• Fibroblast growth factors, in concert with other growth factors, are key regulators of lens fiber cell differentiation. (nih.gov)
  • We show that loss of Erk1/2 in intestinal epithelial cells results in defects in nutrient absorption, epithelial cell migration, and secretory cell differentiation," the authors wrote. (genengnews.com)
  • Here we show that the in vivo administration of MPA triggers massive induction of the key osteoclast differentiation factor RANKL (receptor activator of NF-κB ligand) in mammary-gland epithelial cells. (nature.com)
  • whereas LREC in suprabasal epithelial layers are enriched for more committed progenitor cells, expressing some genes that are associated with stem cell attributes along with those indicative of cell differentiation. (frontiersin.org)
  • This dictates cycles of mammary growth, differentiation, lactation, and regression, during which mammary stem cells (MaSC) provide for the lineages of luminal and basal (myoepithelial) epithelial cells in the ducts and alveoli. (frontiersin.org)
  • The authors sought to identify mechanisms driving the differentiation of mucus cells during the bronchiolisation process. (bmj.com)
  • Methods Pathways governing airway mucus cell differentiation include SRY (sex determining region Y)-box 2 (SOX2), Notch, forkhead box A3(FOXA3)/SAM pointed domain containing ETS transcription factor (SPDEF), epidermal growth factor (EGF) and the EGF-related neuregulins NRG1α and NRG1β. (bmj.com)
  • Results In IPF, the bronchiolised and enlarged distal airspaces stained for SOX2 are consistent with epithelial differentiation characteristic of conducting airway epithelium. (bmj.com)
  • In this work, pathways governing mucus cell differentiation were investigated in lung tissues from patients with IPF and other chronic pulmonary disorders. (bmj.com)
  • Neuregulin1α, which drives mucus cell differentiation in vitro, was expressed in normal airway submucosal glands and in lungs from patients with IPF. (bmj.com)
  • Activation of abnormal respiratory epithelial differentiation programs may contribute to the expression of MUC5B and bronchiolisation of the distal lung, a salient feature of IPF. (bmj.com)
  • The hedgehog pathway regulates epithelial-mesenchymal interactions, differentiation, proliferation and survival during development. (rti.org)
  • performed in vivo lineage tracing studies to determine that expression of the keratin 15 promoter distinguishes a distinct basal stem cell population that is capable of self-renewal, proliferation, and differentiation into squamous-lineage cells. (jci.org)
  • The pattern of cellular growth has long been known, but it is the Italian developmental biologist Rita Levi-Montalcini and the American biochemist Stanley Cohen with their discovery of nerve growth factor (NGF) and epidermal growth factor (EGF), respectively, who could show how the growth and differentiation of a cell is regulated. (nobelprize.org)
  • This unique specialization of cells is termed differentiation. (nobelprize.org)
  • During tissue homeostasis and regeneration epithelial cells must balance proliferation, cell death and differentiation to maintain a functional organ. (ed.ac.uk)
  • Unbiased transcriptome analysis of muscles on day 7 postinjury revealed downregulated genes involved in cell differentiation and metabolic processes in Klf15KO muscles. (bvsalud.org)
  • The present study investigated the effects of GSK2606414 on proliferation, apoptosis, and the expression of activating transcription factor 4 (ATF4), CCAAT/enhancer‑binding protein homologous protein (CHOP) and vascular endothelial growth factor (VEGF) in human retinal pigment epithelial (RPE) cells under endoplasmic reticulum (ER) stress. (spandidos-publications.com)
  • GSK2606414 treatment inhibited RPE cell proliferation in a dose‑dependent manner, however it did not induce apoptosis. (spandidos-publications.com)
  • Disruption of PERK activity has been demonstrated to reduce hydroquinone-induced apoptosis and hypoxia-induced VEGF expression in human RPE cells in vitro ( 5 , 21 ). (spandidos-publications.com)
  • abstract = "Columnar cell hyperplasia (CCH) is the earliest histologically identifiable breast lesion linked to cancer progression and is characterized by increased proliferation, decreased apoptosis and elevated oestrogen receptor α (ERα) expression. (manchester.ac.uk)
  • RANK protects from radiation-induced epithelial apoptosis and controls mammosphere formation. (nature.com)
  • JAM3 knockdown additionally inhibited trophoblast proliferation and increased the number of trophoblasts in the sub-G1 and G2/M phases, indicating cell-cycle disturbance and apoptosis. (bioone.org)
  • The protective role of GB004 on barrier integrity was further supported by immunostaining experiments demonstrating that GB004 treatment protected epithelial cells from TNFa-induced cell apoptosis, improving both epithelial cell number and tight junction protein ZO-1 staining. (ecco-ibd.eu)
