression is rarely due to deletion, mutation, or rearrangement of the MGMT gene, but methylation of discrete regions of the CpG island of MGMT has been associated with the silencing of the gene in cell lines. (aacrjournals.org)
We used methylation-specific PCR to study the promoter methylation of the MGMT gene. (aacrjournals.org)
Analyzing specific loci and using a genome-wide analysis, we show that transcription running across CGIs, associated with specific chromatin modifications, is required for DNA methyltransferase 3B (DNMT3B)-mediated DNA methylation of many naturally occurring intragenic CGIs. (ox.ac.uk)
Importantly, we also show that a subgroup of intragenic CGIs is not sensitive to this process of transcription-mediated methylation and that this correlates with their individual intrinsic capacity to initiate transcription in vivo. (ox.ac.uk)
We propose a general model of how transcription could act as a primary determinant of the patterns of CGI methylation in normal development and differentiation, and in human disease. (ox.ac.uk)
Studies of genes transcribed by RNA polymerase II (Pol II) have shown that open and closed chromatin structures are dynamically regulated through multiple mechanisms, including histone modifications, histone variant incorporation, and DNA methylation (reviewed in reference 17 ). (asm.org)
In mammalian cells, active and silent rDNA promoters are characterized by specific histone modifications, DNA methylation, and positioning of the promoter-bound nucleosome (reviewed in reference 22 ). (asm.org)
Through profiling DNA methylome of individual tumor foci, we found that promoter methylation status of genes involved in detection of chemical stimulus, immune response, and Hippo/YAP1 pathway was significantly changed in mGBM. (thno.org)
Although both CNV and promoter methylation alteration were involved in heterogeneity of different tumor foci from same patients, more CNV events than promoter hypomethylation events were shared by different tumor foci, implying CNV were relatively earlier than promoter methylation alteration during evolution of different tumor foci from same mGBM. (thno.org)

Despite the longstanding correlation between transcription and variable-(diversity)-joining (V(D)J) recombination, it is unknown whether transcription itself can direct recombinase targeting. (duke.edu)
This paper examines the safety implication of recent revelations on the recombination hotspot of the cauliflower mosaic viral (CaMV) promoter, which is in practically all current transgenic crops released commercially or undergoing field trials. (i-sis.org.uk)
New revelations concerning the CaMV recombination hotspot (3) have prompted us to consider the safety implications of the CaMV promoter. (i-sis.org.uk)
Precursor B and T cells assemble functional immunoglobulin (Ig) and T cell receptor (TCR) genes via recombination of numerous variable (V), diversity (D), and joining (J) gene segments. (wustl.edu)
The specificity of V(D)J recombination is due, in large part, to changes in the accessibility of chromatin at target gene segments, which either permits or restricts access to recombinase. (wustl.edu)
Intragenic recombination among ospC genes is known, but the extent to which recombination extended beyond the ospC locus itself is undefined. (cdc.gov)

While CGIs associated with promoters nearly always remain unmethylated, many of the ∼9,000 CGIs lying within gene bodies become methylated during development and differentiation. (ox.ac.uk)
It is reasonable to assume that this translocation corresponds to the consistent rearrangement of one or two genes in 12q13 and/or 16p11, and that the loci thus affected are important in the normal control of fat cell differentiation and proliferation. (lu.se)
We have used Southern blot technique to test whether a gene of the CCAAT/enhancer binding protein (C/EBP) family, CHOP, which maps to 12q13 and is assumed to be involved in adipocyte differentiation, could be the 12q gene in question. (lu.se)
Mutant SPI1 binding at promoters activates gene sets typically promoted by other ETS factors, resulting in enhanced proliferation and decreased terminal B-cell differentiation in model cell lines and primary samples. (ox.ac.uk)
In summary, we describe oncogenic subversion of transcription factor function through subtle alteration of DNA binding leading to cellular proliferation and differentiation arrest. (ox.ac.uk)
Subsequent differentiation allows for rear- analysis of a set of mouse B lineage cell lines rep- rangements of the Ig light-chain (IgL) genes that replace the resenting defined stages of B cell development us- surrogate light-chain genes on the surface of the B cell [8]. (lu.se)
the gene expression profile during B lymphoid differentiation. (lu.se)

