AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsInformation Science
Matrix Metalloproteinase 2Matrix Metalloproteinase 9Matrix Metalloproteinase InhibitorsMatrix Metalloproteinase 14Matrix Metalloproteinase 1Matrix Metalloproteinase 3Matrix MetalloproteinasesMetalloendopeptidasesMatrix Metalloproteinase 13Matrix Metalloproteinase 7Matrix Metalloproteinases, Membrane-AssociatedExtracellular MatrixPromoter Regions, GeneticTissue Inhibitor of Metalloproteinase-2Matrix Metalloproteinase 8Matrix Metalloproteinase 12Tissue Inhibitor of Metalloproteinase-1CollagenasesGelatinasesMatrix Metalloproteinase 10Matrix Metalloproteinase 11Tissue Inhibitor of MetalloproteinasesAntigens, CD147MetalloproteasesProtease InhibitorsMatrix Metalloproteinase 15RNA, MessengerMatrix Metalloproteinases, SecretedMatrix Metalloproteinase 16CollagenCells, CulturedMolecular Sequence DataGene Expression Regulation, EnzymologicExtracellular Matrix ProteinsTissue Inhibitor of Metalloproteinase-3Base SequenceMatrix Metalloproteinase 20Enzyme PrecursorsGene Expression RegulationNeoplasm InvasivenessCell MovementReverse Transcriptase Polymerase Chain ReactionADAM ProteinsFibroblastsCell Line, TumorBlotting, WesternTransfectionTranscription, GeneticGelatinMatrix Metalloproteinase 17Cell LineAmino Acid SequenceDNA-Binding ProteinsBinding SitesUp-RegulationEnzyme ActivationImmunohistochemistryTumor Cells, CulturedGene ExpressionPhenylmercuric AcetateCollagen Type IChondrocytesProtein BindingSignal TransductionDipeptidesTranscriptional ActivationCartilage, ArticularHydroxamic AcidsHemopexinThiophenesCloning, MolecularGenes, ReporterRecombinant ProteinsMice, Inbred C57BLNuclear MatrixSynovial MembraneDisease Models, AnimalProteoglycansEnzyme InhibitorsDNA PrimersOsteoarthritisDoxycyclinePlasmidsSp1 Transcription FactorGene Expression Regulation, NeoplasticMice, KnockoutDown-RegulationMutationFibronectinsEnzyme InductionProcollagen N-EndopeptidaseCartilageTime FactorsTranscription FactorsAggrecansDNALamininCell ProliferationBone MatrixCulture Media, Conditioned
MMPsExtracellularInhibitorGenes2016GenotypeConnective tissueTranscriptionalRac1MRNA levelsMMP1ProteinsApoptosisVitroMMP2MetastasisPolymorphismsInhibitsEnhancerProgressionEnzymesEndothelialFibrosisInvasionRegulationMetastaticPolymorphismSubstrateFragmentGene expressionHuman matrixDeletionPancreasImmune responseActivityActivationCancerZincMalignantCellsAngiogenesisAcademy
MMPs13
  • Matrix metalloproteinases (MMPs) are enzymes capable of breaking down various connective tissue elements. (scite.ai)
  • This study aims to explore the association between the single-nucleotide polymorphisms (SNPs) of genes encoding ECM processing enzymes (a disintegrin and metalloproteinase with thrombospondin motifs [ADAMTSs]), ECM degrading enzymes (matrix metalloproteinases [MMPs]) and their tissue inhibitors of metalloproteinase (TIMPs), and POP. (scite.ai)
  • Matrix metalloproteinases (MMPs) are a family of zinc-dependent proteinases that are capable of cleaving all extra cellular matrix (ECM) substrates. (biomedcentral.com)
  • It might have an important polymorphic association at the promoter regions of several MMPs such as MMP-1 (-1607 1G/2G), MMP-2 (-1306 C/T), MMP-3 (-1171 5A/6A), MMP-9 (-1562 C/T) and TIMP-2 (-418 G/C or C/C). Tissue inhibitors of metalloproteinases (TIMPs) are naturally occurring inhibitors of MMPs, which inhibit the activity of MMPs and control the breakdown of ECM. (biomedcentral.com)
  • Tissue inhibitors of matrix metallo-proteinases (TIMPs) are known to have the ability to inhibit the catalytic activity of MMPs. (biomedcentral.com)
  • Turpeenniemi-Hujanen et al suggested that the expressions of matrix expression of MMPs as well as their tissue inhibitors the TIMPs are associated with the clinical behaviour in head and neck malignancy [ 12 ]. (biomedcentral.com)
  • The active forms of all of the matrix metalloproteinases (MMPs) are inhibited by a family of specific inhibitors, the tissue inhibitors of metalloproteinases (TIMPs). (uea.ac.uk)
  • The underlying mechanisms of matrix destruction in TB remain poorly understood but consideration of the lung extracellular matrix predicts that matrix metalloproteinases (MMPs) will play a central role, owing to their unique ability to degrade fibrillar collagens and other matrix components. (ersjournals.com)