  • The two events, while occurring simultaneously but independently, likely provide a disadvantageous situation in which the newly emerging mesenchymal cell population is more likely to be resistant to apoptosis than the epithelial cell population from which the mesenchymal cell population stemmed. (molvis.org)
  • We also show that Int 407 cells produce CysLTs and blocking this autocrine signaling using three different CysLT1 receptor antagonists for longer time points led to attenuation in cell proliferation and induction of apoptosis in the cells. (lu.se)
  • Sesquiterpene lactones containing a 3-methylenedihydrofuran-2(3H)-one (or α-methylene-γ-lactone) moiety, for example damsin (1), are Michael acceptors that affect biological processes such as cell proliferation, death/apoptosis, and cell migration, by interfering with cell signalling pathways. (lu.se)
  • When DNA becomes damaged, p53 helps determine whether the DNA will be repaired or the cell will self-destruct ( undergo apoptosis ). (medlineplus.gov)
  • 0.01) in the epithelium of subjects with severe asthma as compared with normal subjects, indicating increased cellular proliferation. (atsjournals.org)
  • In subjects with severe asthma, as compared with subjects with mild asthma, normal subjects, and diseased control subjects, we found novel evidence of increased cellular proliferation in the airway contributing to a thickened epithelium and LR. (atsjournals.org)
  • In severe asthma, there is increased cellular proliferation in the airway contributing to a thickened epithelium and lamina reticularis. (atsjournals.org)
  • Immunofluorescent staining of intestinal epithelium tissue shows cell growth (green). (genengnews.com)
  • We isolated four categories of cells from mammary epithelium of female calves: bromodeoxyuridine label retaining epithelial cells (LREC) from basal (LRECb) and embedded layers (LRECe), and epithelial control cells from basal and embedded layers. (frontiersin.org)
  • The stratified organization of the epithelium restricts proliferative cells to the basal layer, and these cells must migrate toward the lumen as they differentiate. (jci.org)
  • The esophageal lumen is lined by a stratified squamous epithelium comprised of proliferative basal cells that differentiate while migrating toward the luminal surface and eventually desquamate. (jci.org)
  • Herein, we have described a long-lived progenitor cell population in the mouse esophageal epithelium that is characterized by expression of keratin 15 ( Krt15 ). (jci.org)
  • Depletion of Krt15 -derived cells resulted in decreased proliferation, thereby leading to atrophy of the esophageal epithelium. (jci.org)
  • These results establish the presence of a long-lived and indispensable Krt15 + progenitor cell population that provides additional perspective on esophageal epithelial biology and the widely prevalent diseases that afflict this epithelium. (jci.org)
  • In the human Repligut intestinal epithelium assay, GB004 significantly reduced cell death and improved barrier integrity in response to pro-inflammatory cytokines. (ecco-ibd.eu)
  • To study oral hyperplastic epithelium, dysplastic epithelium and squamous cell carcinoma todetermine (1) the prevalence of p53 protein immunoreactivity, (2) number of p53 positive cells, and (3) the area of localization of p53 protein immunoreactivity. (bvsalud.org)
  • Two contiguous sections from 30 tissue specimens (10 each from oral hyperplastic epithelium, dysplastic epithelium and squamous cell carcinoma) were subjected to hematoxylin and eosin (H/E) staining for histopathological diagnosis and immunohistochemical (IHC) staining for demonstration of p53. (bvsalud.org)
  • The localization of these p53 positive cells within the strata (i.e. basal/suprabasal, spinous and superficial layers) of epithelium between 3 groups, and also within each group according to histological grades was recorded. (bvsalud.org)
  • However the quantitative analysis of p53 positive cells and their localization in oral epithelium is of importance as a marker for oral squamous cell carcinoma. (bvsalud.org)
  • Formaldehyde-induced nasal squamous cell carcinomas in rats normally lined by squamous epithelium. (cdc.gov)
  • Other intrinsic risk factors include the susceptibility of some subpopulations of fibroblasts and keratinocytes to phenytoin, cyclosporine, and/or nifedipine, and the number of Langerhans cells present in oral epithelium. (medscape.com)
  • Reconstitution of eroded or injured EPITHELIUM by proliferation and migration of EPITHELIAL CELLS from below or adjacent to the damaged site. (bvsalud.org)
  • Ectopic expression of PRL-3 reduced cell capacity for anchorage-dependent growth, anchorage-independent growth, migration, and invasion in vitro , as well as tumorigenesis in vivo . (oncotarget.com)
  • Regulation of cancer cell migration and bone metastasis by RANKL. (nature.com)
  • PDZK1IP1 gene promotes proliferation, migration, and invasion in papillary thyroid carcinoma. (nih.gov)