CreA/CRE1 binds to the promoters of the respective target genes via the consensus motif 5'-SYGGRG-3', whose function in vivo has been shown both in Aspergillus nidulans and Trichoderma reesei [ 9 - 12 ]. (biomedcentral.com)
The genes encode homeodomain-containing transcription factors that control cell fates by regulating the transcription of downstream target genes. (nih.gov)
The transcription factor RBPJ forms a coactivator complex in the presence of a Notch signal, whereas it represses Notch target genes in the absence of a Notch stimulus. (uni-ulm.de)

SNPs that are located in coding gene regions. (scirp.org)
Genome-wide studies in Saccharomyces cerevisiae , for example, have revealed that promoters of most actively transcribed genes are depleted of nucleosomes and that histone density is inversely proportional to the transcription rate within coding regions, suggesting that nucleosomes are dynamically disassembled and reassembled at each passage of the polymerase ( 16 ). (asm.org)
It affects the DNA-binding affinity of the protein and allows the mutant protein to more frequently bind and activate promoter regions with respect to wild-type protein. (ox.ac.uk)
We have characterized the structure and function of the promoter regions of the duplicated MBP genes in shi(mld). (elsevierpure.com)
Among the lambda clones containing promoter regions of the duplicated MBP genes in shi(mld), one (gene 1) had the same restriction enzyme pattern as that in control mice, but another (gene 2) had a rearrangement on a distal part of the promoter. (elsevierpure.com)
Promoter activities of 1.3-kb 5'-flanking regions from respective genes of shi(mld) measured by in vitro run-off assay using HeLa whole-cell extracts were indistinguishable from that of the control MPB gene. (elsevierpure.com)
For some of the genomic regions that are deleted in some neuroblastomas, on 1p, 3p and 11q, candidate tumor suppressor genes have been identified. (biomedcentral.com)

including the two researchers involved in the 2015 work - have used a new active genetic element called a CopyCat element and more traditional genome editing to analyze the control of a gene that coordinates the formation of a simple structure in a fruit fly - a vein in the wing. (elifesciences.org)
Genetic alterations include genetic mutation, gene copy number variation (CNV), loss of heterozygosity (LOH), allelic imbalance (AI) and microsatellite instability (MSI). (spandidos-publications.com)
They underlie genetic disease in roughly 15% of patients with multiple congenital abnormalities and/or mental retardation (MCA/MR). In genetic diagnostics, the pathogenicity of chromosomal aberrations in these patients is typically assessed based on criteria such as phenotypic similarity to other patients with the same or overlapping aberration, absence in healthy individuals, de novo occurrence, and protein coding gene content. (biomedcentral.com)
Mosaic) aneuploidies and chromosomal rearrangements are a frequent cause of idiopathic MCA/MR. Starting in 1959 with the identification of trisomy-21 as the genetic basis of Down syndrome [ 10 ], microscopic observation of metaphase chromosomes has for several decades been the method of choice for detecting chromosome abnormalities in MCA/MR patients. (biomedcentral.com)
Characterization of the chromosomal rearrangements shown in Figure 1 also revealed that two genetic elements (proximal and distal MES [maintenance elements for silencing]), about 70 kb apart in the Scr gene, must be in cis to maintain proper repression. (nih.gov)
Ploidy and MYCN amplification have been used as genetic markers for risk stratification and therapeutic decision making, and, more recently, gene expression profiling and genome-wide DNA copy number analysis have come into the picture as sensitive and specific tools for assessing prognosis. (biomedcentral.com)
The applica tion of new genetic tools also led to the discovery of an important familial neuroblastoma cancer gene, ALK , which is mutated in approximately 8% of sporadic tumors, and genome-wide association studies have unveiled loci with risk alleles for neuroblastoma development. (biomedcentral.com)

