Proliferating Cell Nuclear AntigenCell ProliferationCell DeathApoptosisCause of DeathCells, CulturedCell SurvivalSignal TransductionCell Line, TumorCaspasesDeathCell DivisionCell CycleCell LineCell DifferentiationCaspase 3Proto-Oncogene Proteins c-bcl-2NecrosisMice, Inbred C57BLBlotting, WesternIn Situ Nick-End LabelingTime FactorsDNA FragmentationRNA, MessengerTumor Cells, CulturedImmunohistochemistryEnzyme ActivationMitochondriaFlow CytometryMice, KnockoutRNA, Small InterferingLymphocyte ActivationAutophagyPhosphorylationDose-Response Relationship, DrugTransfectionReactive Oxygen SpeciesReverse Transcriptase Polymerase Chain ReactionBromodeoxyuridinebcl-2-Associated X ProteinGene Expression RegulationCell MovementDown-RegulationCaspase InhibitorsMice, TransgenicProto-Oncogene ProteinsT-LymphocytesEnzyme InhibitorsNeuronsAntigens, CD95Antineoplastic AgentsDeath, Sudden, CardiacFibroblastsUp-RegulationTumor Suppressor Protein p53Molecular Sequence DataGene ExpressionMutationGene Expression Regulation, NeoplasticModels, BiologicalRNA InterferenceEpithelial CellsCell CountApoptosis Regulatory ProteinsRats, Sprague-DawleyStem CellsKi-67 AntigenProto-Oncogene Proteins c-aktTranscription FactorsDisease Models, AnimalBrain DeathMice, Inbred BALB CAmino Acid Chloromethyl KetonesDNA-Binding ProteinsProtein-Serine-Threonine KinasesPoly(ADP-ribose) PolymerasesNeoplasmsFas Ligand ProteinCaspase 8Mice, NudeCytochromes cMembrane Proteinsbcl-X ProteinCell Growth ProcessesPhenotypeCaspase 9Fetal DeathCysteine Proteinase InhibitorsBase SequenceDNARecombinant ProteinsCell NucleusGene Expression Regulation, DevelopmentalAmino Acid SequenceExtracellular Signal-Regulated MAP KinasesMitogen-Activated Protein KinasesNuclear ProteinsCell Cycle ProteinsHydrogen PeroxideTumor Necrosis Factor-alpha