  • We investigated the effects of LTD4 in bringing about changes in survival, proliferation and migration of these cells, all of which are hallmarks of cancer. (lu.se)
  • LTD4 stimulation also led to significant enhancement of cell migration in a PI3K and Rac-dependent manner. (lu.se)
  • MiR-132 was upregulated in the stroma surrounding CCH compared to stoma surrounding normal terminal duct lobular units (TDLUs), and overexpression of miR-132 in immortalized fibroblasts and in fibroblasts co-cultured with epithelial CCH cells caused substantial expression changes of genes involved in metabolism, DNA damage and cell motility. (manchester.ac.uk)
  • The collagen content of the BTC and cellular proliferation of fibroblasts were assessed using colorimetric assays. (researchgate.net)
  • Results: No significant effect on cellular proliferation was noted with the addition of AMA to fibroblasts in culture (p = 0.7). (researchgate.net)
  • Using real-time, quantitative PCR, laser capture microdissection, and immunohistochemistry, distinctive patterns of expression of the hedgehog pathway members patched 1 (PTCH1), smoothened, GLI1, GLI2 and the 3 hedgehog ligands were identified for epithelial cells and stromal fibroblasts in benign breast and breast cancer. (rti.org)
  • However, cyclopamine reduced viability of cancer epithelial cell lines, including MDA-MB-435, but did not specifically affect fibroblasts or epithelial cells from benign breast, including MCF10AT. (rti.org)
  • In the liver, this regulation requires the constant integration of signals by epithelial cells from non-epithelial, niche cells, which includes inflammatory cells and fibroblasts. (ed.ac.uk)
  • Several studies have shown that the interaction of phenytoin, cyclosporine, and nifedipine with epithelial keratinocytes, fibroblasts, and collagen can lead to an overgrowth of gingival tissue in susceptible individuals. (medscape.com)
  • that is histopathological y very simi- T cel s, B cel s, natural kil er cel s, LMP1 of EBV can transform ro- lar to that caused by hepatitis B vi- macrophages, and dendritic cells, dent fibroblasts and is expressed rus (HBV) in humans, but it does so and this humanized mouse model in most of the human cancers as- through a different mechanism. (who.int)
  • Since epithelial-to-mesenchymal transition (EMT) and the acquisition of cancer stem cell traits are important for cancer onset and progression, we sought to determine the role of AUF1 in these two important processes. (nature.com)
  • Microarray profiling of PRL-3 transfectants revealed the pathways potentially involving PRL-3, including the epithelial-mesenchymal transition (EMT), extracellular matrix remodeling, and the WNT signaling pathway. (oncotarget.com)
  • Wu M, Sun Y, Xu F, Liang Y, Liu H, Yi Y. Annexin A2 Silencing Inhibits Proliferation and Epithelial-to-mesenchymal Transition through p53-Dependent Pathway in NSCLCs. (jcancer.org)
  • Mechanistically, our studies showed that knockdown of Annexin A2 increased the expression of p53, which in turn, induced cell cycle G2 arrest and inhibited epithelial-to-mesenchymal transition (EMT). (jcancer.org)
  • The purpose of this study was to identify potential therapeutic strategies to slow down or prevent the expression of early-onset epithelial to mesenchymal transition (EMT) marker proteins (fibronectin and alpha smooth muscle actin, α-SMA) without sacrificing the synthesis and accumulation of the prosurvival protein vascular endothelial growth factor (VEGF) in cultured virally transformed human lens epithelial (HLE) cells. (molvis.org)
  • Adherens junctions (AJs) are required for suppressing this epithelial-mesenchymal transition (EMT) but less is known about the role of tight junctions (TJs) in this process. (jci.org)
  • Through phenotypical analysis, we find epithelial mesenchymal transition and. (lu.se)
  • Through phenotypical analysis, we find epithelial mesenchymal transition and proliferation associated with the immune clusters and mutually exclusive in breast cancers. (lu.se)
  • We previously reported that importin 13 (IPO13), a member of the importin-β family of nuclear import proteins, regulates nuclear import of the glucocorticoid receptor in airway epithelial cells, IPO13 serves as a potential marker for corneal epithelial progenitor cells, and IPO13 is associated with corneal cell proliferation. (molvis.org)
  • Epithelial Sodium Channel Regulates Adult Neural Stem Cell Proliferation in a Flow-Dependent Manner. (oeaw.ac.at)
  • Immune cell infiltration in response to myocyte death regulates extracellular matrix remodeling and scar formation after myocardial infarction (MI). (bvsalud.org)
  • The protein regulates cell growth and division by monitoring DNA damage. (medlineplus.gov)
  • Increasing attention is now being directed at the network of signaling pathways that effect the EMT in lens epithelial cells, with the aim of identifying potential therapeutic targets to inhibit cataract, particularly PCO, which remains a significant clinical problem in ophthalmology. (nih.gov)
  • Conversely, catalytic (C104S) and prenylation-site (C170S) mutants enhanced cell invasion. (oncotarget.com)