One basic problem is how a decrease in tRNA levels, by downregulating Pol III efficiency, influences the expression pattern of protein-coding genes. (mdpi.com)
Phenotypic analysis of these ' in locus ' mutations based on both expression of Kni protein and adult wing phenotypes, reveals novel unexpected features of L2-CRM function including evidence for a chromosome pairing-dependent process that promotes transcription. (elifesciences.org)
This gene encodes a protein with protease activity and is expressed in the placenta. (cancerindex.org)
What does this gene/protein do? (cancerindex.org)
With GABA we observed a decrease in affinity and conformational rearrangements compatible with a less compact nucleo-protein complex but no changes of the DNA bending angle. (unipr.it)
The transcription initiation TFIID complex is composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs). (embl-heidelberg.de)
The human eight twenty-one (ETO, MTG8 or CBFA2T1) and related myeloid transforming gene products MTGR1 and MTG16 as well as the Nervy protein contain the NHR1-4 domains. (embl-heidelberg.de)
One of the few antigens against which mammals develop protective immunity is the highly polymorphic OspC protein, encoded by the ospC gene on the cp26 plasmid. (cdc.gov)
By means of DNA sequencing of a large sample collection of the pathogen from across the United States, we studied the gene for the bacterium's highly diverse OspC protein, protective immunity against which develops in animals. (cdc.gov)
Although these systems aren't known completely, research survey that appearance of cyst encoding protein and genes is normally upregulated, like the Wnt/-catenin pathway functionally. (globaltechbiz.com)

In this study, by characterization of the dominant maize mutant Barren inflorescence3 ( Bif3 ) we identified a tandem-duplicated copy of ZmWUS1 whose expression is dramatically enhanced by the insertion of a short stretch of chimeric proximal promoter sequence. (nature.com)
Reverse sequence analysis showed that the MLLT1 gene was fused to the 16p11.2 region. (cancerindex.org)
Reverse transcription seater auto-encoding an integrase, the integrated portion of the integrated portion has a fixed length forward repair, indicating that the integrated enzyme can distract the target sequence, and the target sequence is multiplied by replication. (techintroduce.com)

In the CZ, WUS activates the CLV3 gene, encoding a short signaling peptide perceived by a series of leucine-rich repeat (LRR)-receptor-like complexes, among which are complexes containing CLV1 and CLV2. (nature.com)

It is therefore included in the bHLHZ family of transcription factors. (wikipedia.org)
Overexpression of ZmWUS1-B is due to multimerized binding sites for type-B RESPONSE REGULATORs (RRs), key transcription factors in cytokinin signaling. (nature.com)
The knirps ( kni ) locus encodes transcription factors required for induction of the L2 wing vein in Drosophila . (elifesciences.org)
Subdomains of the B region (B1 to B5) can be recognised based on differential interactions with various transcription factors. (i-sis.org.uk)
GH17J043079 showed histone activity in human embryonic stem cells, cancerous cells, housed transcription factors specific to liver cells and was enriched with Alu elements, indicative of ability for potential gene rearrangements. (fortuneonline.org)
Discussion at the Vancouver meeting spanned several areas of research, including signaling pathway activation of EMT and the transcription factors and gene targets involved. (rupress.org)
Any of the processes by which cytoplasmic or intercellular factors influence the differential control of gene action in bacteria. (lookformedical.com)
Genes mainly involved in coding adhesion molecules and growth factors have also been found to be upregulated in other types of CAFs, including colon ( 12 ) and pancreatic ( 13 ). (spandidos-publications.com)
In general, ACEs act as conduits for transcription factors, which in turn recruit enzymes that covalently modify or remodel nucleosomes. (wustl.edu)
The interplay between these two transcription factors mainly regulates the expression of PCWDEs. (tuwien.at)
First, the gain of transcription factors-binding site (TF-binding site) which is exemplified with the promoter of TERT or the telomerase reverse transcriptase, the catalytic subunit of telomerase. (cd-genomics.com)
General Significance: Characterization of the GabR DNA binding mode highlights the key role of DNA bending and interactions with bases outside the canonical direct repeats, and might be of general relevance for the action mechanism of MocR transcription factors. (unipr.it)
These genes comprise 289 Transcription Factors (TFs) representing Basic Helix-loop Helix (bHLH), Ethylene Response Factors (ERFs), myeloblastosis (MYB), No apical meristem (NAC), and WRKY amino acid motif (WRKY) type major families known to be involved in the mechanism of stress tolerance. (frontiersin.org)
While these transgenic assays have been important in defining the structure of the cis -regulatory elements and identifying trans -acting factors that bind to them, their functions within the context of the endogenous genes remain poorly understood. (nih.gov)
Cooperative activity of GR with other transcription factors and a plethora of coregulators contribute to the tissue- and context-specific response toward the endogenous and pharmacological glucocorticoids (GCs). (uni-ulm.de)