  • Since we proposed the concept of a matrix degrading phenotype in TB a decade ago, diverse data implicating MMPs as key mediators in TB pathology have accumulated. (ersjournals.com)
  • Triptolide treatment inhibited the expression of tumor promoter Cav-1 and reduced CD147 and MMPs activities at both mRNA and protein levels. (nih.gov)
  • This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). (cancerindex.org)
  • Matrix metalloproteinases (MMPs) have been considered to be associated with tumor progression or poor prognosis. (cancerindex.org)
  • Invasion- and migration-related substances, such as for example matrix metalloproteinases (MMPs), and S100A10 are dysregulated in a variety of cancers cell lines [49C51]. (geogise.com)
Extracellular15
  • which are all enrolled in extracellular matrix (ECM) pathways. (scite.ai)
  • Introduction and hypothesis Extracellular matrix (ECM) synthesis and metabolism abnormalities may influence the pelvic supporting system and lead to the occurrence and development of pelvic organ prolapse (POP). (scite.ai)
  • Whereas intracellular MMP-12 mediates NFKBIA transcription, leading to IFN-α secretion and host protection, extracellular MMP-12 cleaves off the IFN-α receptor 2 binding site of systemic IFN-α, preventing an unchecked immune response. (nih.gov)
  • These findings suggest that inhibiting extracellular MMP-12 could be a new avenue for the development of antiviral treatments. (nih.gov)
  • Lung extracellular matrix destruction is essential to TB transmission and consequently of critical importance to the global success of Mtb. (ersjournals.com)
  • The mechanism whereby Mtb targets the lung apices is unknown, but once it reaches the lung interstititum, breakdown of the extracellular matrix must occur for the pathogen to disseminate via the airways. (ersjournals.com)
  • TGFβ is a pleiotropic cytokine that regulates cell proliferation, contributes to epithelial-to-mesenchymal transition (EMT), suppresses the function of immune cells compromising immune response, contributes to the conversion of fibroblasts to myofibroblasts and causes overproduction of extracellular matrix (ECM) in tissues undergoing fibrosis. (researchsquare.com)
  • Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. (cancerindex.org)
  • It is a 40-kDa cysteine-rich heparin-binding protein that either localizes intracellularly or is usually secreted into the extracellular milieu where it associates with the extracellular matrix and cell surfaces (27 28 Here we demonstrate that inhibits Helicid tumor growth and metastasis decreases angiogenesis and induces apoptosis of melanoma cells as a tumor suppressor in. (antiviralbiologic.com)
  • To look for the function of BRG1 in regulating the appearance of genes involved with melanoma metastasis we portrayed BRG1 within a melanoma cell series that does not have BRG1 appearance and examined adjustments in extracellular matrix and adhesion molecule appearance. (techblessing.com)
  • We discovered that BRG1 modulated the appearance of the subset of extracellular matrix remodeling adhesion and enzymes protein. (techblessing.com)
  • BRG1 altered melanoma adhesion to different extracellular matrix elements Furthermore. (techblessing.com)
  • The development from an initial tumor to metastatic melanoma is normally a multistep procedure which involves detachment from the principal tumor mass invasion in to the dermis migration through the extracellular matrix (ECM) PKC 412 and vasculature and colonization of faraway sites [5 6 Each one of these steps consists of cytoskeletal alterations aswell as adjustments in the tumor cell's connections with neighboring cells and with the ECM [7]. (techblessing.com)
  • and ( 3 ) ineffective repair of elastic fibers and perhaps other extracellular matrix components. (atsjournals.org)
  • Defining the cells and proteinases responsible for destruction of lung extracellular matrix associated with cigarette smoking will be required for development of appropriate proteinase inhibitors for application in COPD. (atsjournals.org)
Inhibitor5
  • Consistent with an unexpected role for MMP-12 in clearing systemic IFN-α, treatment of coxsackievirus type B3-infected wild-type mice with a membrane-impermeable MMP-12 inhibitor elevates systemic IFN-α levels and reduces viral replication in pancreas while sparing intracellular MMP-12. (nih.gov)