  • Annexin A2 has been involved in cancer cell adhesion, invasion and metastasis. (jcancer.org)
  • Moreover, we found that knockdown of Annexin A2 significantly suppressed cell proliferation and invasion of NSCLCs cells. (jcancer.org)
  • Extensive researches demonstrate that Annexin A2 plays important roles in tumor proliferation, invasion and metastasis [ 12 - 14 ]. (jcancer.org)
  • Knockdown of Annexin A2 significantly suppressed cell proliferation and invasion of NSCLCs cells, and the biological effect of Annexin A2 on proliferation and invasion was mediated by the inhibition of p53, which in turn, promoted cell cycle progression and EMT. (jcancer.org)
  • Here, we have investigated the role of ChoK in the development of breast cancer and found that ChoK is both necessary and sufficient for growth factor-induced proliferation in primary human mammary epithelial cells and an absolute requirement for the specific mitogenic response to heregulin in breast tumor-derived cells. (aacrjournals.org)
  • These results demonstrate that ChoK plays an essential role in both normal human mammary epithelial cell proliferation and breast tumor progression. (aacrjournals.org)
  • Ectopic expression of AUF1 also promoted stemness in mammary epithelial cells, and thereby increased the proportion of cancer stem cells. (nature.com)
  • These data prompted us to ask whether AUF1 upregulation could promote EMT as well as stemness in mammary epithelial cells. (nature.com)
  • Genetic inactivation of the RANKL receptor RANK in mammary-gland epithelial cells prevents MPA-induced epithelial proliferation, impairs expansion of the CD49f hi stem-cell-enriched population, and sensitizes these cells to DNA-damage-induced cell death. (nature.com)
  • Previous molecular characterizations of mammary stem cells (MaSC) have utilized fluorescence-activated cell sorting or in vitro cultivation of cells from enzymatically dissociated tissue to enrich for MaSC. (frontiersin.org)
  • During rapid mammary growth in the mouse, label retaining epithelial cells (LREC) appear to retain label by asymmetric distribution of DNA strands, as evidenced by a rapid proliferation index of the LREC ( Smith, 2005 ). (frontiersin.org)
  • During periods of low mammary proliferation, quiescence of the stem cell population may account for retention of label. (frontiersin.org)
  • The LREC in bovine mammary gland appeared to have a modest proliferation rate in which 5.4% of LREC co-expressed Ki-67 ( Capuco, 2007 ). (frontiersin.org)
  • These approaches result in the loss of all histological information pertaining to the in vivo locale of MaSC and progenitor cells. (frontiersin.org)
  • Instead, we used laser microdissection to excise putative progenitor cells and control cells from their in situ locations in cryosections and characterized the molecular properties of these cells. (frontiersin.org)
  • MaSC/progenitor cells were identified based on their ability to retain bromodeoxyuridine for an extended period. (frontiersin.org)
  • To the best of our knowledge, the present study is the first to demonstrate that GSK2606414 has a potential antiproliferative effect in RPE cells in vitro. (spandidos-publications.com)
  • Evaluation of the efficacy of proposed agents in an in vitro model is convenient and allows assessment of the mechanical properties of the bone-tendon interface as well as the effect on fibroblast proliferation and collagen content of the tissue. (researchgate.net)
  • In vitro bioassay for dioxinlike activity based on alterations in epithelial cell proliferation and morphology. (cdc.gov)
  • Their self-renewing potential was investigated by colony forming cells assays and in vitro organotypic culture models. (who.int)
  • Conversely, interfering with BVES function by expressing a dominant-negative mutant in human corneal epithelial cells induced mesenchymal features. (jci.org)
  • We have shown that AUF1 induces EMT and stemness in breast epithelial cells via stabilization of the SNAIL1 and TWIST1 mRNAs, and their consequent upregulation. (nature.com)
  • In this investigation, the cytotoxicity of 23 α-methylene-γ-lactones towards normal breast epithelial MCF-10A cells as well as breast cancer JIMT-1 cells is compared. (lu.se)
  • The miRNA signatures identified in CCH indicate early changes in the epithelial and stromal compartment of CCH and could represent early key alterations in breast cancer progression that potentially could be targeted in novel prevention or treatment schedules. (manchester.ac.uk)
  • Any process that increases the rate, frequency or extent of epithelial cell proliferation that contributes to the progression of the prostate gland over time. (planteome.org)
  • These findings support the development of a potentially relevant therapeutic strategy to undermine the progression of normal cells to the mesenchymal phenotype in the naturally hypoxic lens without subverting cell viability. (molvis.org)