1q23.1 homozygous deletion and downregulation of Fc receptor-like family genes confer poor prognosis in chronic lymphocytic leukemia. (cancerindex.org)

Here we use a well-known human tumor suppressor gene, Breast Cancer Type 1 ( BRCA1 ) and UCSC human genome browser database to report the in-silico putative cis regulatory enhancer element and its features. (fortuneonline.org)
Screening of 288 OS and 1,090 tumors of other types revealed evidence for TP53 rearrangements in 46 (16%) OS, while none were detected in other tumor types, indicating this rearrangement to be highly specific to OS. (oncotarget.com)

The AML1-CBFbeta transcription factor complex is essential for the definitive hematopoiesis of all lineages and is the most frequent target of chromosomal rearrangements in human leukemia. (embl-heidelberg.de)

WUS is a homeodomain transcription factor (TF) produced in the organizing center (OC) domain of apical meristems and is transported via plasmodesmata into the apical domain (called central zone, CZ) to promote proliferation of stem cells 3 . (nature.com)

MAX (also known as myc-associated factor X) is a gene that in humans encodes the MAX transcription factor. (wikipedia.org)
The prostaglandin-endoperoxide synthase 2 gene (PTGS2), which encodes cyclooxygenase-2, was found to upregulate the expression of TGF-β2 ( 14 ). (spandidos-publications.com)

There are three domains in the promoter, the core promoter containing the TATA box (-46 to +8), and two other major domains with enhancer functions. (i-sis.org.uk)
We report a 2kb double elite enhancer, GH17J043079 located within intron 12 of the BRCA1 gene. (fortuneonline.org)
The enhancer interacts with NBR1, NBR2, TMEM106A and RPL27 and VAT1 gene promoters. (fortuneonline.org)
The enhancer is not only able to activate transcription of the Scr promoter that is 35 kb distant but can also activate transcription of the Scr promoter on the homologous chromosome. (nih.gov)
Although the imaginal leg enhancer can activate transcription in all three pairs of legs, it is normally silenced in the second and third pairs of legs. (nih.gov)
Indeed, for sever- with histopathological findings and ulin heavy chain promoter/enhancer. (who.int)

If germline transcription is required only for opening the chromatin locus of S areas, a minimal level of transcription may be adequate and quantitative increment of transcription would not impact. (roma2024.com)
Chromatin also regulates Pol I transcription, although its mechanistic details are less understood. (asm.org)
Active and silent rDNAs have distinct chromatin states at the promoter and within the transcribed region. (asm.org)

Transcription occurs from a nonintegrated, circular minichromosome in the nucleus of the plant cell, and virion DNA is synthesised in the cytoplasm by reverse transcription of the 35S RNA transcript (4, 5). (i-sis.org.uk)
The biosynthesis of DNA from an RNA template is called REVERSE TRANSCRIPTION. (lookformedical.com)
Furthermore, reverse transcription‑quantitative PCR was used to examine the expression levels of circular RNA‑PVT1 (circ‑PVT1), micoRNA‑195‑5p (miR‑195‑5p) and ETS1 in GC tissues and cells. (spandidos-publications.com)
transcription of genes or reverse transcription. (techintroduce.com)

Recently, recurrent genomic rearrangements in intron 1 of TP53 have been described in osteosarcoma (OS), a highly malignant neoplasm of bone belonging to the spectrum of LFS tumors. (oncotarget.com)
ETS genes are targeted through genomic rearrangements in oncogenesis. (ox.ac.uk)

SIGNIFICANCE: The demonstration that a somatic point mutation tips the balance of genome-binding pattern provides a mechanistic paradigm for how missense mutations in transcription factor genes may be oncogenic in human tumors.This article is highlighted in the In This Issue feature, p. 681. (ox.ac.uk)

