• succinate
  • Procollagen-proline dioxygenase catalyzes the following reaction: procollagen L-proline + 2-oxoglutarate + O2 → (2S, 4R)-4-hydroxyproline + succinate + CO2 The mechanism for the reaction is similar to that of other dioxygenases, and occurs in two distinct stages: In the first, a highly reactive Fe(IV)=O species is produced. (wikipedia.org)
  • tRNA
  • Other names in common use include prolyl-tRNA synthetase, prolyl-transferRNA synthetase, prolyl-transfer ribonucleate synthetase, proline translase, prolyl-transfer ribonucleic acid synthetase, prolyl-s-RNA synthetase, and prolinyl-tRNA ligase. (wikipedia.org)
  • catalytic
  • The induction of stress either by glucose withdrawal or by treatment with rapamycin, stimulated degradation of proline and increased PRODH catalytic activity. (wikipedia.org)
  • The catalytic mechanism of proline racemase was late revisited by Buschiazzo, Goytia and collaborators that, in 2006, resolved the structure of the parasite TcPRAC co-crystallyzed with its known competitive inhibitor - pyrrole carboxylic acid (PYC). (wikipedia.org)
  • Mechanism
  • This degradative pathway generates glutamate and alpha-ketoglutarate, products that can play an anaplerotic role for the TCA cycle.The proline cycle is also in a metabolic interlock with the pentose phosphate pathway providing another bioenergetic mechanism. (wikipedia.org)
  • Therefore, the induction of the proline cycle under conditions of nutrient stress may be a mechanism by which cells switch to a catabolic mode for maintaining cellular energy levels. (wikipedia.org)
  • commonly
  • however, proline is commonly found as the first residue of an alpha helix and also in the edge strands of beta sheets. (wikipedia.org)
  • Proline is also commonly found in turns (another kind of secondary structure), and aids in the formation of beta turns. (wikipedia.org)
  • hydroxyproline
  • Based on those elements, enzymes incorrectly described as proline racemases were biochemically proved to be hydroxyproline epimerases (i.e. (wikipedia.org)
  • The second stage involves the abstraction of the pro-R hydrogen atom from C-4 of the proline substrate followed by radical combination, which yields hydroxyproline. (wikipedia.org)
  • include
  • All ProLine Media Centers include as standard Blu-ray movie playback and storage with Profile 2.0 capabilities, Vista Ultimate with SP1 and TV Pack and support up to four CableCard TV tuners for watching and recording HDTV cable channels. (hothardware.com)
  • Known aliases for PRR12 include "proline rich 12" and KIAA1205. (wikipedia.org)
  • novel
  • Novel proline racemases of medical and veterinary importance were described respectively in Clostridium difficile (Q17ZY4) and Trypanosoma vivax (B8LFE4). (wikipedia.org)
  • Detection of Novel Proline 3-Hydroxylase Activities in Streptomyces and Bacillus spp. (wikipedia.org)
  • Products
  • ProLine is a range of own brand electronic products made by Darty plc for BCC in the Netherlands, Darty in France and Vandenborre in Belgium. (wikipedia.org)
  • https
  • LEFT][URL="https://www.thomann.de/gb/thomann_didgeridoo_eucalyp_proline_d.htm"]Thomann Didgeridoo Eucalyp. (thomann.de)
  • transition
  • The zwitterionic character and the H-bonding of proline in the transition state plays an important role in explaining the reaction outcome. (wikipedia.org)
  • An enamine transition state is formed during the reaction and only one proline molecule is involved in forming the transition state. (wikipedia.org)
  • Proline racemase is inhibited by pyrrole-2-carboxylic acid, a transition state analogue that is flat like the transition state. (wikipedia.org)
  • active site
  • The proline racemase active site contains two general bases, each of them a Cys, located on either side of the alpha-carbon of the substrate. (wikipedia.org)
  • additional
  • Updates to the ProLine Series Media Centers add additional features and refresh hardware to bring more powerful digital entertainment capabilities to customers. (hothardware.com)
  • found
  • L-Proline has been found to act as a weak agonist of the glycine receptor and of both NMDA and non-NMDA (AMPA/kainate) ionotropic glutamate receptors. (wikipedia.org)
  • member
  • P500 Media Center ($5,999.00 list) - The newest member of the ProLine Series, the P500 includes three terabytes (2TB useable) of RAID 5 storage, HDMI (with 5.1 channel audio), DVI and component video. (hothardware.com)
  • offers
  • The ProLine offers premium high quality plastic blades, steel blades and steel discs with long life and high wear resistance for optimal performance. (atlascopco.com)
  • Proline offers a huge selection of guitar parts, all made with top-quality components, for today's most popular guitars. (musiciansfriend.com)
  • form
  • This can then either spontaneously cyclize to form 1-pyrroline-5-carboxylic acid, which is reduced to proline by pyrroline-5-carboxylate reductase (using NADH or NADPH), or turned into ornithine by ornithine aminotransferase, followed by cyclisation by ornithine cyclodeaminase to form proline. (wikipedia.org)
  • chain
  • This may account for the curious fact that proline is usually solvent-exposed, despite having a completely aliphatic side chain. (wikipedia.org)
  • role
  • At the present moment Proline Film Studio is working on two movies: «Arventur» by Irina Yevteeva and «The Role» by Konstantin Lopushansky. (wikipedia.org)