  • The acquisition of a mesenchymal phenotype is a critical step in the metastatic progression of epithelial carcinomas. (jci.org)
  • Enriched expression of genes in LRECb was associated with stem cell attributes and identified WNT, TGF-β, and MAPK pathways of self renewal and proliferation. (frontiersin.org)
  • Barrier integrity was assessed by Transepithelial Endothelial Electric Resistance (TEER), HIF-1a target genes were assessed in cell lysates, and tight junction formation and epithelial monolayer viability were investigated by immunofluorescence staining. (ecco-ibd.eu)
  • Inoculation with a high dose strains of LMP1 transgenic mice vide a powerful tool in mechanistic of EBV caused a B-cell lymphopro- were established that express LMP1 studies on the role of individual viral liferative disorder in these mice, under the control of the immunoglob- genes in cancer. (who.int)
  • Cancers occur when genetic mutations build up in critical genes, specifically those that control cell growth and division (proliferation) or the repair of damaged DNA. (medlineplus.gov)
  • Somatic mutations in many different genes have been found in lung cancer cells. (medlineplus.gov)
  • The EGFR and KRAS genes each provide instructions for making a protein that is embedded within the cell membrane. (medlineplus.gov)
  • Although the precise underlying mechanisms of AMD are not fully understood, numerous lines of evidence have indicated that endoplasmic reticulum (ER) stress contributes to the etiology of RPE cell damage and neovascularization formation ( 5 - 7 ). (spandidos-publications.com)
  • These results demonstrate modulation of GLI-mediated transcription in both cancer and benign-derived epithelial cells by cyclopamine and sonic hedgehog, and further suggest that hedgehog signaling contributes to the survival of only the cancer epithelial cells. (rti.org)
  • The signaling pathways involved in initiating the EMT seem to primarily involve the Smad-dependent pathway, whereby TGFbeta binding to specific high affinity cell surface receptors activates the receptor-Smad/Smad4 complex. (nih.gov)
  • The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
  • Furthermore, targeting both pathways causes a more effective suppression of cell proliferation in murine intestinal organoids and human CRC lines. (genengnews.com)
  • Human lens epithelial (HLE) cells survive under hypoxia through complex and interactive signal transduction pathways whose mechanisms of action are not well understood. (molvis.org)
  • When these proteins are turned on (activated) by binding to other molecules, signaling pathways are triggered within cells that promote cell proliferation. (medlineplus.gov)
  • The ERK pathway plays a critical role in embryonic development and tissue repair because it instructs cells to multiply and start dividing, but when overactivated cancer growth often occurs. (genengnews.com)
  • Cell proliferation was assessed using the Cell Counting kit‑8 cell viability assay. (spandidos-publications.com)
  • Biomarkers, cell viability and proliferation were assessed. (ecco-ibd.eu)
  • How mixtures of immune cells associate with cancer cell phenotype and affect pathogenesis is still unclear. (lu.se)
  • In bronchial biopsies from 21 normal subjects, 11 subjects with chronic bronchitis, 9 subjects with mild asthma, and 31 subjects with severe asthma, we evaluated epithelial cell morphology: epithelial thickness, lamina reticularis (LR) thickness, and epithelial desquamation. (atsjournals.org)
  • Have a function in the morphogenesis like tracheal morphology that regulate the cell size and the cell length. (wikipedia.org)
  • Although wild-type mice displayed normal morphology 15 days after injury, tissue regeneration remained incomplete in mice lacking keratin 15 + cells. (jci.org)
  • Here we have defined novel epithelial as well as stromal miRNA signatures from columnar cell hyperplasia lesions compared to normal terminal duct lobular units by using microdissection and miRNA microarrays. (manchester.ac.uk)
  • Pulmonary lesions were most severe in rats, where progressive epithelial- and fibroproliferative changes were observed in the particle overload 250 mg/m3 group. (ecetoc.org)
  • Aspects of cell proliferation in oral epithelial dysplastic lesions. (bvsalud.org)
  • Site-specificity of and cell proliferation would allow DPX and cell proliferation formaldehyde-induced lesions in rats and monkeys implicates data to be interpolated from measurement sites to the rest of the regional tissue susceptibility and dose as factors potentially nasal passage. (cdc.gov)
  • Large cell carcinoma encompasses non-small cell lung cancers that do not appear to be adenocarcinomas or squamous cell carcinomas. (medlineplus.gov)
  • Cell turnover is increased in ulcerative proctocolitis, which might therefore respond to vitamin D3 metabolites. (uea.ac.uk)
  • The findings from this study were published recently in Nature Communications in an article entitled "ERK5 Signalling Rescues Intestinal Epithelial Turnover and Tumour Cell Proliferation upon ERK1/2 Abrogation. (genengnews.com)