All organisms-bacteria, archaea, and eukaryotes-have a transcription initiation factor that contains a structural module that binds within the RNA polymerase (RNAP) active-center cleft and interacts with template-strand single-stranded DNA (ssDNA) in the immediate vicinity of the RNAP active center. (osti.gov)

It was demonstrated that the BRG1 product regulates the expression of Max through direct recruitment to the Max promoter region, and that depletion of BRG1 strongly hinders cell growth, specifically in Max-deficient cells, suggesting that the two together cause synthetic lethality. (wikipedia.org)
used genome editing to make mutations in a stretch of DNA that regulates the gene involved in wing vein formation. (elifesciences.org)
Regulates the activity of cellular genes, including c-myc and c-fos (By similarity). (proteopedia.org)

The effects of these mutations unexpectedly suggested that pairs of chromosomes might be interacting to control the activity of this gene. (elifesciences.org)
The PU.1/SPI1 gene is inactivated by point mutations in human myeloid malignancies. (ox.ac.uk)
There are studies conducted recently which reported the recurrent mutations in the TERT promoter in different cancer types. (cd-genomics.com)

Over time, OspC genes were transferred between strains through recombinations involving the whole or parts of the gene and one or both flanks. (cdc.gov)
We identified 26 Shigella flexneri serotype 2 strains isolated by public health laboratories in the United States during 2001-2013, which encode the Shiga toxin 1a gene ( stx 1a ). (cdc.gov)
Inoculation with a high dose strains of LMP1 transgenic mice vide a powerful tool in mechanistic of EBV caused a B-cell lymphopro- were established that express LMP1 studies on the role of individual viral liferative disorder in these mice, under the control of the immunoglob- genes in cancer. (who.int)

That AsiA induces, rather than merely stabilizes, this rearrangement can be realized by comparison to the homologous structures of region 4 solved in a variety of contexts, including the structure of Thermotoga maritima sigmaA region 4 described herein. (rcsb.org)
When not physically linked, the elements interact with elements on the homologous chromosome and cause derepression of its wild-type Scr gene. (nih.gov)
the toxin genes were determined to be carried by a lambdoid prophage homologous to stx -encoding phages found in STEC ( 13 ). (cdc.gov)

We describe the clinical and molecular features of a child who presented with a large abdominal mass, AML, and a new CK, involving chromosomes 11, 16, and 19 leading to a KMT2A-MLLT1 fusion and 2 extra copies of the ELL gene, thus resulting in the concurrent overexpression of MLLT1 and ELL. (cancerindex.org)

In contrast, genes transcribed by Pol II are organized in a more compact, regularly spaced, nucleosomal structure. (asm.org)
In contrast, little information is available about which genes directly respond to a relief from CCR. (biomedcentral.com)
In contrast to the toxin genes in S. dysenteriae 1, those in STEC are generally carried by lambdoid prophages, which integrate into the host bacterial chromosome ( 9 ). (cdc.gov)

Such phenomenon frequently happens in 5' UTR of TMPRss2 and ETS family genes in prostate cancer. (cd-genomics.com)

In the t(8;21) translocation associated with acute myeloid leukemia (AML), the AML1(CBFA2/PEBP2alphaB) gene is juxtaposed to the MTG8(ETO/CDR) gene. (embl-heidelberg.de)

immature cell is then subjected to negative selection to delete grouped based on their previously defined pheno- self-reactive cells before it leaves the BM to enter peripheral typic features, and a gene expression pattern for lymphoid organs, where it becomes a mature B cell [9]. (lu.se)

This transcription initiation-factor structural module preorganizes template-strand ssDNA to engage the RNAP active center, thereby facilitating binding of initiating nucleotides and enabling transcription initiation from initiating mononucleotides. (osti.gov)
However, this transcription initiation-factor structural module occupies the path of nascent RNA and thus presumably must be displaced before or during initial transcription. (osti.gov)
Binds RNA and may function as a RNA chaperone to induce the RNA structural rearrangements taking place during virus replication (PubMed:18033802). (proteopedia.org)
Second, the fusion of active regulatory elements in oncogenes, genes associated with cancer, because of structural rearrangements. (cd-genomics.com)