  • MiR-21 promoted invasion of fibroblasts by down-regulation of tissue inhibitor of metalloproteinase 3 (TIMP3) expression and increasing of matrix metalloprotein (MMP) expression in fibroblast cells via melanoma-derived exosomes in a time-dependent manner. (dovepress.com)
  • 10 High expression of miR-21 in melanoma cells inhibits mRNA expression of crucial tumor suppressor proteins such as the tissue inhibitor of metalloproteinases 3 (TIMP3). (dovepress.com)
  • In human PTE, hypoxia (1%02, 24hrs) increased total collagen production, decreased MMP-2 actvity and increased Tissue Inhibitor of Metalloproteinase-1 (TIMP-1) protein. (ucl.ac.uk)
  • Western blotting was performed to detect the protein levels of cyclin‑dependent kinase inhibitor P21 (P21), B‑cell lymphoma‑2 (Bcl‑2), matrix metalloproteinase 9 (MMP9) and E26 oncogene homolog 1 (ETS1). (spandidos-publications.com)
Genes5
  • To date, polymorphisms of the promoter domain have been described in MMP-1, -3, -9, -12 to influence the expression level of the genes [ 10 ]. (biomedcentral.com)
  • Genes, chromosomes & cancer 2018 8 57 (12): 653-664. (cdc.gov)
  • En ese sentido, existe un creciente enfoque en la identificación de genes, polimorfismos genéticos asociados y loci de susceptibilidad múltiples. (scielo.br)
  • La presente revisión destaca los genes y polimorfismos genéticos actualmente estudiados, identificados como influyentes en la génesis de la EI, como los genes MMP-3, IL-6, colágeno tipo 1 y receptores de vitamina D y de estrógeno. (scielo.br)
  • Transient-transfection experiments demonstrated that collagen [alpha]1(1) promoter activity is stimulated by hypoxia and that this effect is independent of HIF-1, the transcription factor which regulates transcription in many hypoxia-responsive genes. (ucl.ac.uk)
20161
Genotype2
Connective tissue2
  • Transient transfection of promoter-chloramphenicol O-acetyltransferase reporter constructs into primary human connective tissue fibroblasts shows that a 904 bp fragment that hybridizes to a murine TIMP-1 promoter fragment contains a functional promoter. (uea.ac.uk)
  • Woessner JF Jr.. Matrix metalloproteinases and their inhibitors in connective tissue remodeling. (biocancer.com)
Transcriptional3
  • A 5A type promoter at -1171 bp site of MMP-3 is also known to have a twofold higher transcriptional activity in vitro than that of a 6A type [ 12 ]. (biomedcentral.com)
  • There is evidence that circRNAs are specifically expressed in hematological malignancies or certain developmental stages, indicating that circRNAs have considerable regulatory potential by serving as post-transcriptional regulators ( 11 , 12 ). (spandidos-publications.com)
  • Our aim is to investigate the role of histone methylation (H3K9me3) of Rac1 promoter in dynamic DNA methylation- transcriptional activation. (nature.com)
Rac13
  • Using human retinal endothelial cells in 20 mM D-glucose, H3K9me3 at Rac1 promoter was quantified by chromatin-Immunoprecipitation technique. (nature.com)
  • Compared to cells in normal glucose, high glucose increased H3K9me3 and Suv39H1 binding at Rac1 promoter, and Suv39H1 -siRNA prevented glucose-induced increase 5 hydroxy methyl cytosine (5hmC) and Rac1 mRNA. (nature.com)
  • Thus, H3K9me3 at Rac1 promoter assists in active DNA methylation-hydroxymethylation, activating Rac1 transcription. (nature.com)
MRNA levels1
MMP11
  • Matrix metalloproteinase 1(MMP1), which was downregulated in myelodysplastic syndromes (MDS)-mesenchymal stromal cells (MSCs), was identified as an inhibitory factor of MDS cell proliferation. (cusabio.com)
Proteins2
  • It constitutes fibrous proteins such as collagen and elastin, elongated glycoproteins such as fibronectin and laminin, which provide cell matrix adhesion. (biomedcentral.com)
  • General, our outcomes demonstrate the effectiveness of MI-773 such an instant testing for the recognition of significant developmental ramifications of EDCs promoter travel the manifestation of improved green fluorescent proteins (EGFP) in every arteries throughout embryogenesis [25]. (thetechnoant.info)
Apoptosis3
  • KLFs regulate a wide range of cellular functions, including cell proliferation, apoptosis, differentiation, and neoplastic transformation, by binding to GC-rich promoter regions [ 1 , 2 ]. (medsci.org)
  • Indeed expression of a dominant-negative form of CREB (KCREB) in metastatic melanoma cells sensitizes them to thapsigargin-induced apoptosis (12). (antiviralbiologic.com)