  • Biopsies have demonstrated a measurable repopulation of goblet cells and a decrease in both conjunctival epithelial cell turnover and the number of lymphocytes. (aao.org)
  • Hantavirus titers were high, and we demonstrated virus in macrophages and gill endothelial cells by using in situ hybridization. (cdc.gov)
  • Myeloid immune cells, specifically tumor-associated macrophages (TAMs), may represent potential novel therapeutic targets in HCC, complementing current ablative or immune therapies. (cancerindex.org)
  • Subsequently, we demonstrated that Card9 overexpression increased LCN2 expression, while Card9 KO inhibited necrotic cell-induced LCN2 upregulation in macrophages, likely through NF-κB. (bvsalud.org)
  • Genetic in vivo lineage tracing revealed that the Krt15 promoter marks a long-lived basal cell population able to self-renew, proliferate, and generate differentiated cells, consistent with a progenitor/stem cell population. (jci.org)
  • Transcriptional profiling demonstrated that Krt15 + basal cells are molecularly distinct from Krt15 - basal cells. (jci.org)
  • The expression of p53 in epithelial hyperkeratosis was mainly localized to basal epithelial cells whereas in epithelial dysplasia, it was predominantly localized to spinous epithelial cells. (bvsalud.org)
  • These antibodies are used as fluorescent markers to distinguish subsets of mouse thymic epithelial cells in genetic studies of the thymus . (wikipedia.org)
  • However, he begins from a single cell which contains the genetic material coding for the complete individual. (nobelprize.org)
  • In nearly all cases of lung cancer, these genetic changes are acquired during a person's lifetime and are present only in certain cells in the lung. (medlineplus.gov)
  • In rare cases, the genetic change is inherited and is present in all the body's cells (germline mutations). (medlineplus.gov)
  • Let-7c were among the identified downregulated epithelial miRNAs and its functions were delineated in unique CCH derived cells and breast cancer cell line MCF-7 suggesting anti-proliferative traits potentially due to effects on Myb and ERα. (manchester.ac.uk)
  • Levels of retinoblastoma protein (Rb), Ki67, and Bcl-2 were measured, reflecting cellular proliferation and death. (atsjournals.org)
  • Although intraductal papillomas (IDPs) are benign, they are occasionally involved by a monomorphic, atypical cellular proliferation, morphologically identical to ductal carcinoma in situ (DCIS) or atypical ductal hyperplasia (ADH). (medscape.com)
  • Some diagnose atypical papilloma (also known as papilloma with atypia) if the monomorphic cellular proliferation is smaller than 3 mm in greatest dimension and is low grade, and diagnose DCIS involving a papilloma if the proliferation is 3 mm or larger or is intermediate to high grade. (medscape.com)
  • [ 1 , 2 ] Others advocate the diagnosis of DCIS involving a papilloma irrespective of the size and grade of the atypical cellular proliferation. (medscape.com)
  • Large/central IDP subtypes (L/C ST) may be involved by complex, crowded benign cellular proliferations involved by varying degrees of apocrine metaplasia, which can mimic the histologic features of DCIS (see Microscopic Findings ). (medscape.com)
  • Several studies have shown IDPs involved by suspicious cellular proliferations seen on CNB are more commonly associated with cancer upon excision than IDPs without atypia diagnosed on CNB (see Prognosis and Predictive Factors ). (medscape.com)
  • However, intestinal epithelial cell proliferation is not impeded, implying compensatory mechanisms. (genengnews.com)
  • In this context, in the present study, we examined if exposure of non-transformed intestinal cells to LTD4, a well known inflammatory mediator would make the cells more sensitive to transformation. (lu.se)
  • We observed that stimulation of intestinal epithelial cell line, Int 407 with LTD4 led to enhanced cell survival and proliferation through the activation of series of signaling cascades like Ras, Erk-1/2, p90RSK, and CREB. (lu.se)
  • This suggest that LTD4 signaling through CysLT1 receptor is some how crucial for normal maintenance of intestinal epithelial cells. (lu.se)
  • Airway epithelial and LR thickness was greater in subjects with severe asthma compared with those with mild asthma, normal subjects, and diseased control subjects (p = 0.009 and 0.033, respectively). (atsjournals.org)
  • There was a greater level of apoptotic activity in the airway biopsy in subjects with severe asthma as compared with the normal subjects using the TUNEL assay (p = 0.002), suggesting increased cell death. (atsjournals.org)
  • Conclusion Expression of SOX2 and MUC5B and lack of SPDEF in atypically differentiated cells of bronchiolised distal airspaces are consistent with abnormal programming of airway epithelial cells in IPF. (bmj.com)
