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  • succinate
  • Procollagen-proline dioxygenase catalyzes the following reaction: procollagen L-proline + 2-oxoglutarate + O2 → (2S, 4R)-4-hydroxyproline + succinate + CO2 The mechanism for the reaction is similar to that of other dioxygenases, and occurs in two distinct stages: In the first, a highly reactive Fe(IV)=O species is produced. (wikipedia.org)
  • tRNA
  • Other names in common use include prolyl-tRNA synthetase, prolyl-transferRNA synthetase, prolyl-transfer ribonucleate synthetase, proline translase, prolyl-transfer ribonucleic acid synthetase, prolyl-s-RNA synthetase, and prolinyl-tRNA ligase. (wikipedia.org)
  • catalytic
  • The induction of stress either by glucose withdrawal or by treatment with rapamycin, stimulated degradation of proline and increased PRODH catalytic activity. (wikipedia.org)
  • The catalytic mechanism of proline racemase was late revisited by Buschiazzo, Goytia and collaborators that, in 2006, resolved the structure of the parasite TcPRAC co-crystallyzed with its known competitive inhibitor - pyrrole carboxylic acid (PYC). (wikipedia.org)
  • Mechanism
  • This degradative pathway generates glutamate and alpha-ketoglutarate, products that can play an anaplerotic role for the TCA cycle.The proline cycle is also in a metabolic interlock with the pentose phosphate pathway providing another bioenergetic mechanism. (wikipedia.org)
  • Therefore, the induction of the proline cycle under conditions of nutrient stress may be a mechanism by which cells switch to a catabolic mode for maintaining cellular energy levels. (wikipedia.org)
  • commonly
  • however, proline is commonly found as the first residue of an alpha helix and also in the edge strands of beta sheets. (wikipedia.org)
  • Proline is also commonly found in turns (another kind of secondary structure), and aids in the formation of beta turns. (wikipedia.org)
  • hydroxyproline
  • Based on those elements, enzymes incorrectly described as proline racemases were biochemically proved to be hydroxyproline epimerases (i.e. (wikipedia.org)
  • The second stage involves the abstraction of the pro-R hydrogen atom from C-4 of the proline substrate followed by radical combination, which yields hydroxyproline. (wikipedia.org)
  • rich
  • Known aliases for PRR12 include "proline rich 12" and KIAA1205. (wikipedia.org)
  • One study on the Epstein-Barr virus found close homology between a proline rich region in PRR12 and a 65 amino acid long region at the terminal end of EBNA-2 (a nuclear antigen of the virus). (wikipedia.org)
  • novel
  • Novel proline racemases of medical and veterinary importance were described respectively in Clostridium difficile (Q17ZY4) and Trypanosoma vivax (B8LFE4). (wikipedia.org)
  • Detection of Novel Proline 3-Hydroxylase Activities in Streptomyces and Bacillus spp. (wikipedia.org)
  • brand
  • ProLine is a range of own brand electronic products made by Darty plc for BCC in the Netherlands, Darty in France and Vandenborre in Belgium. (wikipedia.org)
  • guitar
  • Proline offers a huge selection of guitar parts, all made with top-quality components, for today's most popular guitars. (musiciansfriend.com)
  • Whether you're looking to replace a part or jazz up your guitar, ProLine probably has the part you're looking for, at an affordable price. (musiciansfriend.com)
  • transition
  • The zwitterionic character and the H-bonding of proline in the transition state plays an important role in explaining the reaction outcome. (wikipedia.org)
  • An enamine transition state is formed during the reaction and only one proline molecule is involved in forming the transition state. (wikipedia.org)
  • Proline racemase is inhibited by pyrrole-2-carboxylic acid, a transition state analogue that is flat like the transition state. (wikipedia.org)
  • active site
  • The proline racemase active site contains two general bases, each of them a Cys, located on either side of the alpha-carbon of the substrate. (wikipedia.org)
  • offers
  • The ProLine offers premium high quality plastic blades, steel blades and steel discs with long life and high wear resistance for optimal performance. (atlascopco.com)
  • form
  • This can then either spontaneously cyclize to form 1-pyrroline-5-carboxylic acid, which is reduced to proline by pyrroline-5-carboxylate reductase (using NADH or NADPH), or turned into ornithine by ornithine aminotransferase, followed by cyclisation by ornithine cyclodeaminase to form proline. (wikipedia.org)
  • chain
  • This may account for the curious fact that proline is usually solvent-exposed, despite having a completely aliphatic side chain. (wikipedia.org)
  • role
  • At the present moment Proline Film Studio is working on two movies: «Arventur» by Irina Yevteeva and «The Role» by Konstantin Lopushansky. (wikipedia.org)