However, despite its smaller size, most developmental genes and at least half of the disease- and cancer-causing genes in humans are conserved in Drosophila , making Drosophila an excellent model system for the study of human development and disease. (nih.gov)

Moreover, an alternative MTGR1 promoter/5' exon is contained within the alpha1-syntrophin locus. (embl-heidelberg.de)

In most organisms, Pol I exclusively transcribes rRNA genes, of which there are usually 100 to 1,000 copies arranged in tandem. (asm.org)

We show here that the resultant AML1-MTG8 gene product specifically and strongly interacts with an 85-kDa phosphoprotein. (embl-heidelberg.de)

Here we chose to use chemostat cultures on D-glucose as a carbon source at two different growth rates (one repressing and one derepressing [ 16 ]) to investigate the genome-wide changes in gene expression in relation to CRE1 function, using a Δcre1 recombinant mutant strain of T. reesei and corresponding control strain. (biomedcentral.com)

Fusion with the host cell is most likely mediated by both E1 and E2, through conformational rearrangements of the heterodimer required for fusion rather than a classical class II fusion mechanism (PubMed:16533059, PubMed:29505618, PubMed:24698129). (proteopedia.org)

We used a large number of existing chromosomal aberrations in the Scr homeotic gene to investigate the functions of the cis -acting elements within the endogenous gene. (nih.gov)

The coordinated transcription of the genome is the fundamental mechanism in molecular biology. (mdpi.com)
Using whole-genome sequencing of OS, we found features of TP53 intron 1 rearrangements suggesting a unique mechanism correlated with transcription. (oncotarget.com)
The changes in expression of genes involved in regulating the flux of cell wall precursors and starch/sugar content can serve as an adaptive mechanism for soybean survival under stress conditions. (frontiersin.org)
Another signalling mechanism involves high expression of PKC-like genes (21 types) during the process of encystation [48]. (globaltechbiz.com)

Among these are traits that depend on functional meristems, populations of stem cells maintained by the CLAVATA-WUSCHEL (CLV-WUS) negative feedback-loop that controls the expression of the WUS homeobox transcription factor. (nature.com)
In this paper, we report four sets of crystal structures of bacterial initially transcribing complexes that demonstrate and define details of stepwise, RNA-extension-driven displacement of the "σ-finger" of the bacterial transcription initiation factor σ. (osti.gov)
Bacteriophage T4 AsiA is a versatile transcription factor capable of inhibiting host gene expression as an 'anti-sigma' factor while simultaneously promoting gene-specific expression of T4 middle genes in conjunction with T4 MotA. (rcsb.org)
One main factor determining the success of horizontal gene transfer is its tendency to recombine. (i-sis.org.uk)
A Recurrent Activating Missense Mutation in Waldenström Macroglobulinemia Affects the DNA Binding of the ETS Transcription Factor SPI1 and Enhances Proliferation. (ox.ac.uk)
The glucocorticoid receptor (GR) is a bona fide ligand-regulated transcription factor. (uni-ulm.de)

These regulatory elements are poorly conserved, highly heterogenous with limited understanding of their role in gene expression. (fortuneonline.org)
My lab is applying the high-resolution fluorescent imaging methods developed for D. melanogaster to systematically analyze gene expression, and dissect regulatory networks, in other Drosophila species and in several inbred lines of D. melanogaster . (berkeley.edu)
Here, we deciphered the CRE1 regulatory range in the model cellulose and hemicellulose-degrading fungus Trichoderma reesei (anamorph of Hypocrea jecorina ) by profiling transcription in a wild-type and a delta- cre1 mutant strain on glucose at constant growth rates known to repress and de-repress CCR-affected genes. (biomedcentral.com)

The present review summarizes the recent achievements in understanding the gene profiles of CAFs and pays special attention to their possible epigenetic alterations. (spandidos-publications.com)

Aside from that, it has been found out that modifications in ncRNAs or their binding sites can be a signature of cancer since lncRNA MALATI was observed to regulate the expression of genes that are associated with metastasis and upregulated in lung cancer. (cd-genomics.com)