  • Hedgehog-mediated transcription, as indicated by a reporter of GLI-dependent promoter activity and by expression of GLI1 transcripts, was reduced by the hedgehog pathway inhibitor cyclopamine in both MDA-MB-435 cancer epithelial cells and MCF10AT epithelial cells, a cell line derived from benign breast. (rti.org)
  • Molecular Cell Biology. (wikipedia.org)
  • Our results support the use of DNA label retention to identify MaSC and also provide a molecular profile and novel candidate markers for these cells. (frontiersin.org)
  • Background: Vestigial like family member 3 (VGLL3) is associated with the prognosis of epithelial ovarian cancer and soft tissue sarcoma, but its role in gastric cancer (GC) is unclear. (researchgate.net)
  • Further, Krt15 + cells were radioresistant and contributed to esophageal epithelial regeneration following radiation-induced injury. (jci.org)
  • The Journal of Cell Biology. (wikipedia.org)
  • Insights into the biology of stem cells will be gained by confirmation and characterization of candidate MaSC markers identified in this study. (frontiersin.org)
  • In addition, GSK2606414 treatment inhibited eIF2α phosphorylation and reduced CHOP and VEGF mRNA expression levels in RPE cells under TG‑induced ER stress. (spandidos-publications.com)
  • Our studies showed that the expression of PRL-3 mRNA and protein are higher in less invasive human lung adenocarcinoma cells than in highly invasive cell lines. (oncotarget.com)
  • ARPE‑19 human RPE cells were treated with 0.01‑50 µM GSK2606414, and ER stress was induced by thapsigargin (TG) treatment. (spandidos-publications.com)
  • Vitamin D3 reduces human rectal crypt cell production rate (CCPR) and may thereby protect against colorectal cancer. (uea.ac.uk)
  • Results showed that in cultured human-derived retinal pigment epithelial ARPE-19 cells , the extract of Chlorella zofingiensis and its nutritional ingredient astaxanthin exhibited significant inhibitory effects on the formation of endogenous N ε -carboxymethyllysine (CML), a key AGE representative, through the suppression of intracellular oxidative stress. (rsc.org)
  • However, the role and function of PRL-3 in human non-small cell lung cancer cells is unknown. (oncotarget.com)
  • The exciting part of this new study is investigators found that treating both ERK1/2 and the compensatory pathway ERK5 concomitantly with a combination of drug inhibitors halted CRC growth more effectively in both mouse models and human CRC cell lines. (genengnews.com)
  • The researchers were excited by their findings but urged caution at over interpretation of their initial findings and suggested that other classes of inhibitors be tested in combination with ERK5 inhibitors in human CRC cells in preclinical mouse models before any patient trial can begin. (genengnews.com)
  • In this study, we showed that Annexin A2 was evidently overexpressed in human NSCLCs cell lines and NSCLCs tissues. (jcancer.org)
  • Here we investigated gene expression and secretion of soluble factors elicited by GB004 treatment on immune cells and epithelial cells, human monolayer assays and immune co-culture studies to further explore its protective mechanism. (ecco-ibd.eu)
  • In the BioMAP human co-culture assay, cells were treated with GB004 one hour prior to stimulation and incubated for 24-168 hours. (ecco-ibd.eu)
  • Repligut human stem-cell-derived monolayer platforms were used to assess GB004 effects under unstimulated or TNFa stimulation conditions. (ecco-ibd.eu)
  • Furthermore, GB004 demonstrates protective effects on human derived monolayer cultures by reducing cell death, promoting tight junction formation, and improving barrier integrity. (ecco-ibd.eu)
  • Animal models for human tumour mental animals is not easy to answer does induce adult T-cell leukaemia/ viruses that make use of animal virus- for these agents, because cancer bi- lymphoma (ATLL), albeit in monkeys es are scarce. (who.int)
  • In addition, RPE cells proliferate and secrete various proangiogenic factors, including vascular endothelial growth factor (VEGF), which serves an important role in AMD-associated CNV ( 4 ). (spandidos-publications.com)
  • Enzyme-linked immunosorbent assay (ELISA) was used to measure the levels of VEGF in cell culture medium. (molvis.org)
  • The two cell lines were treated with various concentrations of the compounds in dose response assays, and the 50 % inhibitory concentration (IC50) was determined from dose response curves. (lu.se)
  • In a normal mouse model (left), cell growth is controlled, but in a mouse model with the ERK1/2 pathway blocked (right) increased cell proliferation and loss of organization occurred. (genengnews.com)
  • The UCSD team found that an alternative pathway immediately emerges when ERK1/2 is halted, thus allowing tumor cell proliferation to continue. (genengnews.com)
  • Since we were genetically deleting the ERK1/2 pathway, we expected to see less cell proliferation," explained co-lead study author Petrus R. de Jong, M.D., Ph.D., translational scientist at Sanford Burnham Prebys Medical Discovery Institute. (genengnews.com)