  • Peng and Zhang ( 8 ) indicated that propofol inhibited proliferation, but induced apoptosis of SGC-7901 cells by regulating matrix metalloproteinase (MMP)2 ( 8 ). (spandidos-publications.com)
Vitro2
  • The effects of hypoxia on PTE matrix synthesis and degradation were examined using an in vitro model. (ucl.ac.uk)
  • In summary, this thesis demonstrates that hypoxia is a pro-fibrogenic stimulus for PTE in vitro simultaneously increasing matrix production and decreasing turnover. (ucl.ac.uk)
MMP23
  • We discovered that BRG1 is normally recruited towards PKC 412 the MMP2 promoter and straight activates appearance of the metastasis linked gene. (techblessing.com)
  • Previous studies in human cancers revealed an unrecognized interplay between Angiogenin (ANG) and matrix metalloproteinase-2 (MMP2) leading to pronounced tumorigenesis. (oncotarget.com)
  • Mechanistically, ANG negatively regulated DNA methyltransferase 3b (DNMT3b) enzymatic activity by down-regulating its expression and inhibiting its recruitment to the MMP2 promoter. (oncotarget.com)
Metastasis3
  • Degradation of matrix is a key event in progression, invasion and metastasis of potentially malignant and malignant lesions of the head and neck. (biomedcentral.com)
  • Degeneration of matrix is a key event in invasion and metastasis of malignant lesions of the head and neck. (biomedcentral.com)
  • 11 This results in increased matrix metalloproteinase activity, playing a pivotal role in the process of invasion and metastasis. (dovepress.com)
Polymorphisms2
  • This study examines the association of single nucleotide polymorphisms in promoter regions of MMP-1 and MMP-3 with susceptibility to oral squamous cell carcinoma (OSCC). (biomedcentral.com)
  • Polymorphisms of osteoprotegerin were found in promoter region -950T/C but there was no significance (p=1.000). (bvsalud.org)
Inhibits3
  • We found that apigenin markedly inhibits the phorbol-12-myristate-13-acetate (PMA)-induced increase in MMP-9 expression and activity in several cancer cell lines. (spandidos-publications.com)
  • Previous studies have shown that by inhibiting histone H3 deacetylation round the let-7f-2/miR-98 promoter, HDAC10 suppresses HMGA2 expression which target to CP-640186 cyclin A2 promoter, and further inhibits the transcription of cyclin A2 [30,36]. (geogise.com)
  • Data suggest that matrix metalloproteinase-1 and neutrophil elastase may be important but heretofore unrecognized players in stimulating uterine contractions at the time of labor, and they may explain why indomethacin delays, but does not prevent, preterm labor because indomethacin inhibits the prostaglandin component but not the protease component of labor. (cusabio.com)
Enhancer1
  • Computer analysis reveals 10 consensus sequences for Sp1, six for activating protein 1 (AP-1), six for polyoma enhancer A3 (PEA3), 12 for AP-2 and five CCAAT boxes. (uea.ac.uk)
Progression2
  • Egeblad M, Werb Z.. New functions for the matrix metalloproteinases in cancer progression. (biocancer.com)
  • Evidence suggests that both cell cycle inhibitors (such as P21 and P27) and promoters (such as cyclins E1 and D1) play a vital role in malignancy progression [37C39]. (geogise.com)
Enzymes1
  • Epigenetic legislation of gene appearance often involves adjustments in chromatin framework that are catalyzed by chromatin redecorating enzymes [11 12 Two classes of enzymes remodel chromatin framework by catalyzing covalent histone adjustments or by hydrolyzing ATP to mobilize nucleosomes [13]. (techblessing.com)
Endothelial2
  • mRNA appearance by binding c-Jun to its promoter and JNK3 marketed endothelial cell migration for angiogenesis [18]. (cancerhugs.com)
  • 80] further demonstrated that JNK mediated Indibulin Egr-1 for migration and proliferation, and matrix metalloproteinase-2 (MMP-2) and membrane type-1 (MT1)-MMP for proteolysis in endothelial cells. (cancerhugs.com)
Fibrosis2
  • [ 12 ] but their addition to areca nut chewing can be a risk for oral submucous fibrosis. (medscape.com)
  • [ 12 ] Commercially freeze-dried products such as pan masala, guthka, and mawa have higher concentrations of areca nut per chew and appear to cause oral submucous fibrosis more rapidly than self-prepared conventional betel quid, which contains smaller amounts of areca nut. (medscape.com)
Invasion2
  • Release of an invasion promoter E-cadherin fragment by matrilysin and stromelysin-1. (biocancer.com)