Recent innovations have helped to develop prescription drugs against certain prostate cancer types, showing gene alterations that prevent the repair of damaged DNA or activate the body's anti-cancer natural immune defense. (mdpi.com)
A panel of genes has been identified whose cancer genome alterations may predict whether non-metastatic prostate cancer would go on to metastasize. (mdpi.com)

Activation of CLV3 in the OC is prevented by the action of WUS in conjunction with the GRAS-transcription regulators HAIRY MERISTEMs (HAMs) 4 , 5 . (nature.com)
Gene or gene domains or intense genes with advances into new regulators. (techintroduce.com)

However, the complete list of its gene targets is not known. (biomedcentral.com)

May repress the promoter of p53, and sequester CREB3 and SP110 isoform 3/Sp110b in the cytoplasm (By similarity). (proteopedia.org)

In Drosophila , the homeotic genes specify cell identities at both embryonic and adult stages. (nih.gov)

The target interaction between miR‑195‑5p and circ‑PVT1 or ETS1 was predicted through bioinformatics analysis, and verified by dual‑luciferase reporter gene assay. (spandidos-publications.com)
Using a transgenic assay, we identified at least five DNA fragments from the Scr gene that silence transcription from a reporter gene. (nih.gov)

One of the important groups of conserved developmental genes are the homeotic genes. (nih.gov)

A distinct ZmFCP1-FEA3 ligand-receptor combination, originally identified in maize, prevents WUS gene expression in the region below the OC (also called rib zone, RZ), thus confining WUS expression within the OC of meristems 6 . (nature.com)

More recently the Max gene becomes mutated and becomes inactivated in small cell lung cancer (SCLC). (wikipedia.org)
One of the most powerful technologies that could target specific genes of mutation that are associated with cancer is by using cancer panels that utilize next-generation sequencing approach. (cd-genomics.com)
This has been documented using miRNA sequestration for the BRAF gene which is a gene associated with several cancer types such as breast cancer. (cd-genomics.com)
The activity of these genes may help to guide treatment decision for non-metastatic cancer with the choice for non-aggressive versus debilitating aggressive options. (mdpi.com)

These results are consistent with another study concerning the gene expression profiling of breast CAFs, which were detected using a complementary DNA microarray ( 15 ). (spandidos-publications.com)

Chromosomal mapping by in situ hybridization suggested that the duplicated MBP genes were located closely to each other at the distal part of chromosome 18. (elsevierpure.com)
Finally, we summarize the possible molecular consequences of chromosome aberrations for gene expression and function, and we discuss approaches for identification and unraveling the molecular determinants of congenital disease phenotypes. (biomedcentral.com)
Lateral gene transfers resulted in different linkages between the ospC gene and loci of the chromosome or other plasmids. (cdc.gov)

Thus, a precise characterization of KMT2A-r and the fusion partner genes, especially in CKs, is of interest for managing AML. (cancerindex.org)

Both promoter and intragenic CGIs may also become abnormally methylated as a result of genome rearrangements and in malignancy. (ox.ac.uk)

Anatomy13

Organisms4

Diseases9

Chemicals and Drugs62

Analytical, Diagnostic and Therapeutic Techniques and Equipment21

Phenomena and Processes67

Information Science3

Proteins11

Regulation21

Transcriptional11

Sequences21

Enhancers6

Upstream4

Methylation9

Recombination6

Differentiation7

Target genes3

Regions7

Genetic7

Protein10

Sequence3

Activates1

Factors15

Deletion1

Tumor2

Chromosomal rearrangements1

Homeodomain transcription1

Encodes2

Enhancer6

Chromatin3

Reverse transcription4

Genomic rearrangements2

Tumors1

Polymerase1

Regulates3

Mutations3

Strains3

Homologous3

Chromosomes1

Contrast3

Family genes1

Translocation1

Lymphoid1

Structural4

Humans1

Locus1

RRNA1

Interacts1

Genome-wide1

Conformational rearrangements1

Endogenous1

Mechanism4

Factor6

Regulatory3

Epigenetic1

Regulate1

Prostate Cancer2

Regulators2

Targets1

Repress1

Embryonic1

Reporter gene2

Developmental1

Receptor1

Cancer4

Consistent1

Chromosome3

Characterization1

Intragenic1