  • Therapies aimed at targeting ERK1/2 likely fail because this mechanism is allowing proliferation through a different pathway," noted senior study author Eyal Raz, M.D., professor of medicine at UC San Diego School of Medicine. (genengnews.com)
  • This is an underappreciated escape pathway for tumor cells. (genengnews.com)
  • If you block one pathway, cancer cells usually mutate and find another pathway that ultimately allows for a recurrence of cancer growth," remarked co-lead study author Koji Taniguchi, M.D., Ph.D., senior researcher at the Keio University School of Medicine in Tokyo. (genengnews.com)
  • Here we investigated the role of IPO13 in the pathogenesis of pterygium and the underlying mechanism including interaction with other cell proliferation-related factors: keratin 17 (K17), a lesional protein and a member of the type I keratins, and c-Jun, a protein of the activator protein-1 complex. (molvis.org)
  • Keratin also protects epithelial cells from damage or stress. (wikipedia.org)
  • This week in the JCI , a study led by Anil Rustgi at the University of Pennsylvania identifies keratin 15 as a marker for a subpopulation of proliferative stem cells in the esophagus that are indispensible for maintaining homeostasis as well as regenerating tissue following injury. (jci.org)
  • These findings indicate that keratin 15 + progenitors give rise to a population of squamous epithelial cells that are critical to recovery from injury and disease. (jci.org)
  • Stimulation of hedgehog signaling induces carcinogenesis or promotes cell survival in cancers of multiple organs. (rti.org)
  • NSCLCs including adenocarcinoma, squamous cell carcinoma and large cell carcinoma, constitute 80% of all lung cancers [ 2 ]. (jcancer.org)
  • Higher p53 positive cell counts were demonstrated in oral squamous cell carcinoma compared to hyperplastic and dysplastic tissues. (bvsalud.org)
  • Prognostic significance of p53 expression in oral squamous cell carcinoma without neck node metastases. (bvsalud.org)
  • early event of malignant transformation and has a predictive value for developing oral squamous cell carcinoma. (bvsalud.org)
  • preneoplastic oral lesion and oral squamous cell carcinoma. (bvsalud.org)
  • 9. Iamaroon A, Khemaleelakul U, Pongsiriwet S, Pintong J. Co-expression of p53 and Ki67 and lack of EBV expression in oral squamous cell carcinoma. (bvsalud.org)
  • Expression of p53 in leukoplakia and squamous cell carcinoma of the oral mucosa: correlation with expression of Ki67. (bvsalud.org)
  • Non-small cell lung cancer is divided into three main subtypes: adenocarcinoma, squamous cell carcinoma, and large cell lung carcinoma. (medlineplus.gov)
  • Moreover, AUF1 knockdown sensitized breast cancer cells to the killing effect of cisplatin. (nature.com)
  • In cultured PECs, overexpression or knockdown of the IPO13 gene increased or decreased PEC proliferation, respectively. (molvis.org)
  • The protein encoded by this gene is a mitogen-inducible monokine and is one of the major HIV-suppressive factors produced by CD8+ T-cells. (cancerindex.org)
  • The TP53 gene provides instructions for making a protein, called p53, that is located in the nucleus of cells throughout the body, where it attaches (binds) directly to DNA. (medlineplus.gov)
  • Pterygium epithelial cells (PECs) were cultured in keratinocyte serum-free defined medium to examine the expression of IPO13 and K17. (molvis.org)
  • JAM3 expression in cell-cell junctions decreased with the formation of syncytiotrophoblasts. (bioone.org)
  • Furthermore, H 2 O 2 -induced oxidative stress reduced JAM3 expression in trophoblasts and cell culture supernatants. (bioone.org)
  • Similarly, the majority of CRC cell lines tested exhibited decreased BVES expression and promoter DNA hypermethylation, a modification associated with transcriptional silencing. (jci.org)
  • Treatment with a DNA-demethylating agent restored BVES expression in CRC cell lines, indicating that methylation represses BVES expression. (jci.org)
  • DESIGN: Proliferation, mitosis and the expression of progenitor lineage markers were assessed in normal squamous oesophagus from 10 patients by immunofluorescence on 3D epithelial whole mounts. (who.int)
  • Expression of cell cycle proteins in head and neck cancer correlates with tumour site rather than tobacco use. (bvsalud.org)
  • Associated with these foci of epithelial proliferation were interstitial particle accumulation and alveolar septal fibrosis. (ecetoc.org)
  • In orthodontic patients, gingival overgrowth has been suggested to be due to nickel accumulation and epithelial cell proliferation. (medscape.com)
  • Similar to the results reported in the interspecies, pigment-grade TiO2 study, progressive epithelial and fibro proliferative changes were observed in rats exposed to 10 mg/m3 TiO2 particles. (ecetoc.org)
  • These results show that LMP1 , mour viruses classified by IARC in EBV-specific T-cell response. (who.int)
  • The 4x and 10x objectives can obtain images of cells grown on standard tissue culture well plates. (sheffield.ac.uk)