  • Regulation of matrix metalloproteinase expression in tumor invasion. (biocancer.com)
Regulation3
  • This suggests an alternative mechanism for regulation of the collagen [alpha]1(1) promoter by hypoxia. (ucl.ac.uk)
  • van Wart HE, Birkedal-Hansen H.. The cysteine switch: a principle of regulation of metalloproteinase activity with potential applicability to the entire matrix metalloproteinase gene family. (biocancer.com)
  • Taken together, these observations suggest a role of matrix metalloproteinases in the establishment of asymmetric organ development, likely through the regulation of morphogenetic signals. (bmj.com)
Metastatic1
  • Matrix metalloproteinase-12 expression correlates with local recurrence and metastatic disease in non-small cell lung cancer patients. (findmedarticle.com)
Polymorphism2
  • A 2G type of single nucleotide polymorphism (SNP) at -1607 bp site in the promoter domain of MMP-1 creates a sequence, 5'-GGA-3,' that is the core recognition sequence of the binding site for Ets family transcription factors. (biomedcentral.com)
  • The aim of this paper was to analyze the presence of polymorphism in the promoter region T/C950 of the osteoprotegerin gene and its distribution in diabetic patients with periodontitis, when compared to the control group. (bvsalud.org)
Substrate2
  • We also identified dual-regulated substrates that are repressed both by MMP-12 binding to the substrate's gene exons and by MMP-12-mediated cleavage of the substrate protein itself. (nih.gov)
  • Nagase H, Ogata Y, Suzuki K, Enghild JJ, Salvesen G.. Substrate specificities and activation mechanisms of matrix metalloproteinases. (biocancer.com)
Fragment1
  • The region hybridizing with a murine TIMP-1 promoter fragment has been subcloned and analysed further. (uea.ac.uk)
Gene expression2
Human matrix1
  • Molecular Cloning and Expression of Collagenase-3, a Novel Human Matrix Metalloproteinase Produced by Breast Carcinomas. (biocancer.com)
Deletion1
  • Results We identified a homozygous 2 bp deletion in MMP21, encoding matrix metalloproteinase-21, as the sole coding mutation that segregated with the phenotype. (bmj.com)
Pancreas1
Immune response1
  • Once implanted at the apex, Mtb must engage the host immune response to drive matrix destruction, resulting in cavities within which it proliferates exponentially. (ersjournals.com)
Activity1
  • PMA caused about a 5-fold induction in MMP-9 promoter activity, which was also suppressed by apigenin treatment in Caski cells. (spandidos-publications.com)
Activation3
  • Structure of human pro-matrix metalloproteinase-2: activation mechanism revealed. (biocancer.com)
  • Activation of metalloproteinase (MMP) 2 appearance greatly contributed towards the BRG1 induced upsurge in melanoma invasiveness. (techblessing.com)
  • At the same time, the IFN- γ also participates in the activation of macrophages in the inflammatory response of IDD and jointly affects the immune microenvironment of IDD [ 12 ]. (hindawi.com)
Cancer2
  • Matrix metalloproteinase ( MMP ) is known to be involved in the initial and progressive stages of cancer development, and in the aggressive phenotypes of cancer. (biomedcentral.com)
  • Matrix metalloproteinase inhibitors and cancer: trials and tribulations. (biocancer.com)
Zinc1
  • Matrix metalloproteinase are a family of zinc dependent endopeptidases that are capable of degrading most components of the extra cellular matrix (ECM) [ 7 - 9 ]. (biomedcentral.com)
Malignant1
  • 7 It has been shown that miR-21 is a promoter of oncogenes and is highly expressed in several malignant tumors. (dovepress.com)
Cells4
  • Interferon-α (IFN-α) is essential for antiviral immunity, but in the absence of matrix metalloproteinase-12 (MMP-12) or IκBα (encoded by NFKBIA) we show that IFN-α is retained in the cytosol of virus-infected cells and is not secreted. (nih.gov)
  • We show here that after macrophage secretion, MMP-12 is transported into virus-infected cells. (nih.gov)
  • In HeLa cells MMP-12 is also translocated to the nucleus, where it binds to the NFKBIA promoter, driving transcription. (nih.gov)
  • Stem Cells 32(1):301-12, 2014. (mdanderson.org)
Angiogenesis1
  • It is influenced by angiogenesis, cell-cell and cell-extra cellular matrix (ECM) interactions. (biomedcentral.com)
Academy1
  • Journal of the European Academy of Dermatology and Venereology : JEADV 2014 Dec 28 (12): 1732-7. (cdc.gov)